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Just launched! The new Advocate Newsletter More Here

View the latest Fall 2019 Group Meeting Schedule Here

Registration for the Fall 2019 Group Meeting remains open More Here

Just announced! 

The First Robert L. Comis, MD Translational Science Symposium
Big Data and AI in ECOG-ACRIN: Directions for Cancer Research
Thursday, October 24, 12:00 – 3:30 PM
More Here


Don’t miss the September newsletter More Here 

Accepting ComboMATCH concept sheets until further notice More Here

New! Do you know about the new TMIST newsletter More Here 

Latest News

TAILORx: New data are published September 30, 2019 in JAMA Oncology and orally presented at the European Society for Medical Oncology (ESMO) 2019 Congress. This is the fourth peer-reviewed publication for TAILORx, which continues to define new standards in early breast cancer. More Here


The results of leukemia trial E1912 are published in The New England Journal of Medicine. Tait Shanafelt, MD (Stanford University) and colleagues report that treatment with the combination of ibrutinib and rituximab is superior to standard treatment for patients 70 years of age or younger, with chronic lymphocytic leukemia (CLL) More Here 


The Journal of Clinical Oncology has published the results of the ACRIN 6685 trial. Val J. Lowe, MD (Mayo Clinic) and colleagues report that surgical planning for head and neck cancer benefits from FDG-PET/CT, especially in patients who are clinically node-negative  More Here


San Antonio Breast Cancer Symposium honors ECOG-ACRIN vice chair Joseph A. Sparano, MD with its prestigious William L. McGuire Memorial Lecture Award More Here




Amy Curtis, MD (Spartanburg Medical Center): Women are intrigued by the many questions asked in TMIST Conversation with The Cancer Letter




  • ASCO updates guidelines for early breast cancer based on TAILORx, MINDACT trials News Article

  • TAILORx data guides adjuvant therapy in younger breast cancer patients Press Release

  • The New England Journal of Medicine publishes analysis of a pre-specified secondary analysis that adds new information to the original TAILORx findings NEJM Article

  • “The Precision of Evidence Needed to Practice “Precision Medicine” NEJM Accompanying Editorial

  • Updated ASCO guidelines establish TAILORx-defined cutoffs for determining chemotherapy benefit with the Oncotype DX Breast Recurrence Score® test in node-negative breast cancer Press Release

  • One Year Post-TAILORx: Attitudes Shift and Questions Linger in Breast Cancer Recurrence Testing GenomeWeb (requires free registration) 

  • Using Genomic Profiling to Guide Treatment Decisions for ER-Positive Breast Cancers, by Harold J. Burstein, MD, PhD CancerNetwork

  • New TAILORx Data Provide Treatment Guidance for Women Under 50 With Early Breast Cancer The ASCO Post


  • Arm H finds the combination of dabrafenib and trametinib effective in a heavily pre-treated cohort of 17 distinct tumor types–several rare–with BRAF mutations Press Release

  • Keith Flaherty, MD, ECOG-ACRIN study chair, comments on targeted drugs in an article on basket trials published in Xconomy National


  • Final results show no benefit from pazopanib in advanced kidney cancer after surgery to remove metastases Press Release

  • ASCO 2019: Randomized, Double-Blind Phase III Study of Pazopanib versus Placebo in Patients with Metastatic Renal Cell Carcinoma who have no Evidence of Disease Following Metastasectomy – Medical Oncologist Perspective UroToday
  • No benefit from pazopanib in advanced kidney cancer after surgery to remove metastases Medical Xpress


  • Final results demonstrate that lenalidomide reduces the risk that precancer myeloma will progress to overt multiple myeloma in high-risk individuals Press Release


  • Low-Dose Ipilimumab Demonstrates Overall Survival Advantage Over High-Dose Interferon-alpha2b in Resected High-Risk Melanoma ASCO Daily News

Group Meeting Highlights



Welcome to the ECOG-ACRIN Cancer Research Group website, the source of information about the cooperative group that was formed by the merger of the Eastern Cooperative Oncology Group (ECOG) and the American College of Radiology Imaging Network (ACRIN). We are excited to share news of our collaborative effort to design and conduct ground-breaking translational and clinical research.

The merger brought together the strengths and capabilities of two highly respected organizations. Since 1955, ECOG has performed practice-changing multicenter cancer clinical trials, working with more than 6000 physicians, nurses, pharmacists, statisticians, clinical research associates, and cancer research advocates from the United States and around the world. ACRIN, the premier imaging science program in the nation, complements ECOG’s research efforts with its expertise in early detection, imaging diagnosis, comparative-effectiveness research, and cost-effectiveness analysis. Now, as a single entity, we aim to achieve earlier cancer detection, more successful therapeutic intervention, higher rates of prevention, and better patient outcomes.

We look forward to sharing our research and partnering with you, as we reshape the future of patient care.


Robert L. Comis, MD
Group Co-Chair

Mitchell D. Schnall, MD, PhD
Group Co-Chair
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