Therapeutic Studies Program

The Therapeutic Studies Program contains the largest concentration of clinical investigators of the three scientific programs in the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN). Therapeutic Studies is the term that the Group uses to refer to its broad portfolio of treatment trials. The overarching research objective for this program is to assemble and maintain a multi-disciplinary community of investigators to develop and conduct phase II and phase III clinical trials to advance standards of care for cancer patients.

Within the program are 12 groups of researchers, each developing disease-focused studies of cancer therapy and creating extensive research opportunities for early-career investigators. Nine large committees focus on breast, gastrointestinal, genitourinary, head and neck, leukemia, lymphoma, melanoma, myeloma, and thoracic tumors. Smaller working groups study brain cancer, gynecologic cancer, and sarcoma.

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1Learn More About this Program

Leadership: A Group deputy chair represents this program on the ECOG-ACRIN Executive Committee. Leadership for each of the 12 committees and working groups is as follows: a pair of physician-researchers who serve as Chair and Co-Chair, and Imaging Chair from the medical-imaging discipline, and a Community Co-Chair who brings the perspective of physician-scientists who serve patients in community hospitals and belong to the NCI Community Oncology Research Program (NCORP).

Members: The individuals who participate in this program come from the cancer centers, hospitals, clinics, NCORPS, and NCI National Clinical Trials Network (NCTN) that are members of ECOG-ACRIN. Each committee and working group includes physicians, scientists, oncology nurses, clinical research associates, patient advocates/patient representatives, and other healthcare professionals devoted to performing research into therapeutic interventions. There is treatment and medical-imaging expertise across the program.

Cross-Program Integration: The Therapeutic Studies Program serves as the venue for interaction between methology investigators in the other two scientific programs--Biomarker Sciences and Cancer Control and Outcomes. For example, the disease-site committees and working groups in the Therapeutic Studies Program are the main venue for collaboration with researchers in the Cancer Control and Outcomes Program. Similarly, the Biomarker Sciences Program committees exist to to incorporate predictive/prognostic molecular and imaging biomarkers into therapeutic trials whenever possible.

This three-program structure provides venues for the broad range of constituents across multiple disciplines--necessary to develop and execute a balanced, science-driven trial portfolio. Through it, ECOG-ACRIN contributes tremendous opportunities to the National Cancer Institute's NCTN and NCORP research programs.

Program Chair



Represents the program as a deputy chair on the Executive Committee

Suresh S. Ramalingam, MD

Emory University and the Winship Cancer Institute Biography

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Breast Cancer Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Antonio C. Wolff, MD

Johns Hopkins University and The Sidney Kimmel Comprehensive Cancer Center
Biography

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Angela M DeMichele, MD, MSCE

University of Pennsylvania and the Abramson Cancer Center
Biography

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Christopher E. Comstock, MD

Memorial Sloan Kettering Cancer Center
Biography

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Thomas J. Saphner, MD

Aurora Health Care
Biography

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Gastrointestinal Cancer Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Jordan D. Berlin, MD

Vanderbilt University and the Vanderbilt-Ingram Cancer Center
Biography

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Kim A. Reiss Binder, MD

University of Pennsylvania and the Abramson Cancer Center
Biography

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Terence Z. Wong, MD, PhD

Duke University and the Duke Cancer Institute
Biography

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Xin Yao, MD

ThedaCare Regional Cancer Center
Biography

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Genitourinary Cancer Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Michael A. Carducci, MD

Johns Hopkins University and The Sidney Kimmel Comprehensive Cancer Center
Biography

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Naomi B. Haas, MD

University of Pennsylvania and the Abramson Cancer Center
Biography

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Terence Z. Wong, MD, PhD

Duke University and the Duke Cancer Institute
Biography

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Daniel H. Shevrin, MD

NorthShore University Health System
Biography

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Head and Neck Cancer Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Barbara A. Burtness, MD

Yale University and the Yale Cancer Center
Biography

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Robert L. Ferris, MD, PhD

University of Pittsburgh Cancer Institute
Biography

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Rathan Subramaniam, MD, PhD

University of Otago (New Zealand)
Biography

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Mei Tang, MD

Greater Balitmore Medical Center
Biography

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Leukemia Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Mark R. Litzow, MD

Mayo Clinic Rochester and the Mayo Clinic Cancer Center
Biography

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Selina M. Luger, MD

University of Pennsylvania and the Abramson Cancer Center
Biography

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Lale Kostakoglu, MD, MPH

University of Virginia
Biography

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Ali W. Bseiso, MD

Southwest General Health Center
Biography

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Lymphoma Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Brad S. Kahl, MD

Washington University in St. Louis and the Siteman Cancer Center
Biography

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Andrew M. Evens, DO, MSc

Rutgers Cancer Institute of New Jersey
Biography

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Lale Kostakoglu, MD, MPH

University of Virginia
Biography

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Paul A. S. Fishkin, MD

Illinois CancerCare
Biography

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Melanoma Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Jedd D. Wolchok, MD, PhD

Memorial Sloan Kettering Cancer Center
Biography

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Janice M. Mehnert, MD

New York University and the Perlmutter Cancer Center
Biography

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Michael D. Farwell, MD

University of Pennsylvania and the Abramson Cancer Center
Biography

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Gary I. Cohen, MD

Consultant

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Myeloma Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

S. Vincent Rajkumar, MD

Mayo Clinic Rochester and the Mayo Clinic Cancer Center
Biography

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Sagar Lonial, MD

Emory University and the Winship Cancer Institute
Biography

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Lale Kostakoglu, MD, MPH

University of Virginia
Biography

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Matthias Weiss, MD

Wisconsin NCORP/
ThedaCare
Biography (to come)

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Thoracic Cancer Committee



Chair

Co-Chair

Imaging Chair

Community Co-Chair

Julie R. Brahmer, MD

Johns Hopkins University and The Sidney Kimmel Comprehensive Cancer Center
Biography

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Hossein Borghaei, DO

Fox Chase Cancer Center
Biography

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Kim L. Sandler, MD

Vanderbilt University Ingram Cancer Center
Biography

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Kurt R. Oettel, MD

Wisconsin NCORP
Gundersen Health System
Biography

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Brain Tumor Working Group



Co-Chair

Co-Chair

Imaging Chair

Community Co-Chair

Lawrence R. Kleinberg, MD

Johns Hopkins University and The Sidney Kimmel Comprehensive Cancer Center
Biography

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David H. Schiff, MD

University of Virginia and the UVA Cancer Center
Biography

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Daniel P. Barboriak, MD

Duke University and the Duke Cancer Institute
Biography

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Jerrold L. Boxerman, MD, PhD

Lifespan Health System – Rhode Island Medical Imaging
Biography

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Gynecologic Cancer Working Group



Chair

Imaging Chair

Community Co-Chair

Russell J. Schilder, MD

Thomas Jefferson University and the Sidney Kimmel Cancer Center
Biography

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Priya Bhosale, MD

MD Anderson Cancer Center
Biography

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Mitchell I. Edelson, MD

Abington – Jefferson Health
Biography

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Sarcoma Working Group



Chair

Co-Chair and Community Co-Chair

Imaging Chair

Kenneth Cardona, MD, FACS

Emory University and the Winship Cancer Institute
Biography

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Richard F. Riedel, MD

Duke University and the Duke Cancer Institute
Biography

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Ronnie A. Sebro, MD, PhD

Mayo Clinic in Florida
Biography (link to come)

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ECOG-ACRIN Cancer Research Group