Numerous clinical trials are always open and enrolling patients in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults 18 years of age and older who have or are at risk of developing cancer. The table below contains a list of all active clinical trials, with links to the educational and recruitment materials that are publicly available to patients and researchers.

The trials below are listed alphabetically by cancer type. To sort, hover over any of the column headings and click the up/down arrows. You can also search by keyword. To access the educational and recruitment material for a particular trial, click on the trial ID.

Cancer TypeTrial ID/Educational MaterialTarget Patient Population
VariousEAQ202Ages 18-39 with any type of cancer except basal cell carcinoma
VariousEAQ222CD / CostCOMAges 18+ with any type of solid cancer of any stage
VariousEAY191 / ComboMATCHPatients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (advanced)
VariousEAY191-E4 /
Metastatic (advanced) solid tumors that are progressing after treatment with taxane chemotherapy
VariousEAY191-E5 /
Metastatic (advanced) solid tumors with a KRAS G12C mutation
AnusEA2176Metastatic (advanced), not able to be removed by surgery (inoperable)
AnusEA2182 / DECREASESquamous cell type, no prior treatment
BladderEA8212 / BRIDGEHigh risk; has not spread to the muscleย 
BloodE4412 Hodgkin lymphoma
BloodEA4151 Mantle cell lymphoma
BloodEA9152 Acute lymphoblastic leukemia (ALL)
BloodEA9171 / BLAST MRD CML 1Chronic myelogenous leukemia (CML)
BloodEA9181Acute lymphoblastic leukemia (ALL)
BloodEA9213Acute lymphoblastic leukemia (ALL), T-cell Type
BloodEAA173 / DETER-SMMSmoldering myeloma
BloodEAA181 / EQUATEMyeloma, newly diagnosed
BloodEAQ211Survivors of Hodgkin or Non-Hodgkin lymphoma, age 15-39 when diagnosed
BloodNHLBI-MDS / The National MDS StudySuspected myelodysplastic syndrome


Glioblastoma, newly diagnosed
BreastEA1151 / TMISTWomen planning for regular mammograms
BreastEA1211 / DIRECTEarly stage, HER2 positive type
BreastEAQ221CD / CONCURxPMetastatic (advanced)
Colorectal EA2222 / PUMPMetastatic (advanced to the liver), not able to be removed by surgery (inoperable)
EsophagusEA2174Locally advanced, able to be removed by surgery (operable)
Esophagus and StomachEA2183Metastatic (advanced), HER2 negative type
GallbladderEA2197 / OPT-INDiscovered at time of surgery to remove the gallbladder
Head and NeckEA3132p53-mutated squamous cell type, after surgery
Head and NeckEA3191Squamous cell carcinoma of the head and neck that has come back after initial therapy
Head and NeckEA3202Metastatic (advanced) squamous cell type that has returned after treatment with immune checkpoint inhibitors
Head and NeckEA3211Metastatic (advanced) squamous cell carcinoma
Kidney EA8211 / SOARMetastatic (advanced) renal cell carcinoma
LungEA5162 Non-small cell type, metastatic (advanced)
LungEA5181Non-small cell type, not able to be removed by surgery (inoperable)
LungEA5182 Non-small cell type, metastatic (advanced)
LungEA5221 / ACHIEVE Non-small cell type, metastatic (advanced)
Melanoma (Skin)EA6141Metastatic (advanced)
Melanoma (Skin)EA6192 / PET-StopMetastatic (advanced)
Melanoma (Skin)EA6194Able to be removed by surgery (operable)
Merkel Cell (Skin)EA6174 / STAMPAble to be removed by surgery (operable)
PancreasEA2185Patients with non-cancerous pancreas cysts
PancreasEA2186 / GIANTMetastatic (advanced), older (aged 70+)
PancreasEA2192 / APOLLOHas been surgically removed and has a BRCA1, BRCA2, or PALB2 mutation
PenisEA8134 / InPACTSpread to nearby tissue or lymph nodes (locally advanced)
ProstateEA8171Newly diagnosed, before surgery
ProstateEA8184On close monitoring; at low risk of progressing
ProstateEA8191 / INDICATEHas come back after surgery
RectumEA2201Locally advanced, MSI-H or dMMR type
SarcomaEA7211 / STRASS 2Able to be removed by surgery (operable); at high risk of returning
StomachEA2212Gastric (stomach) and/or gastroesophageal junction cancer, able to be removed by surgery (operable)
ThroatEA3161HPV positive type
Upper Urinary TractEA8192High grade (aggressive)
ECOG-ACRIN Cancer Research Group