Numerous clinical trials are always open and enrolling patients in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults 18 years of age and older who have or are at risk of developing cancer. The table below contains a list of all active clinical trials, with links to the educational and recruitment materials that are publicly available to patients and researchers.

The trials below are listed alphabetically by cancer type. To sort, hover over any of the column headings and click the up/down arrows. You can also search by keyword. To access the educational and recruitment material for a particular trial, click on the trial ID.

Cancer TypeTarget Patient PopulationTrial ID/Educational Material
VariousMetastatic (advanced) solid tumors, lymphomas, or myeloma and also rare cancer types with no standard treatment availableEAY131 / NCI-MATCH
AnyAges 18-39 with any type of cancer except basal cell carcinomaEAQ202
AnyCurrent smokers wanting to stopEAQ171CD
AnyCancer patients with pneumonitis (lung inflammation)EAQ172
AnusMetastatic (advanced), not able to be removed by surgery (inoperable)EA2176
AnusSquamous cell type, no prior treatmentEA2182 / DECREASE
Bile Duct Metastatic (advanced) cholangiocarcinomaEA2187
Blood Acute lymphoblastic leukemia (ALL)EA9152
BloodAcute lymphoblastic leukemia (ALL) EA9181
Blood Chronic myeloid leukemia (CML)EA9171 / BLAST MRD CML 1
Blood Hodgkin lymphomaE4412
Blood Mantle cell lymphomaEA4151
Blood Mantle cell lymphomaEA4181
BloodMyeloma, newly diagnosed EAA181 / EQUATE
BloodSmoldering myeloma EAA173 / DETER-SMM
Blood Previously diagnosed with multiple myeloma and on lenalidomide EAA171 / OPTIMUM
BloodSuspected myelodysplastic syndromesNHLBI-MDS / The National MDS Study
BladderSpread to lymph nodesEA8185 / INSPIRE
BrainRecurrent glioblastomaEAF151
BreastWomen planning for regular mammogramsEA1151 / TMIST
BreastHER2 positive typeEA1181 / CompassHER2 pCR
BreastMetastatic (advanced) with bone or mostly bone diseaseEA1183 / FEATURE
BreastNewly diagnosed, metastatic (advanced)EAI142
BreastBlack women with breast cancerEAZ171
BreastWomen who decline the TMIST breast cancer screening trialEAQ201
EsophagusLocally advanced, able to be removed by surgery (operable)EA2174
Esophagus and StomachMetastatic (advanced), HER2 negative typeEA2183
GallbladderDiscovered at time of surgery to remove the gallbladderEA2197 / OPT-IN
Head and Neckp53-mutated squamous cell type, after surgeryEA3132
Head and NeckSquamous cell type, able to be removed by surgery (operable)EA3191
Head and NeckMetastatic (advanced) squamous cell type that has returned after treatment with immune checkpoint inhibitorsEA3202
Kidney or ThyroidBlood pressure managementEAQ191 / CARISMA
Lung Non-small cell type, metastatic (advanced)EA5162
LungNon-small cell type, metastatic (advanced)EA5163 / S1709 / INSIGNA
LungNon-small cell type, not able to be removed by surgery (inoperable)EA5181
Lung Non-small cell type, metastatic (advanced)EA5182
Lung Non-small cell, non-squamous typeEA5191
LungNon-small cell type, able to be removed by surgery (operable)E4512, an ALCHEMIST Trial
Nose and SinusSquamous cell, HPV positive typeEA3163
PancreasPatients with non-cancerous pancreas cystsEA2185
PancreasMetastatic (advanced), older (aged 70+)EA2186 / GIANT
PancreasAfter surgery and BRCA1, BRCA2, or PALB2 typeEA2192 / APOLLO
PenisMetastatic (advanced)EA8134 / InPACT
ProstateNewly diagnosed, before surgeryEA8171
ProstateWithin 6 weeks of surgery (radical prostatectomy) and at highest risk of progression to metastatic (advanced) stageEA8183 / ERADICATE
ProstateOn active surveillance, with very low, low, or favorable intermediate risk of progressingEA8184
ProstateRise in PSA after surgery (radical prostatectomy)EA8191 / INDICATE
RectumLocally advanced, MSI-high or dMMR typeEA2201
Skin Melanoma, metastatic (advanced)EA6141
Skin Melanoma, Merkel cell typeEA6174 / STAMP
Skin Melanoma, cutaneous or unknown primary typeEA6183
SkinMelanoma, locally advanced, not able to be removed by surgery (inoperable), BRAF V600E or BRAF V600K typeEA6191 / BAMM2
Skin Melanoma, metastatic (advanced)EA6192 / PET-Stop
SkinMelanoma, able to be removed by surgery (operable)EA6194
ThroatSquamous cell oropharyngeal carcinoma, HPV positive typeEA3161
Upper Urinary TractHigh grade (aggressive)EA8192