Numerous clinical trials are always open and enrolling patients in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults 18 years of age and older who have or are at risk of developing cancer. The table below contains a list of all active clinical trials, with links to the educational and recruitment materials that are publicly available to patients and researchers.
The trials below are listed alphabetically by cancer type. To sort, hover over any of the column headings and click the up/down arrows. You can also search by keyword. To access the educational and recruitment material for a particular trial, click on the trial ID.
| Cancer Type | Trial ID/Educational Material | Target Patient Population |
|---|---|---|
| Various | EAY191 / ComboMATCH | Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (advanced) |
| Various | EAY191-E4 | Metastatic (advanced) solid tumors that are progressing after treatment with taxane chemotherapy |
| Any | EAQ202 | Ages 18-39 with any type of cancer except basal cell carcinoma |
| Any | EAQ172 | Cancer patients with pneumonitis (lung inflammation) |
| Anus | EA2176 | Metastatic (advanced), not able to be removed by surgery (inoperable) |
| Anus | EA2182 / DECREASE | Squamous cell type, no prior treatment |
| Bladder | EA8185 / INSPIRE | Has spread to the lymph nodes |
| Bladder | EA8212 / BRIDGE | High risk; has not spread to the muscle |
| Blood | E4412 | Hodgkin lymphoma |
| Blood | EA4151 | Mantle cell lymphoma |
| Blood | EA9152 | Acute lymphoblastic leukemia (ALL) |
| Blood | EA9171 / BLAST MRD CML 1 | Chronic myelogenous leukemia (CML) |
| Blood | EA9181 | Acute lymphoblastic leukemia (ALL) |
| Blood | EA9213 | Acute lymphoblastic leukemia (ALL), T-cell Type |
| Blood | EAA173 / DETER-SMM | Smoldering myeloma |
| Blood | EAA181 / EQUATE | Myeloma, newly diagnosed |
| Blood | EAQ211 | Survivors of Hodgkin or Non-Hodgkin lymphoma, age 15-39 when diagnosed |
| Blood | NHLBI-MDS / The National MDS Study | Suspected myelodysplastic syndromes |
| Breast | EA1151 / TMIST | Women planning for regular mammograms |
| Breast | EA1181 / CompassHER2 pCR | HER2 positive type |
| Breast | EA1183 / FEATURE | Metastatic (advanced) with bone or mostly bone disease |
| Breast | EA1211 / DIRECT | Early stage, HER2 positive type |
| Esophagus | EA2174 | Locally advanced, able to be removed by surgery (operable) |
| Esophagus and Stomach | EA2183 | Metastatic (advanced), HER2 negative type |
| Gallbladder | EA2197 / OPT-IN | Discovered at time of surgery to remove the gallbladder |
| Head and Neck | EA3132 | p53-mutated squamous cell type, after surgery |
| Head and Neck | EA3191 | Squamous cell carcinoma of the head and neck that has come back after initial therapy |
| Head and Neck | EA3202 | Metastatic (advanced) squamous cell type that has returned after treatment with immune checkpoint inhibitors |
| Head and Neck | EA3211 | Metastatic (advanced) squamous cell carcinoma |
| Kidney | EA8211 / SOAR | Metastatic (advanced) renal cell carcinoma |
| Kidney or Thyroid | EAQ191 / CARISMA | Blood pressure management |
| Liver | EA2205 | Metastatic (advanced) or not able to be removed by surgery (inoperable) |
| Lung | EA5162 | Non-small cell type, metastatic (advanced) |
| Lung | EA5163 / S1709 / INSIGNA | Non-small cell type, metastatic (advanced) |
| Lung | EA5181 | Non-small cell type, not able to be removed by surgery (inoperable) |
| Lung | EA5182 | Non-small cell type, metastatic (advanced) |
| Lung | EA5191 | Non-small cell, non-squamous type |
| Lung | E4512, an ALCHEMIST Trial | Non-small cell type, able to be removed by surgery (operable) |
| Melanoma (Skin) | EA6141 | Metastatic (advanced) |
| Melanoma (Skin) | EA6174 / STAMP | Merkel cell type |
| Melanoma (Skin) | EA6192 / PET-Stop | Metastatic (advanced) |
| Melanoma (Skin) | EA6194 | Able to be removed by surgery (operable) |
| Nose and Sinus | EA3163 | Squamous cell type, able to be removed by surgery (operable) |
| Pancreas | EA2185 | Patients with non-cancerous pancreas cysts |
| Pancreas | EA2186 / GIANT | Metastatic (advanced), older (aged 70+) |
| Pancreas | EA2192 / APOLLO | Has been surgically removed and has a BRCA1, BRCA2, or PALB2 mutation |
| Penis | EA8134 / InPACT | Spread to nearby tissue or lymph nodes (locally advanced) |
| Prostate | EA8171 | Newly diagnosed, before surgery |
| Prostate | EA8184 | On close monitoring; at low risk of progressing |
| Prostate | EA8191 / INDICATE | Has come back after surgery |
| Rectum | EA2201 | Locally advanced, MSI-H or dMMR type |
| Sarcoma | EA7211 / STRASS 2 | Able to be removed by surgery (operable); at high risk of returning |
| Stomach | EA2212 | Gastric (stomach) and/or gastroesophageal junction cancer, able to be removed by surgery (operable) |
| Throat | EA3161 | HPV positive type |
| Upper Urinary Tract | EA8192 | High grade (aggressive) |
