Active Clinical Trials

Numerous clinical trials are always active (i.e., open and enrolling patients) in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults who have or are at risk of developing cancer. This section of the website contains a searchable list of all active trials. On the table below, hover over any of the column headings and click the up/down arrows to sort. You can also search by keyword. To access more information about a particular trial, click on the trial ID.

Cancer TypeTrial ID/More InfoTarget Patient PopulationStudy TypeECOG-ACRIN Oversight Committee(s)
VariousEAQ202Ages 18-39 with any type of cancer except basal cell carcinomaObservation (Patient Reporting) Health Equity; Adolescent and Young Adult Oncology
VariousEAQ222CD / CostCOMAges 18+ with any type of solid cancer of any stageInterventionCancer Care Delivery Research
VariousEAY191 / ComboMATCHPatients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (advanced)Patient RegistrationDevelopmental Therapeutics
VariousEAY191-E4 /

Metastatic (advanced) solid tumors that are progressing after treatment with taxane chemotherapy

TreatmentDevelopmental Therapeutics

Metastatic (advanced) solid tumorsย with a KRAS G12C mutation

TreatmentDevelopmental Therapeutics
AnusEA2176Metastatic (advanced), not able to be removed by surgery (inoperable)TreatmentGastrointestinal
AnusEA2182 / DECREASESquamous cell type, no prior treatmentTreatmentGastrointestinal
BladderEA8212 / BRIDGEHigh risk; has not spread to the muscleย TreatmentGenitourinary
BloodE4412 Hodgkin lymphomaTreatmentLymphoma
BloodEA4151 Mantle cell lymphomaTreatmentLymphoma
BloodEA9152 Acute lymphoblastic leukemia (ALL)TreatmentLeukemia
BloodEA9171 / BLAST MRD CML 1Chronic myelogenous leukemia (CML)TreatmentLeukemia
BloodEA9181Acute lymphoblastic leukemia (ALL) TreatmentLeukemia
BloodEA9213Acute lymphoblastic leukemia (ALL), T-cell TypeTreatmentLeukemia
BloodEAA173 / DETER-SMMSmoldering myeloma TreatmentMyeloma
BloodEAA181 / EQUATEMyeloma, newly diagnosed Treatment Myeloma

Survivors of Hodgkin or Non-Hodgkin lymphoma, age 15-39 when diagnosed

ObservationHealth Equity; Adolescent and Young Adult Oncology
BloodNHLBI-MDS / The National MDS StudySuspected myelodysplastic syndromeScreening/Early DetectionLeukemia


Glioblastoma, newly diagnosed

ImagingBrain Cancer Working Group
BreastEA1151 / TMISTWomen planning for regular mammogramsScreening/Early DetectionImaging; Prevention; Breast
BreastEA1211 / DIRECTEarly stage, HER2 positive typeImagingBreast
Breast EAQ221CD / CONCURxPMetastatic (advanced)InterventionCancer Care Delivery Research
Colorectal EA2222 / PUMPMetastatic (advanced to the liver), not able to be removed by surgery (inoperable)TreatmentGastrointestinal
EsophagusEA2174Locally advanced, able to be removed by surgery (operable)TreatmentGastrointestinal
Esophagus and StomachEA2183Metastatic (advanced), HER2 negative typeTreatmentGastrointestinal
GallbladderEA2197 / OPT-INDiscovered at time of surgery to remove the gallbladderTreatmentGastrointestinal
Head and NeckEA3132p53-mutated squamous cell type, after surgeryTreatmentHead and Neck
Head and NeckEA3191Squamous cell carcinoma of the head and neck that has come back after initial therapyTreatmentHead and Neck
Head and NeckEA3202Metastatic (advanced) squamous cell type that has returned after treatment with immune checkpoint inhibitorsTreatment Head and Neck
Head and NeckEA3211Metastatic (advanced) squamous cell carcinomaTreatmentHead and Neck
Kidney EA8211 / SOAR

Metastatic (advanced) renal cell carcinoma

LiverEA2205Metastatic (advanced) or not able to be removed by surgery (inoperable)TreatmentGastrointestinal
LungEA5162 Non-small cell type, metastatic (advanced)TreatmentThoracic
LungEA5181Non-small cell type, not able to be removed by surgery (inoperable)TreatmentThoracic
LungEA5182 Non-small cell type, metastatic (advanced)TreatmentThoracic
LungEA5221 / ACHIEVENon-small cell type, metastatic (advanced) in older patients aged 70+TreatmentThoracic; Geriatric Oncology
LungE4512, an ALCHEMIST TrialNon-small cell type, able to be removed by surgery (operable)TreatmentThoracic
Melanoma (Skin)EA6141Metastatic (advanced)TreatmentMelanoma
Melanoma (Skin)EA6192 / PET-StopMetastatic (advanced)TreatmentMelanoma
Melanoma (Skin)EA6194Able to be removed by surgery (operable)TreatmentMelanoma
Merkel Cell (Skin)EA6174 / STAMPAble to be removed by surgery (operable) TreatmentMelanoma
PancreasEA2185Patients with non-cancerous pancreas cystsScreening/Early DetectionGastrointestinal
PancreasEA2192 / APOLLOHas been surgically removed and has a BRCA1, BRCA2, or PALB2 mutationTreatmentGastrointestinal
PenisEA8134 / InPACTSpread to nearby tissue or lymph nodes (locally advanced)TreatmentGenitourinary
ProstateEA8171Newly diagnosed, before surgeryImaging/Treatment PlanningGenitourinary
ProstateEA8184On close monitoring; at low risk of progressingPreventionGenitourinary
ProstateEA8191 / INDICATEHas come back after surgeryTreatmentGenitourinary
RectumEA2201Locally advanced, MSI-H or dMMR typeTreatmentGastrointestinal
Sarcoma (Soft Tissue Cancer)EA7211 / STRASS 2Able to be removed by surgery (operable); at high risk of returning TreatmentSarcoma

Gastric (stomach) and/or gastroesophageal junction cancer, able to be removed by surgery (operable)ย 

ThroatEA3161HPV positive typeTreatmentHead and Neck
Upper Urinary TractEA8192High grade (aggressive)TreatmentGenitourinary
ECOG-ACRIN Cancer Research Group