Active Clinical Trials
Numerous clinical trials are always active (i.e., open and enrolling patients) in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults who have or are at risk of developing cancer. This section of the website contains a searchable list of all active trials. On the table below, hover over any of the column headings and click the up/down arrows to sort. You can also search by keyword. To access more information about a particular trial, click on the trial ID.
| Cancer Type | Trial ID/More Info | Target Patient Population | Study Type | ECOG-ACRIN Oversight Committee(s) |
|---|---|---|---|---|
| Various | EAY191 / ComboMATCH | Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (advanced) | Patient Registration | Developmental Therapeutics |
| Various | EAY191-E4 | Metastatic (advanced) solid tumors that are progressing after treatment with taxane chemotherapy | Treatment | Developmental Therapeutics |
| Any | EAQ202 | Ages 18-39 with any type of cancer except basal cell carcinoma | Observation (Patient Reporting) | Cancer Control and Survivorship Committee and its Patient-Reported Outcomes Working Group; Health Equity Committee and its Adolescent and Young Adult Oncology Subcommittee |
| Any | EAQ172 | Cancer patients with pneumonitis (lung inflammation) | Treatment | Cancer Control and Survivorship |
| Anus | EA2176 | Metastatic (advanced), not able to be removed by surgery (inoperable) | Treatment | Gastrointestinal |
| Anus | EA2182 / DECREASE | Squamous cell type, no prior treatment | Treatment | Gastrointestinal |
| Bladder | EA8185 / INSPIRE | Has spread to the lymph nodes | Treatment | Genitourinary |
| Bladder | EA8212 / BRIDGE | High risk; has not spread to the muscle | Treatment | Genitourinary |
| Blood | EA9152 | Acute lymphoblastic leukemia (ALL) | Treatment | Leukemia |
| Blood | EA9181 | Acute lymphoblastic leukemia (ALL) | Treatment | Leukemia |
| Blood | EA9213 | Acute lymphoblastic leukemia (ALL), T-cell Type | Treatment | Leukemia |
| Blood | EA9171 / BLAST MRD CML 1 | Chronic myelogenous leukemia (CML) | Treatment | Leukemia |
| Blood | E4412 | Hodgkin lymphoma | Treatment | Lymphoma |
| Blood | EA4151 | Mantle cell lymphoma | Treatment | Lymphoma |
| Blood | EAA181 / EQUATE | Myeloma, newly diagnosed | Treatment | Myeloma |
| Blood | EAA173 / DETER-SMM | Smoldering myeloma | Treatment | Myeloma |
| Blood | PrE0905 | Acute myeloid leukemia with FLT3 mutation | Treatment | N/A (PrECOG) |
| Blood | NHLBI-MDS / The National MDS Study | Suspected myelodysplastic syndromes | Screening/Early Detection | Leukemia |
| Brain | EAF151 | Recurrent glioblastoma | Treatment | Brain Cancer Working Group |
| Breast | EA1151 / TMIST | Women planning for regular mammograms | Screening/Early Detection | Imaging; Prevention; Breast |
| Breast | EA1181 / CompassHER2 pCR | HER2 positive type | Treatment | Breast |
| Breast | EA1183 / FEATURE | Metastatic (advanced) with bone or mostly bone disease | Imaging | Breast |
| Breast | EA1211 / DIRECT | HER-2 positive, early stage | Treatment | Breast |
| Esophagus | EA2174 | Locally advanced, able to be removed by surgery (operable) | Treatment | Gastrointestinal |
| Esophagus and Stomach | EA2183 | Metastatic (advanced), HER2 negative type | Treatment | Gastrointestinal |
| Gallbladder | EA2197 / OPT-IN | Discovered at time of surgery to remove the gallbladder | Treatment | Gastrointestinal |
| Head and Neck | EA3132 | p53-mutated squamous cell type, after surgery | Treatment | Head and Neck |
| Head and Neck | EA3191 | Squamous cell carcinoma of the head and neck that has come back after initial therapy | Treatment | Head and Neck |
| Head and Neck | EA3202 | Metastatic (advanced) squamous cell type that has returned after treatment with immune checkpoint inhibitors | Treatment | Head and Neck |
| Kidney or Thyroid | EAQ191 / CARISMA | Blood pressure management | Treatment | Cancer Control and Survivorship |
| Liver | EA2205 | Metastatic (advanced) or not able to be removed by surgery (inoperable) | Treatment | Gastrointestinal |
| Lung | EA5162 | Non-small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | EA5163 / S1709 / INSIGNA | Non-small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | EA5181 | Non-small cell type, not able to be removed by surgery (inoperable) | Treatment | Thoracic |
| Lung | EA5182 | Non-small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | EA5191 | Non-small cell, non-squamous type | Treatment | Thoracic |
| Lung | E4512, an ALCHEMIST Trial | Non-small cell type, able to be removed by surgery (operable) | Treatment | Thoracic |
| Melanoma (Skin) | EA6141 | Metastatic (advanced) | Treatment | Melanoma |
| Melanoma (Skin) | EA6174 / STAMP | Merkel cell type | Treatment | Melanoma |
| Melanoma (Skin) | EA6192 / PET-Stop | Metastatic (advanced) | Treatment | Melanoma |
| Melanoma (Skin) | EA6194 | Able to be removed by surgery (operable) | Treatment | Melanoma |
| Mesothelioma | PrE0506 / DREAM3R6 | Advanced pleural | Treatment | N/A (PrECOG) |
| Nose and Sinus | EA3163 | Squamous cell type, able to be removed by surgery | Treatment | Head and Neck |
| Pancreas | EA2185 | Patients with non-cancerous pancreas cysts | Screening/Early Detection | Gastrointestinal |
| Pancreas | EA2186 / GIANT | Metastatic (advanced), older (aged 70+) | Treatment | Gastrointestinal; Geriatric Oncology Working Group |
| Pancreas | EA2192 / APOLLO | Has been surgically removed and has a BRCA1, BRCA2, or PALB2 mutation | Treatment | Gastrointestinal |
| Penis | EA8134 / InPACT | Metastatic (advanced) | Treatment | Genitourinary |
| Prostate | EA8171 | Newly diagnosed, before surgery | Imaging/Treatment Planning | Genitourinary |
| Prostate | EA8184 | On close monitoring; at low risk of progressing | Prevention | Genitourinary |
| Prostate | EA8191 / INDICATE | Has come back after surgery | Treatment | Genitourinary |
| Rectum | EA2201 | Locally advanced, MSI-H or dMMR type | Treatment | Gastrointestinal |
| Throat | EA3161 | HPV positive type | Treatment | Head and Neck |
| Upper Urinary Tract | EA8192 | High grade (aggressive) | Treatment | Genitourinary |