Non-Cancerous Pancreas Cysts

EA2185



Comparing Two Methods to Follow Patients with Pancreatic Cysts

STATUS: Active


The purpose of this study is to compare the two approaches for monitoring pancreatic cysts. The study doctors want to compare more frequent monitoring vs less frequent monitoring in order to learn which monitoring method leads to better outcome for patients with pancreatic cysts.
  • Patient must be >= 50 years and =< 75 years of age

  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1

  • Patient must not have acute pancreatitis or a history of chronic pancreatitis

  • Patient must have received a CT, MRI, or EUS within 6 months prior to randomization that revealed one or more >= 1 cm pancreatic cyst (s)

  • Patients of childbearing potential must not be known to be pregnant

  • Patient must not have a prior diagnosis of pancreatic malignancy of any type

  • Patient must not have a history of pancreatic resection

  • Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst or classic serous cystic lesion) are not eligible

  • Patient must not have a family history of pancreatic adenocarcinoma in one or more first-degree relatives (biological parents, full siblings or children)

  • Patient must not have pancreatic cyst morphology that would prompt immediate surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic duct >= 10 mm, cyst causing obstructive jaundice)

  • Patient must not have a comorbid illness that precludes pancreatic cyst resection

  • Patient must not be participating in an already established surveillance program

Canada
Ontario
Hamilton
Juravinski Cancer Centre at Hamilton Health Sciences
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Korea, Republic of
Seoul
Yonsei University Health System-Severance Hospital
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Email: ihcc@yuhs.ac

Gyeonggi-do
Goyang-si
National Cancer Center-Korea
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United States
AK
Anchorage
Alaska Breast Care and Surgery LLC
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Email: AKPAMC.OncologyResearchSupport@providence.org

Alaska Oncology and Hematology LLC
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Email: AKPAMC.OncologyResearchSupport@providence.org

Alaska Women's Cancer Care
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Anchorage Associates in Radiation Medicine
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Anchorage Oncology Centre
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Anchorage Radiation Therapy Center
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Katmai Oncology Group
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Providence Alaska Medical Center
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Email: AKPAMC.OncologyResearchSupport@providence.org

AL
Birmingham
University of Alabama at Birmingham Cancer Center
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Email: tmyrick@uab.edu

Mobile
University of South Alabama Mitchell Cancer Institute
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AR
Little Rock
University of Arkansas for Medical Sciences
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AZ
Phoenix
Mayo Clinic Hospital in Arizona
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Scottsdale
Mayo Clinic in Arizona
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CA
Burbank
Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Chico
Enloe Medical Center
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Encinitas
UC San Diego Health System - Encinitas
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La Jolla
UC San Diego Moores Cancer Center
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Los Angeles
UCLA / Jonsson Comprehensive Cancer Center
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San Diego
UC San Diego Medical Center - Hillcrest
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San Francisco
UCSF Medical Center-Mission Bay
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UCSF Medical Center-Mount Zion
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UCSF Medical Center-Parnassus
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CT
Derby
Smilow Cancer Hospital-Derby Care Center
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Fairfield
Smilow Cancer Hospital Care Center-Fairfield
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Glastonbury
Smilow Cancer Hospital Care Center at Glastonbury
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Greenwich
Smilow Cancer Hospital Care Center at Greenwich
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Guilford
Smilow Cancer Hospital Care Center - Guiford
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Hamden
Smilow Cancer Hospital-Hamden Care Center
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Hartford
Smilow Cancer Hospital Care Center at Saint Francis
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New Haven
Smilow Cancer Center/Yale-New Haven Hospital
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Yale University
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Yale-New Haven Hospital Saint Raphael Campus
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North Haven
Yale-New Haven Hospital North Haven Medical Center
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Orange
Smilow Cancer Hospital-Orange Care Center
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Torrington
Smilow Cancer Hospital-Torrington Care Center
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Trumbull
Smilow Cancer Hospital Care Center-Trumbull
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Waterbury
Smilow Cancer Hospital-Waterbury Care Center
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Waterford
Smilow Cancer Hospital Care Center - Waterford
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Email: canceranswers@yale.edu

West Haven
Veterans Affairs Connecticut Healthcare System-West Haven Campus
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DC
Washington
MedStar Georgetown University Hospital
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FL
Fort Myers
Regional Cancer Center-Lee Memorial Health System
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Email: ecog.rss@jimmy.harvard.edu

GA
Atlanta
Emory Saint Joseph's Hospital
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Emory University Hospital Midtown
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Emory University Hospital/Winship Cancer Institute
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IA
Iowa City
University of Iowa/Holden Comprehensive Cancer Center
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ID
Boise
Saint Luke's Cancer Institute - Boise
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Email: eslinget@slhs.org

Fruitland
Saint Luke's Cancer Institute - Fruitland
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Email: eslinget@slhs.org

Meridian
Saint Luke's Cancer Institute - Meridian
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Email: eslinget@slhs.org

Nampa
Saint Luke's Cancer Institute - Nampa
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Email: eslinget@slhs.org

Twin Falls
Saint Luke's Cancer Institute - Twin Falls
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Email: eslinget@slhs.org

IL
Barrington
Advocate Good Shepherd Hospital
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Bloomington
Bromenn Lifecare Center
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Email: Research@Carle.com

Illinois CancerCare-Bloomington
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Email: andersonj@illinoiscancercare.com

Canton
Illinois CancerCare-Canton
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Email: andersonj@illinoiscancercare.com

Carbondale
Memorial Hospital of Carbondale
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Email: clinical.research@sih.net

Carterville
SIH Cancer Institute
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Email: clinical.research@sih.net

Carthage
Illinois CancerCare-Carthage
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Email: andersonj@illinoiscancercare.com

Centralia
Centralia Oncology Clinic
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Email: morganthaler.jodi@mhsil.com

Chicago
Advocate Illinois Masonic Medical Center
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Northwestern University
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Email: cancer@northwestern.edu

Crystal Lake
AMG Crystal Lake - Oncology
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Email: advocateresearch@advocate.com

Danville
Carle on Vermilion
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Email: Research@carle.com

DeKalb
Northwestern Medicine Cancer Center Kishwaukee
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Email: Donald.Smith3@nm.org

Decatur
Cancer Care Specialists of Illinois - Decatur
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Email: morganthaler.jodi@mhsil.com

Decatur Memorial Hospital
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Email: morganthaler.jodi@mhsil.com

Dixon
Illinois CancerCare-Dixon
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Downers Grove
Advocate Good Samaritan Hospital
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Email: Barbara.barhamand@advocatehealth.com

Effingham
Carle Physician Group-Effingham
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Email: Research@carle.com

Crossroads Cancer Center
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Email: morganthaler.jodi@mhsil.com

Elgin
Advocate Sherman Hospital
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Elmhurst
Elmhurst Memorial Hospital
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Email: Jrohde@emhc.org

Eureka
Illinois CancerCare-Eureka
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Email: andersonj@illinoiscancercare.com

Evanston
NorthShore University HealthSystem-Evanston Hospital
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Galesburg
Illinois CancerCare-Galesburg
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Email: andersonj@illinoiscancercare.com

Western Illinois Cancer Treatment Center
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Geneva
Northwestern Medicine Cancer Center Delnor
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Email: Donald.Smith3@nm.org

Glenview
NorthShore University HealthSystem-Glenbrook Hospital
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Harvey
Ingalls Memorial Hospital
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Email: clinicaltrials@ingalls.org

Hazel Crest
Advocate South Suburban Hospital
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Highland Park
NorthShore University HealthSystem-Highland Park Hospital
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Kewanee
Illinois CancerCare-Kewanee Clinic
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Email: andersonj@illinoiscancercare.com

Lake Forest
Northwestern Medicine Lake Forest Hospital
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Email: cancertrials@northwestern.edu

Libertyville
AMG Libertyville - Oncology
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Email: advocateresearch@advocatehealth.com

Condell Memorial Hospital
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Email: advocateresearch@advocatehealth.com

Macomb
Illinois CancerCare-Macomb
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Email: andersonj@illinoiscancercare.com

Mattoon
Carle Physician Group-Mattoon/Charleston
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Email: Research@carle.com

Naperville
Edward Hospital/Cancer Center
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Normal
Bromenn Regional Medical Center
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Email: Research@Carle.com

Carle Cancer Institute Normal
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Email: Research@Carle.com

O'Fallon
Cancer Care Center of O'Fallon
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Email: morganthaler.jodi@mhsil.com

Oak Lawn
Advocate Christ Medical Center
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Ottawa
Illinois CancerCare-Ottawa Clinic
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Email: andersonj@illinoiscancercare.com

Park Ridge
Advocate Lutheran General Hospital
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Pekin
Illinois CancerCare-Pekin
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Email: andersonj@illinoiscancercare.com

Peoria
Illinois CancerCare-Peoria
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Email: andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
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Email: andersonj@illinoiscancercare.com

Peru
Illinois CancerCare-Peru
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Email: andersonj@illinoiscancercare.com

Valley Radiation Oncology
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Plainfield
Edward Hospital/Cancer Center?Plainfield
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Email: Cancerresearch@edward.org

Princeton
Illinois CancerCare-Princeton
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Email: andersonj@illinoiscancercare.com

Springfield
Memorial Medical Center
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Email: pallante.beth@mhsil.com

Southern Illinois University School of Medicine
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Springfield Clinic
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Swansea
Southwest Illinois Health Services LLP
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Email: lynns@thecancercenter.com

Urbana
Carle Cancer Center
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Email: Research@carle.com

The Carle Foundation Hospital
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Email: Research@carle.com

Warrenville
Northwestern Medicine Cancer Center Warrenville
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Email: Donald.Smith3@nm.org

Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com

IN
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

LA
Baton Rouge
LSU Health Baton Rouge-North Clinic
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Email: research@ololrmc.com

Mary Bird Perkins Cancer Center
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Email: clinicalresearch@marybird.com

Our Lady of The Lake
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Our Lady of the Lake Physicians Group - Medical Oncology
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Email: research@ololrmc.com

MD
Glen Burnie
UM Baltimore Washington Medical Center/Tate Cancer Center
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MI
Ann Arbor
University of Michigan Comprehensive Cancer Center
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Battle Creek
Bronson Battle Creek
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Email: crcwm-regulatory@crcwm.org

Dearborn
Beaumont Hospital - Dearborn
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Farmington Hills
Beaumont Hospital - Farmington Hills
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Grand Rapids
Helen DeVos Children's Hospital at Spectrum Health
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Email: crcwm-regulatory@crcwm.org

Spectrum Health at Butterworth Campus
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Email: crcwm-regulatory@crcwm.org

Trinity Health Grand Rapids Hospital
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Email: crcwm-regulatory@crcwm.org

Kalamazoo
Ascension Borgess Cancer Center
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Email: crcwm-regulatory@crcwm.org

Borgess Medical Center
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Email: crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
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Email: crcwm-regulatory@crcwm.org

West Michigan Cancer Center
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Email: crcwm-regulatory@crcwm.org

Muskegon
Trinity Health Muskegon Hospital
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Email: crcwm-regulatory@crcwm.org

Niles
Lakeland Hospital Niles
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Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
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Email: connie.szczepanek@crcwm.org

Reed City
Spectrum Health Reed City Hospital
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Email: crcwm-regulatory@crcwm.org

Royal Oak
Cancer Care Associates PC
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Comprehensive Medical Center PLLC
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Hematology Oncology Consultants PC
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Oakland Colon Rectal Associates
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Oakland Medical Group
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William Beaumont Hospital-Royal Oak
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Saint Joseph
Lakeland Medical Center Saint Joseph
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Email: crcwm-regulatory@crcwm.org

Marie Yeager Cancer Center
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Email: crcwm-regulatory@crcwm.org

Traverse City
Munson Medical Center
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Email: crcwm-regulatory@crcwm.org

Troy
Hematology Oncology Consultants PC-Troy
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Michigan Institute of Urology-Town Center
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William Beaumont Hospital - Troy
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Wyoming
Metro Health Hospital
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Email: crcwm-regulatory@crcwm.org

MN
Bemidji
Sanford Joe Lueken Cancer Center
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Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Thief River Falls
Sanford Thief River Falls Medical Center
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Worthington
Sanford Cancer Center Worthington
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MO
Cape Girardeau
Saint Francis Medical Center
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Email: sfmc@sfmc.net

Southeast Cancer Center
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Farmington
Parkland Health Center - Farmington
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Jefferson City
Capital Region Southwest Campus
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Email: swooden@mail.crmc.org

Saint Louis
Missouri Baptist Medical Center
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Washington University School of Medicine
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact

Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact

Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Contact: Site Public Contact

MT
Missoula
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org

NC
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Contact: Site Public Contact
Email: cancerclinicaltrials@med.unc.edu

Greenville
East Carolina University
Contact: Site Public Contact
Email: eubankss@ecu.edu

ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Fargo
Sanford Broadway Medical Center
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Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Medical Center Fargo
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Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford South University Medical Center
Contact: Site Public Contact

Southpointe-Sanford Medical Center Fargo
Contact: Site Public Contact

NH
Lebanon
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Contact: Site Public Contact
Email: cancer.research.nurse@dartmouth.edu

NJ
Freehold
CentraState Medical Center
Contact: Site Public Contact

Morristown
Morristown Medical Center
Contact: Site Public Contact

Pennington
Capital Health Medical Center-Hopewell
Contact: Site Public Contact
Email: clinicaltrials@capitalhealth.org

Plainsboro
Penn Medicine Princeton Health
Contact: Site Public Contact

Summit
Overlook Hospital
Contact: Site Public Contact

NM
Albuquerque
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: LByatt@nmcca.org

NY
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org

Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org

Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org

Buffalo
Roswell Park Cancer Institute
Contact: Site Public Contact
Email: askroswell@roswellpark.org

New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Contact: Site Public Contact
Email: CancerTrials@nyulangone.org

OH
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Cincinnati
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Cleveland
MetroHealth Medical Center
Contact: Site Public Contact
Email: dstrater@metrohealth.org

Columbus
Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu

Dayton
Dayton Physician LLC-Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Kettering
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Springfield
Springfield Regional Cancer Center
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Email: clinical.trials@daytonncorp.org

Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

OK
Oklahoma City
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu

OR
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org

Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org

Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org

Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org

Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org

Portland
Oregon Health and Science University
Contact: Site Public Contact
Email: trials@ohsu.edu

Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org

Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact

PA
Allentown
Saint Luke's Cancer Center - Allentown
Contact: Site Public Contact

Bethlehem
Saint Luke's University Hospital-Bethlehem Campus
Contact: Site Public Contact

Bryn Mawr
Bryn Mawr Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org

Collegeville
Main Line Health Center-Collegeville
Contact: Site Public Contact
Email: turzoe@mlhs.org

Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Easton
Saint Luke's Hospital-Anderson Campus
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu

Exton
Main Line Health Center-Exton
Contact: Site Public Contact
Email: turzoe@mlhs.org

Media
Riddle Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org

Paoli
Paoli Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org

Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact

Thomas Jefferson University Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu

University of Pennsylvania/Abramson Cancer Center
Contact: Site Public Contact

Quakertown
Saint Luke's Hospital-Quakertown Campus
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu

Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Wynnewood
Lankenau Medical Center
Contact: Site Public Contact
Email: turzoe@mlhs.org

PR
Bayamon
Cancer Center-Metro Medical Center Bayamon
Contact: Site Public Contact

Caguas
HIMA San Pablo Oncologic Hospital
Contact: Site Public Contact

Manati
Doctors Cancer Center
Contact: Site Public Contact

Ponce
Instituto Oncologia Moderna Ponce
Contact: Site Public Contact

San Juan
Centro Comprensivo de Cancer de UPR
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu

Primary Care Physician Group
Contact: Site Public Contact

San Juan City Hospital
Contact: Site Public Contact

San Juan Community Oncology Group
Contact: Site Public Contact

RI
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu

SC
Boiling Springs
Prisma Health Cancer Institute - Spartanburg
Contact: Site Public Contact

Charleston
Bon Secours Saint Francis Hospital
Contact: Site Public Contact
Email: Courtney.Roldan@RoperSaintFrancis.com

Roper Hospital
Contact: Site Public Contact
Email: Courtney.Roldan@RoperSaintFrancis.com

Clinton
Prisma Health Cancer Institute - Laurens
Contact: Site Public Contact

Columbia
Prisma Health Baptist Hospital
Contact: Site Public Contact

Prisma Health Richland Hospital
Contact: Site Public Contact

Easley
Prisma Health Cancer Institute - Easley
Contact: Site Public Contact
Email: Kim.Williams3@prismahealth.org

Georgetown
Tidelands Georgetown Memorial Hospital
Contact: Site Public Contact
Email: broe@tidelandshealth.org

Greenville
Prisma Health Cancer Institute - Butternut
Contact: Site Public Contact

Prisma Health Cancer Institute - Eastside
Contact: Site Public Contact

Prisma Health Cancer Institute - Faris
Contact: Site Public Contact

Prisma Health Greenville Memorial Hospital
Contact: Site Public Contact

Greer
Prisma Health Cancer Institute - Greer
Contact: Site Public Contact

Seneca
Prisma Health Cancer Institute - Seneca
Contact: Site Public Contact

SD
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org

TN
Knoxville
University of Tennessee - Knoxville
Contact: Site Public Contact

Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org

Nashville
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact

TX
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu

Houston
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Contact: Site Public Contact
Email: burton@bcm.edu

UT
Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu

VA
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: uvacancertrials@hscmail.mcc.virginia.edu

Fairfax
Inova Schar Cancer Institute
Contact: Site Public Contact
Email: Stephanie.VanBebber@inova.org

Falls Church
Inova Fairfax Hospital
Contact: Site Public Contact
Email: Stephanie.VanBebber@inova.org

Richmond
VCU Massey Cancer Center at Stony Point
Contact: Site Public Contact
Email: ctoclinops@vcu.edu

Virginia Commonwealth University/Massey Cancer Center
Contact: Site Public Contact
Email: CTOclinops@vcu.edu

Winchester
Valley Health / Winchester Medical Center
Contact: Site Public Contact

WI
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org

Eau Claire
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org

Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Janesville
Mercyhealth Hospital and Cancer Center - Janesville
Contact: Site Public Contact
Email: oncologyclinicaltrials@mhemail.org

Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org

Madison
University of Wisconsin Carbone Cancer Center
Contact: Site Public Contact

Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org

Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Milwaukee
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org

Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org

Racine
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org

Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org

Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org

Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org

Wauwatosa
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org

West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

WV
Bridgeport
United Hospital Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu

Martinsburg
WVUH-Berkely Medical Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu

Morgantown
West Virginia University Healthcare
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu

Parkersburg
Camden Clark Medical Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu

PRIMARY OBJECTIVE:
I. To compare the rates of unfavorable clinical outcomes in the two arms.

SECONDARY OBJECTIVES:
I. To compare rates of major surgical morbidity and/or mortality between arms.
II. To compare pancreatic cancer incidence and all-cause mortality across arms.
III. Compare institutional (direct) costs.
IV. Compare healthcare utilization of imaging, invasive testing, surgical, and other procedures across the two surveillance arms.
V. Compare patient (out-of-pocket and other indirect) costs.
VI. Describe diagnostic test and treatment pathways by arm.
VII. Compare patient reports of quality of life (QOL), situational anxiety.
VIII. Compare patient report of financial distress.
IX. Compare rates of non-adherence by arm assignment.
X. To evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer.

EXPLORATORY OBJECTIVE:
I. To evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM A (LOW INTENSITY SURVEILLANCE): Patients undergo magnetic resonance imaging (MRI) or computed tomography (CT) at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative endoscopic ultrasound (EUS), repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years.

ARM B (HIGH INTENSITY SURVEILLANCE): Patients undergo MRI or CT. Patients with >= 1 and < 2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with >= 2 and < 3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst >= 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months.

After completion of imaging procedures, patients are followed up for 5 years from the date of registration.

Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.


The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its NCI Community Oncology Research Program (NCORP).


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