Melanoma (Skin Cancer)
EA6141
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients with Advanced Melanoma
STATUS: Active
This phase II/III trial studies the side effects of nivolumab and ipilimumab when given together with or without sargramostim and to see how well they work in treating patients with stage III-IV melanoma that cannot be removed by surgery (unresectable) and that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Colony-stimulating factors, such as sargramostim, may increase the production of white blood cells. It is not yet known whether nivolumab and ipilimumab are more effective with or without sargramostim in treating patients with melanoma.
- All patients must be >= 18 years of age
- Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1
- Patients must have known BRAF mutational status of tumor; wild-type (WT) or mutated, prior to randomization
- Patients must not be pregnant or breast-feeding due to use of cytotoxic immunotherapy and risk of teratogenic side effects; all patients of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy; a patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients must not conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse from the time of study registration and continuing (for patients of child bearing potential) for at least 5 months after the last dose of protocol treatment; patients of childbearing potential must also not donate eggs during this same time period
- Patients must have unresectable stage III or stage IV melanoma according to American Joint Committee on Cancer (AJCC) version (v)7; patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive
- Patients must have measurable disease per RECIST 1.1 criteria; all sites of disease must be evaluated within 4 weeks prior to randomization
- Patients may have had prior systemic therapy in the adjuvant setting (e.g. interferon, BRAF, or MEK agents). Patients may have had prior anti-CTLA-4 in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment. Patients may have had any prior anti-PD-1 or anti-PD-L1 agent in the adjuvant setting, if at least one year from last dose of treatment has passed prior to beginning treatment
- Patients may not have had any prior ipilimumab and/or anti-PD-1/PD-L1 agent in the metastatic setting
- Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to randomization and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 2 weeks prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 4 weeks from randomization and patients must be fully recovered from post-surgical complications
- Patients must not receive any other investigational agents while on study or within four weeks prior to randomization
- Patient must not have received any live vaccine within 30 days prior to randomization, while participating in the study, and for 4 weeks (28 days) after the last dose of protocol treatment; live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine; patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 19 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed); if possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)
- Patients are ineligible if they have any currently active central nervous system (CNS) metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery) that have been stable on head magnetic resonance imaging (MRI) or contrast computed tomography (CT) scan for at least 4 weeks following treatment and within 4 weeks prior to randomization are eligible; patients must not have taken any steroids =< 14 days prior to randomization for the purpose of managing their brain metastases; patients with only whole brain irradiation for treatment of CNS metastases will be ineligible
- Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for > 3 years prior to the time of randomization
- White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)
- Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)
- Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)
- Hemoglobin >= 9 g/dL (obtained within 4 weeks prior to randomization)
- Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)
- Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)
- Total bilirubin =< 1.5 x ULN except patients with normal direct bilirubin; those patients with known Gilbert’s syndrome must have total bilirubin < 3 x ULN (obtained within 4 weeks prior to randomization)
- Serum lactate dehydrogenase (LDH) =< 10 X ULN (obtained within 4 weeks prior to randomization)
- Patients must not have any serious or unstable pre-existing medical conditions (aside from malignancy exceptions specified above), including but not limited to, ongoing or active infection requiring parenteral antibiotics on day 1, history of bleeding diathesis or need for concurrent anticoagulation (international normalized ratio [INR] =< 1.5 and partial thromboplastin time [PTT] within 1.1 x ULN), or psychiatric illness/social situations that would limit compliance with study requirements, interfere with patient's safety, or obtaining informed consent
- Patients with human immunodeficiency virus (HIV) infection are ineligible; due to the mechanism of action of ipilimumab and GM-CSF, activity and side effects in an immune compromised patient are unknown
- Patients with evidence of active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection are not eligible; patients with cleared HBV and HCV (0 viral load) infection will be allowed
- Patients must not have autoimmune disorders or conditions of immunosuppression that require current ongoing treatment with systemic corticosteroids (or other systemic immunosuppressants), including oral steroids (e.g., prednisone, dexamethasone) or continuous use of topical steroid creams or ointments or ophthalmologic steroids; a history of occasional (but not continuous) use of steroid inhalers is allowed; replacement doses of steroids for patients with adrenal insufficiency are allowed; patients who discontinue use of these classes of medication for at least 2 weeks prior to randomization are eligible if, in the judgment of the treating physician investigator, the patient is not likely to require resumption of treatment with these classes of drugs during the study
- Exclusion from this study also includes patients with a history of symptomatic autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis [scleroderma], systemic lupus erythematosus, Sjogren's syndrome, autoimmune vasculitis [e.g., Wegener’s granulomatosis]); motor neuropathy considered of autoimmune origin (e.g., Guillain-Barre syndrome and myasthenia gravis); other CNS autoimmune disease (e.g., multiple sclerosis)
- Patients with autoimmune hypothyroid disease or type I diabetes on replacement treatment are eligible
- Patients must not have a history of inflammatory bowel disease or diverticulitis (history of diverticulosis is allowed)
- Patients must not have other significant medical, surgical, or psychiatric conditions or require any medication or treatment that in the opinion of the investigator may interfere with compliance, make the administration of the study drugs hazardous or obscure the interpretation of adverse events (AEs), such as a condition associated with frequent diarrhea; patients must not have an active infection requiring current treatment with parenteral antibiotics
United States
AL
Birmingham
University of Alabama at Birmingham Cancer Center
Contact: Site Public Contact
Email: tmyrick@uab.edu
AR
Little Rock
CARTI Cancer Center
Contact: Site Public Contact
Email: Research@CARTI.com
John L McClellan Memorial Veterans Hospital
Contact: Site Public Contact
Email: richard.dennis2@va.gov
AZ
Kingman
Kingman Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
CA
Anaheim
Kaiser Permanente-Anaheim
Contact: Site Public Contact
Email: clinical.trials@kp.org
Arroyo Grande
PCR Oncology
Contact: Site Public Contact
Email: research@sncrf.org
Auburn
Sutter Auburn Faith Hospital
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Baldwin Park
Kaiser Permanente-Baldwin Park
Contact: Site Public Contact
Email: clinical.trials@kp.org
Bellflower
Kaiser Permanente-Bellflower
Contact: Site Public Contact
Email: clinical.trials@kp.org
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Burlingame
Mills-Peninsula Medical Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Davis
Sutter Davis Hospital
Contact: Site Public Contact
Email: NCIclinicaltrials@sutterhealth.org
Duarte
City of Hope Comprehensive Cancer Center
Contact: Site Public Contact
Email: becomingapatient@coh.org
Dublin
Kaiser Permanente Dublin
Contact: Site Public Contact
Fontana
Kaiser Permanente-Fontana
Contact: Site Public Contact
Email: clinical.trials@kp.org
Fremont
Palo Alto Medical Foundation-Fremont
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Fresno
Kaiser Permanente-Fresno
Contact: Site Public Contact
Email: Kpoct@kp.org
Harbor City
Kaiser Permanente South Bay
Contact: Site Public Contact
Email: clinical.trials@kp.org
Irvine
Kaiser Permanente-Irvine
Contact: Site Public Contact
Email: clinical.trials@kp.org
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Contact: Site Public Contact
Email: ucstudy@uci.edu
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Contact: Site Public Contact
Email: clinical.trials@kp.org
Kaiser Permanente West Los Angeles
Contact: Site Public Contact
Email: clinical.trials@kp.org
Modesto
Kaiser Permanente-Modesto
Contact: Site Public Contact
Email: Kpoct@kp.org
Memorial Medical Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Novato
Sutter Cancer Research Consortium
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Oakland
Kaiser Permanente-Oakland
Contact: Site Public Contact
Email: Kpoct@kp.org
Ontario
Kaiser Permanente-Ontario
Contact: Site Public Contact
Email: clinical.trials@kp.org
Orange
Saint Joseph Hospital - Orange
Contact: Site Public Contact
UC Irvine Health/Chao Family Comprehensive Cancer Center
Contact: Site Public Contact
Email: ucstudy@uci.edu
Palo Alto
Palo Alto Medical Foundation Health Care
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Stanford Cancer Institute Palo Alto
Contact: Site Public Contact
Email: ccto-office@stanford.edu
Panorama City
Kaiser Permanente - Panorama City
Contact: Site Public Contact
Email: clinical.trials@kp.org
Richmond
Kaiser Permanente-Richmond
Contact: Site Public Contact
Email: Kpoct@kp.org
Riverside
Kaiser Permanente-Riverside
Contact: Site Public Contact
Email: clinical.trials@kp.org
Roseville
Kaiser Permanente-Roseville
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Cancer Centers Radiation Oncology Services-Roseville
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Sutter Roseville Medical Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Sacramento
Kaiser Permanente Downtown Commons
Contact: Site Public Contact
Email: kpoct@kp.org
Kaiser Permanente Sacramento Medical Center
Contact: Site Public Contact
Email: Kpoct@kp.org
Kaiser Permanente-South Sacramento
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Medical Center Sacramento
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
San Diego
Kaiser Permanente-San Diego Mission
Contact: Site Public Contact
Email: clinical.trials@kp.org
Kaiser Permanente-San Diego Zion
Contact: Site Public Contact
Email: clinical.trials@kp.org
Naval Medical Center -San Diego
Contact: Site Public Contact
San Francisco
California Pacific Medical Center-Pacific Campus
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
San Jose
Kaiser Permanente-Santa Teresa-San Jose
Contact: Site Public Contact
Email: Kpoct@kp.org
San Leandro
Kaiser Permanente San Leandro
Contact: Site Public Contact
Email: Kpoct@kp.org
San Marcos
Kaiser Permanente-San Marcos
Contact: Site Public Contact
Email: clinical.trials@kp.org
San Mateo
Mills Health Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
San Rafael
Kaiser Permanente-San Rafael
Contact: Site Public Contact
Email: Kpoct@kp.org
Kaiser San Rafael-Gallinas
Contact: Site Public Contact
Email: Kpoct@kp.org
Santa Barbara
Ridley-Tree Cancer Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Contact: Site Public Contact
Email: Kpoct@kp.org
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Santa Cruz Radiation Oncology Medical Group
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Santa Rosa
Sutter Pacific Medical Foundation
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Stockton
Kaiser Permanente-Stockton
Contact: Site Public Contact
Email: Kpoct@kp.org
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Upland
City of Hope Upland
Contact: Site Public Contact
Email: becomingapatient@coh.org
Vacaville
Kaiser Permanente Medical Center-Vacaville
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Contact: Site Public Contact
Email: hempell@sutterhealth.org
Vallejo
Kaiser Permanente-Vallejo
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Solano Medical Center/Cancer Center
Contact: Site Public Contact
Email: clinicalresearch@sutterhealth.org
Walnut Creek
Kaiser Permanente-Walnut Creek
Contact: Site Public Contact
Email: Kpoct@kp.org
Woodland Hills
Kaiser Permanente-Woodland Hills
Contact: Site Public Contact
Email: clinical.trials@kp.org
CO
Aurora
The Medical Center of Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Boulder
Boulder Community Foothills Hospital
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Boulder Community Hospital
Contact: Site Public Contact
Email: jbloomfield@co-cancerresearch.org
Rocky Mountain Cancer Centers-Boulder
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Colorado Springs
Penrose-Saint Francis Healthcare
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Rocky Mountain Cancer Centers-Penrose
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saint Francis Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Denver
Kaiser Permanente-Franklin
Contact: Site Public Contact
Email: kristi.m.bronkan@kp.org
Porter Adventist Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Presbyterian - Saint Lukes Medical Center - Health One
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rose Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
SCL Health Saint Joseph Hospital
Contact: Site Public Contact
Email: peaksresearch@imail.org
Durango
Mercy Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Southwest Oncology PC
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Englewood
Mountain Blue Cancer Care Center - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Swedish Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Melanoma and Skin Cancer Institute
Contact: Site Public Contact
Email: ryan.weight@theskincancerinstitute.com
Greeley
Banner North Colorado Medical Center
Contact: Site Public Contact
Email: BMDACCResearchCOMailbox@bannerhealth.com
Lafayette
Kaiser Permanente-Rock Creek
Contact: Site Public Contact
Email: kristi.m.bronkan@kp.org
Lakewood
Saint Anthony Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lone Tree
Kaiser Permanente-Lone Tree
Contact: Site Public Contact
Email: kristi.m.bronkan@kp.org
Sky Ridge Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Longmont
Longmont United Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Loveland
Banner McKee Medical Center
Contact: Site Public Contact
Email: BMDACCResearchCOMailbox@bannerhealth.com
Parker
Parker Adventist Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Pueblo
Saint Mary Corwin Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Wheat Ridge
Intermountain Health Lutheran Hospital
Contact: Site Public Contact
Email: peaksresearch@imail.org
CT
Glastonbury
Smilow Cancer Hospital Care Center at Glastonbury
Contact: Site Public Contact
Email: canceranswers@yale.edu
Guilford
Smilow Cancer Hospital Care Center - Guilford
Contact: Site Public Contact
Email: canceranswers@yale.edu
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Contact: Site Public Contact
Email: canceranswers@yale.edu
New Haven
Smilow Cancer Center/Yale-New Haven Hospital
Contact: Site Public Contact
Email: canceranswers@yale.edu
Yale University
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterford
Smilow Cancer Hospital Care Center - Waterford
Contact: Site Public Contact
Email: canceranswers@yale.edu
DC
Washington
MedStar Georgetown University Hospital
Contact: Site Public Contact
MedStar Washington Hospital Center
Contact: Site Public Contact
FL
Aventura
UM Sylvester Comprehensive Cancer Center at Aventura
Contact: Site Public Contact
Coral Gables
UM Sylvester Comprehensive Cancer Center at Coral Gables
Contact: Site Public Contact
Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Contact: Site Public Contact
Fort Lauderdale
Holy Cross Hospital
Contact: Site Public Contact
Email: eileen.georgi@holy-cross.com
Miami
UM Sylvester Comprehensive Cancer Center at Kendall
Contact: Site Public Contact
University of Miami Miller School of Medicine-Sylvester Cancer Center
Contact: Site Public Contact
Plantation
UM Sylvester Comprehensive Cancer Center at Plantation
Contact: Site Public Contact
Tampa
Moffitt Cancer Center
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
Moffitt Cancer Center - McKinley Campus
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
Moffitt Cancer Center-International Plaza
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
GA
Athens
University Cancer and Blood Center LLC
Contact: Site Public Contact
Email: research@universitycancer.com
Atlanta
Emory University Hospital/Winship Cancer Institute
Contact: Site Public Contact
Northside Hospital
Contact: Site Public Contact
Email: ClinicalTrials@northside.com
Augusta
Augusta University Medical Center
Contact: Site Public Contact
Email: ga_cares@augusta.edu
Cumming
Northside Hospital-Forsyth
Contact: Site Public Contact
Email: clinicaltrials@northside.com
Decatur
Dekalb Medical Center
Contact: Site Public Contact
Email: clinicaltrialsoncology@dekalbmedical.org
Duluth
Northside Hospital - Duluth
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Lawrenceville
Northside Hospital - Gwinnett
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
Summit Cancer Care-Candler
Contact: Site Public Contact
HI
Aiea
Hawaii Cancer Care - Westridge
Contact: Site Public Contact
Email: info@hawaiicancercare.com
Pali Momi Medical Center
Contact: Site Public Contact
Queen's Cancer Center - Pearlridge
Contact: Site Public Contact
Straub Pearlridge Clinic
Contact: Site Public Contact
The Cancer Center of Hawaii-Pali Momi
Contact: Site Public Contact
Ewa Beach
The Queen's Medical Center - West Oahu
Contact: Site Public Contact
Email: rohta@queens.org
Honolulu
Hawaii Cancer Care Inc - Waterfront Plaza
Contact: Site Public Contact
Email: i.webster@hawaiicancercare.com
Hawaii Cancer Care Inc-Liliha
Contact: Site Public Contact
Hawaii Diagnostic Radiology Services LLC
Contact: Site Public Contact
Email: mmiyoshi@hawaiidrs.com
Island Urology
Contact: Site Public Contact
Email: virginia@cc.hawaii.edu
Kaiser Permanente Moanalua Medical Center
Contact: Site Public Contact
Email: shelley.a.clark@kp.org
Kapiolani Medical Center for Women and Children
Contact: Site Public Contact
Kuakini Medical Center
Contact: Site Public Contact
Queen's Cancer Cenrer - POB I
Contact: Site Public Contact
Queen's Cancer Center - Kuakini
Contact: Site Public Contact
Queen's Medical Center
Contact: Site Public Contact
Straub Clinic and Hospital
Contact: Site Public Contact
The Cancer Center of Hawaii-Liliha
Contact: Site Public Contact
University of Hawaii Cancer Center
Contact: Site Public Contact
Kahului
Straub Medical Center - Kahului Clinic
Contact: Site Public Contact
Email: lori.kam@hawaiipacifichealth.org
Kailua
Castle Medical Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Contact: Site Public Contact
IA
Ames
Mary Greeley Medical Center
Contact: Site Public Contact
McFarland Clinic - Ames
Contact: Site Public Contact
Email: ksoder@mcfarlandclinic.com
Boone
McFarland Clinic - Boone
Contact: Site Public Contact
Council Bluffs
Alegent Health Mercy Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Heartland Oncology and Hematology LLP
Contact: Site Public Contact
Methodist Jennie Edmundson Hospital
Contact: Site Public Contact
Email: kathryn.bartz@nmhs.org
Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
Contact: Site Public Contact
Email: Liza.brandes@nmhs.org
Fort Dodge
McFarland Clinic - Trinity Cancer Center
Contact: Site Public Contact
Jefferson
McFarland Clinic - Jefferson
Contact: Site Public Contact
Marshalltown
McFarland Clinic - Marshalltown
Contact: Site Public Contact
Sioux City
Siouxland Regional Cancer Center
Contact: Site Public Contact
Email: HoopingarnerT@jencc.com
ID
Boise
Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Meridian
Idaho Urologic Institute-Meridian
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
IL
Aurora
Advocate Outpatient Center - Aurora
Contact: Site Public Contact
Email: ncorp@aah.org
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Barrington
Advocate Good Shepherd Hospital
Contact: Site Public Contact
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Joseph Medical Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Chicago
Advocate Illinois Masonic Medical Center
Contact: Site Public Contact
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Crystal Lake
AMG Crystal Lake - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocate.com
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@Carle.com
DeKalb
Northwestern Medicine Cancer Center Kishwaukee
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Downers Grove
Advocate Good Samaritan Hospital
Contact: Site Public Contact
Email: Barbara.barhamand@advocatehealth.com
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Elgin
Advocate Sherman Hospital
Contact: Site Public Contact
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
Contact: Site Public Contact
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Geneva
Northwestern Medicine Cancer Center Delnor
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Contact: Site Public Contact
Northwestern Medicine Glenview Outpatient Center
Contact: Site Public Contact
Grayslake
Northwestern Medicine Grayslake Outpatient Center
Contact: Site Public Contact
Hazel Crest
Advocate South Suburban Hospital
Contact: Site Public Contact
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Contact: Site Public Contact
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Lake Forest
Northwestern Medicine Lake Forest Hospital
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Libertyville
AMG Libertyville - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Condell Memorial Hospital
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
HSHS Saint Elizabeth's Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Oak Lawn
Advocate Christ Medical Center
Contact: Site Public Contact
Advocate Outpatient Center - Oak Lawn
Contact: Site Public Contact
Email: ncorp@aah.org
Orland Park
Northwestern Medicine Orland Park
Contact: Site Public Contact
Email: nctnprogram_rhlccc@northwestern.edu
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Palos Heights
Advocate High Tech Medical Park
Contact: Site Public Contact
Email: ncorp@aah.org
Park Ridge
Advocate Lutheran General Hospital
Contact: Site Public Contact
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Medical Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Springfield
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Springfield Memorial Hospital
Contact: Site Public Contact
Email: pallante.beth@mhsil.com
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Warrenville
Northwestern Medicine Cancer Center Warrenville
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Evansville
Deaconess Clinic Downtown
Contact: Site Public Contact
Email: Research@Deaconess.com
Indianapolis
Franciscan Health Indianapolis
Contact: Site Public Contact
Indiana University/Melvin and Bren Simon Cancer Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Michigan City
Franciscan Saint Anthony Health-Michigan City
Contact: Site Public Contact
Woodland Cancer Care Center
Contact: Site Public Contact
Email: sally.arnett@franciscanalliance.org
Mooresville
Franciscan Health Mooresville
Contact: Site Public Contact
Newburgh
Chancellor Center for Oncology
Contact: Site Public Contact
Email: Research@Deaconess.com
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
KS
Chanute
Cancer Center of Kansas - Chanute
Contact: Site Public Contact
Email: research@viachristi.org
Dodge City
Cancer Center of Kansas - Dodge City
Contact: Site Public Contact
Email: research@viachristi.org
El Dorado
Cancer Center of Kansas - El Dorado
Contact: Site Public Contact
Email: research@viachristi.org
Fort Scott
Cancer Center of Kansas - Fort Scott
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Hays
HaysMed
Contact: Site Public Contact
Independence
Cancer Center of Kansas-Independence
Contact: Site Public Contact
Email: research@viachristi.org
Kansas City
University of Kansas Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Kingman
Cancer Center of Kansas-Kingman
Contact: Site Public Contact
Email: research@viachristi.org
Lawrence
Lawrence Memorial Hospital
Contact: Site Public Contact
Email: Stephanie.Norris@LMH.ORG
Liberal
Cancer Center of Kansas-Liberal
Contact: Site Public Contact
Email: research@viachristi.org
Manhattan
Cancer Center of Kansas-Manhattan
Contact: Site Public Contact
Email: research@viachristi.org
McPherson
Cancer Center of Kansas - McPherson
Contact: Site Public Contact
Email: research@viachristi.org
Newton
Cancer Center of Kansas - Newton
Contact: Site Public Contact
Email: research@viachristi.org
Olathe
Olathe Health Cancer Center
Contact: Site Public Contact
Email: atheCCResearch@kumc.edu
Overland Park
University of Kansas Cancer Center-Overland Park
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
University of Kansas Hospital-Indian Creek Campus
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Parsons
Cancer Center of Kansas - Parsons
Contact: Site Public Contact
Email: research@viachristi.org
Pittsburg
Freeman Physician Group of Pittsburg
Contact: Site Public Contact
Email: BNMathew@freemanhealth.com
Pratt
Cancer Center of Kansas - Pratt
Contact: Site Public Contact
Email: research@viachristi.org
Salina
Cancer Center of Kansas - Salina
Contact: Site Public Contact
Email: research@viachristi.org
Salina Regional Health Center
Contact: Site Public Contact
Email: mleepers@srhc.com
Topeka
Cotton O'Neil Cancer Center / Stormont Vail Health
Contact: Site Public Contact
University of Kansas Health System Saint Francis Campus
Contact: Site Public Contact
Wellington
Cancer Center of Kansas - Wellington
Contact: Site Public Contact
Email: research@viachristi.org
Westwood
University of Kansas Hospital-Westwood Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Associates In Womens Health
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: research@viachristi.org
Winfield
Cancer Center of Kansas - Winfield
Contact: Site Public Contact
Email: research@viachristi.org
KY
Crestview Hills
Oncology Hematology Care Inc-Crestview
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Louisville
The James Graham Brown Cancer Center at University of Louisville
Contact: Site Public Contact
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: ctoinfo@louisville.edu
LA
Baton Rouge
LSU Health Baton Rouge-North Clinic
Contact: Site Public Contact
Email: research@ololrmc.com
Louisiana Hematology Oncology Associates LLC
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Mary Bird Perkins Cancer Center
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Medical Center of Baton Rouge
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org
Ochsner Health Center-Summa
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org
Ochsner High Grove
Contact: Site Public Contact
Email: Camielle.beck@ochsner.org
Our Lady of The Lake
Contact: Site Public Contact
Our Lady of the Lake Physician Group
Contact: Site Public Contact
Email: research@ololrmc.com
Covington
Mary Bird Perkins Cancer Center - Covington
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Northshore Oncology Associates-Covington
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Houma
Mary Bird Perkins Cancer Center - Houma
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Oncology Center of The South Incorporated
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Kenner
Ochsner Medical Center Kenner
Contact: Site Public Contact
Email: awendt@ochsner.org
Monroe
Ochsner LSU Health Monroe Medical Center
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Ochsner Medical Center Jefferson
Contact: Site Public Contact
Email: Elisemarie.curry@ochsner.org
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Shreveport
CHRISTUS Highland Medical Center
Contact: Site Public Contact
Email: Nancy.hassan@christushealth.org
LSU Health Sciences Center at Shreveport
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
MA
Boston
Beth Israel Deaconess Medical Center
Contact: Site Public Contact
Dana-Farber Cancer Institute
Contact: Site Public Contact
Massachusetts General Hospital Cancer Center
Contact: Site Public Contact
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Baltimore
Greater Baltimore Medical Center
Contact: Site Public Contact
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Contact: Site Public Contact
Saint Agnes Hospital
Contact: Site Public Contact
Sinai Hospital of Baltimore
Contact: Site Public Contact
Email: pridgely@lifebridgehealth.org
Cumberland
UPMC Western Maryland
Contact: Site Public Contact
Randallstown
Northwest Hospital Center
Contact: Site Public Contact
Email: cancerinstitute@lifebridgehealth.org
ME
Augusta
Harold Alfond Center for Cancer Care
Contact: Site Public Contact
Bangor
Eastern Maine Medical Center
Contact: Site Public Contact
Brewer
Lafayette Family Cancer Center-EMMC
Contact: Site Public Contact
Kennebunk
Maine Center for Cancer Medicine-Kennebunk
Contact: Site Public Contact
Email: research@newecs.org
Scarborough
Maine Center for Cancer Medicine-Scarborough
Contact: Site Public Contact
Email: research@newecs.org
MI
Adrian
Hickman Cancer Center
Contact: Site Public Contact
Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Caro
Caro Cancer Center
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Chelsea
Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Dearborn
Corewell Health Dearborn Hospital
Contact: Site Public Contact
Detroit
Henry Ford Health Saint John Hospital
Contact: Site Public Contact
Email: Kkeenan1@hfhs.org
East China
Henry Ford River District Hospital
Contact: Site Public Contact
Email: kforman1@hfhs.org
Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: wstrong@ghci.org
Hurley Medical Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: kforman1@hfhs.org
Henry Ford Saint John Hospital - Academic
Contact: Site Public Contact
Email: kforman1@hfhs.org
Henry Ford Saint John Hospital - Breast
Contact: Site Public Contact
Email: karen.forman@ascension.org
Jackson
Allegiance Health
Contact: Site Public Contact
Email: CTOResearch@hfhs.org
Kalamazoo
Ascension Borgess Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ascension Borgess Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Lansing
University of Michigan Health - Sparrow Lansing
Contact: Site Public Contact
Email: harsha.trivedi@umhsparrow.org
Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Macomb Township
Henry Ford Saint John Hospital - Macomb Medical
Contact: Site Public Contact
Email: kforman1@hfhs.org
Henry Ford Warren Hospital - Breast Macomb
Contact: Site Public Contact
Email: kforman1@hfhs.org
Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Monroe
Toledo Clinic Cancer Centers-Monroe
Contact: Site Public Contact
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Pontiac
Hope Cancer Center
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Michigan Healthcare Professionals Pontiac
Contact: Site Public Contact
Email: Emily.Crofts@trinity-health.org
Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Saint Joseph Mercy Oakland Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Royal Oak
Corewell Health William Beaumont University Hospital
Contact: Site Public Contact
Saginaw
MyMichigan Medical Center Saginaw
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Southfield
Henry Ford Health Providence Southfield Hospital
Contact: Site Public Contact
Email: kfife3@hfhs.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: karen.forman@ascension.org
Tawas City
MyMichigan Medical Center Tawas
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Troy
Corewell Health Beaumont Troy Hospital
Contact: Site Public Contact
Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Henry Ford Health Warren Hospital
Contact: Site Public Contact
Email: kforman1@hfhs.org
Henry Ford Madison Heights Hospital - Breast
Contact: Site Public Contact
Email: kforman1@hfhs.org
Henry Ford Warren Hospital - GLCMS
Contact: Site Public Contact
Email: kforman1@hfhs.org
Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: karen.forman@ascension.org
West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
MN
Aitkin
Riverwood Healthcare Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Baxter
Essentia Health - Baxter Clinic
Contact: Site Public Contact
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Brainerd
Essentia Health Saint Joseph's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Duluth
Essentia Health Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Miller-Dwan Hospital
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Ely
Essentia Health - Ely Clinic
Contact: Site Public Contact
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Contact: Site Public Contact
International Falls
Essentia Health - International Falls Clinic
Contact: Site Public Contact
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Moose Lake
Essentia Health - Moose Lake Clinic
Contact: Site Public Contact
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Virginia
Essentia Health Virginia Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Chesterfield
Saint Luke's Hospital
Contact: Site Public Contact
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: amy.franken@health.missouri.edu
Kansas City
University Health Truman Medical Center
Contact: Site Public Contact
University of Kansas Cancer Center - North
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
North Kansas City
University of Kansas Cancer Center at North Kansas City Hospital
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: Trisha.England2@mymlc.com
Saint Louis
Missouri Baptist Medical Center
Contact: Site Public Contact
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
MS
Jackson
University of Mississippi Medical Center
Contact: Site Public Contact
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Logan Health Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
NC
Asheville
AdventHealth Infusion Center Asheville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Wayne Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Hendersonville
Margaret R Pardee Memorial Hospital
Contact: Site Public Contact
Email: pardeecancerresearch@unchealth.unc.edu
Jacksonville
Onslow Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kenansville
ECU Health Oncology Kenansville
Contact: Site Public Contact
Email: research@ecuhealth.org
Kinston
ECU Health Oncology Kinston
Contact: Site Public Contact
Email: research@ecuhealth.org
Richlands
ECU Health Oncology Richlands
Contact: Site Public Contact
Email: research@ecuhealth.org
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Jamestown
Essentia Health - Jamestown Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
NE
Lincoln
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
North Platte
Great Plains Health Callahan Cancer Center
Contact: Site Public Contact
Email: mwilwerding@canceralliance-ne.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Creighton University Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Contact: Site Public Contact
Nebraska Methodist Hospital
Contact: Site Public Contact
Oncology Associates PC
Contact: Site Public Contact
Email: info@oa-oc.com
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
NH
Lebanon
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Contact: Site Public Contact
Email: cancer.research.nurse@dartmouth.edu
NJ
Basking Ridge
Memorial Sloan Kettering Basking Ridge
Contact: Site Public Contact
Hackensack
Hackensack University Medical Center
Contact: Site Public Contact
Neptune
Jersey Shore Medical Center
Contact: Site Public Contact
Red Bank
Riverview Medical Center/Booker Cancer Center
Contact: Site Public Contact
NM
Albuquerque
Lovelace Medical Center-Saint Joseph Square
Contact: Site Public Contact
Email: AYost@nmcca.org
New Mexico Oncology Hematology Consultants
Contact: Site Public Contact
Email: CLee@nmcca.org
Presbyterian Kaseman Hospital
Contact: Site Public Contact
Email: WBurman@phs.org
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: HSC-ClinicalTrialInfo@salud.unm.edu
Rio Rancho
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Contact: Site Public Contact
Email: WBurman@phs.org
Santa Fe
Christus Saint Vincent Regional Cancer Center
Contact: Site Public Contact
Email: Olivia.Sloan@nmcancercare.com
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Buffalo
Roswell Park Cancer Institute
Contact: Site Public Contact
Email: askroswell@roswellpark.org
Commack
Memorial Sloan Kettering Commack
Contact: Site Public Contact
Cooperstown
Mary Imogene Bassett Hospital
Contact: Site Public Contact
Email: CancerClinicalTrials@bassett.org
New York
Memorial Sloan Kettering Cancer Center
Contact: Site Public Contact
NYP/Weill Cornell Medical Center
Contact: Site Public Contact
Rochester
University of Rochester
Contact: Site Public Contact
West Harrison
Memorial Sloan Kettering Westchester
Contact: Site Public Contact
OH
Avon
UH Seidman Cancer Center at UH Avon Health Center
Contact: Site Public Contact
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Canton
Cleveland Clinic Mercy Hospital
Contact: Site Public Contact
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Cincinnati
Oncology Hematology Care Inc-Anderson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Blue Ash
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Eden Park
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Mercy West
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
University of Cincinnati Cancer Center-UC Medical Center
Contact: Site Public Contact
Email: cancer@uchealth.com
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
MetroHealth Medical Center
Contact: Site Public Contact
Email: ababal@metrohealth.org
Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Doctors Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Grant Medical Center
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Mount Carmel East Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mount Carmel Health Center West
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Riverside Methodist Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
The Mark H Zangmeister Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Good Samaritan Hospital - Dayton
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Premier Blood and Cancer Center
Contact: Site Public Contact
Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Grady Memorial Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Dublin
Columbus Oncology and Hematology Associates
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Dublin Methodist Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Fairfield
Oncology Hematology Care Inc-Healthplex
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Cancer Care and Infusion
Contact: Site Public Contact
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Zangmeister Center Grove City
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Kettering
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Lima
Saint Rita's Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mansfield
OhioHealth Mansfield Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Marysville
Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Maumee
Toledo Clinic Cancer Centers-Maumee
Contact: Site Public Contact
Email: pshoup@toledoclinic.com
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Contact: Site Public Contact
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Middletown
Dayton Physicians LLC-Signal Point
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
New Albany
Mount Carmel New Albany Surgical Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Newark Radiation Oncology
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Oregon
Saint Charles Hospital
Contact: Site Public Contact
Perrysburg
Mercy Health Perrysburg Cancer Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Sidney
Dayton Physicians LLC-Wilson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Sylvania
ProMedica Flower Hospital
Contact: Site Public Contact
Email: PCIOncResearch@promedica.org
Toledo
Mercy Health Sylvania Radiation Oncology Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mercy Health - Saint Vincent Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Contact: Site Public Contact
Email: PCIOncResearch@promedica.org
Toledo Clinic Cancer Centers-Toledo
Contact: Site Public Contact
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
West Chester
University of Cincinnati Cancer Center-West Chester
Contact: Site Public Contact
Email: cancer@uchealth.com
Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Westlake
UH Seidman Cancer Center at Saint John Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Wilmington
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
OK
Oklahoma City
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Saint Luke's Cancer Center - Allentown
Contact: Site Public Contact
Beaver
UPMC-Heritage Valley Health System Beaver
Contact: Site Public Contact
Email: haneydl@upmc.edu
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Saint Luke's University Hospital-Bethlehem Campus
Contact: Site Public Contact
Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Easton
Saint Luke's Hospital-Anderson Campus
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Erie
UPMC Hillman Cancer Center Erie
Contact: Site Public Contact
Email: haneydl@upmc.edu
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Indiana
IRMC Cancer Center
Contact: Site Public Contact
Email: haneydl@upmc.edu
Johnstown
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Contact: Site Public Contact
Lewisburg
Geisinger Medical Oncology-Lewisburg
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lewistown
Lewistown Hospital
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact
Mechanicsburg
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Contact: Site Public Contact
Email: haneydl@upmc.edu
Moon Township
UPMC Hillman Cancer Center in Coraopolis
Contact: Site Public Contact
Email: haneydl@upmc.edu
Pittsburgh
UPMC-Magee Womens Hospital
Contact: Site Public Contact
UPMC-Passavant Hospital
Contact: Site Public Contact
UPMC-Presbyterian Hospital
Contact: Site Public Contact
UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact
UPMC-Saint Margaret
Contact: Site Public Contact
UPMC-Shadyside Hospital
Contact: Site Public Contact
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact
Pottsville
Geisinger Cancer Services-Pottsville
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Quakertown
Saint Luke's Hospital - Upper Bucks Campus
Contact: Site Public Contact
Sayre
Guthrie Medical Group PC-Robert Packer Hospital
Contact: Site Public Contact
Scranton
Community Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact
State College
Geisinger Medical Group
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Stroudsburg
Saint Luke's Hospital - Monroe Campus
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Contact: Site Public Contact
Washington
UPMC Cancer Center-Washington
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC Washington Hospital Radiation Oncology
Contact: Site Public Contact
Email: cancer@washingtonhospital.org
West Reading
Reading Hospital
Contact: Site Public Contact
Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Williamsport
UPMC Susquehanna
Contact: Site Public Contact
RI
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu
SC
Bluffton
Saint Joseph's/Candler - Bluffton Campus
Contact: Site Public Contact
Email: underberga@sjchs.org
Greenville
Saint Francis Cancer Center
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Saint Francis Hospital
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Hilton Head Island
South Carolina Cancer Specialists PC
Contact: Site Public Contact
Email: underberga@sjchs.org
SD
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org
TN
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Contact: Site Public Contact
Knoxville
Thompson Cancer Survival Center
Contact: Site Public Contact
Thompson Cancer Survival Center - West
Contact: Site Public Contact
Maryville
Thompson Oncology Group-Maryville
Contact: Site Public Contact
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Contact: Site Public Contact
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
Oak Ridge
Thompson Oncology Group-Oak Ridge
Contact: Site Public Contact
TX
Dallas
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT
Farmington
Farmington Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
South Jordan
South Jordan Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
VA
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: uvacancertrials@hscmail.mcc.virginia.edu
Fredericksburg
Hematology Oncology Associates of Fredericksburg Inc
Contact: Site Public Contact
Email: cvaughn@hoafredericksburg.com
Lynchburg
Centra Alan B Pearson Regional Cancer Center
Contact: Site Public Contact
Email: Kevin.Patel@centrahealth.com
Richmond
Virginia Cancer Institute
Contact: Site Public Contact
Email: smoore@vacancer.com
Virginia Commonwealth University/Massey Cancer Center
Contact: Site Public Contact
Email: CTOclinops@vcu.edu
Winchester
Shenandoah Oncology PC
Contact: Site Public Contact
Email: William.Houck@usoncology.com
VT
Burlington
University of Vermont Medical Center
Contact: Site Public Contact
Email: rpo@uvm.edu
University of Vermont and State Agricultural College
Contact: Site Public Contact
Email: rpo@uvm.edu
WA
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Contact: Site Public Contact
Email: Memorial-ClinicalTrials@yvmh.org
WI
Antigo
Langlade Hospital and Cancer Center
Contact: Site Public Contact
Email: Juli.Alford@aspirus.org
Ashland
Duluth Clinic Ashland
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Northwest Wisconsin Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org
Chippewa Falls
Marshfield Clinic-Chippewa Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Cudahy
Aurora Saint Luke's South Shore
Contact: Site Public Contact
Email: ncorp@aurora.org
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Fond Du Lac
Aurora Health Center-Fond du Lac
Contact: Site Public Contact
Email: ncorp@aurora.org
Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org
Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Bellin Memorial Hospital
Contact: Site Public Contact
Johnson Creek
University of Wisconsin Carbone Cancer Center - Johnson Creek
Contact: Site Public Contact
Email: clinicaltrials@cancer.wisc.edu
Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org
La Crosse
Gundersen Lutheran Medical Center
Contact: Site Public Contact
Email: cancerctr@gundersenhealth.org
Madison
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Contact: Site Public Contact
Email: clinicaltrials@cancer.wisc.edu
University of Wisconsin Carbone Cancer Center - University Hospital
Contact: Site Public Contact
Email: clinicaltrials@cancer.wisc.edu
Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Medford
Aspirus Medford Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Milwaukee
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Medical College of Wisconsin
Contact: Site Public Contact
Minocqua
Marshfield Medical Center - Minocqua
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mukwonago
ProHealth D N Greenwald Center
Contact: Site Public Contact
Email: research.institute@phci.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Contact: Site Public Contact
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org
Racine
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org
Rhinelander
Aspirus Cancer Care - James Beck Cancer Center
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Rice Lake
Lakeview Medical Center-Marshfield Clinic
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org
Stevens Point
Aspirus Cancer Care - Stevens Point
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org
Waukesha
Aurora Cancer Care-Waukesha
Contact: Site Public Contact
Email: ncorp@aurora.org
ProHealth Waukesha Memorial Hospital
Contact: Site Public Contact
UW Cancer Center at ProHealth Care
Contact: Site Public Contact
Email: Chanda.miller@phci.org
Wausau
Aspirus Regional Cancer Center
Contact: Site Public Contact
Marshfield Clinic-Wausau Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wauwatosa
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org
West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Aspirus Cancer Care - Wisconsin Rapids
Contact: Site Public Contact
Marshfield Clinic - Wisconsin Rapids Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
WV
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
Huntington
Edwards Comprehensive Cancer Center
Contact: Site Public Contact
Email: Christina.Cole@chhi.org
PRIMARY OBJECTIVE: I. To compare the overall survival (OS) of nivolumab/ipilimumab/sargramostim (GM-CSF) versus nivolumab/ipilimumab. SECONDARY OBJECTIVES: I. To evaluate progression free survival (PFS) of patients treated with nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab. II. To assess for differences in tolerability, specifically the rate of grade III or higher adverse events, between nivolumab/ipilimumab/GM-CSF versus nivolumab/ipilimumab. III. To evaluate immune-related response rate (based on immune-related response criteria) and response rate (based on Response Evaluation Criteria in Solid Tumors [RECIST] criteria) and to compare them. EXPLORATORY TOBACCO USE OBJECTIVES: I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications). II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms. III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization. IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit. OUTLINE: Patients are randomized to 1 of 2 treatment arms. ARM A: INDUCTION THERAPY: Patients receive nivolumab intravenously (IV) over 30 minutes on day 1 of each cycle, ipilimumab IV over 30 minutes on day 1 of each age, and sargramostim subcutaneously (SC) on days 1-14 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab and sargramostim as in induction therapy. Patients with partial response (PR), stable disease (SD), or complete response (CR) at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo magnetic resonance imaging (MRI), computed tomography (CT) scan, and blood sample collection throughout the study. Patients may also undergo a multigated acquisition (MUGA) during screening, as well as an echocardiography (ECHO) throughout the trial as clinically indicated. ARM B: INDUCTION THERAPY: Patients receive nivolumab and ipilimumab as in Arm I. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE THERAPY: Patients receive nivolumab as in induction therapy. Patients with PR, SD, or CR at 24 weeks may continue maintenance therapy for up to 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo MRI, CT scan, and blood sample collection throughout the study. Patients may also undergo a MUGA during screening, as well as an ECHO throughout the trial as clinically indicated. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its National Clinical Trials Network.