European Urology Focus publishes an update on the EA8212 (BRIDGE) trial for early bladder cancer

The ongoing phase 3 trial EA8212 (BRIDGE) is enrolling patients with early-stage bladder cancer to compare gemcitabine+docetaxel chemotherapy (GEMDOCE) to standard first-line bacillus Calmette-Guerin (BCG) immunotherapy. Study chair Max Kates, MD (Johns Hopkins University) and colleagues discuss the study, including the preliminary data on GEMDOCE justifying it, in a new Clinical Studies Update in European Urology Focus.

While BCG provides long-term recurrence-free survival for some patients, 30-50% will have a recurrence within 2 years. In addition, there are dose-limiting toxicities with BCG and unpredictable access due to manufacturing issues and increased global demand. During the BCG shortages, many urologists have turned to GEMDOCE as a replacement. BRIDGE is a necessary next step in demonstrating the non-inferiority of the GEMDOCE regimen compared to BCG in the frontline setting.

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Learn more about the BRIDGE trial on ecog-acrin.org.