Active Clinical Trials
Numerous clinical trials are always active (i.e., open and enrolling patients) in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults who have or are at risk of developing cancer. This section of the website contains a searchable list of all active trials. On the table below, hover over any of the column headings and click the up/down arrows to sort. You can also search by keyword. To access more information about a particular trial, click on the trial ID.
| Cancer Type | Trial ID/More Info | Target Patient Population | Study Type | ECOG-ACRIN Oversight Committee(s) |
|---|---|---|---|---|
| Various | EAQ222CD / CostCOM | Ages 18+ with any type of solid cancer of any stage | Observation | Cancer Care Delivery Research |
| Various | EAQ223 / SUPPORT | Cancer patients at community-based treatment sites | Interventional | Health Equity |
| Various | EAY191 / ComboMATCH | Patients with solid tumors that have spread to nearby tissue or lymph nodes (locally advanced) or other places in the body (advanced) | Patient Registration | Developmental Therapeutics |
| Various | EAY191-E5/ ComboMATCH-E5 | Metastatic (advanced) solid tumors with a KRAS G12C mutation | Treatment | Developmental Therapeutics |
| Bladder | EA8231 | Has spread nearby (locally advanced) or has advanced to other places in the body (metastatic) | Treatment | Genitourinary |
| Blood (Leukemia) | EA9213 | Acute lymphoblastic leukemia (ALL), T-cell Type | Treatment | Leukemia |
| Blood (Leukemia) | Acute myeloid leukemia (AML) | Treatment | Leukemia | |
| Blood (Lymphoma) | EA4231 | B-cell lymphoma (a type of non-Hodgkin lymphoma) | Treatment | Lymphoma |
| Blood (Lymphoma) | EA4232 / PTCL-STAT | Peripheral T-cell lymphoma (a type of non-Hodgkin lymphoma) | Treatment | Lymphoma |
| Blood (Myeloma) | EAA173 / DETER-SMM | Smoldering (early) | Treatment | Myeloma |
| Blood (Myeloma) | EAA181 / EQUATE | Newly diagnosed | Treatment | Myeloma |
| Blood (Myeloma) | EAA241 | Newly diagnosed, and with kidney failure | Treatment | Myeloma |
| Brain | Glioblastoma, newly diagnosed | Imaging | Brain Cancer Working Group | |
| Breast | EA1241 / TAILORx / RxPONDER | Participants in the TAILORx and RxPONDER trials | Observation | Breast |
| Breast | EAQ221CD / CONCURxP | Patients taking a CDK4/6 inhibitor | Observation | Cancer Care Delivery Research |
| Colorectal | EA2222 / PUMP | Metastatic (advanced to the liver), not able to be removed by surgery (inoperable) | Treatment | Gastrointestinal |
| Esophagus | EA2174 | Locally advanced, able to be removed by surgery (operable) | Treatment | Gastrointestinal |
| Head and Neck | EA3132 | p53-mutated squamous cell carcinoma, after surgery | Treatment | Head and Neck |
| Head and Neck | EA3191 | Squamous cell carcinoma of the head and neck that has come back after initial therapy | Treatment | Head and Neck |
| Lung | EA5162 | Non-small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | EA5182 | Non-small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | EA5221 / ACHIEVE | Non-small cell type, metastatic (advanced) in older patients aged 70+ | Treatment | Thoracic; Geriatric Oncology |
| Lung | PrE0510 | Small cell type, metastatic (advanced) | Treatment | Thoracic |
| Lung | PrE1702 | Non-small cell type, with EGFR mutation, metastatic (advanced) | Observation | Thoracic |
| Melanoma (Skin Cancer) | EA6232 | History of melanoma and currently being monitored for atypical moles | Therapeutic Prevention | Melanoma; Prevention |
| Melanoma (Skin Cancer) | EA6244 | Newly diagnosed, early-stage in older patients aged 75+ | Intervention | Melanoma; Geriatric Oncology |
| Pancreas | EA2185 | Monitoring patients with non-cancerous pancreas cysts | Observation | Gastrointestinal |
| Pancreas | EA2192 / APOLLO | Has been surgically removed and has a BRCA1, BRCA2, or PALB2 mutation | Treatment | Gastrointestinal |
| Penis | EA8134 / InPACT | Spread to nearby tissue or lymph nodes (locally advanced) | Treatment | Genitourinary |
| Prostate | EA8191 / INDICATE | Has come back after surgery | Treatment | Genitourinary |
| Sarcoma (Soft Tissue) | EA7211 / STRASS 2 | Able to be removed by surgery (operable); at high risk of returning | Treatment | Sarcoma |
| Sarcoma (Soft Tissue) | EA7222 | Metastatic (advanced), not able to be removed by surgery | Treatment | Sarcoma |
| Stomach | EA2234 / STOPGAP II | Gastric (stomach) or gastroesophageal cancer that has spread to the abdominal cavity | Treatment | Gastrointestinal |
| Thyroid | EA3231 | Differentiated and BRAF V600E-mutated type that has spread after standard treatment | Treatment | Head and Neck |
| Upper Urinary Tract | EA8192 | High grade (aggressive) | Treatment | Genitourinary |