Breast Cancer
EAZ171
Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients with Stage I-III Breast Cancer
STATUS: Closed to Accrual
This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer. Drugs used in chemotherapy, such as docetaxel and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving docetaxel or paclitaxel may work better than other methods in reducing chemotherapy-induced peripheral neuropathy in patients with breast cancer.
- Patients must be women with a known stage I-III invasive breast cancer diagnosis
- Patients must be capable and willing to provide informed consent
- Patients must have plans to receive either neoadjuvant or adjuvant: * Every 3-week docetaxel x 4-6 cycles OR * Weekly paclitaxel x 4 cycles * NOTE: Recommended therapies for various therapy regimens are outlined based on estrogen receptor (ER)/progesterone receptor (PR)/HER2 and nodal status. Where there are options, the treating physician will choose a regimen best fitted for that patient. If the physician does not feel any of the regimens are the best fit for the patient, the patient should not be enrolled. Physicians will also document why a regimen was felt to be inappropriate when an option. Patients who have already started the anthracycline portion of their therapy are eligible assuming they have not yet begun the taxane portion and assuming they will be receiving one of the regimens deemed appropriate for her disease setting
- Patients must self-identify their race as black, African American, or of African descent; patients may be of any ethnicity
- Patients must not have received prior taxane or prior/concurrent platinum therapy
- Patients must not have received neoadjuvant anti-HER2 therapy
- Patients with a history of other cancers are eligible if they have not received prior taxane or platinum or vinca alkaloid therapy
- Patients must not have pre-existing peripheral neuropathy
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Patients must not have a total bilirubin > upper limit of normal (ULN) (must be obtained within 3 weeks prior to registration)
- Patients must not have aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) above 1.5 times the ULN concomitant with alkaline phosphatase above 2.5 times the ULN (must be obtained within 3 weeks prior to registration)
- Patients must not be pregnant or lactating * All patients of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy * A patient of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy, or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients of childbearing potential must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study
United States
AK
Anchorage
Alaska Breast Care and Surgery LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Fairbanks
Fairbanks Memorial Hospital
Contact: Site Public Contact
Email: Veronica.Stevenson@foundationhealth.org
AL
Birmingham
University of Alabama at Birmingham Cancer Center
Contact: Site Public Contact
Email: tmyrick@uab.edu
AR
Ft. Smith
Mercy Hospital Fort Smith
Contact: Site Public Contact
Jonesboro
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Contact: Site Public Contact
Email: Emily.Carvell@bmhcc.org
AZ
Kingman
Kingman Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
CA
Arroyo Grande
PCR Oncology
Contact: Site Public Contact
Email: research@sncrf.org
Burbank
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Contact: Site Public Contact
Email: Najee.Boucher@providence.org
Dublin
Epic Care-Dublin
Contact: Site Public Contact
Emeryville
Bay Area Breast Surgeons Inc
Contact: Site Public Contact
Epic Care Partners in Cancer Care
Contact: Site Public Contact
Martinez
Contra Costa Regional Medical Center
Contact: Site Public Contact
Oakland
Alta Bates Summit Medical Center - Summit Campus
Contact: Site Public Contact
Bay Area Tumor Institute
Contact: Site Public Contact
Email: lradke@bati.org
Walnut Creek
Epic Care Cyberknife Center
Contact: Site Public Contact
Email: somega@bati.org
CO
Aurora
Rocky Mountain Cancer Centers-Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Medical Center of Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Boulder
Boulder Community Foothills Hospital
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Boulder Community Hospital
Contact: Site Public Contact
Email: jbloomfield@co-cancerresearch.org
Rocky Mountain Cancer Centers-Boulder
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Centennial
Rocky Mountain Cancer Centers - Centennial
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Denver
Cancer Center of Colorado at Sloan's Lake
Contact: Site Public Contact
Colorado Blood Cancer Institute
Contact: Site Public Contact
Email: info@westernstatesncorp.org
National Jewish Health-Main Campus
Contact: Site Public Contact
Email: glicht@co-cancerresearch.org
Presbyterian - Saint Lukes Medical Center - Health One
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Midtown
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Rose
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rose Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
SCL Health Saint Joseph Hospital
Contact: Site Public Contact
Email: alan.franklin@sclhealth.org
The Women's Imaging Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Western Surgical Care
Contact: Site Public Contact
Englewood
Mountain Blue Cancer Care Center - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Swedish Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Melanoma and Skin Cancer Institute
Contact: Site Public Contact
Email: ryan.weight@theskincancerinstitute.com
Golden
National Jewish Health-Western Hematology Oncology
Contact: Site Public Contact
Email: glicht@co-cancerresearch.org
Grand Junction
Saint Mary's Hospital and Regional Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
Greeley
Banner North Colorado Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Lafayette
Good Samaritan Hospital - Cancer Centers of Colorado
Contact: Site Public Contact
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Littleton
Rocky Mountain Cancer Centers-Littleton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Sky Ridge Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Loveland
Banner McKee Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Thornton
National Jewish Health-Northern Hematology Oncology
Contact: Site Public Contact
Email: glicht@co-cancerresearch.org
Rocky Mountain Cancer Centers-Thornton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Wheat Ridge
Intermountain Health Lutheran Hospital
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
DC
Washington
MedStar Washington Hospital Center
Contact: Site Public Contact
Sibley Memorial Hospital
Contact: Site Public Contact
Email: jquiver1@jhmi.edu
DE
Lewes
Beebe Medical Center
Contact: Site Public Contact
Email: Dmiskin@Beebehealthcare.org
Millville
Beebe South Coastal Health Campus
Contact: Site Public Contact
Email: Dmiskin@Beebehealthcare.org
Newark
Christiana Care Health System-Christiana Hospital
Contact: Site Public Contact
Email: mhayden@christianacare.org
Delaware Clinical and Laboratory Physicians PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Helen F Graham Cancer Center
Contact: Site Public Contact
Email: mhayden@christianacare.org
Medical Oncology Hematology Consultants PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Rehoboth Beach
Beebe Health Campus
Contact: Site Public Contact
Email: Dmiskin@Beebehealthcare.org
Seaford
TidalHealth Nanticoke / Allen Cancer Center
Contact: Site Public Contact
Email: anna-maria.howard@peninsula.org
Wilmington
Christiana Care Health System-Wilmington Hospital
Contact: Site Public Contact
Email: mhayden@christianacare.org
FL
Fort Lauderdale
Holy Cross Hospital
Contact: Site Public Contact
Gainesville
University of Florida Health Science Center - Gainesville
Contact: Site Public Contact
Email: cancer-center@ufl.edu
GA
Atlanta
Emory Saint Joseph's Hospital
Contact: Site Public Contact
Emory University Hospital Midtown
Contact: Site Public Contact
Emory University Hospital/Winship Cancer Institute
Contact: Site Public Contact
Grady Health System
Contact: Site Public Contact
Northside Hospital
Contact: Site Public Contact
Email: ClinicalTrials@northside.com
Columbus
John B Amos Cancer Center
Contact: Site Public Contact
Email: cdean@iacthealth.com
Duluth
Northside Hospital - Duluth
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Lawrenceville
Northside Hospital - Gwinnett
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
Snellville
Suburban Hematology Oncology Associates - Snellville
Contact: Site Public Contact
Email: Clinical.trials@northside.com
ID
Boise
Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact
Email: eslinget@slhs.org
Fruitland
Saint Luke's Cancer Institute - Fruitland
Contact: Site Public Contact
Email: eslinget@slhs.org
Meridian
Saint Luke's Cancer Institute - Meridian
Contact: Site Public Contact
Email: eslinget@slhs.org
Nampa
Saint Luke's Cancer Institute - Nampa
Contact: Site Public Contact
Email: eslinget@slhs.org
Twin Falls
Saint Luke's Cancer Institute - Twin Falls
Contact: Site Public Contact
Email: eslinget@slhs.org
IL
Alton
Saint Anthony's Health
Contact: Site Public Contact
Aurora
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Chicago
John H Stroger Jr Hospital of Cook County
Contact: Site Public Contact
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@carle.com
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Mount Vernon
Good Samaritan Regional Health Center
Contact: Site Public Contact
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Springfield
Memorial Medical Center
Contact: Site Public Contact
Email: pallante.beth@mhsil.com
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Avon
IU Health West Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Carmel
IU Health North Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Crown Point
Northwest Cancer Center - Main Campus
Contact: Site Public Contact
Dyer
Northwest Oncology LLC
Contact: Site Public Contact
Hobart
Northwest Cancer Center - Hobart
Contact: Site Public Contact
Saint Mary Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Indianapolis
IU Health Methodist Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Indiana University/Melvin and Bren Simon Cancer Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Saint Catherine Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Sidney and Lois Eskenazi Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Springmill Medical Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Munster
The Community Hospital
Contact: Site Public Contact
Women's Diagnostic Center - Munster
Contact: Site Public Contact
Email: mnicholson@comhs.org
Valparaiso
Northwest Cancer Center - Valparaiso
Contact: Site Public Contact
Email: patricia.a.nelson@comhs.org
KS
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
LA
Baton Rouge
LSU Health Baton Rouge-North Clinic
Contact: Site Public Contact
Email: research@ololrmc.com
Louisiana Hematology Oncology Associates
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Louisiana Hematology Oncology Associates LLC
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Mary Bird Perkins Cancer Center
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Our Lady of The Lake
Contact: Site Public Contact
Our Lady of the Lake Medical Oncology
Contact: Site Public Contact
Email: research@ololrmc.com
Our Lady of the Lake Physician Group
Contact: Site Public Contact
Email: research@ololrmc.com
Woman's Hospital
Contact: Site Public Contact
Email: Clinicalreserach@marybird.com
Covington
Northshore Oncology Associates-Covington
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Houma
Terrebonne General Medical Center
Contact: Site Public Contact
Email: ann.hooks@tgmc.com
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
MA
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Mercy Medical Center
Contact: Site Public Contact
MD
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Contact: Site Public Contact
Email: jhcccro@jhmi.edu
MedStar Good Samaritan Hospital
Contact: Site Public Contact
Email: Barbara.rector@medstar.net
Saint Agnes Hospital
Contact: Site Public Contact
Sinai Hospital of Baltimore
Contact: Site Public Contact
Email: pridgely@lifebridgehealth.org
Easton
University of Maryland Shore Medical Center at Easton
Contact: Site Public Contact
Email: Christina.weisenborn@umm.edu
Randallstown
Northwest Hospital Center
Contact: Site Public Contact
Email: cancerinstitute@lifebridgehealth.org
Westminster
William E Kahlert Regional Cancer Center/Sinai Hospital
Contact: Site Public Contact
MI
Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Caro
Caro Cancer Center
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Chelsea
Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Detroit
Ascension Saint John Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
East China
Great Lakes Cancer Management Specialists-Doctors Park
Contact: Site Public Contact
Email: karen.forman@ascension.org
Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: wstrong@ghci.org
Hurley Medical Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Grosse Pointe Woods
Academic Hematology Oncology Specialists
Contact: Site Public Contact
Email: karen.forman@ascension.org
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Grosse Pointe Woods
Contact: Site Public Contact
Email: karen.forman@ascension.org
Kalamazoo
Ascension Borgess Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Borgess Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Lansing
University of Michigan Health - Sparrow Lansing
Contact: Site Public Contact
Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Macomb Township
Contact: Site Public Contact
Email: karen.forman@ascension.org
Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Niles
Corewell Health Lakeland Hospitals - Niles Hospital
Contact: Site Public Contact
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Pontiac
Hope Cancer Center
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Michigan Healthcare Professionals Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Saint Joseph Mercy Oakland Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saginaw
MyMichigan Medical Center Saginaw
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Saint Joseph
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: karen.forman@ascension.org
Tawas City
MyMichigan Medical Center Tawas
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Great Lakes Cancer Management Specialists-Macomb Professional Building
Contact: Site Public Contact
Email: karen.forman@ascension.org
Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Warren
Contact: Site Public Contact
Email: karen.forman@ascension.org
Saint John Macomb-Oakland Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
MN
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact
Branson
Cox Cancer Center Branson
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Creve Coeur
Siteman Cancer Center at West County Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: swooden@mail.crmc.org
Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net
Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: research@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact
Mercy Hospital South
Contact: Site Public Contact
Email: janet.lesko@mercy.net
Missouri Baptist Medical Center
Contact: Site Public Contact
Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact
Siteman Cancer Center at Christian Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Siteman Cancer Center-South County
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Washington University School of Medicine
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
Washington
Mercy Hospital Washington
Contact: Site Public Contact
MS
Columbus
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Grenada
Baptist Cancer Center-Grenada
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
MT
Billings
Saint Vincent Frontier Cancer Center
Contact: Site Public Contact
Saint Vincent Healthcare
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact
Missoula
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org
NE
Bellevue
Nebraska Medicine-Bellevue
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Omaha
Nebraska Medicine-Village Pointe
Contact: Site Public Contact
University of Nebraska Medical Center
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
NJ
Englewood
Englewood Hospital and Medical Center
Contact: Site Public Contact
Hamilton
The Cancer Institute of New Jersey Hamilton
Contact: Site Public Contact
Morristown
Morristown Medical Center
Contact: Site Public Contact
Mullica Hill
Inspira Medical Center Mullica Hill
Contact: Site Public Contact
Email: DeNigrisJ@ihn.org
New Brunswick
Rutgers Cancer Institute of New Jersey
Contact: Site Public Contact
Sewell
Sidney Kimmel Cancer Center Washington Township
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Somerville
Robert Wood Johnson University Hospital Somerset
Contact: Site Public Contact
Email: Siby.Varughese@rwjbh.org
Summit
Overlook Hospital
Contact: Site Public Contact
Teaneck
Holy Name Hospital
Contact: Site Public Contact
Vineland
Inspira Medical Center Vineland
Contact: Site Public Contact
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org
Rochester
University of Rochester
Contact: Site Public Contact
OH
Akron
Cleveland Clinic Akron General
Contact: Site Public Contact
Email: CancerAnswer@ccf.org
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: sheree@columbusccop.org
Chardon
Geauga Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
MetroHealth Medical Center
Contact: Site Public Contact
Email: dstrater@metrohealth.org
Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: sheree@columbusccop.org
Doctors Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grant Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel East Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel Health Center West
Contact: Site Public Contact
Email: sheree@columbusccop.org
Riverside Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
The Mark H Zangmeister Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grady Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dublin
Columbus Oncology and Hematology Associates
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dublin Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Gahanna
Central Ohio Breast and Endocrine Surgery
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Lima
Saint Rita's Medical Center
Contact: Site Public Contact
Mansfield
OhioHealth Mansfield Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark Radiation Oncology
Contact: Site Public Contact
Email: sheree@columbusccop.org
Parma
University Hospitals Parma Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Perrysburg
Mercy Health Perrysburg Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Ravenna
University Hospitals Portage Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Toledo
Mercy Health Sylvania Radiation Oncology Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mercy Health - Saint Vincent Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Wadsworth
University Hospitals Sharon Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Westlake
UH Seidman Cancer Center at Saint John Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
OK
Oklahoma City
Mercy Hospital Oklahoma City
Contact: Site Public Contact
OR
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org
Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Portland
Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact
PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Bryn Mawr
Bryn Mawr Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: mhayden@christianacare.org
Collegeville
Main Line Health Center-Collegeville
Contact: Site Public Contact
Email: turzoe@mlhs.org
East Norriton
Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Exton
Main Line Health Center-Exton
Contact: Site Public Contact
Email: turzoe@mlhs.org
Hazleton
Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Media
Riddle Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Paoli
Paoli Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact
Jefferson Torresdale Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Temple University Hospital
Contact: Site Public Contact
Thomas Jefferson University Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Wynnewood
Lankenau Medical Center
Contact: Site Public Contact
Email: turzoe@mlhs.org
SC
Bluffton
Saint Joseph's/Candler - Bluffton Campus
Contact: Site Public Contact
Email: underberga@sjchs.org
Charleston
Medical University of South Carolina
Contact: Site Public Contact
Email: hcc-clinical-trials@musc.edu
Georgetown
Tidelands Georgetown Memorial Hospital
Contact: Site Public Contact
Email: broe@tidelandshealth.org
Greenwood
Self Regional Healthcare
Contact: Site Public Contact
Email: nmcgaha@selfregional.org
Hilton Head Island
South Carolina Cancer Specialists PC
Contact: Site Public Contact
Email: underberga@sjchs.org
West Columbia
Lexington Medical Center
Contact: Site Public Contact
Email: LMCIRB@lexhealth.org
TN
Collierville
Baptist Memorial Hospital and Cancer Center-Collierville
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Baptist Memorial Hospital for Women
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
TX
Beaumont
Baptist Hospitals of Southeast Texas Cancer Center
Contact: Site Public Contact
Port Arthur
Baptist Regional Cancer Network-Cancer Center of Southeast Texas
Contact: Site Public Contact
UT
American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Cedar City
Sandra L Maxwell Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Logan
Logan Regional Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Murray
Intermountain Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Ogden
McKay-Dee Hospital Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Provo
Utah Valley Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Riverton
Riverton Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Saint George
Saint George Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Salt Lake City
LDS Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Utah Cancer Specialists-Salt Lake City
Contact: Site Public Contact
Email: officeofresearch@imail.org
VA
Fishersville
Augusta Health Center for Cancer and Blood Disorders
Contact: Site Public Contact
Mechanicsville
Bon Secours Memorial Regional Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Midlothian
Bon Secours Saint Francis Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Bon Secours Westchester Emergency Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Norfolk
Bon Secours DePaul Medical Center
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
Portsmouth
Bon Secours Maryview Medical Center
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
Richmond
Bon Secours Cancer Institute at Reynolds Crossing
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Bon Secours Saint Mary's Hospital
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Suffolk
Bon Secours Health Center at Harbour View
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
WA
Aberdeen
Providence Regional Cancer System-Aberdeen
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Auburn
MultiCare Auburn Medical Center
Contact: Site Public Contact
Email: research@multicare.org
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Centralia
Providence Regional Cancer System-Centralia
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Edmonds
Swedish Cancer Institute-Edmonds
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Everett
Providence Regional Cancer Partnership
Contact: Site Public Contact
Email: marilyn.birchman@providence.org
Gig Harbor
MultiCare Gig Harbor Medical Park
Contact: Site Public Contact
Email: research@multicare.org
Issaquah
Swedish Cancer Institute-Issaquah
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Contact: Site Public Contact
Email: research@kadlecmed.org
Lacey
Providence Regional Cancer System-Lacey
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Longview
PeaceHealth Saint John Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Puyallup
MultiCare Good Samaritan Hospital
Contact: Site Public Contact
Email: research@multicare.org
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Seattle
Pacific Gynecology Specialists
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Sedro-Woolley
PeaceHealth United General Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Shelton
Providence Regional Cancer System-Shelton
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Deaconess Cancer and Blood Specialty Center - North
Contact: Site Public Contact
Email: research@multicare.org
Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Contact: Site Public Contact
Email: research@multicare.org
Tacoma
Mary Bridge Children's Hospital and Health Center
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Tacoma General Hospital
Contact: Site Public Contact
Email: research@multicare.org
Vancouver
PeaceHealth Southwest Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Contact: Site Public Contact
Email: Cheryl.Dodd@providence.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Contact: Site Public Contact
Email: Memorial-ClinicalTrials@yvmh.org
Yelm
Providence Regional Cancer System-Yelm
Contact: Site Public Contact
Email: deidre.dillon@providence.org
WI
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org
Cudahy
Aurora Saint Luke's South Shore
Contact: Site Public Contact
Email: ncorp@aurora.org
Fond Du Lac
Aurora Health Center-Fond du Lac
Contact: Site Public Contact
Email: ncorp@aurora.org
Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org
Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org
Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org
Milwaukee
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org
Racine
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org
Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org
Wauwatosa
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org
West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
WY
Cheyenne
Cheyenne Regional Medical Center-West
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
PRIMARY OBJECTIVE: I. Prospectively validate a prior germline predictor of paclitaxel-induced peripheral neuropathy (TIPN) using the Common Terminology Criteria for Adverse Events (CTCAE). Specifically, this study will demonstrate that patients with a high-risk TIPN genotype have significantly more grade 2-4 TIPN than patients with a low risk genotype. SECONDARY OBJECTIVES: I. Validate a prior germline predictor of TIPN using the Functional Assessment of Cancer Therapy (FACT)/Gynecologic Oncology Group (GOG)-Neurotoxicity (NTX) neurotoxicity subscale in Arm A. II. Compare grade 2-4 TIPN based on CTCAE between weekly paclitaxel (Arm A) versus (vs.) every three-week docetaxel (Arm B). III. Prospectively confirm dose reductions due to TIPN are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry. IV. Prospectively confirm dose reductions due to any cause are lower for every three-week docetaxel compared with weekly paclitaxel in a prospective cohort of patients of African ancestry. V. Assess the ability of the high-risk genotype to predict TIPN risk for docetaxel. CORRELATIVE STUDY OBJECTIVES: I. Identify novel markers of TIPN and elucidate the mechanism. II. Whole genome sequencing of germline blood to evaluate for additional predictors of TIPN. III. Create induced pluripotent stem cell (iPSC) derived neurons from patient samples. IIIa. Evaluate whether clinical findings can be mimicked in vitro. IIIb. Evaluate gene expression (ribonucleic acid [RNA] sequencing [seq]) and the epigenome at baseline versus after exposure in those prone to TIPN versus those not. IV. Create a biorepository of patient derived samples for future translational research. PATIENT REPORTED OUTCOME OBJECTIVES: I. Compare grade 2-4 TIPN (moderate to life threatening) based on Patient Reported Outcomes (PRO)-CTCAE items between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B). II. Prospectively compare FACT/GOG-NTX Health-Related Quality of Life (HRQoL) scores (from the FACT-General [G] portion and Patient-Reported Outcomes Measurement Information System [PROMIS] Physical Function version [v.]2 Short Form [SF] 10a, scores between every three-week docetaxel and weekly paclitaxel and between high risk and low risk genotypes (Arm A) in a cohort of African ancestry. III. Compare Chemotherapy-Induced Peripheral Neuropathy (CIPN)-20 sensory neuropathy score between weekly paclitaxel (Arm A) vs. every three-week docetaxel (Arm B). IV. Compare the impact on financial toxicity (Comprehensive Score for Financial Toxicity [COST] scores) for every three-week docetaxel compared with weekly paclitaxel. V. Examine associations between social determinants of health (zip code, marital status, education, income & insurance status) and dose reductions and treatment discontinuation. OUTLINE: Patients are assigned to 1 of 2 arms. ARM A: Patients receive paclitaxel intravenously (IV) over 3 hours once weekly. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive trastuzumab and/or pertuzumab per institution routine care per treating physician’s discretion. ARM B: Patients receive docetaxel IV over 1 hour once every 3 weeks. Treatment repeats every 21 days for 4-6 cycles in the absence of disease progression or unacceptable toxicity. Patients may also receive cyclophosphamide, doxorubicin, trastuzumab, and/or pertuzumab per institution routine care per treating physician’s discretion. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its NCI Community Oncology Research Program (NCORP).