Prostate Cancer
EA8153 / CHAARTED2
Abiraterone Acetate and Antiandrogen Therapy with or without Cabazitaxel and Prednisone in Treating Patients with Metastatic, Castration-Resistant Prostate Cancer Previously Treated with Docetaxel
STATUS: Closed to Accrual
This randomized phase II trial studies how well abiraterone acetate and antiandrogen therapy, with or without cabazitaxel and prednisone, work in treating patients with castration-resistant prostate cancer previously treated with docetaxel that has spread to other parts of the body. Androgens can cause the growth of prostate cancer cells. Hormone therapy using abiraterone acetate and antiandrogen therapy may fight prostate cancer by lowering and/or blocking the use of androgens by the tumor cells. Drugs used in chemotherapy, such as cabazitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Anti-inflammatory drugs, such as prednisone lower the body’s immune response and are used with other drugs in the treatment of some types of cancer. Giving abiraterone acetate and antiandrogen therapy with or without cabazitaxel and prednisone may help kill more tumor cells.
- Histologically confirmed diagnosis of prostate cancer (adenocarcinoma of the prostate)
- Previous chemotherapy with at least 3 cycles of docetaxel for hormone-sensitive metastatic prostate cancer
- Metastatic disease as evidenced by the presence of soft tissue and/or bone metastases on imaging studies (CT/magnetic resonance imaging [MRI] of abdomen/pelvis, bone scintigraphy or NaF PET/CT)
- Ability to swallow abiraterone acetate tablets as a whole
- All patients must be receiving standard of care androgen deprivation treatment (surgical castration versus LHRH agonist or antagonist treatment); subjects receiving LHRH agonist or antagonist must continue treatment throughout the time on this study
- Patients must have castrate serum level of testosterone of < 50 ng/dL (< 1.73 nmol/L), confirmed =< 4 weeks prior to randomization
- Patients must have progressive disease while receiving androgen deprivation therapy defined by any one of the following as per the Prostate Cancer Clinical Trials Working Group 3 (PCWG3) criteria for PSA, measurable disease or non-measurable (bone) disease during treatment with ADT: * PSA: At least two consecutive rises in serum PSA, obtained at a minimum of 1-week intervals, with the final value >= 1.0 ng/mL, confirmed =< 4 weeks prior to randomization OR * Measurable disease (by RECIST 1.1): > 20% increase in the sum of the longest diameters of all measurable lesions or the development of new measurable lesions; the short axis of a target lymph node must be more that 15 mm to be assessed for change in size OR * Non-measurable (bone) disease: The appearance of two or more new areas of uptake on bone scan (or NaF PET/CT) consistent with metastatic disease compared to previous imaging during castration therapy; the increased uptake of pre-existing lesions on bone scan will not be taken to constitute progression, and ambiguous results must be confirmed by other imaging modalities (e.g. X-ray, CT or MRI); clinical decisions about response or progression will be based on CT and bone scans
- Patients may or may not have been treated previously with a nonsteroidal antiandrogen, such as flutamide, bicalutamide or nilutamide; for patients previously treated with an antiandrogen, they must be off treatment for at least 4 weeks (for flutamide) or 6 weeks (for bicalutamide or nilutamide) prior to registration and must have shown PSA progression after discontinuing the anti-androgen
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
- Absolute neutrophil count (ANC) >= 1500/mm^3 (=< 4 weeks prior to randomization)
- Hemoglobin (HgB) >= 9.0 gr/dL (=< 4 weeks prior to randomization)
- Platelets >= 100,000/mm^3 (=< 4 weeks prior to randomization)
- Creatinine < 2.0 mg/dL (=< 4 weeks prior to randomization)
- Patients must be informed of the experimental nature of the study and its potential risks, and must sign an Institutional Review Board (IRB)-approved written informed consent form indicating such an understanding
- Patients with resected or irradiated brain metastases or those treated with stereotactic radiation therapy are eligible to enroll, provided that they do not require treatment with steroids that exceeds 10 mg of prednisone daily or equivalent
- Sexually active males must use an accepted and effective method of double barrier contraception (vasectomy must be combined with a physical barrier method) or abstain from sexual intercourse for the duration of their participation in the study and for 26 weeks after the last dose of study drug
- Any prior chemotherapy or androgen receptor (AR)-directed therapy for CRPC, (e.g. docetaxel, cabazitaxel, mitoxantrone, abiraterone acetate, ketoconazole, or enzalutamide); previous treatment with radium-223 or sipuleucel-T, or other immunotherapy-based treatment is allowed
- Pure small cell or other variant (non-adenocarcinoma) prostate cancer histology for which treatment with abiraterone would not be considered appropriate
- Patients may not be receiving other therapeutic investigational agents or be receiving concurrent anticancer therapy other than standard androgen deprivation therapy; concurrent treatment with agents to prevent skeletal-related events (such as zoledronic acid or denosumab) will be allowed as long as it was initiated prior to study registration or there are plans to initiate it after cycle 2 day 1
- Any medical condition for which prednisone (corticosteroid) is contraindicated
- If total bilirubin is > upper limit of normal (ULN) (NOTE: in subjects with Gilbert’s syndrome, if total bilirubin is > ULN, measure direct and indirect bilirubin and if direct bilirubin is within normal range, subject may be eligible) or
- Alanine (ALT) or aspartate (AST) aminotransferase > 1.5 x ULN
- Active infection requiring treatment with antibiotics
- History of adrenal insufficiency or hypoaldosteronism
- Myocardial infarction or arterial thrombotic event =< 6 months of randomization, heart failure of New York Heart Association class II or higher, uncontrolled angina, severe uncontrolled ventricular arrhythmia
- External beam radiation therapy =< 2 weeks of registration
- Prior history of allergic reactions to granulocyte colony-stimulating factor (G-CSF)
- Prior history of allergic reactions to docetaxel and/or to medications formulated with polysorbate 80
- History of active malignancy; patients with a history of cancer that has been adequately treated and are free of disease recurrence for 3 years or more are allowed to participate; patients with non-melanoma skin cancers or carcinoma in situ of the bladder that have been adequately excised are eligible to participate
- Life expectancy of < 12 months at screening
- Grade >= 2 neuropathy
- Uncontrolled hypertension (systolic BP >= 160 mmHg or diastolic blood pressure [BP] >= 100 mmHg). Patients with a history of hypertension are allowed to enroll provided blood pressure is controlled with anti-hypertensive treatment
- NaF PET/CT OPTIONAL SUB-STUDY ELIGIBILITY CRITERIA
- Ability to lie still for imaging
- Weight =< 300 lbs (pounds)
- Metastatic disease confined predominantly to the bones
United States
AK
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Fairbanks Memorial Hospital
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Mercy Hospital Fort Smith
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Pacific Central Coast Health Center-San Luis Obispo
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Mills Health Center
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Palo Alto Medical Foundation-Santa Cruz
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Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
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Vacaville
Kaiser Permanente Medical Center-Vacaville
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Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo
Kaiser Permanente-Vallejo
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Sutter Solano Medical Center/Cancer Center
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Walnut Creek
Epic Care Cyberknife Center
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Kaiser Permanente-Walnut Creek
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CO
Aurora
Rocky Mountain Cancer Centers-Aurora
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The Medical Center of Aurora
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Boulder
Boulder Community Foothills Hospital
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Boulder Community Hospital
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Centennial
Rocky Mountain Cancer Centers - Centennial
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Colorado Springs
Penrose-Saint Francis Healthcare
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Rocky Mountain Cancer Centers-Penrose
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Denver
Cancer Center of Colorado at Sloan's Lake
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Colorado Blood Cancer Institute
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Denver Health Medical Center
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National Jewish Health-Main Campus
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Porter Adventist Hospital
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Presbyterian - Saint Lukes Medical Center - Health One
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Rocky Mountain Cancer Centers-Midtown
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Rocky Mountain Cancer Centers-Rose
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Rose Medical Center
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SCL Health Saint Joseph Hospital
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The Women's Imaging Center
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Western Surgical Care
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Durango
Mercy Medical Center
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Southwest Oncology PC
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Englewood
Mountain Blue Cancer Care Center - Swedish
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Swedish Medical Center
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Golden
Mountain Blue Cancer Care Center
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National Jewish Health-Western Hematology Oncology
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Grand Junction
Grand Valley Oncology
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Saint Mary's Hospital and Regional Medical Center
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Greeley
Banner North Colorado Medical Center
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Lafayette
Good Samaritan Hospital - Cancer Centers of Colorado
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Lakewood
Rocky Mountain Cancer Centers-Lakewood
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Saint Anthony Hospital
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Littleton
Littleton Adventist Hospital
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Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
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Sky Ridge Medical Center
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Longmont
Longmont United Hospital
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Loveland
Banner McKee Medical Center
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Parker
Parker Adventist Hospital
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Pueblo
Rocky Mountain Cancer Centers - Pueblo
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Saint Mary Corwin Medical Center
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Thornton
National Jewish Health-Northern Hematology Oncology
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Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge
Intermountain Health Lutheran Hospital
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CT
Derby
Smilow Cancer Hospital-Derby Care Center
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Email: canceranswers@yale.edu
Fairfield
Smilow Cancer Hospital Care Center-Fairfield
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Email: canceranswers@yale.edu
Greenwich
Greenwich Hospital
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Guilford
Smilow Cancer Hospital Care Center - Guilford
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Hartford
Smilow Cancer Hospital Care Center at Saint Francis
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Middletown
Middlesex Hospital
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Email: beth_slifer@midhosp.org
New Haven
Smilow Cancer Center/Yale-New Haven Hospital
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Yale University
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Email: canceranswers@yale.edu
North Haven
Yale-New Haven Hospital North Haven Medical Center
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Trumbull
Smilow Cancer Hospital Care Center-Trumbull
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Waterbury
Smilow Cancer Hospital-Waterbury Care Center
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Waterford
Smilow Cancer Hospital Care Center - Waterford
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DC
Washington
George Washington University Medical Center
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MedStar Georgetown University Hospital
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Sibley Memorial Hospital
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DE
Dover
Bayhealth Hospital Kent Campus
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Lewes
Beebe Medical Center
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Milford
Bayhealth Hospital Sussex Campus
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Millville
Beebe South Coastal Health Campus
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Newark
Christiana Care Health System-Christiana Hospital
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Delaware Clinical and Laboratory Physicians PA
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Helen F Graham Cancer Center
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Medical Oncology Hematology Consultants PA
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Rehoboth Beach
Beebe Health Campus
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Seaford
TidalHealth Nanticoke / Allen Cancer Center
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Wilmington
Christiana Care Health System-Wilmington Hospital
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GA
Atlanta
Emory Saint Joseph's Hospital
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Emory University Hospital Midtown
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Emory University Hospital/Winship Cancer Institute
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Grady Health System
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Columbus
John B Amos Cancer Center
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Decatur
Atlanta VA Medical Center
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Newnan
CTCA at Southeastern Regional Medical Center
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HI
Aiea
Hawaii Cancer Care - Westridge
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Pali Momi Medical Center
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Queen's Cancer Center - Pearlridge
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The Cancer Center of Hawaii-Pali Momi
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Honolulu
Hawaii Cancer Care Inc - Waterfront Plaza
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Hawaii Cancer Care Inc-Liliha
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Island Urology
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Email: virginia@cc.hawaii.edu
Kaiser Permanente Moanalua Medical Center
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Kapiolani Medical Center for Women and Children
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Kuakini Medical Center
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Queen's Cancer Cenrer - POB I
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Queen's Cancer Center - Kuakini
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Queen's Medical Center
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Straub Clinic and Hospital
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The Cancer Center of Hawaii-Liliha
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University of Hawaii Cancer Center
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Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
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IA
Ames
Mary Greeley Medical Center
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McFarland Clinic - Ames
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Email: ksoder@mcfarlandclinic.com
Boone
McFarland Clinic - Boone
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Clive
Mercy Cancer Center-West Lakes
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Email: clinicaltrials@sfmc-gi.org
Mission Cancer and Blood - West Des Moines
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Council Bluffs
Alegent Health Mercy Hospital
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Creston
Greater Regional Medical Center
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Des Moines
Broadlawns Medical Center
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Iowa Lutheran Hospital
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Iowa Methodist Medical Center
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Mercy Medical Center - Des Moines
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Mission Cancer and Blood - Des Moines
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Mission Cancer and Blood - Laurel
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Fort Dodge
McFarland Clinic - Trinity Cancer Center
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Trinity Regional Medical Center
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Iowa City
University of Iowa/Holden Comprehensive Cancer Center
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Jefferson
McFarland Clinic - Jefferson
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Marshalltown
McFarland Clinic - Marshalltown
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West Des Moines
Mercy Medical Center-West Lakes
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Email: clinicaltrials@sfmc-gi.org
Methodist West Hospital
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ID
Boise
Saint Alphonsus Cancer Care Center-Boise
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Email: stephanie.couch@stjoeshealth.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
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Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
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Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
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Email: stephanie.couch@stjoeshealth.org
Meridian
Idaho Urologic Institute-Meridian
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Email: stephanie.couch@stjoeshealth.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
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Email: stephanie.couch@stjoeshealth.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
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Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
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Email: mccinfo@mtcancer.org
IL
Aurora
Rush - Copley Medical Center
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Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
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Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
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Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
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Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
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Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
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Email: rhamrick@dmhhs.org
Chicago
Northwestern University
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Email: cancer@northwestern.edu
Danville
Carle at The Riverfront
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Email: Research@carle.com
DeKalb
Northwestern Medicine Cancer Center Kishwaukee
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Email: Donald.Smith3@nm.org
Decatur
Cancer Care Specialists of Illinois - Decatur
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Email: rhamrick@dmhhs.org
Decatur Memorial Hospital
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Email: rhamrick@dmhhs.org
Dixon
Illinois CancerCare-Dixon
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Effingham
Carle Physician Group-Effingham
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Email: Research@carle.com
Crossroads Cancer Center
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Email: rhamrick@dmhhs.org
Eureka
Illinois CancerCare-Eureka
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Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
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Galesburg
Illinois CancerCare-Galesburg
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Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
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Geneva
Northwestern Medicine Cancer Center Delnor
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Email: Donald.Smith3@nm.org
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
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Harvey
Ingalls Memorial Hospital
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Email: clinicaltrials@ingalls.org
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Contact: Site Public Contact
Joliet
Duly Health and Care Joliet
Contact: Site Public Contact
Email: maureenc@jolietoncology.com
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Lake Forest
Northwestern Medicine Lake Forest Hospital
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Mount Vernon
Good Samaritan Regional Health Center
Contact: Site Public Contact
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Skokie
North Shore Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Springfield
Memorial Medical Center
Contact: Site Public Contact
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Warrenville
Northwestern Medicine Cancer Center Warrenville
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Evansville
Deaconess Clinic Downtown
Contact: Site Public Contact
Email: Research@Deaconess.com
Fort Wayne
Parkview Hospital Randallia
Contact: Site Public Contact
Email: parkviewresearch@parkview.com
Parkview Regional Medical Center
Contact: Site Public Contact
Indianapolis
Indiana University/Melvin and Bren Simon Cancer Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Richard L. Roudebush Veterans Affairs Medical Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Sidney and Lois Eskenazi Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Mishawaka
Memorial Regional Cancer Center Day Road
Contact: Site Public Contact
Email: ctsucontact@westat.com
Newburgh
Chancellor Center for Oncology
Contact: Site Public Contact
Email: Research@Deaconess.com
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
South Bend
Memorial Hospital of South Bend
Contact: Site Public Contact
KS
Coffeyville
Coffeyville Regional Medical Center
Contact: Site Public Contact
Fairway
University of Kansas Clinical Research Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
Hays
HaysMed
Contact: Site Public Contact
Kansas City
University of Kansas Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
University of Kansas Cancer Center-West
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Lawrence
Lawrence Memorial Hospital
Contact: Site Public Contact
Email: Stephanie.Norris@LMH.ORG
Lenexa
Kansas Institute of Medicine Cancer and Blood Center
Contact: Site Public Contact
Email: aroland@kccop.org
Minimally Invasive Surgery Hospital
Contact: Site Public Contact
Email: aroland@kccop.org
Olathe
Olathe Health Cancer Center
Contact: Site Public Contact
Email: Jeni.wakefield@olathehealth.org
Overland Park
Menorah Medical Center
Contact: Site Public Contact
Email: aroland@kccop.org
University of Kansas Cancer Center-Overland Park
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Pittsburg
Ascension Via Christi - Pittsburg
Contact: Site Public Contact
Email: jennifer.jameson@ascension.org
Salina
Salina Regional Health Center
Contact: Site Public Contact
Email: mleepers@srhc.com
Topeka
University of Kansas Health System Saint Francis Campus
Contact: Site Public Contact
Westwood
University of Kansas Hospital-Westwood Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Wichita
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
KY
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Corbin
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Lexington
Saint Joseph Hospital East
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
University of Kentucky/Markey Cancer Center
Contact: Site Public Contact
London
Saint Joseph London
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Louisville
Jewish Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
LA
Metairie
East Jefferson General Hospital
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
LSU Healthcare Network / Metairie Multi-Specialty Clinic
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Veteran's Administration Medical Center - New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
MA
Fitchburg
Simonds-Sinon Regional Cancer Center
Contact: Site Public Contact
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Annapolis
Luminis Health Anne Arundel Medical Center
Contact: Site Public Contact
Email: research@aahs.org
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Contact: Site Public Contact
Email: jhcccro@jhmi.edu
Bethesda
Walter Reed National Military Medical Center
Contact: Site Public Contact
ME
Augusta
Harold Alfond Center for Cancer Care
Contact: Site Public Contact
Belfast
Waldo County General Hospital
Contact: Site Public Contact
Biddeford
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Contact: Site Public Contact
Email: LLemire@mmc.org
Norway
Stephens Memorial Hospital
Contact: Site Public Contact
Email: OncClinicalResearch@mmc.org
Rockport
Penobscot Bay Medical Center
Contact: Site Public Contact
Email: ClinicalResearch@mmc.org
Sanford
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Contact: Site Public Contact
Email: LLemire@mmc.org
South Portland
Maine Medical Partners - South Portland
Contact: Site Public Contact
Email: ClinicalResearch@mmc.org
MI
Adrian
Hickman Cancer Center
Contact: Site Public Contact
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bay City
McLaren Cancer Institute-Bay City
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Bloomfield
McLaren Cancer Institute-Bloomfield
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Clarkston
McLaren Cancer Institute-Clarkston
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Detroit
Wayne State University/Karmanos Cancer Institute
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Farmington Hills
Weisberg Cancer Treatment Center
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Flint
McLaren Cancer Institute-Flint
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Singh and Arora Hematology Oncology PC
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Kalamazoo
Borgess Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Lansing
Karmanos Cancer Institute at McLaren Greater Lansing
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Lapeer
McLaren Cancer Institute-Lapeer Region
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Monroe
Toledo Clinic Cancer Centers-Monroe
Contact: Site Public Contact
Mount Clemens
McLaren Cancer Institute-Macomb
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Niles
Corewell Health Lakeland Hospitals - Niles Hospital
Contact: Site Public Contact
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Petoskey
McLaren Cancer Institute-Northern Michigan
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Port Huron
Huron Medical Center PC
Contact: Site Public Contact
Email: research@sncrf.org
Lake Huron Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Saint Joseph
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
MN
Aitkin
Riverwood Healthcare Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Brainerd
Essentia Health Saint Joseph's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Duluth
Essentia Health Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Miller-Dwan Hospital
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Contact: Site Public Contact
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Contact: Site Public Contact
Email: coborncancercenter@centracare.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Virginia
Essentia Health Virginia Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact
Branson
Cox Cancer Center Branson
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Columbia
MU Health - University Hospital/Ellis Fischel Cancer Center
Contact: Site Public Contact
Creve Coeur
Siteman Cancer Center at West County Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Independence
Centerpoint Medical Center LLC
Contact: Site Public Contact
Email: aroland@kccop.org
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: swooden@mail.crmc.org
Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net
Kansas City
Research Medical Center
Contact: Site Public Contact
Email: aroland@kccop.org
The University of Kansas Cancer Center-South
Contact: Site Public Contact
Email: ctnursenav@kumc.edu
University Health Truman Medical Center
Contact: Site Public Contact
University of Kansas Cancer Center - North
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: kaysmith@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact
Mercy Hospital South
Contact: Site Public Contact
Email: janet.lesko@mercy.net
Missouri Baptist Medical Center
Contact: Site Public Contact
Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact
Siteman Cancer Center at Christian Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Siteman Cancer Center-South County
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Veteran's Affairs Medical Center - Saint Louis
Contact: Site Public Contact
Email: ctsucontact@westat.com
Washington University School of Medicine
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
Washington
Mercy Hospital Washington
Contact: Site Public Contact
MS
Grenada
Baptist Cancer Center-Grenada
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Jackson
University of Mississippi Medical Center
Contact: Site Public Contact
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org
Saint Vincent Frontier Cancer Center
Contact: Site Public Contact
Saint Vincent Healthcare
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls Clinic
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Missoula
Community Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
NC
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Wayne Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Greenville
East Carolina University
Contact: Site Public Contact
Email: eubankss@ecu.edu
Jacksonville
Onslow Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kenansville
ECU Health Oncology Kenansville
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Kinston
ECU Health Oncology Kinston
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Richlands
ECU Health Oncology Richlands
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Washington
Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
Contact: Site Public Contact
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Jamestown
Essentia Health - Jamestown Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
NE
Grand Island
Nebraska Cancer Specialists/Oncology Hematology West PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Heartland Hematology and Oncology
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Lincoln
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Creighton University Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Hematology and Oncology Consultants PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
NJ
Cape May Court House
AtlantiCare Health Park-Cape May Court House
Contact: Site Public Contact
Egg Harbor Township
AtlantiCare Surgery Center
Contact: Site Public Contact
Teaneck
Holy Name Hospital
Contact: Site Public Contact
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Cancer Therapy and Integrative Medicine
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org
Middletown
Garnet Health Medical Center
Contact: Site Public Contact
Email: jgerlach@garnethealth.org
OH
Akron
Cleveland Clinic Akron General
Contact: Site Public Contact
Email: CancerAnswer@ccf.org
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Chardon
Geauga Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Columbus
Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Good Samaritan Hospital - Dayton
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Elyria
Mercy Cancer Center-Elyria
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering
First Dayton Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Maumee
Toledo Clinic Cancer Centers-Maumee
Contact: Site Public Contact
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Contact: Site Public Contact
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Parma
University Hospitals Parma Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Perrysburg
Mercy Health Perrysburg Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Sylvania
ProMedica Flower Hospital
Contact: Site Public Contact
Toledo
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Contact: Site Public Contact
Toledo Clinic Cancer Centers-Toledo
Contact: Site Public Contact
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Westlake
UHHS-Westlake Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
OK
Lawton
Cancer Centers of Southwest Oklahoma Research
Contact: Site Public Contact
Oklahoma City
Mercy Hospital Oklahoma City
Contact: Site Public Contact
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
Tulsa
Cancer Treatment Centers of America
Contact: Site Public Contact
Email: ctsucontact@westat.com
Oklahoma Cancer Specialists and Research Institute-Tulsa
Contact: Site Public Contact
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
PA
Abington
Jefferson Abington Hospital
Contact: Site Public Contact
Beaver
UPMC-Heritage Valley Health System Beaver
Contact: Site Public Contact
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: mhayden@christianacare.org
Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact
Harrisburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Contact: Site Public Contact
Email: klitchfield@PINNACLEHEALTH.org
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Hershey
Penn State Milton S Hershey Medical Center
Contact: Site Public Contact
Email: CTO@hmc.psu.edu
Johnstown
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Contact: Site Public Contact
Lewisburg
Geisinger Medical Oncology-Lewisburg
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lewistown
Lewistown Hospital
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact
Moon Township
UPMC Hillman Cancer Center in Coraopolis
Contact: Site Public Contact
Philadelphia
Temple University Hospital
Contact: Site Public Contact
University of Pennsylvania/Abramson Cancer Center
Contact: Site Public Contact
Pittsburgh
UPMC-Magee Womens Hospital
Contact: Site Public Contact
UPMC-Mercy Hospital
Contact: Site Public Contact
UPMC-Passavant Hospital
Contact: Site Public Contact
UPMC-Presbyterian Hospital
Contact: Site Public Contact
UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact
UPMC-Saint Margaret
Contact: Site Public Contact
UPMC-Shadyside Hospital
Contact: Site Public Contact
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact
Pottsville
Geisinger Cancer Services-Pottsville
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Sayre
Guthrie Medical Group PC-Robert Packer Hospital
Contact: Site Public Contact
Scranton
Community Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact
State College
Geisinger Medical Group
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Contact: Site Public Contact
Washington
UPMC Washington Hospital Radiation Oncology
Contact: Site Public Contact
Email: cancer@washingtonhospital.org
West Reading
Reading Hospital
Contact: Site Public Contact
Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Williamsport
UPMC Susquehanna
Contact: Site Public Contact
Willow Grove
Asplundh Cancer Pavilion
Contact: Site Public Contact
PR
Bayamon
Cancer Center-Metro Medical Center Bayamon
Contact: Site Public Contact
Caguas
HIMA San Pablo Oncologic Hospital
Contact: Site Public Contact
Manati
Doctors Cancer Center
Contact: Site Public Contact
Ponce
Instituto Oncologia Moderna Ponce
Contact: Site Public Contact
San Juan
Centro Comprensivo de Cancer de UPR
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
San Juan City Hospital
Contact: Site Public Contact
San Juan Community Oncology Group
Contact: Site Public Contact
RI
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu
SD
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org
TN
Bristol
Bristol Regional Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Chattanooga
Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Collierville
Baptist Memorial Hospital and Cancer Center-Collierville
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Contact: Site Public Contact
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Johnson City
Wellmont Medical Associates Oncology and Hematology-Johnson City
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Kingsport
Ballad Health Cancer Care – Kingsport
Contact: Site Public Contact
Email: Justin.reynolds@balladhealth.org
Wellmont Holston Valley Hospital and Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Contact: Site Public Contact
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
Ooltewah
Memorial GYN Plus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
TX
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Conroe
MD Anderson in The Woodlands
Contact: Site Public Contact
Email: askmdanderson@mdanderson.org
Dallas
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Fort Worth
UT Southwestern/Simmons Cancer Center-Fort Worth
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Houston
Lyndon Baines Johnson General Hospital
Contact: Site Public Contact
M D Anderson Cancer Center
Contact: Site Public Contact
Email: askmdanderson@mdanderson.org
MD Anderson West Houston
Contact: Site Public Contact
Email: askmdanderson@mdanderson.org
League City
MD Anderson League City
Contact: Site Public Contact
Email: askmdanderson@mdanderson.org
Richardson
UT Southwestern Clinical Center at Richardson/Plano
Contact: Site Public Contact
Email: Suzanne.cole@utsouthwestern.edu
San Antonio
University of Texas Health Science Center at San Antonio
Contact: Site Public Contact
Email: phoresearchoffice@uthscsa.edu
Sugar Land
MD Anderson in Sugar Land
Contact: Site Public Contact
Email: askmdanderson@mdanderson.org
UT
American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Cedar City
Sandra L Maxwell Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Farmington
Farmington Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
Logan
Logan Regional Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Murray
Intermountain Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Ogden
McKay-Dee Hospital Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Provo
Utah Valley Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Riverton
Riverton Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Saint George
Saint George Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
LDS Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Utah Cancer Specialists-Salt Lake City
Contact: Site Public Contact
Email: officeofresearch@imail.org
South Jordan
South Jordan Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
VA
Bristol
Wellmont Medical Associates-Bristol
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: PAS9E@virginia.edu
Martinsville
Sovah Health Martinsville
Contact: Site Public Contact
Email: sharon.hubbard@lpnt.net
Mechanicsville
Bon Secours Memorial Regional Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Midlothian
Bon Secours Saint Francis Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Norfolk
Bon Secours DePaul Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Norton
Southwest VA Regional Cancer Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Portsmouth
Bon Secours Maryview Medical Center
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Richmond
Bon Secours Cancer Institute at Reynolds Crossing
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Bon Secours Saint Mary's Hospital
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
Suffolk
Bon Secours Health Center at Harbour View
Contact: Site Public Contact
Email: Jaime_scott@bshsi.org
WA
Auburn
MultiCare Auburn Medical Center
Contact: Site Public Contact
Email: research@multicare.org
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Enumclaw
Saint Elizabeth Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Federal Way
Saint Francis Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Gig Harbor
MultiCare Gig Harbor Medical Park
Contact: Site Public Contact
Email: research@multicare.org
Lakewood
Saint Clare Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Puyallup
MultiCare Good Samaritan Hospital
Contact: Site Public Contact
Email: research@multicare.org
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Silverdale
Saint Michael Cancer Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Deaconess Cancer and Blood Specialty Center - North
Contact: Site Public Contact
Email: research@multicare.org
Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Contact: Site Public Contact
Email: research@multicare.org
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Mary Bridge Children's Hospital and Health Center
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Tacoma General Hospital
Contact: Site Public Contact
Email: research@multicare.org
Northwest Medical Specialties PLLC
Contact: Site Public Contact
Email: research@southsoundcare.org
WI
Appleton
ThedaCare Regional Cancer Center
Contact: Site Public Contact
Email: ResearchDept@thedacare.org
Ashland
Duluth Clinic Ashland
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Northwest Wisconsin Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Chippewa Falls
Marshfield Clinic-Chippewa Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Eau Claire
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Green Bay
Saint Vincent Hospital Cancer Center Green Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Saint Vincent Hospital Cancer Center at Saint Mary's
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Johnson Creek
University of Wisconsin Carbone Cancer Center - Johnson Creek
Contact: Site Public Contact
Email: lynda.persico@uwmf.wisc.edu
Ladysmith
Marshfield Medical Center - Ladysmith
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Madison
University of Wisconsin Carbone Cancer Center - University Hospital
Contact: Site Public Contact
Manitowoc
Holy Family Memorial Hospital
Contact: Site Public Contact
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Menomonee Falls
Froedtert Menomonee Falls Hospital
Contact: Site Public Contact
Milwaukee
Medical College of Wisconsin
Contact: Site Public Contact
Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Wausau
Marshfield Clinic-Wausau Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
West Bend
Froedtert West Bend Hospital/Kraemer Cancer Center
Contact: Site Public Contact
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
WV
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
WY
Cheyenne
Cheyenne Regional Medical Center-West
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
Cody
Billings Clinic-Cody
Contact: Site Public Contact
Email: research@billingsclinic.org
Sheridan
Welch Cancer Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
PRIMARY OBJECTIVES: I. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with castration-resistant prostate cancer (CRPC) that have previously received docetaxel and androgen deprivation therapy (ADT) for hormone-sensitive prostate cancer (HSPC) can improve progression-free survival (PFS) compared to abiraterone acetate alone. SECONDARY OBJECTIVES: I. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can increase the percentage of change in prostate-specific antigen (PSA) from baseline to week 12 of treatment as well as the maximum decline in PSA that occurs at any point after treatment compared to abiraterone acetate alone. II. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel for HSPC can prolong time to PSA progression compared to abiraterone acetate alone. III. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel for HSPC can improve radiographic response (per Response Evaluation Criteria in Solid Tumors [RECIST] 1.1) compared to abiraterone acetate alone. IV. To assess whether the addition of 6 cycles of cabazitaxel to abiraterone acetate in patients with CRPC that have previously received docetaxel and ADT for HSPC can prolong the overall survival (OS) compared to abiraterone acetate alone. V. To assess safety and tolerability of the combination of 6 cycles of cabazitaxel and abiraterone acetate. EXPLORATORY OBJECTIVES: I. To examine whether patients with circulating tumor cells (CTCs) positive for AR-V7 at baseline have a longer radiographic or clinical PFS to the combination of cabazitaxel and abiraterone acetate vs. abiraterone acetate alone. II. To examine whether the addition of cabazitaxel to abiraterone acetate can change the AR-V7 status of patients who are positive at study entry. III. To examine whether the addition of cabazitaxel to abiraterone acetate has any impact on future development of AR-V7 positivity at the time of disease progression. IMAGING OBJECTIVES: I. To assess if the changes in total tumor burden from baseline to week 12 as assessed with sodium fluoride (NaF) positron emission tomography (PET)/computed tomography (CT) will differ between two arms. II. To correlate total tumor burden at the baseline as assessed with NaF PET/CT with the PFS. III. To correlate heterogeneity of response from baseline to week 12 as assessed with NaF PET/CT with the PFS. TOBACCO USE OBJECTIVES: I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events (both clinical and hematologic) and dose modifications). II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms. III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization. IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit OUTLINE: Patients are randomized to 1 of 2 arms. ARM A: Patients receive abiraterone acetate orally (PO) once daily (QD) on days 1-21, prednisone PO twice daily (BID) on days 1-21. Courses of abiraterone acetate and prednisone repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients receive cabazitaxel intravenously (IV) over 1 hour on day 1, and treatment with cabazitaxel repeats every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients also receive standard of care antiandrogen therapy with either luteinizing hormone-releasing hormone (LHRH) agonist or antagonist, or surgical castration with bilateral orchiectomy. ARM B: Patients receive abiraterone acetate and prednisone as in Arm A. Patients also receive standard of care antiandrogen therapy with either LHRH agonist or antagonist, or surgical castration with bilateral orchiectomy. After completion of study treatment, patients are followed up every 3 or 6 months and then annually for up to 5 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed and conducted this trial with funding from the National Cancer Institute through its National Clinical Trials Network.