Pancreas or Gastrointestinal Tract Cancer

EA2142



Cisplatin, Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients with Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery

STATUS: Closed to Accrual


This phase II trial studies how well temozolomide and capecitabine work compared to standard treatment with cisplatin or carboplatin and etoposide in treating patients with neuroendocrine carcinoma of the gastrointestinal tract or pancreas that has spread to other parts of the body (metastatic) or cannot be removed by surgery (unresectable). Drugs used in chemotherapy, such as temozolomide, capecitabine, cisplatin, carboplatin and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Certain types of neuroendocrine carcinomas may respond better to treatments other than the current standard treatment of cisplatin and etoposide. It is not yet known whether temozolomide and capecitabine may work better than cisplatin or carboplatin and etoposide in treating patients with this type of neuroendocrine carcinoma, called non-small cell neuroendocrine carcinoma.
  • Patients must have a locally advanced and unresectable or metastatic gastroenteropancreatic neuroendocrine carcinoma that is either known or suspected to be of gastrointestinal (GI) origin; primary tumors arising from the lung, gynecologic organs or prostate are not permitted

  • Patients must have pathologically/histologically confirmed tumor of non-small cell histology

  • Patients must have a Ki-67 proliferative index of 20-100% OR at least 10 mitotic figures per 10 high powered fields

  • Patients must have measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria; baseline measurements and evaluations of all sites of disease must be obtained within 4 weeks prior to randomization and must be acquired by multiphasic computed tomography (CT) or contrast magnetic resonance imaging (MRI) * NOTE: positron emission tomography (PET)-CT scans are allowed provided the CT portion of the exam is equivalent to a diagnostic CT scan and includes both oral and IV contrast

  • Patients may not have had any prior systemic treatment (chemotherapy, targeted therapy, peptide receptor radionuclide therapy [PRRT]); prior palliative radiation is permitted but radiated lesions may not be used for measurement

  • Patients may not have received any of the protocol agents within 5 years prior to randomization

  • Any prior surgeries must have been completed at least 4 weeks prior to randomization

  • Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2

  • Patients may not be receiving any other investigational agents while on study treatment

  • Patients may not be receiving Coumadin while on treatment; other anticoagulants are allowed

  • Leukocytes >= 3,000/mm^3 (within less than or equal to 14 days prior to randomization)

  • Absolute neutrophil count >= 1,500/mm^3 (within less than or equal to 14 days prior to randomization)

  • Hemoglobin >= 9 g/dL (within less than or equal to 14 days prior to randomization)

  • Platelets >= 100,000/mm^3 (within less than or equal to 14 days prior to randomization)

  • Total bilirubin =< institutional upper limit of normal (ULN) or =< 1.5 x institutional ULN (if the patient has liver metastases) (within less than or equal to 14 days prior to randomization)

  • Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN or (=< 5 x institutional ULN if the patient has liver metastases) (within less than or equal to 14 days prior to randomization)

  • Serum creatinine =< 1.5 x institutional ULN and creatinine clearance >= 60 ml/min (within less than or equal to 14 days prior to randomization) * NOTE: creatinine clearance must be calculated using the Cockcroft-Gault equation

  • Patients must have a life expectancy of >= 12 weeks as determined clinically by the treating physician

  • Patients with brain metastases (either remote or current) or presence of carcinomatous meningitis are not eligible

  • Patients with known dihydropyrimidine dehydrogenase (DPD) deficiency will be excluded as the use of capecitabine is contraindicated in these patients

  • Patients must NOT have active or uncontrolled infection, symptomatic heart failure, unstable angina pectoris, cardiac arrhythmia or a serious psychiatric illness/social situation that would limit compliance with study requirements

  • Patients with impaired decision making capacity may participate in the study if a legal authorized representative is available to consent

  • Patients must NOT have a history of allergic reactions attributed to compounds of similar chemical or biochemical composition to cisplatin, carboplatin, etoposide, temozolomide or capecitabine

  • Patients must NOT have absorption issues that would limit the ability to absorb study agents

  • Patients with a history of the following within =< 12 months of study entry are not eligible: * Arterial thromboembolic events * Unstable angina * Myocardial Infarction

  • Patients with symptomatic peripheral vascular disease are not eligible

  • Patients must NOT have previous or concurrent malignancy; exceptions are made for patients who meet any of the following conditions: * Non-melanoma skin cancer, in situ cervical cancer, superficial bladder cancer, or breast cancer in situ OR * Prior malignancy completely excised or removed and patient has been continuously disease free for > 5 years OR * Prior malignancy cured by non-surgical modalities and patient has been continuously disease free for > 5 years

  • Women must not be pregnant or breast-feeding due to potential harm to the fetus from cisplatin, carboplatin, etoposide, temozolomide and/or capecitabine * All females of childbearing potential must have a blood test or urine study within 2 weeks prior to randomization to rule out pregnancy * A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months).

  • Women of childbearing potential and sexually active males must be strongly advised to use an accepted and effective method of contraception or to abstain from sexual intercourse for the duration of their participation in the study

  • Patients must be able to swallow pills

  • Patients must be able to tolerate CT or magnetic resonance (MR) imaging including contrast agents as required for the treatment and the protocol

  • Patients who are known to have human immunodeficiency virus (HIV) or are on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with cisplatin, carboplatin, etoposide, temozolomide, and/or capecitabine; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy; appropriate studies will be undertaken in patients receiving combination antiretroviral therapy when indicated

United States
AR
Ft. Smith
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AZ
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Palo Alto Medical Foundation-Santa Cruz
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Mission Hope Medical Oncology - Santa Maria
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Palo Alto Medical Foundation-Sunnyvale
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Vacaville
Kaiser Permanente Medical Center-Vacaville
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Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo
Kaiser Permanente-Vallejo
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Aurora
University of Colorado Hospital
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Penrose-Saint Francis Healthcare
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Porter Adventist Hospital
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Mercy Medical Center
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Golden
Mountain Blue Cancer Care Center
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Rocky Mountain Cancer Centers-Lakewood
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Saint Anthony Hospital
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Littleton Adventist Hospital
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Longmont United Hospital
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Parker
Parker Adventist Hospital
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Pueblo
Rocky Mountain Cancer Centers - Pueblo
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Saint Mary Corwin Medical Center
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Thornton
Rocky Mountain Cancer Centers-Thornton
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DC
Washington
MedStar Washington Hospital Center
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Sibley Memorial Hospital
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DE
Frankford
Beebe South Coastal Health Campus
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Lewes
Beebe Medical Center
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Newark
Christiana Care Health System-Christiana Hospital
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Christiana Gynecologic Oncology LLC
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Delaware Clinical and Laboratory Physicians PA
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Helen F Graham Cancer Center
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Medical Oncology Hematology Consultants PA
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Rehoboth Beach
Beebe Health Campus
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Seaford
TidalHealth Nanticoke / Allen Cancer Center
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Wilmington
Christiana Care Health System-Wilmington Hospital
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FL
Fort Lauderdale
Holy Cross Hospital
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GA
Atlanta
Emory Saint Joseph's Hospital
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Emory University Hospital Midtown
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Emory University Hospital/Winship Cancer Institute
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Grady Health System
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Emory Johns Creek Hospital
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Macon
Medical Center of Central Georgia
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HI
Honolulu
Kaiser Permanente Moanalua Medical Center
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IA
Ames
Mary Greeley Medical Center
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McFarland Clinic PC - Ames
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Email: ksoder@mcfarlandclinic.com

Boone
McFarland Clinic PC-Boone
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Clive
Medical Oncology and Hematology Associates-West Des Moines
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Mercy Cancer Center-West Lakes
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Council Bluffs
Alegent Health Mercy Hospital
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Creston
Greater Regional Medical Center
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Des Moines
Mercy Medical Center - Des Moines
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Mission Cancer and Blood - Laurel
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Fort Dodge
McFarland Clinic PC-Trinity Cancer Center
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Jefferson
McFarland Clinic PC-Jefferson
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Marshalltown
McFarland Clinic PC-Marshalltown
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Sioux City
Siouxland Regional Cancer Center
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West Des Moines
Mercy Medical Center-West Lakes
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ID
Boise
Saint Alphonsus Cancer Care Center-Boise
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Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
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Coeur D'Alene
Kootenai Health - Coeur d'Alene
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Emmett
Walter Knox Memorial Hospital
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Meridian
Idaho Urologic Institute-Meridian
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Nampa
Saint Alphonsus Medical Center-Nampa
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Post Falls
Kootenai Clinic Cancer Services - Post Falls
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Sandpoint
Kootenai Cancer Clinic
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IL
Aurora
Rush - Copley Medical Center
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Bloomington
Illinois CancerCare-Bloomington
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Saint Joseph Medical Center
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Burr Ridge
Loyola Center for Health at Burr Ridge
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Canton
Illinois CancerCare-Canton
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Carbondale
Memorial Hospital of Carbondale
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Carterville
SIH Cancer Institute
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Carthage
Illinois CancerCare-Carthage
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Centralia
Centralia Oncology Clinic
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Chicago
Northwestern University
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Carle on Vermilion
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DeKalb
Northwestern Medicine Cancer Center Kishwaukee
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Decatur
Cancer Care Specialists of Illinois - Decatur
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Illinois CancerCare-Dixon
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Effingham
Carle Physician Group-Effingham
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Geneva
Northwestern Medicine Cancer Center Delnor
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Loyola Medicine Homer Glen
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Northwestern Medicine Lake Forest Hospital
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Illinois CancerCare-Macomb
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Mattoon
Carle Physician Group-Mattoon/Charleston
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Maywood
Loyola University Medical Center
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Melrose Park
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
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Mount Vernon
Good Samaritan Regional Health Center
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New Lenox
UC Comprehensive Cancer Center at Silver Cross
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O'Fallon
Cancer Care Center of O'Fallon
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Orland Park
University of Chicago Medicine-Orland Park
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Ottawa
Illinois CancerCare-Ottawa Clinic
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Radiation Oncology of Northern Illinois
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Pekin
Illinois CancerCare-Pekin
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OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Peoria
Illinois CancerCare-Peoria
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Peru
Illinois CancerCare-Peru
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Valley Radiation Oncology
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Princeton
Illinois CancerCare-Princeton
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Springfield
Central Illinois Hematology Oncology Center
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Memorial Medical Center
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Southern Illinois University School of Medicine
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Springfield Clinic
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Swansea
Southwest Illinois Health Services LLP
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Urbana
Carle Cancer Center
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The Carle Foundation Hospital
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Warrenville
Northwestern Medicine Cancer Center Warrenville
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Yorkville
Rush-Copley Healthcare Center
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IN
Evansville
Deaconess Clinic Downtown
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Michigan City
Franciscan Saint Anthony Health-Michigan City
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Woodland Cancer Care Center
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Email: sally.arnett@franciscanalliance.org

Newburgh
Chancellor Center for Oncology
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Richmond
Reid Health
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Email: clinical.trials@daytonncorp.org

KS
Chanute
Cancer Center of Kansas - Chanute
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Email: Keisha.humphries@ascension.org

Coffeyville
Coffeyville Regional Medical Center
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Dodge City
Cancer Center of Kansas - Dodge City
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El Dorado
Cancer Center of Kansas - El Dorado
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Fort Scott
Cancer Center of Kansas - Fort Scott
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Garden City
Central Care Cancer Center - Garden City
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Great Bend
Central Care Cancer Center - Great Bend
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Hays
HaysMed University of Kansas Health System
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Independence
Cancer Center of Kansas-Independence
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Kansas City
University of Kansas Cancer Center
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Kingman
Cancer Center of Kansas-Kingman
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Lawrence
Lawrence Memorial Hospital
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Lenexa
Kansas Institute of Medicine Cancer and Blood Center
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Minimally Invasive Surgery Hospital
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Liberal
Cancer Center of Kansas-Liberal
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Email: Keisha.humphries@ascension.org

Manhattan
Cancer Center of Kansas-Manhattan
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Email: Keisha.humphries@ascension.org

McPherson
Cancer Center of Kansas - McPherson
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Email: Keisha.humphries@ascension.org

Newton
Cancer Center of Kansas - Newton
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Email: Keisha.humphries@ascension.org

Olathe
Olathe Health Cancer Center
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Overland Park
Menorah Medical Center
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University of Kansas Cancer Center-Overland Park
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Parsons
Cancer Center of Kansas - Parsons
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Email: Keisha.humphries@ascension.org

Pittsburg
Ascension Via Christi - Pittsburg
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Email: jennifer.jameson@ascension.org

Pratt
Cancer Center of Kansas - Pratt
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Email: Keisha.humphries@ascension.org

Salina
Cancer Center of Kansas - Salina
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Email: Keisha.humphries@ascension.org

Salina Regional Health Center
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Email: mleepers@srhc.com

Topeka
University of Kansas Health System Saint Francis Campus
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Wellington
Cancer Center of Kansas - Wellington
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Email: Keisha.humphries@ascension.org

Westwood
University of Kansas Hospital-Westwood Cancer Center
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Email: KUCC_Navigation@kumc.edu

Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org

Associates In Womens Health
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org

Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org

Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org

Winfield
Cancer Center of Kansas - Winfield
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org

KY
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Corbin
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Crestview Hills
Oncology Hematology Care Inc-Crestview
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Lexington
Saint Joseph Hospital East
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

University of Kentucky/Markey Cancer Center
Contact: Site Public Contact

London
Saint Joseph London
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Louisville
Jewish Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

LA
Alexandria
Christus Saint Frances Cabrini Hospital
Contact: Site Public Contact
Email: tammy.debona@christushealth.org

Baton Rouge
Medical Center of Baton Rouge
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org

Ochsner Health Center-Summa
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org

Ochsner High Grove
Contact: Site Public Contact
Email: Gregory.Johnstone@ochsner.org

Kenner
Ochsner Medical Center Kenner
Contact: Site Public Contact
Email: cris.molina@ochsner.org

Lake Charles
CHRISTUS Lake Charles Medical Center
Contact: Site Public Contact
Email: laura.smith2@christushealth.org

Monroe
Ochsner LSU Health Monroe Medical Center
Contact: Site Public Contact
Email: LPost@lsuhsc.edu

New Orleans
Ochsner Medical Center Jefferson
Contact: Site Public Contact
Email: Gregory.Johnstone@ochsner.org

Shreveport
LSU Health Sciences Center at Shreveport
Contact: Site Public Contact
Email: LPost@lsuhsc.edu

MA
Boston
Beth Israel Deaconess Medical Center
Contact: Site Public Contact

Dana-Farber Cancer Institute
Contact: Site Public Contact

Massachusetts General Hospital Cancer Center
Contact: Site Public Contact

Springfield
Mercy Medical Center
Contact: Site Public Contact

MD
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Contact: Site Public Contact
Email: jhcccro@jhmi.edu

Sinai Hospital of Baltimore
Contact: Site Public Contact
Email: pridgely@lifebridgehealth.org

Randallstown
Northwest Hospital Center
Contact: Site Public Contact
Email: cancerinstitute@lifebridgehealth.org

Westminster
William E Kahlert Regional Cancer Center/Sinai Hospital
Contact: Site Public Contact

MI
Ann Arbor
Saint Joseph Mercy Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

University of Michigan Comprehensive Cancer Center
Contact: Site Public Contact

Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Brighton
Saint Joseph Mercy Brighton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Brownstown
Henry Ford Cancer Institute-Downriver
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Canton
Saint Joseph Mercy Canton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Caro
Caro Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Chelsea
Saint Joseph Mercy Chelsea
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Clinton Township
Henry Ford Macomb Hospital-Clinton Township
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Dearborn
Henry Ford Medical Center-Fairlane
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Detroit
Ascension Saint John Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Henry Ford Hospital
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Wayne State University/Karmanos Cancer Institute
Contact: Site Public Contact
Email: ctoadmin@karmanos.org

East China
Great Lakes Cancer Management Specialists-Doctors Park
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Farmington Hills
Weisberg Cancer Treatment Center
Contact: Site Public Contact
Email: ctoadmin@karmanos.org

Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Hurley Medical Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Grand Rapids
Helen DeVos Children's Hospital at Spectrum Health
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Spectrum Health at Butterworth Campus
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Grosse Pointe Woods
Academic Hematology Oncology Specialists
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Michigan Breast Specialists-Grosse Pointe Woods
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Jackson
Allegiance Health
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Kalamazoo
Borgess Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Lansing
Sparrow Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Michigan Breast Specialists-Macomb Township
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Monroe
Monroe Cancer Center
Contact: Site Public Contact
Email: ctsucontact@westat.com

Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Niles
Lakeland Hospital Niles
Contact: Site Public Contact

Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org

Novi
Henry Ford Medical Center-Columbus
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

Pontiac
21st Century Oncology-Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Hope Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Saint Joseph Mercy Oakland
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Port Huron
Huron Medical Center PC
Contact: Site Public Contact
Email: research@sncrf.org

Lake Huron Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

Reed City
Spectrum Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Saginaw
Ascension Saint Mary's Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Saint Joseph
Lakeland Medical Center Saint Joseph
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Marie Yeager Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Shelby Township
Henry Ford Macomb Health Center - Shelby Township
Contact: Site Public Contact
Email: tpearce1@hfhs.org

Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Tawas City
Ascension Saint Joseph Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Great Lakes Cancer Management Specialists-Macomb Professional Building
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Michigan Breast Specialists-Warren
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Saint John Macomb-Oakland Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

West Bloomfield
Henry Ford West Bloomfield Hospital
Contact: Site Public Contact
Email: CTOResearch@hfhs.org

West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Wyoming
Metro Health Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org

Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

MN
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Rochester
Mayo Clinic in Rochester
Contact: Site Public Contact

Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact

Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact

Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact

Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org

Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact

Branson
Cox Cancer Center Branson
Contact: Site Public Contact

Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net

Southeast Cancer Center
Contact: Site Public Contact

Creve Coeur
Siteman Cancer Center at West County Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact

Independence
Centerpoint Medical Center LLC
Contact: Site Public Contact
Email: aroland@kccop.org

Jefferson City
Capital Region Southwest Campus
Contact: Site Public Contact
Email: swooden@mail.crmc.org

Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com

Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net

Kansas City
Research Medical Center
Contact: Site Public Contact
Email: aroland@kccop.org

Truman Medical Centers
Contact: Site Public Contact

University of Kansas Cancer Center - North
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu

Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu

Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: kaysmith@phelpshealth.org

Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact

Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com

Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact

Mercy Hospital South
Contact: Site Public Contact
Email: janet.lesko@mercy.net

Missouri Baptist Medical Center
Contact: Site Public Contact

Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact

Siteman Cancer Center at Christian Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Siteman Cancer Center-South County
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Washington University School of Medicine
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu

Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact

Springfield
CoxHealth South Hospital
Contact: Site Public Contact

Mercy Hospital Springfield
Contact: Site Public Contact

Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact

Sunset Hills
Missouri Baptist Outpatient Center-Sunset Hills
Contact: Site Public Contact

Washington
Mercy Hospital Washington
Contact: Site Public Contact

MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org

Saint Vincent Healthcare
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Bozeman
Bozeman Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact

Great Falls
Benefis Healthcare- Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Great Falls Clinic
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Helena
Saint Peter's Community Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Missoula
Community Medical Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org

NC
Asheville
AdventHealth Infusion Center Asheville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com

Cary
Duke Cancer Institute Cary
Contact: Site Public Contact

Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com

Clyde
AdventHealth Infusion Center Haywood
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com

Durham
Duke University Medical Center
Contact: Site Public Contact

Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com

Wayne Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com

Hendersonville
AdventHealth Hendersonville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com

Jacksonville
Onslow Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com

Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com

Raleigh
Duke Raleigh Hospital
Contact: Site Public Contact

Washington
Marion L Shepard Cancer Center at Vidant Beaufort Hospital
Contact: Site Public Contact

ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Fargo
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Clinic North-Fargo
Contact: Preston D. Steen

Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford South University Medical Center
Contact: Site Public Contact

NE
Grand Island
CHI Health Saint Francis
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Heartland Hematology and Oncology
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Lincoln
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Creighton University Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Hematology and Oncology Consultants PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

NH
Lebanon
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Contact: Site Public Contact
Email: cancer.research.nurse@dartmouth.edu

NJ
Mullica Hill
Inspira Medical Center Mullica Hill
Contact: Site Public Contact
Email: DeNigrisJ@ihn.org

Vineland
Inspira Medical Center Vineland
Contact: Site Public Contact

NM
Albuquerque
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: LByatt@nmcca.org

NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org

GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org

OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org

Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org

Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org

Cancer Therapy and Integrative Medicine
Contact: Site Public Contact
Email: research@sncrf.org

Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org

Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org

Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org

Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org

GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org

GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org

GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org

Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org

Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org

Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org

OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org

OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org

OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org

Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org

Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org

Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org

University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org

Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org

Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org

Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org

Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org

Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org

Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org

NY
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org

Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org

Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org

New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
Contact: Site Public Contact
Email: nr2616@cumc.columbia.edu

OH
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: sheree@columbusccop.org

Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Chardon
Geauga Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Oncology Hematology Care Inc-Anderson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Oncology Hematology Care Inc-Blue Ash
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Oncology Hematology Care Inc-Eden Park
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Oncology Hematology Care Inc-Mercy West
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

University of Cincinnati Cancer Center-UC Medical Center
Contact: Site Public Contact
Email: uchealthnews@uc.edu

Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Cleveland Clinic Cancer Center/Fairview Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

Cleveland Clinic Foundation
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

MetroHealth Medical Center
Contact: Site Public Contact
Email: dstrater@metrohealth.org

Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: sheree@columbusccop.org

Doctors Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Grant Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Mount Carmel East Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Mount Carmel Health Center West
Contact: Site Public Contact
Email: sheree@columbusccop.org

Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu

Riverside Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

The Mark H Zangmeister Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Dayton
Dayton Physician LLC-Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Good Samaritan Hospital - Dayton
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Delaware Radiation Oncology
Contact: Site Public Contact
Email: sheree@columbusccop.org

Grady Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Dublin
Dublin Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Elyria
Mercy Cancer Center-Elyria
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Fairfield
Oncology Hematology Care Inc-Healthplex
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Independence
Cleveland Clinic Cancer Center Independence
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

Kettering
First Dayton Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Mansfield
OhioHealth Mansfield Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Mayfield Heights
Hillcrest Hospital Cancer Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

UH Seidman Cancer Center at Landerbrook Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Middletown
Dayton Physicians LLC-Signal Point
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Newark Radiation Oncology
Contact: Site Public Contact
Email: sheree@columbusccop.org

Parma
University Hospitals Parma Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

Sandusky
North Coast Cancer Care
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Sidney
Dayton Physicians LLC-Wilson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Strongsville
Cleveland Clinic Cancer Center Strongsville
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

Sylvania
ProMedica Flower Hospital
Contact: Site Public Contact

Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Contact: Site Public Contact

Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Wadsworth
University Hospitals Sharon Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Warrensville Heights
South Pointe Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

West Chester
University of Cincinnati Cancer Center-West Chester
Contact: Site Public Contact
Email: clinicaltrials@ucphysicians.com

Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org

Westlake
UH Seidman Cancer Center at Saint John Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

UHHS-Westlake Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org

Wooster
Cleveland Clinic Wooster Family Health and Surgery Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org

Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org

Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: sheree@columbusccop.org

OK
Lawton
Cancer Centers of Southwest Oklahoma Research
Contact: Site Public Contact

Oklahoma City
Mercy Hospital Oklahoma City
Contact: Site Public Contact

University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu

OR
Baker City
Saint Alphonsus Medical Center-Baker City
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Ontario
Saint Alphonsus Medical Center-Ontario
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Beaver
UPMC-Heritage Valley Health System Beaver
Contact: Site Public Contact

Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: mhayden@christianacare.org

Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact

Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org

Hershey
Penn State Milton S Hershey Medical Center
Contact: Site Public Contact
Email: CTO@hmc.psu.edu

Johnstown
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Contact: Site Public Contact

Lewisburg
Geisinger Medical Oncology-Lewisburg
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Lewistown
Lewistown Hospital
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact

Moon Township
UPMC Hillman Cancer Center in Coraopolis
Contact: Site Public Contact

Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact

University of Pennsylvania/Abramson Cancer Center
Contact: Site Public Contact

Pittsburgh
UPMC Jefferson Regional Radiation Oncology
Contact: Site Public Contact

UPMC-Magee Womens Hospital
Contact: Site Public Contact

UPMC-Passavant Hospital
Contact: Site Public Contact

UPMC-Presbyterian Hospital
Contact: Site Public Contact

UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact

UPMC-Saint Margaret
Contact: Site Public Contact

UPMC-Shadyside Hospital
Contact: Site Public Contact

University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact

Pottsville
Geisinger Cancer Services-Pottsville
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Scranton
Community Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact

State College
Geisinger Medical Group
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

Uniontown
UPMC Uniontown Hospital Radiation Oncology
Contact: Site Public Contact

Washington
UPMC Washington Hospital Radiation Oncology
Contact: Site Public Contact
Email: cancer@washingtonhospital.org

Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu

SC
Anderson
AnMed Health Cancer Center
Contact: Site Public Contact
Email: rhonda.ballew@anmedhealth.org

Boiling Springs
Prisma Health Cancer Institute - Spartanburg
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Charleston
Medical University of South Carolina
Contact: Site Public Contact
Email: hcc-clinical-trials@musc.edu

Easley
Prisma Health Cancer Institute - Easley
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Greenville
Prisma Health Cancer Institute - Butternut
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Prisma Health Cancer Institute - Eastside
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Prisma Health Cancer Institute - Faris
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Prisma Health Greenville Memorial Hospital
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Greer
Prisma Health Cancer Institute - Greer
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

Seneca
Prisma Health Cancer Institute - Seneca
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org

SD
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org

TN
Chattanooga
Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Ooltewah
Memorial GYN Plus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

TX
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org

Dallas
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu

UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu

Fort Worth
UT Southwestern/Simmons Cancer Center-Fort Worth
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu

Houston
Houston Methodist Hospital
Contact: Site Public Contact

Methodist Willowbrook Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com

Richardson
UT Southwestern Clinical Center at Richardson/Plano
Contact: Site Public Contact
Email: Suzanne.cole@utsouthwestern.edu

San Antonio
University of Texas Health Science Center at San Antonio
Contact: Site Public Contact
Email: phoresearchoffice@uthscsa.edu

Sugar Land
Houston Methodist Sugar Land Hospital
Contact: Site Public Contact

UT
Farmington
Farmington Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu

Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu

University of Utah Sugarhouse Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu

WI
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org

Chippewa Falls
Marshfield Clinic-Chippewa Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Fond Du Lac
Aurora Health Center-Fond du Lac
Contact: Site Public Contact
Email: ncorp@aurora.org

Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org

Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Johnson Creek
UW Cancer Center Johnson Creek
Contact: Site Public Contact
Email: lynda.persico@uwmf.wisc.edu

Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org

Ladysmith
Marshfield Clinic - Ladysmith Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Madison
University of Wisconsin Carbone Cancer Center
Contact: Site Public Contact

Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org

Bay Area Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Milwaukee
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org

Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Medical College of Wisconsin
Contact: Site Public Contact

Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com

Oshkosh
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org

Racine
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org

Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org

Stevens Point
Ascension Saint Michael's Hospital
Contact: Site Public Contact
Email: ClinicalResearchAWI@ascension.org

Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org

Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org

Waukesha
Aurora Cancer Care-Waukesha
Contact: Site Public Contact
Email: ncorp@aurora.org

Wausau
Marshfield Clinic-Wausau Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Wauwatosa
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org

West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org

Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

Wisconsin Rapids
Marshfield Clinic - Wisconsin Rapids Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org

WY
Cody
Big Horn Basin Cancer Center
Contact: Site Public Contact
Email: ctsucontact@westat.com

Billings Clinic-Cody
Contact: Site Public Contact
Email: research@billingsclinic.org

Sheridan
Welch Cancer Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org

PRIMARY OBJECTIVE:
I. To assess the progression free survival (PFS) of platinum (cisplatin or carboplatin) and etoposide versus the PFS of temozolomide and capecitabine in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas.

SECONDARY OBJECTIVES:
I. To assess the response rate (RR) of platinum (cisplatin or carboplatin) and etoposide versus the RR of temozolomide and capecitabine in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas.
II. To assess the overall survival (OS) of platinum (cisplatin or carboplatin) and etoposide versus the OS of temozolomide and capecitabine in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas.
III. To evaluate the toxicities associated with the combination of temozolomide and capecitabine and the combination of platinum (cisplatin or carboplatin) and etoposide, respectively, in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas.

LABORATORY RESEARCH OBJECTIVES:
I. To assess the impact of each treatment regimen on PFS, RR and OS based on marker Ki-67 index in patients with advanced G3 non-small cell gastroenteropancreatic neuroendocrine carcinomas.
II. To assess the prognostic significance of well differentiated versus poorly differentiated non-small cell gastroenteropancreatic neuroendocrine tumors in relationship to survival and response to treatment.
III. To assess the agreement in Ki-67 status between that reported by institutional pathologist and that reported by central pathology review.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM A: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14 and temozolomide PO once daily (QD) on days 10-14. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

ARM B: Patients receive cisplatin intravenously (IV) on days 1-3 or carboplatin IV on day 1. Patients also receive etoposide IV on days 1-3. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 30 days, then every 3 months for 2 years and then every 6 months for 3 years.

Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.


The ECOG-ACRIN Cancer Research Group designed and conducted this trial with funding from the National Cancer Institute through its National Clinical Trials Network.


EA2142 (Closed)
ECOG-ACRIN Cancer Research Group