Breast Cancer
EA1181 / CompassHER2 pCR
Testing the Effect of Decreasing Chemotherapy in Patients with HER2-Positive Breast Cancer Without Evidence of Remaining Cancer after Receiving Pre-Surgery Chemotherapy and HER2-Targeted Therapy
STATUS: Closed to Accrual
This phase II trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of tumor cells, known as HER2 receptors. When trastuzumab attaches to HER2 receptors, the signals that tell the cells to grow are blocked and the tumor cell may be marked for destruction by the body’s immune system. Pertuzumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Giving paclitaxel, trastuzumab, and pertuzumab may enable fewer chemotherapy drugs to be given without compromising patient outcomes compared to the usual treatment.
- Patient must be >= 18 years of age
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Patient must have histologically confirmed HER2-positive primary invasive breast carcinoma, determined by local testing. The tumor must have either HER2 immunohistochemistry (IHC) result of 3+ or HER2/CEP17 ratio >= 2 with >= 4.0 HER2 signals per cell by in situ hybridization (ISH). Tumors with HER2/CEP17 ISH ratio < 2 are ineligible, even if HER2 copy number is > 6, unless HER2 IHC result is 3+
- Patients hormone receptor (ER and PR) status must be known and will be determined by local testing. Patients with either hormone receptor–positive or hormone receptor- negative HER2-positive breast cancer are eligible
- Patients must have AJCC 8th edition stage II or IIIa according to anatomic staging table at diagnosis * Patients without nodal involvement (cN0) are eligible if T size > 2.0 cm (T2-3) ** NOTE: Cohort for patients with 2-3 cm, ER+ and node negative HER2-positive/ER-positive disease closed on July 27, 2022 * Patients with HER2-positive/ER-negative disease without nodal involvement (cN0) are eligible if T size > 2.0 cm (T2-3) ** NOTE: Cohort for HER2-postive/ER-negative patients closed on May 18, 2023 * Patients with HER2-positive/ER-positive disease without nodal involvement (cN0) are eligible if T size > 3.0 cm * Patients with nodal involvement (cN1-2) are eligible if T1-3 * Patients with clinical T4 or N3 disease are not eligible
- Patient must be willing and able (i.e., have no contraindication) to receive standard adjuvant therapy, consisting of HER2-directed therapy, radiation (if indicated) and endocrine therapy (if ER+) if achieving pCR at surgery
- Patient with bilateral invasive breast cancers are eligible if both cancers are HER2-positive at least one meets protocol eligibility and neither cancer renders the patient ineligible
- Patients with multiple ipsilateral invasive tumors are eligible as long as all tumors are HER2-positive, and at least one tumor focus meets eligibility criteria. Multiple lesions that appear part of the same index tumor do not require additional biopsy/HER2 testing. However, even if biopsy is not deemed necessary, consideration must be given to placing a clip in any lesion that is 1 cm or further from the primary tumor to ensure that all tumor is removed at surgery AND that the pathologist can locate all primary sites of tumor to assess pathologic response at surgery
- Patients must not have impaired decision-making capacity
- Patient must not have a history of any prior (ipsilateral or contralateral) invasive breast cancer * One exception: a patient with a history of T1N0 triple negative breast cancer diagnosed more than 10 years earlier, who remains disease free is eligible
- Patient must not have prior ipsilateral ductal breast carcinoma in situ (DCIS). Patients with prior lobular breast carcinoma in situ (LCIS), atypical hyperplasia, other high risk benign lesions or contralateral DCIS (without evidence of microinvasion) are eligible. Current ipsilateral or contralateral DCIS (diagnosed at the time of the current invasive cancer) is permitted * NOTE: Patients currently receiving endocrine therapy for prior contralateral DCIS are eligible
- Patient must not have stage IV (metastatic) breast cancer * Staging studies (CT chest/abdomen/pelvis and a bone scan or PET-CT scan) are required for stage III disease (according to AJCC cancer staging manual anatomic staging table, 8th edition) or those with abnormal baseline liver function tests (LFTs), symptoms (e.g., new bone pain) or abnormal physical exam findings (National Comprehensive Cancer Network [NCCN] guidelines version [V]1.2019)
- Patient must not have T4 and/or N3 disease, including inflammatory breast cancer
- Patient must not have any prior treatment for the current breast cancer, including surgery, chemotherapy, hormonal therapy, radiation or experimental therapy
- Patients with a history of other non-breast malignancies are eligible if they have been disease-free for at least 5 years, and are deemed by the investigator to be at low risk for recurrence of that malignancy * Patients with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, basal cell or squamous cell carcinoma of the skin, melanoma-in-situ and localized papillary or follicular thyroid cancer who have completed recommended treatment including surgery. Patients with any other cancers within the last 5 years are ineligible
- Patents must have a left ventricular ejection fraction (LVEF) within normal institutional parameters (or >= 50%)
- Patients must not have > grade 1 peripheral neuropathy of any etiology
- Patients must have a bilateral mammogram and a diagnostic breast ultrasound (on the side of the cancer[s]) (with or without breast MRI) performed at screening. An axillary ultrasound on the side of the cancer(s) is also required. Comprehensive breast and axillary imaging must be performed within 60 days of registration (i.e. the patient’s mammogram/ breast ultrasound /axillary ultrasound OR their breast MRI). Either mammogram/ultrasound (including imaging of the ipsilateral axilla) or breast MRI must be performed within 60 days of registration
- Baseline imaging of the ipsilateral axilla by ultrasound is mandatory. For subjects with axillary lymph node(s) suspicious on clinical exam or imaging, patient must be willing to have a needle aspiration or core biopsy to determine the presence of metastatic disease in the lymph nodes. A clip must be placed in the involved axillary lymph node. (If there are more than 1 suspicious axillary nodes, only one clipped node is required). Alternatives to a clip that reliably mark the involved node for removal at surgery are acceptable (e.g., carbon tattooing, Savi scout, radiofrequency identification [RFID] etc.)
- Patient must not have a concurrent serious medical condition that would preclude completion of study therapy. For example, uncontrolled hypertension (systolic > 180 mm Hg and/or diastolic > 100 mm Hg) or clinically significant (i.e., active) cardiovascular disease: cerebrovascular accident/stroke or myocardial infarction within 6 months prior to registration, unstable angina, congestive heart failure (CHF) or serious cardiac arrhythmia requiring medication and other concurrent serious diseases that may interfere with planned treatment
- Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used. Patients must also not expect to conceive from the time of registration, while on study treatment, and until at least 7 months after the last dose of study treatment. * All patients of childbearing potential must have a blood test or urine study within 14 days prior to registration to rule out pregnancy. If the pregnancy test (e.g., human chorionic gonadotropin [HCG] level) is abnormal but is felt to represent a false positive test for pregnancy (e.g., due to treatments being administered for egg harvesting, or because of recent miscarriage), a note by the treating gynecologist explaining why the team is confident the woman is not pregnant is required * A patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patient of childbearing potential and sexually active patients must use accepted and effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for 7 months after the last dose of study treatment
- Patient must be willing and able to sign informed consent
- Leukocytes >= 3,000/mcL (obtained =< 28 days prior to protocol registration)
- Absolute neutrophil count >= 1,500/mcL (obtained =< 28 days prior to protocol registration)
- Platelets >= 100,000/mcL (obtained =< 28 days prior to protocol registration)
- Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 28 days prior to protocol registration)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 28 days prior to protocol registration)
- Creatinine =< 1.5 x institutional ULN (obtained =< 28 days prior to protocol registration)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
United States
AK
Anchorage
Alaska Breast Care and Surgery LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Fairbanks
Fairbanks Memorial Hospital
Contact: Site Public Contact
Email: Veronica.Stevenson@foundationhealth.org
AL
Birmingham
University of Alabama at Birmingham Cancer Center
Contact: Site Public Contact
Email: tmyrick@uab.edu
AR
Ft. Smith
Mercy Hospital Fort Smith
Contact: Site Public Contact
Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Jonesboro
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Contact: Site Public Contact
Email: Emily.Carvell@bmhcc.org
Little Rock
CARTI Cancer Center
Contact: Site Public Contact
Email: Research@CARTI.com
AZ
Kingman
Kingman Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Phoenix
Cancer Center at Saint Joseph's
Contact: Site Public Contact
Email: Research-cancerinstitute@dignityhealth.org
Tucson
Banner University Medical Center - Tucson
Contact: Site Public Contact
Email: UACC-IIT@uacc.arizona.edu
University of Arizona Cancer Center-North Campus
Contact: Site Public Contact
Email: UACC-IIT@uacc.arizona.edu
University of Arizona Cancer Center-Orange Grove Campus
Contact: Site Public Contact
CA
Arroyo Grande
Mission Hope Medical Oncology - Arroyo Grande
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
PCR Oncology
Contact: Site Public Contact
Email: research@sncrf.org
Auburn
Sutter Auburn Faith Hospital
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Contact: Site Public Contact
Email: Najee.Boucher@providence.org
Burlingame
Mills-Peninsula Medical Center
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Cameron Park
Marshall Cancer Center
Contact: Site Public Contact
Email: cancerservices@marshallmedical.org
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Carmichael
Mercy Cancer Center - Carmichael
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Mercy San Juan Medical Center
Contact: Site Public Contact
Email: OncologyResearch@DignityHealth.org
Castro Valley
Eden Hospital Medical Center
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Concord
John Muir Medical Center-Concord
Contact: Site Public Contact
Davis
Sutter Davis Hospital
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Dublin
Epic Care-Dublin
Contact: Site Public Contact
Elk Grove
Mercy Cancer Center - Elk Grove
Contact: Site Public Contact
Email: OncologyResearch@DignityHealth.org
Emeryville
Bay Area Breast Surgeons Inc
Contact: Site Public Contact
Epic Care Partners in Cancer Care
Contact: Site Public Contact
Fremont
Palo Alto Medical Foundation-Fremont
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Washington Hospital
Contact: Site Public Contact
Huntington Beach
Keck Medicine of USC Huntington Beach
Contact: Site Public Contact
Email: karenn@pacshoresoncology.com
Los Angeles
Los Angeles General Medical Center
Contact: Site Public Contact
USC / Norris Comprehensive Cancer Center
Contact: Site Public Contact
Martinez
Contra Costa Regional Medical Center
Contact: Site Public Contact
Marysville
Fremont - Rideout Cancer Center
Contact: Site Public Contact
Modesto
Memorial Medical Center
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Newport Beach
USC Norris Oncology/Hematology-Newport Beach
Contact: Site Public Contact
Novato
Sutter Cancer Research Consortium
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Oakland
Alta Bates Summit Medical Center - Summit Campus
Contact: Site Public Contact
Bay Area Tumor Institute
Contact: Site Public Contact
Email: lradke@bati.org
Orange
Saint Joseph Hospital - Orange
Contact: Site Public Contact
Palm Springs
Desert Regional Medical Center
Contact: Site Public Contact
Palo Alto
Palo Alto Medical Foundation Health Care
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Stanford Cancer Institute Palo Alto
Contact: Site Public Contact
Email: ccto-office@stanford.edu
Pasadena
Keck Medical Center of USC Pasadena
Contact: Site Public Contact
Rocklin
Mercy Cancer Center - Rocklin
Contact: Site Public Contact
Email: OncologyResearch@DignityHealth.org
Roseville
Sutter Cancer Centers Radiation Oncology Services-Roseville
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Sutter Roseville Medical Center
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Sacramento
Mercy Cancer Center - Sacramento
Contact: Site Public Contact
Email: OncologyResearch@DignityHealth.org
Sutter Medical Center Sacramento
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Saint Helena
Saint Helena Hospital
Contact: Site Public Contact
Salinas
Salinas Valley Memorial
Contact: Site Public Contact
Email: tnielsen2@svmh.com
San Francisco
California Pacific Medical Center-Pacific Campus
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Zuckerberg San Francisco General Hospital
Contact: Site Public Contact
Email: Paul.Couey@ucsf.edu
San Jose
Stanford Cancer Center South Bay
Contact: Site Public Contact
Email: ccto-office@stanford.edu
San Luis Obispo
Pacific Central Coast Health Center-San Luis Obispo
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Santa Maria
Mission Hope Medical Oncology - Santa Maria
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Santa Rosa
Sutter Pacific Medical Foundation
Contact: Site Public Contact
Email: hempell@sutterhealth.org
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Truckee
Gene Upshaw Memorial Tahoe Forest Cancer Center
Contact: Site Public Contact
Vacaville
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Contact: Site Public Contact
Email: hempell@sutterhealth.org
Vallejo
Sutter Solano Medical Center/Cancer Center
Contact: Site Public Contact
Email: Melanie.Cook@sutterhealth.org
Walnut Creek
Epic Care Cyberknife Center
Contact: Site Public Contact
Email: somega@bati.org
John Muir Medical Center-Walnut Creek
Contact: Site Public Contact
Woodland
Woodland Memorial Hospital
Contact: Site Public Contact
Email: OncologyResearch@DignityHealth.org
CO
Aurora
Rocky Mountain Cancer Centers-Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Medical Center of Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
UCHealth University of Colorado Hospital
Contact: Site Public Contact
Boulder
Boulder Community Foothills Hospital
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Boulder
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Centennial
Rocky Mountain Cancer Centers - Centennial
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Colorado Springs
Memorial Hospital North
Contact: Site Public Contact
Penrose-Saint Francis Healthcare
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Rocky Mountain Cancer Centers-Penrose
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Saint Francis Cancer Center
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
UCHealth Memorial Hospital Central
Contact: Site Public Contact
Denver
Colorado Blood Cancer Institute
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Porter Adventist Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Presbyterian - Saint Lukes Medical Center - Health One
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Midtown
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Rose
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rose Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
The Women's Imaging Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
UCHealth - Cherry Creek
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Western Surgical Care
Contact: Site Public Contact
Durango
Mercy Medical Center
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Southwest Oncology PC
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Englewood
Mountain Blue Cancer Care Center - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Swedish Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Melanoma and Skin Cancer Institute
Contact: Site Public Contact
Email: ryan.weight@theskincancerinstitute.com
Fort Collins
Cancer Care and Hematology-Fort Collins
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Poudre Valley Hospital
Contact: Site Public Contact
Grand Junction
Grand Valley Oncology
Contact: Site Public Contact
Email: gvoclinicaltrials@gjhosp.org
Greeley
Banner North Colorado Medical Center
Contact: Site Public Contact
Email: BMDACCResearchCOMailbox@bannerhealth.com
UCHealth Greeley Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Highlands Ranch
UCHealth Highlands Ranch Hospital
Contact: Site Public Contact
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Saint Anthony Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Littleton
Littleton Adventist Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Rocky Mountain Cancer Centers-Littleton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Lone Tree
Rocky Mountain Cancer Centers-Sky Ridge
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Sky Ridge Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
UCHealth Lone Tree Health Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Longmont
Longmont United Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Rocky Mountain Cancer Centers-Longmont
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Loveland
Banner McKee Medical Center
Contact: Site Public Contact
Email: BMDACCResearchCOMailbox@bannerhealth.com
Medical Center of the Rockies
Contact: Site Public Contact
Parker
Parker Adventist Hospital
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Pueblo
Saint Mary Corwin Medical Center
Contact: Site Public Contact
Email: ResearchTracking@Centura.Org
Thornton
Rocky Mountain Cancer Centers-Thornton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
CT
Bridgeport
Hartford HealthCare - Saint Vincent's Medical Center
Contact: Site Public Contact
Derby
Smilow Cancer Hospital-Derby Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Fairfield
Smilow Cancer Hospital Care Center-Fairfield
Contact: Site Public Contact
Email: canceranswers@yale.edu
Glastonbury
Smilow Cancer Hospital Care Center at Glastonbury
Contact: Site Public Contact
Email: canceranswers@yale.edu
Greenwich
Smilow Cancer Hospital Care Center at Greenwich
Contact: Site Public Contact
Email: canceranswers@yale.edu
Guilford
Smilow Cancer Hospital Care Center - Guilford
Contact: Site Public Contact
Email: canceranswers@yale.edu
Hartford
Hartford Hospital
Contact: Site Public Contact
Smilow Cancer Hospital Care Center at Saint Francis
Contact: Site Public Contact
Email: canceranswers@yale.edu
Meriden
Midstate Medical Center
Contact: Site Public Contact
New Britain
The Hospital of Central Connecticut
Contact: Site Public Contact
New Haven
Smilow Cancer Center/Yale-New Haven Hospital
Contact: Site Public Contact
Email: canceranswers@yale.edu
Yale University
Contact: Site Public Contact
Email: canceranswers@yale.edu
North Haven
Yale-New Haven Hospital North Haven Medical Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Orange
Smilow Cancer Hospital-Orange Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Stamford
Smilow Cancer Hospital Care Center at Long Ridge
Contact: Site Public Contact
Email: canceranswers@yale.edu
Stamford Hospital/Bennett Cancer Center
Contact: Site Public Contact
Torrington
Smilow Cancer Hospital-Torrington Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Trumbull
Smilow Cancer Hospital Care Center-Trumbull
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterford
Smilow Cancer Hospital Care Center - Waterford
Contact: Site Public Contact
Email: canceranswers@yale.edu
DC
Washington
Kaiser Permanente-Capitol Hill Medical Center
Contact: Site Public Contact
Sibley Memorial Hospital
Contact: Site Public Contact
Email: jquiver1@jhmi.edu
DE
Lewes
Beebe Medical Center
Contact: Site Public Contact
Email: research@beebehealthcare.org
Millville
Beebe South Coastal Health Campus
Contact: Site Public Contact
Email: research@beebehealthcare.org
Newark
Christiana Care Health System-Christiana Hospital
Contact: Site Public Contact
Email: lbarone@christianacare.org
Delaware Clinical and Laboratory Physicians PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Helen F Graham Cancer Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Medical Oncology Hematology Consultants PA
Contact: Site Public Contact
Email: lbarone@christianacare.org
Rehoboth Beach
Beebe Health Campus
Contact: Site Public Contact
Email: research@beebehealthcare.org
Seaford
TidalHealth Nanticoke / Allen Cancer Center
Contact: Site Public Contact
Email: anna-maria.howard@peninsula.org
Wilmington
Christiana Care Health System-Wilmington Hospital
Contact: Site Public Contact
Email: lbarone@christianacare.org
FL
Altamonte Springs
AdventHealth Altamonte
Contact: Site Public Contact
Aventura
Mount Sinai Comprehensive Cancer Center at Aventura
Contact: Site Public Contact
Email: yenrique@msmc.com
UM Sylvester Comprehensive Cancer Center at Aventura
Contact: Site Public Contact
Celebration
AdventHealth Celebration
Contact: Site Public Contact
Clearwater
Morton Plant Hospital
Contact: Site Public Contact
Coral Gables
UM Sylvester Comprehensive Cancer Center at Coral Gables
Contact: Site Public Contact
Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Contact: Site Public Contact
Gainesville
University of Florida Health Science Center - Gainesville
Contact: Site Public Contact
Email: cancer-center@ufl.edu
Hollywood
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Contact: Site Public Contact
Email: OHR@mhs.net
Jacksonville
Mayo Clinic in Florida
Contact: Site Public Contact
Kissimmee
AdventHealth Kissimmee
Contact: Site Public Contact
Miami
UM Sylvester Comprehensive Cancer Center at Kendall
Contact: Site Public Contact
University of Miami Miller School of Medicine-Sylvester Cancer Center
Contact: Site Public Contact
Miami Beach
Mount Sinai Medical Center
Contact: Site Public Contact
Email: yenrique@msmc.com
Orlando
AdventHealth East Orlando
Contact: Site Public Contact
AdventHealth Medical Group Urology at Orlando
Contact: Site Public Contact
AdventHealth Orlando
Contact: Site Public Contact
Email: FH.Cancer.Research@flhosp.org
Pembroke Pines
Memorial Hospital West
Contact: Site Public Contact
Plantation
UM Sylvester Comprehensive Cancer Center at Plantation
Contact: Site Public Contact
Safety Harbor
Mease Countryside Hospital
Contact: Site Public Contact
Email: research.cto@baycare.org
Winter Haven
Winter Haven Hospital
Contact: Site Public Contact
Winter Park
AdventHealth Winter Park
Contact: Site Public Contact
GA
Atlanta
Emory Saint Joseph's Hospital
Contact: Site Public Contact
Emory University Hospital Midtown
Contact: Site Public Contact
Emory University Hospital/Winship Cancer Institute
Contact: Site Public Contact
Grady Health System
Contact: Site Public Contact
Northside Hospital
Contact: Site Public Contact
Email: ClinicalTrials@northside.com
Dalton
Hamilton Medical Center - Peeples Cancer Institute
Contact: Site Public Contact
Email: crogers@hhcs.org
Duluth
Northside Hospital - Duluth
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Lawrenceville
Northside Hospital - Gwinnett
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
Snellville
Suburban Hematology Oncology Associates - Snellville
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Thomasville
Lewis Hall Singletary Oncology Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
IA
Ames
Mary Greeley Medical Center
Contact: Site Public Contact
McFarland Clinic - Ames
Contact: Site Public Contact
Email: ksoder@mcfarlandclinic.com
Boone
McFarland Clinic - Boone
Contact: Site Public Contact
Carroll
Saint Anthony Regional Hospital
Contact: Site Public Contact
Email: sbenson@iora.org
Cedar Rapids
Mercy Hospital
Contact: Site Public Contact
Oncology Associates at Mercy Medical Center
Contact: Site Public Contact
Clive
Mercy Cancer Center-West Lakes
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - West Des Moines
Contact: Site Public Contact
Council Bluffs
Alegent Health Mercy Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Creston
Greater Regional Medical Center
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Davenport
Genesis Cancer Care Institute
Contact: Site Public Contact
Email: turnerk@genesishealth.com
Genesis Medical Center - East Campus
Contact: Site Public Contact
Email: turnerk@genesishealth.com
Iowa Cancer Specialists
Contact: Site Public Contact
Email: turnerk@genesishealth.com
Des Moines
Broadlawns Medical Center
Contact: Site Public Contact
Iowa Lutheran Hospital
Contact: Site Public Contact
Iowa Methodist Medical Center
Contact: Site Public Contact
Mercy Medical Center - Des Moines
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - Des Moines
Contact: Site Public Contact
Mission Cancer and Blood - Laurel
Contact: Site Public Contact
Fort Dodge
McFarland Clinic - Trinity Cancer Center
Contact: Site Public Contact
Trinity Regional Medical Center
Contact: Site Public Contact
Jefferson
McFarland Clinic - Jefferson
Contact: Site Public Contact
Marshalltown
McFarland Clinic - Marshalltown
Contact: Site Public Contact
Sioux City
Siouxland Regional Cancer Center
Contact: Site Public Contact
Email: HoopingarnerT@jencc.com
West Des Moines
Mercy Medical Center-West Lakes
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Methodist West Hospital
Contact: Site Public Contact
ID
Boise
Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact
Email: eslinget@slhs.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Fruitland
Saint Luke's Cancer Institute - Fruitland
Contact: Site Public Contact
Email: eslinget@slhs.org
Meridian
Idaho Urologic Institute-Meridian
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Meridian
Contact: Site Public Contact
Email: eslinget@slhs.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Luke's Cancer Institute - Nampa
Contact: Site Public Contact
Email: eslinget@slhs.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Cancer Institute - Twin Falls
Contact: Site Public Contact
Email: eslinget@slhs.org
IL
Alton
Saint Anthony's Health
Contact: Site Public Contact
Aurora
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Barrington
Advocate Good Shepherd Hospital
Contact: Site Public Contact
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Saint Mary's Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Chicago
Advocate Illinois Masonic Medical Center
Contact: Site Public Contact
Mount Sinai Hospital Medical Center
Contact: Site Public Contact
Email: suhi@sinai.org
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Rush University Medical Center
Contact: Site Public Contact
Email: clinical_trials@rush.edu
Swedish Covenant Hospital
Contact: Site Public Contact
University of Chicago Comprehensive Cancer Center
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
University of Illinois
Contact: Site Public Contact
Crystal Lake
AMG Crystal Lake - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocate.com
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@Carle.com
DeKalb
Northwestern Medicine Cancer Center Kishwaukee
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Downers Grove
Advocate Good Samaritan Hospital
Contact: Site Public Contact
Email: Barbara.barhamand@advocatehealth.com
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Elgin
Advocate Sherman Hospital
Contact: Site Public Contact
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
Contact: Site Public Contact
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Geneva
Northwestern Medicine Cancer Center Delnor
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Contact: Site Public Contact
Grayslake
Northwestern Medicine Grayslake Outpatient Center
Contact: Site Public Contact
Harvey
Ingalls Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@ingalls.org
Hazel Crest
Advocate South Suburban Hospital
Contact: Site Public Contact
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Contact: Site Public Contact
Joliet
Duly Health and Care Joliet
Contact: Site Public Contact
Email: Karen.Sceniak@dulyhealthandcare.com
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Lake Forest
Northwestern Medicine Lake Forest Hospital
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Libertyville
AMG Libertyville - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Condell Memorial Hospital
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Mount Vernon
Good Samaritan Regional Health Center
Contact: Site Public Contact
New Lenox
UC Comprehensive Cancer Center at Silver Cross
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Oak Lawn
Advocate Christ Medical Center
Contact: Site Public Contact
Orland Park
Northwestern Medicine Orland Park
Contact: Site Public Contact
Email: nctnprogram_rhlccc@northwestern.edu
University of Chicago Medicine-Orland Park
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Park Ridge
Advocate Lutheran General Hospital
Contact: Site Public Contact
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Rockford
UW Health Carbone Cancer Center Rockford
Contact: Site Public Contact
Email: lkline@uwhealth.org
Silvis
Genesis Cancer Center - Silvis
Contact: Site Public Contact
Email: turnerk@genesishealth.com
Skokie
North Shore Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Springfield
Memorial Medical Center
Contact: Site Public Contact
Email: pallante.beth@mhsil.com
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Warrenville
Northwestern Medicine Cancer Center Warrenville
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Carmel
IU Health North Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Crown Point
Northwest Cancer Center - Main Campus
Contact: Site Public Contact
Dyer
Northwest Oncology LLC
Contact: Site Public Contact
Hobart
Northwest Cancer Center - Hobart
Contact: Site Public Contact
Saint Mary Medical Center
Contact: Site Public Contact
Email: CancerResearch@COMHS.org
Indianapolis
Community Cancer Center East
Contact: Site Public Contact
Email: lcheri@ecommunity.com
Community Cancer Center North
Contact: Site Public Contact
Email: lcheri@ecommunity.com
Community Cancer Center South
Contact: Site Public Contact
Email: lcheri@ecommunity.com
Indiana University/Melvin and Bren Simon Cancer Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Saint Catherine Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Sidney and Lois Eskenazi Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Kokomo
Community Howard Regional Health
Contact: Site Public Contact
Email: oncology@communityhoward.org
Munster
The Community Hospital
Contact: Site Public Contact
Women's Diagnostic Center - Munster
Contact: Site Public Contact
Email: mnicholson@comhs.org
New Albany
Baptist Health Floyd
Contact: Site Public Contact
Email: ctsucontact@westat.com
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Valparaiso
Northwest Cancer Center - Valparaiso
Contact: Site Public Contact
Email: CancerResearch@COMHS.org
KS
Chanute
Cancer Center of Kansas - Chanute
Contact: Site Public Contact
Email: research@viachristi.org
Dodge City
Cancer Center of Kansas - Dodge City
Contact: Site Public Contact
Email: research@viachristi.org
El Dorado
Cancer Center of Kansas - El Dorado
Contact: Site Public Contact
Email: research@viachristi.org
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
Independence
Cancer Center of Kansas-Independence
Contact: Site Public Contact
Email: research@viachristi.org
Kingman
Cancer Center of Kansas-Kingman
Contact: Site Public Contact
Email: research@viachristi.org
Liberal
Cancer Center of Kansas-Liberal
Contact: Site Public Contact
Email: research@viachristi.org
Manhattan
Cancer Center of Kansas-Manhattan
Contact: Site Public Contact
Email: research@viachristi.org
McPherson
Cancer Center of Kansas - McPherson
Contact: Site Public Contact
Email: research@viachristi.org
Newton
Cancer Center of Kansas - Newton
Contact: Site Public Contact
Email: research@viachristi.org
Parsons
Cancer Center of Kansas - Parsons
Contact: Site Public Contact
Email: research@viachristi.org
Pratt
Cancer Center of Kansas - Pratt
Contact: Site Public Contact
Email: research@viachristi.org
Salina
Cancer Center of Kansas - Salina
Contact: Site Public Contact
Email: research@viachristi.org
Wellington
Cancer Center of Kansas - Wellington
Contact: Site Public Contact
Email: research@viachristi.org
Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: research@viachristi.org
Winfield
Cancer Center of Kansas - Winfield
Contact: Site Public Contact
Email: research@viachristi.org
KY
Ashland
King's Daughter's Medical Center
Contact: Site Public Contact
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Corbin
Baptist Health Corbin
Contact: Site Public Contact
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lexington
Baptist Health Lexington
Contact: Site Public Contact
Saint Joseph Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Saint Joseph Hospital East
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
University of Kentucky/Markey Cancer Center
Contact: Site Public Contact
London
Saint Joseph London
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Louisville
Baptist Health Louisville
Contact: Site Public Contact
Email: Cbcresearch@bhsi.com
Jewish Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: ctoinfo@louisville.edu
Madisonville
Baptist Health Madisonville/Merle Mahr Cancer Center
Contact: Site Public Contact
Mount Sterling
Saint Joseph Mount Sterling
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Paducah
Baptist Health Paducah
Contact: Site Public Contact
Mercy Health - Paducah Cancer Center
Contact: Site Public Contact
Email: BJWarner@mercy.com
Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
LA
Covington
Ochsner Hematology Oncology North Shore - Covington (West Region)
Contact: Site Public Contact
Email: Cheryl.kesler@ochsner.org
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Ochsner Medical Center Jefferson
Contact: Site Public Contact
Email: Elisemarie.curry@ochsner.org
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Shreveport
LSU Health Sciences Center at Shreveport
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
MA
Beverly
Beverly Hospital
Contact: Site Public Contact
Boston
Beth Israel Deaconess Medical Center
Contact: Site Public Contact
Boston Medical Center
Contact: Site Public Contact
Dana-Farber Cancer Institute
Contact: Site Public Contact
Tufts Medical Center
Contact: Site Public Contact
Email: ContactUsCancerCenter@TuftsMedicalCenter.org
Burlington
Lahey Hospital and Medical Center
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
Foxborough
Dana-Farber Cancer Institute at Foxborough
Contact: Site Public Contact
Gloucester
Addison Gilbert Hospital
Contact: Site Public Contact
Lowell
Lowell General Hospital
Contact: Site Public Contact
Email: ghincks@lowellgeneral.org
Methuen
Dana Farber-Merrimack Valley
Contact: Site Public Contact
Milford
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Contact: Site Public Contact
Peabody
Lahey Medical Center-Peabody
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
South Weymouth
Dana-Farber/Brigham and Women's Cancer Center at South Shore
Contact: Site Public Contact
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Winchester
Winchester Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Annapolis
Luminis Health Anne Arundel Medical Center
Contact: Site Public Contact
Email: research@luminishealth.org
Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center
Contact: Site Public Contact
Email: jhcccro@jhmi.edu
Kaiser Permanente-Woodlawn Medical Center
Contact: Site Public Contact
Sinai Hospital of Baltimore
Contact: Site Public Contact
Email: pridgely@lifebridgehealth.org
Elkton
Christiana Care - Union Hospital
Contact: Site Public Contact
Email: sstewart@uhcc.com
Gaithersburg
Kaiser Permanente-Gaithersburg Medical Center
Contact: Site Public Contact
Kensington
Kaiser Permanente - Kensington Medical Center
Contact: Site Public Contact
Largo
Kaiser Permanente - Largo Medical Center
Contact: Site Public Contact
Lutherville
Kaiser Permanente Lutherville - Timonium Medical Center
Contact: Site Public Contact
Randallstown
Northwest Hospital Center
Contact: Site Public Contact
Email: cancerinstitute@lifebridgehealth.org
Westminster
William E Kahlert Regional Cancer Center/Sinai Hospital
Contact: Site Public Contact
ME
Augusta
Harold Alfond Center for Cancer Care
Contact: Site Public Contact
Belfast
Waldo County General Hospital
Contact: Site Public Contact
Biddeford
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Contact: Site Public Contact
Email: LLemire@mmc.org
Brewer
Lafayette Family Cancer Center-EMMC
Contact: Site Public Contact
Kennebunk
Maine Center for Cancer Medicine-Kennebunk
Contact: Site Public Contact
Email: research@newecs.org
Rockport
Penobscot Bay Medical Center
Contact: Site Public Contact
Email: ClinicalResearch@mmc.org
Sanford
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Contact: Site Public Contact
Email: LLemire@mmc.org
Scarborough
Maine Center for Cancer Medicine-Scarborough
Contact: Site Public Contact
Email: research@newecs.org
Maine Medical Center- Scarborough Campus
Contact: Site Public Contact
Email: wrighd@mmc.org
South Portland
Maine Medical Partners - South Portland
Contact: Site Public Contact
Email: ClinicalResearch@mmc.org
Topsham
Maine Center for Cancer Medicine-Topsham
Contact: Site Public Contact
Email: research@newecs.org
MI
Ann Arbor
University of Michigan Comprehensive Cancer Center
Contact: Site Public Contact
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Brighton
University of Michigan - Brighton Center for Specialty Care
Contact: Site Public Contact
Detroit
Wayne State University/Karmanos Cancer Institute
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Farmington Hills
Weisberg Cancer Treatment Center
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Kalamazoo
Ascension Borgess Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ascension Borgess Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Niles
Corewell Health Lakeland Hospitals - Niles Hospital
Contact: Site Public Contact
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Novi
Henry Ford Health Providence Novi Hospital
Contact: Site Public Contact
Email: karen.fife@ascension.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Saint Joseph
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Southfield
Henry Ford Health Providence Southfield Hospital
Contact: Site Public Contact
Email: karen.fife@ascension.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
MN
Aitkin
Riverwood Healthcare Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Baxter
Essentia Health - Baxter Clinic
Contact: Site Public Contact
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Brainerd
Essentia Health Saint Joseph's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Duluth
Essentia Health Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Miller-Dwan Hospital
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Ely
Essentia Health - Ely Clinic
Contact: Site Public Contact
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Contact: Site Public Contact
International Falls
Essentia Health - International Falls Clinic
Contact: Site Public Contact
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Moose Lake
Essentia Health - Moose Lake Clinic
Contact: Site Public Contact
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Rochester
Mayo Clinic in Rochester
Contact: Site Public Contact
Saint Cloud
Coborn Cancer Center at Saint Cloud Hospital
Contact: Site Public Contact
Email: coborncancercenter@centracare.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Virginia
Essentia Health Virginia Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Branson
Cox Cancer Center Branson
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Chesterfield
Saint Luke's Hospital
Contact: Site Public Contact
Columbia
MU Health - University Hospital/Ellis Fischel Cancer Center
Contact: Site Public Contact
Creve Coeur
Siteman Cancer Center at West County Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: swooden@mail.crmc.org
Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net
Osage Beach
Lake Regional Hospital
Contact: Site Public Contact
Email: clinicaltrials@lakeregional.com
Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: research@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact
Mercy Hospital South
Contact: Site Public Contact
Email: Danielle.Werle@mercy.net
Missouri Baptist Medical Center
Contact: Site Public Contact
Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact
Siteman Cancer Center at Christian Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Siteman Cancer Center-South County
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Washington University School of Medicine
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Saint Peters
Siteman Cancer Center at Saint Peters Hospital
Contact: Site Public Contact
Email: info@siteman.wustl.edu
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
Washington
Mercy Hospital Washington
Contact: Site Public Contact
MS
Columbus
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Grenada
Baptist Cancer Center-Grenada
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Gulfport
Gulfport Memorial Hospital
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Jackson
University of Mississippi Medical Center
Contact: Site Public Contact
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Pascagoula
Singing River Hospital
Contact: Site Public Contact
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls Clinic
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Missoula
Community Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org
NC
Albemarle
Atrium Health Stanly/LCI-Albemarle
Contact: Site Public Contact
Cary
Rex Hematology Oncology Associates-Cary
Contact: Site Public Contact
Email: CancCtrOncologyClinicalResearch@unchealth.unc.edu
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Contact: Site Public Contact
Email: cancerclinicaltrials@med.unc.edu
Charlotte
Atrium Health Pineville/LCI-Pineville
Contact: Site Public Contact
Atrium Health University City/LCI-University
Contact: Site Public Contact
Carolinas Medical Center/Levine Cancer Institute
Contact: Site Public Contact
Novant Health Carolina Surgical - Randolph
Contact: Site Public Contact
Email: kashah@novanthealth.org
Novant Health Presbyterian Medical Center
Contact: Site Public Contact
Email: kashah@novanthealth.org
Clemmons
Novant Health Colon and Rectal Clinic
Contact: Site Public Contact
Email: kashah@novanthealth.org
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Concord
Atrium Health Cabarrus/LCI-Concord
Contact: Site Public Contact
Forest City
Levine Cancer Institute - Rutherford
Contact: Site Public Contact
Garner
Rex Hematology Oncology Associates-Garner
Contact: Site Public Contact
Email: CancCtrOncologyClinicalResearch@unchealth.unc.edu
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Greensboro
Novant Health Breast Surgery - Greensboro
Contact: Site Public Contact
Hendersonville
Margaret R Pardee Memorial Hospital
Contact: Site Public Contact
Email: pardeecancerresearch@unchealth.unc.edu
Hillsborough
University of North Carolina-Hillsborough Campus
Contact: Site Public Contact
Email: cancerclinicaltrials@med.unc.edu
Huntersville
Novant Health Cancer Institute - Huntersville
Contact: Site Public Contact
Email: kashah@novanthealth.org
Novant Health Presbyterian Medical Center Huntersville
Contact: Site Public Contact
Email: kashah@novanthealth.org
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kernersville
Novant Health Cancer Institute - Kernersville
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
Lincolnton
Atrium Health Lincoln/LCI-Lincolnton
Contact: Site Public Contact
Matthews
Levine Cancer Institute - Union West
Contact: Site Public Contact
Matthews Radiation Oncology Center
Contact: Site Public Contact
Email: kashah@novanthealth.org
Novant Health Cancer Institute - Matthews
Contact: Site Public Contact
Email: kashah@novanthealth.org
Monroe
Atrium Health Union/LCI-Union
Contact: Site Public Contact
Mooresville
Novant Health Cancer Institute - Mooresville
Contact: Site Public Contact
Email: kashah@novanthealth.org
Mount Airy
Novant Health Cancer Institute - Mount Airy
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
North Wilkesboro
Novant Health Cancer Institute - Wilkesboro
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
Pinehurst
FirstHealth of the Carolinas-Moore Regional Hospital
Contact: Site Public Contact
Email: jcwilliams@firsthealth.org
Raleigh
Rex Hematology Oncology Associates-Blue Ridge
Contact: Site Public Contact
UNC Rex Cancer Center of Wakefield
Contact: Site Public Contact
Email: CancCtrOncologyClinicalResearch@unchealth.unc.edu
UNC Rex Healthcare
Contact: Site Public Contact
Email: CancCtrOncologyClinicalResearch@unchealth.unc.edu
Salisbury
Novant Health Cancer Institute - Rowan
Contact: Site Public Contact
Email: kashah@novanthealth.org
Rowan Regional Medical Center
Contact: Site Public Contact
Email: nnechiporchik@novanthealth.org
Shelby
Atrium Health Cleveland/LCI-Cleveland
Contact: Site Public Contact
Stateville
Novant Health Cancer Institute - Statesville
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
Thomasville
Novant Health Cancer Institute - Thomasville
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
Winston-Salem
Novant Health Forsyth Medical Center
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Medical Center Fargo
Contact: Site Public Contact
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Southpointe-Sanford Medical Center Fargo
Contact: Site Public Contact
Jamestown
Essentia Health - Jamestown Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
NE
Bellevue
Nebraska Medicine-Bellevue
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Grand Island
Nebraska Cancer Specialists/Oncology Hematology West PC
Contact: Site Public Contact
Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lincoln
Cancer Partners of Nebraska
Contact: Site Public Contact
Email: research@cancerpartners.com
Cancer Partners of Nebraska - Pine Lake
Contact: Site Public Contact
Email: research@cancerpartners.com
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Creighton University Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Nebraska Medicine-Village Pointe
Contact: Site Public Contact
University of Nebraska Medical Center
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
NH
Concord
New Hampshire Oncology Hematology PA-Concord
Contact: Site Public Contact
Lebanon
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Contact: Site Public Contact
Email: cancer.research.nurse@dartmouth.edu
Manchester
Elliot Hospital
Contact: Site Public Contact
Solinsky Center for Cancer Care
Contact: Site Public Contact
NJ
Basking Ridge
Memorial Sloan Kettering Basking Ridge
Contact: Site Public Contact
Elizabeth
Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Contact: Site Public Contact
Hackensack
Hackensack University Medical Center
Contact: Site Public Contact
Hamilton
The Cancer Institute of New Jersey Hamilton
Contact: Site Public Contact
Jersey City
Jersey City Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Lakewood
Monmouth Medical Center Southern Campus
Contact: Site Public Contact
Email: mary.danish@rwjbh.org
Livingston
Saint Barnabas Medical Center
Contact: Site Public Contact
Email: joanne.loeb@rwjbh.org
Long Branch
Monmouth Medical Center
Contact: Site Public Contact
Email: mary.danish@rwjbh.org
Middletown
Memorial Sloan Kettering Monmouth
Contact: Site Public Contact
Montvale
Memorial Sloan Kettering Bergen
Contact: Site Public Contact
Morristown
Morristown Medical Center
Contact: Site Public Contact
Mullica Hill
Inspira Medical Center Mullica Hill
Contact: Site Public Contact
Email: DeNigrisJ@ihn.org
New Brunswick
Rutgers Cancer Institute of New Jersey
Contact: Site Public Contact
Newark
Newark Beth Israel Medical Center
Contact: Site Public Contact
Email: Christine.Kosmides@rwjbh.org
Rutgers New Jersey Medical School
Contact: Site Public Contact
Sewell
Sidney Kimmel Cancer Center Washington Township
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Somerville
Robert Wood Johnson University Hospital Somerset
Contact: Site Public Contact
Email: Siby.Varughese@rwjbh.org
Summit
Overlook Hospital
Contact: Site Public Contact
Teaneck
Holy Name Hospital
Contact: Site Public Contact
Toms River
Community Medical Center
Contact: Site Public Contact
Email: Lennette.Gonzales@rwjbh.org
Vineland
Inspira Medical Center Vineland
Contact: Site Public Contact
NM
Albuquerque
Lovelace Medical Center-Saint Joseph Square
Contact: Site Public Contact
Email: AYost@nmcca.org
Lovelace Women's Hospital
Contact: Site Public Contact
Email: AYost@nmcca.org
Presbyterian Kaseman Hospital
Contact: Site Public Contact
Email: WBurman@phs.org
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: HSC-ClinicalTrialInfo@salud.unm.edu
Las Cruces
Memorial Medical Center - Las Cruces
Contact: Site Public Contact
Email: Kim.Hoffman@lpnt.net
Rio Rancho
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Contact: Site Public Contact
Email: WBurman@phs.org
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Auburn
Hematology Oncology Associates of Central New York-Auburn
Contact: Site Public Contact
Binghamton
Lourdes Hospital
Contact: Site Public Contact
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org
Brooklyn
Maimonides Medical Center
Contact: Site Public Contact
Mount Sinai Brooklyn
Contact: Site Public Contact
Email: CCTO@mssm.edu
New York-Presbyterian/Brooklyn Methodist Hospital
Contact: Site Public Contact
Email: Adg9003@nyp.org
Buffalo
Roswell Park Cancer Institute
Contact: Site Public Contact
Email: askroswell@roswellpark.org
Camillus
Hematology Oncology Associates of CNY at Camillus
Contact: Site Public Contact
Commack
Memorial Sloan Kettering Commack
Contact: Site Public Contact
East Hills
The Cancer Institute at Saint Francis Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
East Syracuse
Hematology Oncology Associates of Central New York-East Syracuse
Contact: Site Public Contact
Flushing
The New York Hospital Medical Center of Queens
Contact: Site Public Contact
Email: ctsucontact@westat.com
Glens Falls
Glens Falls Hospital
Contact: Site Public Contact
Mineola
NYU Langone Hospital - Long Island
Contact: Site Public Contact
Email: cancertrials@nyulangone.org
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Contact: Site Public Contact
Email: CancerTrials@nyulangone.org
Memorial Sloan Kettering Cancer Center
Contact: Site Public Contact
Mount Sinai Chelsea
Contact: Site Public Contact
Email: CCTO@mssm.edu
Mount Sinai Hospital
Contact: Site Public Contact
Email: CCTO@mssm.edu
Mount Sinai West
Contact: Site Public Contact
Email: CCTO@mssm.edu
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
Contact: Site Public Contact
Email: nr2616@cumc.columbia.edu
NYP/Weill Cornell Medical Center
Contact: Site Public Contact
Oswego
Upstate Cancer Center at Oswego
Contact: Site Public Contact
Email: McDowelE@upstate.edu
Rochester
University of Rochester
Contact: Site Public Contact
Stony Brook
Stony Brook University Medical Center
Contact: Site Public Contact
Syracuse
SUNY Upstate Medical Center-Community Campus
Contact: Site Public Contact
State University of New York Upstate Medical University
Contact: Site Public Contact
Uniondale
Memorial Sloan Kettering Nassau
Contact: Site Public Contact
Valley Stream
South Nassau Cancer Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
Verona
Upstate Cancer Center at Verona
Contact: Site Public Contact
Email: McDowelE@upstate.edu
Webster
Wilmot Cancer Institute at Webster
Contact: Site Public Contact
Email: WCICTOresearch@urmc.rochester.edu
West Harrison
Memorial Sloan Kettering Westchester
Contact: Site Public Contact
White Plains
Dickstein Cancer Treatment Center
Contact: Site Public Contact
Email: mcortese@wphospital.org
OH
Alliance
Aultman Alliance Community Hospital
Contact: Site Public Contact
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Canton
Aultman Health Foundation
Contact: Site Public Contact
Email: ClinicalReserachDept@aultman.com
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
The Christ Hospital
Contact: Site Public Contact
TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
MetroHealth Medical Center
Contact: Site Public Contact
Email: dstrater@metrohealth.org
Columbus
Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Premier Blood and Cancer Center
Contact: Site Public Contact
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Cancer Care and Infusion
Contact: Site Public Contact
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Independence
Cleveland Clinic Cancer Center Independence
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Kettering
First Dayton Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Mansfield
Cleveland Clinic Cancer Center Mansfield
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Mayfield Heights
Hillcrest Hospital Cancer Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Sandusky
North Coast Cancer Care
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Steubenville
Trinity's Tony Teramana Cancer Center
Contact: Site Public Contact
Strongsville
Cleveland Clinic Cancer Center Strongsville
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Sylvania
ProMedica Flower Hospital
Contact: Site Public Contact
Email: PCIOncResearch@promedica.org
Toledo
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Contact: Site Public Contact
Email: PCIOncResearch@promedica.org
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
WPAFB
Wright-Patterson Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warrensville Heights
South Pointe Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Wooster
Cleveland Clinic Wooster Family Health and Surgery Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
OK
Lawton
Cancer Centers of Southwest Oklahoma Research
Contact: Site Public Contact
Oklahoma City
Mercy Hospital Oklahoma City
Contact: Site Public Contact
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org
Gresham
Legacy Mount Hood Medical Center
Contact: Site Public Contact
Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Oregon City
Providence Willamette Falls Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Portland
Legacy Good Samaritan Hospital and Medical Center
Contact: Site Public Contact
Email: cancer@lhs.org
Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact
Tualatin
Legacy Meridian Park Hospital
Contact: Site Public Contact
PA
Altoona
UPMC Altoona
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Beaver
UPMC-Heritage Valley Health System Beaver
Contact: Site Public Contact
Email: haneydl@upmc.edu
Bryn Mawr
Bryn Mawr Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Butler
UPMC Hillman Cancer Center at Butler Health System
Contact: Site Public Contact
Email: haneydl@upmc.edu
Camp Hill
UPMC Camp Hill
Contact: Site Public Contact
Carlisle
Carlisle Regional Cancer Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Chambersburg
Chambersburg Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Collegeville
Main Line Health Center-Collegeville
Contact: Site Public Contact
Email: turzoe@mlhs.org
Cranberry Township
UPMC Hillman Cancer Center - Passavant - Cranberry
Contact: Site Public Contact
Email: haneydl@upmc.edu
Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
East Norriton
Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Ephrata
Ephrata Cancer Center
Contact: Site Public Contact
Erie
Saint Vincent Hospital
Contact: Site Public Contact
UPMC Hillman Cancer Center Erie
Contact: Site Public Contact
Email: haneydl@upmc.edu
Exton
Main Line Health Center-Exton
Contact: Site Public Contact
Email: turzoe@mlhs.org
Farrell
UPMC Cancer Center at UPMC Horizon
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Gettysburg
Adams Cancer Center
Contact: Site Public Contact
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact
Greenville
Oncology Hematology Associates
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC Hillman Cancer Center in Greenville/UPMC Horizon
Contact: Site Public Contact
Email: haneydl@upmc.edu
Hanover
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Harrisburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Contact: Site Public Contact
Email: klitchfield@PINNACLEHEALTH.org
UPMC Pinnacle Harrisburg
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Hershey
Penn State Milton S Hershey Medical Center
Contact: Site Public Contact
Email: CTO@hmc.psu.edu
Indiana
IRMC Cancer Center
Contact: Site Public Contact
Email: haneydl@upmc.edu
Jefferson Hills
Jefferson Hospital
Contact: Site Public Contact
Email: ddefazio@wpahs.org
Johnstown
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Contact: Site Public Contact
Lancaster
Lancaster General Ann B Barshinger Cancer Institute
Contact: Site Public Contact
Lancaster General Hospital
Contact: Site Public Contact
Lebanon
Sechler Family Cancer Center
Contact: Site Public Contact
Email: doxenberg@wellspan.org
Lewisburg
Geisinger Medical Oncology-Lewisburg
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lewistown
Lewistown Hospital
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact
Meadville
Yolanda G Barco Oncology Institute
Contact: Site Public Contact
Email: ctsucontact@westat.com
Mechanicsburg
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Contact: Site Public Contact
Email: haneydl@upmc.edu
Media
Riddle Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Monroeville
Forbes Hospital
Contact: Site Public Contact
UPMC Hillman Cancer Center - Monroeville
Contact: Site Public Contact
Email: haneydl@upmc.edu
Moon Township
UPMC Hillman Cancer Center in Coraopolis
Contact: Site Public Contact
Email: haneydl@upmc.edu
Mount Pleasant
UPMC Hillman Cancer Center - Part of Frick Hospital
Contact: Site Public Contact
Email: haneydl@upmc.edu
Natrona Heights
UPMC Cancer Center-Natrona Heights
Contact: Site Public Contact
New Castle
UPMC Hillman Cancer Center - New Castle
Contact: Site Public Contact
Email: haneydl@upmc.edu
Newtown Square
Bryn Mawr Health Center
Contact: Site Public Contact
Email: turzoe@mlhs.org
North Huntingdon
Arnold Palmer Cancer Center Medical Oncology Norwin
Contact: Site Public Contact
Email: haneydl@upmc.edu
Paoli
Paoli Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact
Jefferson Methodist Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Jefferson Torresdale Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Temple University Hospital
Contact: Site Public Contact
Thomas Jefferson University Hospital
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
University of Pennsylvania/Abramson Cancer Center
Contact: Site Public Contact
Phoenixville
Phoenixville Hospital
Contact: Site Public Contact
Pittsburgh
Allegheny General Hospital
Contact: Site Public Contact
Oncology Hematology Association
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC-Magee Womens Hospital
Contact: Site Public Contact
UPMC-Mercy Hospital
Contact: Site Public Contact
UPMC-Passavant Hospital
Contact: Site Public Contact
UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact
UPMC-Saint Margaret
Contact: Site Public Contact
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact
West Penn Hospital
Contact: Site Public Contact
Pottsville
Geisinger Cancer Services-Pottsville
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Reading
Penn State Health Saint Joseph Medical Center
Contact: Site Public Contact
Email: dward1@pennstatehealth.psu.edu
Scranton
Community Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact
State College
Geisinger Medical Group
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Uniontown
UPMC Cancer Center-Uniontown
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC Uniontown Hospital Radiation Oncology
Contact: Site Public Contact
Washington
UPMC Cancer Center-Washington
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC Washington Hospital Radiation Oncology
Contact: Site Public Contact
Email: cancer@washingtonhospital.org
West Chester
Chester County Hospital
Contact: Site Public Contact
West Mifflin
UPMC West Mifflin-Cancer Center Jefferson
Contact: Site Public Contact
West Reading
Reading Hospital
Contact: Site Public Contact
Wexford
Wexford Health and Wellness Pavilion
Contact: Site Public Contact
Email: Dawnmarie.DeFazio@ahn.org
Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Williamsport
Divine Providence Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Willow Grove
Asplundh Cancer Pavilion
Contact: Site Public Contact
Email: ONCTrialNow@jefferson.edu
Wynnewood
Lankenau Medical Center
Contact: Site Public Contact
Email: turzoe@mlhs.org
York
Cancer Care Associates of York
Contact: Site Public Contact
UPMC Memorial
Contact: Site Public Contact
WellSpan Health-York Cancer Center
Contact: Site Public Contact
WellSpan Health-York Hospital
Contact: Site Public Contact
PR
Bayamon
Cancer Center-Metro Medical Center Bayamon
Contact: Site Public Contact
Caguas
HIMA San Pablo Oncologic Hospital
Contact: Site Public Contact
Manati
Doctors Cancer Center
Contact: Site Public Contact
Ponce
Instituto Oncologia Moderna Ponce
Contact: Site Public Contact
San Juan
Centro Comprensivo de Cancer de UPR
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
PROncology
Contact: Site Public Contact
Email: info@PRoncology.com
Primary Care Physician Group
Contact: Site Public Contact
San Juan City Hospital
Contact: Site Public Contact
San Juan Community Oncology Group
Contact: Site Public Contact
RI
Providence
Women and Infants Hospital
Contact: Site Public Contact
Warwick
Kent Hospital
Contact: Site Public Contact
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu
SC
Bluffton
Saint Joseph's/Candler - Bluffton Campus
Contact: Site Public Contact
Email: underberga@sjchs.org
Greenville
Saint Francis Cancer Center
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Saint Francis Hospital
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Hilton Head Island
South Carolina Cancer Specialists PC
Contact: Site Public Contact
Email: underberga@sjchs.org
Rock Hill
Levine Cancer Institute-Rock Hill
Contact: Site Public Contact
SD
Aberdeen
Avera Cancer Institute-Aberdeen
Contact: Site Public Contact
Email: oncregulatory@avera.org
Pierre
Avera Cancer Institute at Pierre
Contact: Site Public Contact
Email: OncRegulatory@avera.org
Sioux Falls
Avera Cancer Institute
Contact: Site Public Contact
Email: OncRegulatory@avera.org
TN
Bristol
Bristol Regional Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Collierville
Baptist Memorial Hospital and Cancer Center-Collierville
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Contact: Site Public Contact
Kingsport
Ballad Health Cancer Care – Kingsport
Contact: Site Public Contact
Email: Justin.reynolds@balladhealth.org
Wellmont Holston Valley Hospital and Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Contact: Site Public Contact
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
TX
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Dallas
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern Simmons Cancer Center - RedBird
Contact: Site Public Contact
Email: canceranswerline@utsouthwestern.edu
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Fort Worth
Tarrant County Hospital District/JPS Health Network
Contact: Site Public Contact
Email: macosta02@jpshealth.org
UT Southwestern/Simmons Cancer Center-Fort Worth
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Houston
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Contact: Site Public Contact
Email: burton@bcm.edu
Ben Taub General Hospital
Contact: Site Public Contact
Laredo
Doctor's Hospital of Laredo
Contact: Site Public Contact
Richardson
UT Southwestern Clinical Center at Richardson/Plano
Contact: Site Public Contact
Email: Suzanne.cole@utsouthwestern.edu
UT
Farmington
Farmington Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
University of Utah Sugarhouse Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
South Jordan
South Jordan Health Center
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
VA
Bristol
Wellmont Medical Associates-Bristol
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Burke
Kaiser Permanente-Burke Medical Center
Contact: Site Public Contact
Email: Diane.Fisher@nsmtp.kp.org
Chesapeake
Cancer Specialists of Tidewater Limited
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Gloucester
Peninsula Cancer Institute-Gloucester
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Martinsville
Sovah Health Martinsville
Contact: Site Public Contact
Email: sharon.hubbard@lpnt.net
McLean
Kaiser Permanente Tysons Corner Medical Center
Contact: Site Public Contact
Mechanicsville
Bon Secours Memorial Regional Medical Center
Contact: Site Public Contact
Email: anne_carmellat@bshsi.org
Midlothian
Bon Secours Saint Francis Medical Center
Contact: Site Public Contact
Email: anne_carmellat@bshsi.org
Bon Secours Westchester Emergency Center
Contact: Site Public Contact
Email: anne_carmellat@bshsi.org
Newport News
Peninsula Cancer Institute-Newport News
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Norfolk
Bon Secours DePaul Medical Center
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
Norton
Southwest VA Regional Cancer Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Portsmouth
Bon Secours Maryview Medical Center
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
Richmond
Bon Secours Cancer Institute at Reynolds Crossing
Contact: Site Public Contact
Email: Anne_caramella@bshsi.org
Bon Secours Richmond Community Hospital
Contact: Site Public Contact
Email: anne_carmellat@bshsi.org
Bon Secours Saint Mary's Hospital
Contact: Site Public Contact
Email: anne_carmellat@bshsi.org
VCU Massey Cancer Center at Stony Point
Contact: Site Public Contact
Email: ctoclinops@vcu.edu
Virginia Commonwealth University/Massey Cancer Center
Contact: Site Public Contact
Email: CTOclinops@vcu.edu
South Hill
VCU Community Memorial Health Center
Contact: Site Public Contact
Email: nemer.elmouallem@vcuhealth.org
Suffolk
Bon Secours Health Center at Harbour View
Contact: Site Public Contact
Email: Marylou_Anton@bshsi.org
Cancer Specialists of Tidewater-Suffolk
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Virginia Beach
Peninsula Cancer Institute-Cancer Specialists of Tidewater
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Williamsburg
Peninsula Cancer Institute-Williamsburg
Contact: Site Public Contact
Email: casey.morris@rivhs.com
Woodbridge
Kaiser Permanente-Caton Hill Medical Center
Contact: Site Public Contact
Email: Leslie.K.Greenberg@kp.org
VT
Saint Johnsbury
Dartmouth Cancer Center - North
Contact: Site Public Contact
Email: cancer.research.nurse@hitchcock.org
WA
Aberdeen
Providence Regional Cancer System-Aberdeen
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Contact: Site Public Contact
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Centralia
Providence Regional Cancer System-Centralia
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Edmonds
Swedish Cancer Institute-Edmonds
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Enumclaw
Saint Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Everett
Providence Regional Cancer Partnership
Contact: Site Public Contact
Email: marilyn.birchman@providence.org
Federal Way
Saint Francis Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Issaquah
Swedish Cancer Institute-Issaquah
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Contact: Site Public Contact
Email: research@kadlecmed.org
Lacey
Providence Regional Cancer System-Lacey
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Lakewood
Saint Clare Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Longview
PeaceHealth Saint John Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Seattle
Pacific Gynecology Specialists
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Sedro-Woolley
PeaceHealth United General Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Shelton
Providence Regional Cancer System-Shelton
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Silverdale
Saint Michael Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Northwest Medical Specialties PLLC
Contact: Site Public Contact
Email: research@southsoundcare.org
Vancouver
Legacy Cancer Institute Medical Oncology and Day Treatment
Contact: Site Public Contact
Email: oncologyresearch@lhs.org
Legacy Salmon Creek Hospital
Contact: Site Public Contact
PeaceHealth Southwest Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Contact: Site Public Contact
Email: Cheryl.Dodd@providence.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Contact: Site Public Contact
Email: Memorial-ClinicalTrials@yvmh.org
Yelm
Providence Regional Cancer System-Yelm
Contact: Site Public Contact
Email: deidre.dillon@providence.org
WI
Antigo
Langlade Hospital and Cancer Center
Contact: Site Public Contact
Email: Juli.Alford@aspirus.org
Appleton
Ascension Saint Elizabeth Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
ThedaCare Regional Cancer Center
Contact: Site Public Contact
Email: ResearchDept@thedacare.org
Ashland
Duluth Clinic Ashland
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Northwest Wisconsin Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Berlin
ThedaCare Cancer Care - Berlin
Contact: Site Public Contact
Email: ResearchDept@thedacare.org
Brookfield
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org
Chilton
Ascension Calumet Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
Chippewa Falls
Marshfield Clinic-Chippewa Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Cudahy
Aurora Saint Luke's South Shore
Contact: Site Public Contact
Email: ncorp@aurora.org
Eau Claire
HSHS Sacred Heart Hospital
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Contact: Site Public Contact
Mayo Clinic Health System-Eau Claire Clinic
Contact: Site Public Contact
Franklin
Ascension Saint Francis - Reiman Cancer Center
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Ascension Southeast Wisconsin Hospital - Franklin
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org
Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Saint Vincent Hospital Cancer Center Green Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Saint Vincent Hospital Cancer Center at Saint Mary's
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Hayward
Essentia Health-Hayward Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Johnson Creek
University of Wisconsin Carbone Cancer Center - Johnson Creek
Contact: Site Public Contact
Email: lynda.persico@uwmf.wisc.edu
Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org
La Crosse
Gundersen Lutheran Medical Center
Contact: Site Public Contact
Email: cancerctr@gundersenhealth.org
Mayo Clinic Health System-Franciscan Healthcare
Contact: Site Public Contact
Ladysmith
Marshfield Medical Center - Ladysmith
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Madison
University of Wisconsin Carbone Cancer Center - University Hospital
Contact: Site Public Contact
Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Medford
Aspirus Medford Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Mequon
Ascension Columbia Saint Mary's Hospital Ozaukee
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Milwaukee
Ascension Columbia Saint Mary's Hospital - Milwaukee
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Ascension Saint Francis Hospital
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mukwonago
ProHealth D N Greenwald Center
Contact: Site Public Contact
Email: research.institute@phci.org
Neenah
ThedaCare Regional Medical Center - Neenah
Contact: Site Public Contact
Email: ResearchDept@thedacare.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Contact: Site Public Contact
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Oshkosh
Ascension Mercy Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org
Racine
Ascension All Saints Hospital
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org
Rhinelander
Aspirus Cancer Care - James Beck Cancer Center
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sheboygan
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org
Spooner
Essentia Health-Spooner Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Stevens Point
Aspirus Cancer Care - Stevens Point
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org
Superior
Essentia Health Saint Mary's Hospital - Superior
Contact: Site Public Contact
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org
Waukesha
ProHealth Waukesha Memorial Hospital
Contact: Site Public Contact
UW Cancer Center at ProHealth Care
Contact: Site Public Contact
Email: Chanda.miller@phci.org
Waupaca
ThedaCare Cancer Care - Waupaca
Contact: Site Public Contact
Email: ResearchDept@thedacare.org
Wausau
Aspirus Regional Cancer Center
Contact: Site Public Contact
Marshfield Clinic-Wausau Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wauwatosa
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org
West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Aspirus Cancer Care - Wisconsin Rapids
Contact: Site Public Contact
Marshfield Clinic - Wisconsin Rapids Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
WV
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
WY
Cheyenne
Cheyenne Regional Medical Center-West
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
Cody
Billings Clinic-Cody
Contact: Site Public Contact
Email: research@billingsclinic.org
Sheridan
Welch Cancer Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
PRIMARY OBJECTIVES: I. To determine if 3-year recurrence-free survival (RFS) is greater than 92% among clinical stages II or IIIa patients (by American Joint Committee on Cancer [AJCC] cancer staging manual anatomic staging table, 8th edition) with HER2-positive/estrogen receptor (ER)-positive breast cancer who achieve pathologic complete response (pCR) (ypT0/is ypN0) after preoperative therapy with 12 weeks of a taxane, trastuzumab (or Food and Drug Administration [FDA] approved biosimilar) and pertuzumab (THP x 12). Post-operatively, patients will receive standard of care adjuvant locoregional therapy, plus completion of 12 months of HER2-targeted therapy (and standard adjuvant endocrine therapy for patients with estrogen receptor-positive disease). II. To determine if 3-year recurrence-free survival (RFS) is greater than 92% among clinical stages II or IIIa patients (by AJCC cancer staging manual anatomic staging table, 8th edition) with HER2-positive/ER-negative breast cancer who achieve pCR (ypT0/is ypN0) after preoperative therapy with 12 weeks of a taxane, trastuzumab (or FDA approved biosimilar) and pertuzumab (THP x 12). Post-operatively, patients will receive standard of care adjuvant locoregional therapy, plus completion of 12 months of HER2-targeted therapy (and no adjuvant endocrine therapy for patients with estrogen receptor-negative disease). SECONDARY OBJECTIVES: I. To determine 3-year IDFS (invasive disease-free survival), DDFS (distant disease-free survival), DRFS (distant relapse-free survival), RFI (recurrence-free interval), OS (overall survival) and breast cancer-specific survival in patients who achieve pCR (and by pretreatment clinical stage). (Secondary Clinical Objective) II. To determine 3-year EFS (event-free survival) in all patients from time of study registration. (Secondary Clinical Objective) III. To evaluate safety and tolerability for all patients during the pre-operative phase and for patients who attain pCR and de-escalate therapy (Arm A) until the completion of post-surgery protocol assigned therapy (i.e., until the end of trastuzumab and pertuzumab [HP] therapy). (Secondary Clinical Objective) IV. To evaluate the association of ER status in the untreated primary tumor with pathologic response and with long-term survival outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Secondary Correlative Objective) V. To evaluate the associations of detection of circulating tumor cells (CTCs) in the blood at baseline with pCR. (Secondary Correlative Objective) VI. To evaluate the association of detection of CTCs in the blood at baseline, after 3 weeks of THP, after 12 weeks of THP (before surgery), after surgery before any additional therapy, and after completion of HER2-targeted therapy with RFS in patients who achieve pCR or not. (Secondary Correlative Objective) VII. To determine if breast magnetic resonance imaging (MRI) radiomics signatures reflecting intratumor heterogeneity and microenvironment at baseline are predictive of pCR. (Secondary Correlative Objective) VIII. To evaluate the association between tumor infiltrating lymphocytes (TILs) in the baseline tumor and 3-yr RFS in all patients. (Secondary Correlative Objective) IX. To evaluate the associations between TILs in the baseline tumor with pCR in all patients. (Secondary Correlative Objective) X. To evaluate the association between HER2DX risk score in the baseline tumor and RFS in patients who achieved pCR after neoadjuvant THP therapy (i.e., arm A). (Secondary Correlative Objective) XI. To evaluate the association between HER2DX risk score in the baseline tumor and RFS in patients who had residual disease after neoadjuvant THP therapy (i.e., arm B). (Secondary Correlative Objective) XII. To evaluate the associations between HER2DX pCR likelihood score in the baseline tumor with pCR in patients with HER2-positive/ER-positive disease and in patients with HER2-positive/ER-negative disease, separately. (Secondary Correlative Objective) EXPLORATORY OBJECTIVES: I. To determine 3-year RFS, IDFS (invasive disease-free survival), DDFS (distant disease-free survival), DRFS (distant relapse-free survival), RFI (recurrence-free interval), OS (overall survival) and breast cancer-specific survival in patients who do not achieve pCR (and by pretreatment clinical stage). (Exploratory Clinical Objective) II. To determine the pathologic response to THP neoadjuvant therapy, as assessed by residual cancer burden (RCB). (Exploratory Clinical Objective) III. To determine the association between residual cancer burden (RCB) and all described standardized definitions for efficacy end points (STEEP) criteria outcomes. (Exploratory Clinical Objective) IV. To determine the false negative rate (FNR) of limited staging procedures (defined as sentinel lymph node biopsy [SLNB] plus removal of clipped node) in patients who undergo such procedures with a planned axillary lymph node dissection (ALND). (Exploratory Clinical Objective) V. To determine axillary pCR rates as a function of the burden of disease at presentation as determined on pre-treatment ultrasound (US) and the axillary staging technique (SLNB plus ensuring removal of clipped node versus ALND). (Exploratory Clinical Objective) VI. To evaluate the associations between plasma tumor cell-free deoxyribonucleic acid (DNA) (cfDNA) tumor-specific mutations (baseline and after therapy) with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Exploratory Correlative Objective) VII. To evaluate the associations between tumor infiltrating lymphocytes (TILs) in the baseline tumor with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS and breast cancer-specific survival), and in the residual tumor with long-term outcomes. (Exploratory Correlative Objective) VIII. To evaluate the associations between immune activation gene signatures in the baseline tumor and pathologic response as well as outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS and breast cancer-specific survival). (Exploratory Correlative Objective) IX. To evaluate the association of intrinsic subtype at baseline with outcomes (pathologic response and survival). (Exploratory Correlative Objective) X. To determine the frequency of change in intrinsic subtype between pretreatment tumor specimen and residual disease at the time of surgery and to evaluate any association with survival. (Exploratory Correlative Objective) XI. To evaluate the associations between DNA copy number, DNA mutations, ribonucleic acid (RNA) expression and protein expression in the baseline tumor and changes from baseline to post-THP therapy with pathologic response and long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS, and breast cancer-specific survival). (Exploratory Correlative Objective) XII. To determine if functional dynamic contrast-enhanced (DCE)-MRI markers (e.g., functional tumor volume, signal enhancement ratio) reflecting tumor vascularity at baseline are predictive of treatment outcome (pCR and EFS). (Exploratory Correlative Objective) XIII. To determine if breast MRI radiomics signatures at post-treatment/presurgery are predictive of treatment outcome (pCR and EFS). (Exploratory Correlative Objective) XIV. To investigate the performance of combined modeling incorporating radiomics and other prognostic markers (e.g., ER, progesterone receptor [PR], intrinsic subtype, tumor infiltrating lymphocytes [TILs] levels) to predict treatment response in women with HER2+ breast cancer. (Exploratory Correlative Objective) XV. To evaluate the association between TILs in the baseline tumor with pCR and 3-yr RFS in patients with HER2-positive/ER-positive breast cancer and in patients with HER2-positive/ER-negative breast cancer, separately. (Exploratory Correlative Objective) XVI. To evaluate the association between TILs in the baseline tumor with 3-yr RFS in patients in Arm A (i.e., patients who have pCR) and those in Arm B (i.e., no pCR), separately. (Exploratory Correlative Objective) XVII. To evaluate the associations between TILs in the residual tumor with 3-yr RFS in patients in Arm B. (Exploratory Correlative Objective) XVIII. To evaluate the association between TILs in the baseline tumor with other long-term outcomes (including EFS, IDFS, DDFS, DRFS, RFI, OS and Breast Cancer-Specific Survival) in all patients and separately in patients with HER2-positive/ER-positive disease and in patients with HER2-positive/ER-negative disease. This association will also be evaluated separately for patents in Arm A and Arm B. (Exploratory Correlative Objective) XIX. To evaluate the associations between changes in TILs in the baseline tumor and residual cancer at surgery with long-term outcomes (including RFS, EFS, IDFS, DDFS, DRFS, RFI, OS and Breast Cancer-Specific Survival), for patients in Arm B. (Exploratory Correlative Objective) XX. To evaluate the associations between TILs in the baseline tumor and RCB score in all patients, and separately in patients with HER2-positive/ER-positive disease and in patients with HER2-positive/ER-negative disease. (Exploratory Correlative Objective) XXI. To evaluate the association between HER2DX risk score in the baseline tumor and RFS in patients who achieved pCR after neoadjuvant THP therapy (i.e., arm A) in HER2-positive/ER-positive breast cancer and HER2-positive/ER-negative breast cancer, separately. (Exploratory Correlative Objective) XXII. To evaluate the association between HER2DX risk score in the baseline tumor and RFS in patients who had residual disease after neoadjuvant THP therapy (i.e., arm B) in HER2-positive/ER-positive breast cancer and HER2-positive/ER-negative breast cancer, separately. (Exploratory Correlative Objective) XXIII. To evaluate the association between HER2DX risk score in the baseline tumor with other long-term outcomes (including EFS, IDFS, DDFS, DRFS, RFI, OS and breast cancer-specific survival) for patents in arm A and arm B, separately. (Exploratory Correlative Objective) XXIV. To evaluate the associations between HER2DX pCR likelihood score in the baseline tumor and RCB score in all patients, and separately in patients with HER2-positive/ER-positive disease and in patients with HER2-positive/ER-negative disease. (Exploratory Correlative Objective) XXV. To evaluate the discrimination and calibration performance of HER2DX pCR likelihood score in terms of pCR in all patients, and separately in patients with HER2-positive/ER-positive disease and in patients with HER2-positive/ER-negative disease. (Exploratory Correlative Objective) XXVI. To evaluate the discrimination and calibration performance of HER2DX risk score in terms of RFS in arm A patients. (Exploratory Correlative Objective) XXVII. To evaluate the discrimination and calibration performance of HER2DX risk score in terms of RFS in arm B patients. (Exploratory Correlative Objective) XXVIII. To evaluate the association of CTCs and change at 3 weeks and 12 weeks with pCR. (Exploratory Correlative Objective) XXIX. To evaluate the association of change in CTCs with RFS. (Exploratory Correlative Objective) XXX. To evaluate the association of CTC phenotype and change with pCR and RFS. (Exploratory Correlative Objective) OUTLINE: PRE-OPERATIVE/NEOADJUVANT THERAPY: Patients receive either paclitaxel or nab-paclitaxel intravenously (IV) on days 1, 8 and 15, or docetaxel IV on day 1 at the discretion of the treating oncologist. Patients also receive trastuzumab IV on day 1 and weekly thereafter, and pertuzumab IV on day 1. Patients may substitute trastuzumab-hyaluronidase subcutaneously (SC) over 2-5 minutes on day 1 in place of trastuzumab or pertuzumab-trastuzumab-hyaluronidase SC over 8 minutes on day 1 of cycle 1 and over 5 minutes on day 1 of cycles 2-4 in place of trastuzumab and pertuzumab. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. However, if surgery occurs later than 21 days after the 4th cycle of trastuzumab and pertuzumab, patients receive an additional cycle of trastuzumab and pertuzumab before surgery. SURGERY: Within 126 days (18 weeks) after the first dose of neoadjuvant therapy, patients undergo standard of care lumpectomy and/or mastectomy. POST-OPERATIVE/ADJUVANT THERAPY: Patients are assigned to 1 of 2 arms. ARM A: Patients with pCR after surgery receive trastuzumab and pertuzumab IV on day 1. Patients may substitute trastuzumab-hyaluronidase SC over 2-5 minutes on day 1 in place of trastuzumab or pertuzumab-trastuzumab-hyaluronidase SC over 5 minutes on day 1 in place of trastuzumab and pertuzumab. Treatment repeats every 21 days for up to 13 cycles in the absence of disease progression or unacceptable toxicity. Patients may also undergo standard of care radiation therapy and receive hormone therapy if appropriate. ARM B: Patients with remaining tumor after surgery receive standard of care trastuzumab emtansine for 14 doses in the absence of disease progression or unacceptable toxicity. Patients may also receive additional standard of care chemotherapy, as well as hormone therapy if appropriate. All patients undergo echocardiogram (ECHO) or multigated acquisition scan (MUGA) during screening and then every 3 months during pre-operative and post-operative therapy. Patients undergo mammogram and ultrasound with or without MRI during screening, and up to one week before cycle 4 day 1. Patients may undergo mammogram annually for 15 years. Patients undergo collection of blood cycle 1 day 1, cycle 2 day 1, pre-surgery, post-surgery, on the day of the first post-surgery systemic therapy, and after completion of all HER2-targeted therapy. Patients may undergo computed tomography (CT) and bone scan or positron emission tomography (PET)/CT during screening. After completion of study treatment, patients are followed up every 3 months for 12 months, every 6 months for 1-5 years, then annually for 5-15 years from date of surgery.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its National Clinical Trials Network.