Numerous clinical trials are always open and enrolling patients in the ECOG-ACRIN Cancer Research Group, which focuses its research on adults 18 years of age and older who have or are at risk of developing cancer. This section of the website contains links to all materials that are publicly available to patients and researchers.

To access materials for a particular trial, click on the trial ID in the list below.

Cancer Type

Trial ID and Target Patient Population
Any Solid Tumor, Lymphoma, or Myeloma, or Cancer Type with No Standard Treatment Available NCI-MATCH / EAY131 – Eligibility Based on Genetic Testing
Brain EAF151 – Glioblastoma, Recurrent
Breast EA1151 / TMIST – Screening Mammography
EA1181 / CompassHER2 pCR – HER2-Positive
EA1183 / FEATURE – Bone-dominant, Metastatic
EAI142 – Newly Diagnosed, Advanced
EAZ171 – Treating Neuropathy in Black Women
Cancer Care Delivery Research EAQ171CD – Any Cancer, Stop-Smoking Counseling
Cancer Control EAQ172 – Any Cancer, Treatment of Lung Inflammation
and Survivorship EAQ191 / CARISMA – Blood Pressure Management
Gastrointestinal EA2165 – Anal
EA2174 – Esophagus
EA2176 – Anal (Treatment-Naïve)
EA2182 / DECREASE – Anal, Squamous Cell
EA2183 – Esophagus and Gastric
EA2185 – Surveillance of Non-Cancerous Pancreas Cysts
EA2186 / GIANT – Pancreatic, Advanced (Aged 65+)
EA2187 – Bile Duct (Cholangiocarcinoma), Advanced
EA2192 / APOLLO – Pancreatic Cancer (Resected, with BRAC1, BRCA2, or PALB2 mutation)
EA2197 / OPT-IN – Gallbladder
EA2201 – Rectal Adenocarcinoma (MSI-H or dMMR Tumors)
7151 – Detection of Colon Cancer (By Invitation Only)
Genitourinary EA8134 / InPACT – Penis
EA8143 / PROSPER RCC – Kidney
EA8171 – Prostate (Imaging/Treatment Planning)
EA8183 / ERADICATE – Prostate (Post Prostatectomy)
EA8184 – Prostate
EA8185 / INSPIRE – Bladder, Node Positive
EA8191 / INDICATE – Prostate, Recurrent
EA8192 – Upper Tract Urothelial, High Grade
Gynecologic None at this time
Head and Neck EA3132 – p53-Mutated Squamous Cell, After Surgery
EA3161 – Oropharyngeal Squamous Cell Carcinoma (Throat), HPV-Positive
EA3163 – Nose and Sinus, Squamous Cell
EA3191 – Recurrent Squamous Cell, High Risk Features
Leukemia EA9152 – Acute Lymphoblastic Leukemia (T-cell or B-cell)
EA9171 / BLAST MRD CML I – Chronic Myeloid Leukemia
EA9181 – Acute Lymphoblastic Leukemia (BCR-ABL-positive)
NHLBI-MDS / The National MDS Study – Observation of Myelodysplastic Syndromes
Lymphoma EA4151 – Mantle Cell
EA4181 – Mantle Cell
E4412 – Hodgkin
PrE0404 – Mantle Cell
PrE0405 – Mantle Cell
Melanoma EA6134 / DREAMseq – Advanced, BRAFV600-Mutated
EA6141 – Advanced
EA6174 / STAMP – Merkel Cell, After Surgery
EA6183 – Cutaneous or Unknown Primary
EA6191 / BAMM2 – Advanced, BRAF V600E/K
EA6192 / PET-Stop – Advanced
EA6194 – Operable
Myeloma EAA171 / OPTIMUM – Multiple Myeloma (Previously Diagnosed)
EAA173 / DETER-SMM – Smoldering Myeloma
EAA181 / EQUATE – Multiple Myeloma (Newly Diagnosed)
Prevention EAZ171 – Neuropathy in Black Women
Thoracic (Lung Cancer) EA5162 – Non-Small Cell, Advanced
EA5163 / S1709 / INSIGNA –  Non-Small Cell, Advanced
EA5181 – Non-Small Cell, Unresectable
EA5182 – Non-Small Cell, Advanced
EA5191 – Non-Squamous Non-Small Cell
E4512, an ALCHEMIST trial – Non-Small Cell, Operable
Lung-MAP – Non-Small Cell, Advanced