Skin Cancer
EA6134 / DREAMseq
Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients with Stage III-IV BRAFV600 Melanoma
STATUS: Closed to Accrual
This phase III trial studies how well initial treatment with ipilimumab and nivolumab followed by dabrafenib and trametinib works and compares it to initial treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab in treating patients with stage III-IV melanoma that contains a mutation known as BRAFV600 and cannot be removed by surgery (unresectable). Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Dabrafenib and trametinib may block tumor growth by targeting the BRAFV600 gene. It is not yet known whether treating patients with ipilimumab and nivolumab followed by dabrafenib and trametinib is more effective than treatment with dabrafenib and trametinib followed by ipilimumab and nivolumab.
- STEP 1
- Age >= 18 years. Because no dosing or adverse event data are currently available on the use of dabrafenib or dabrafenib + trametinib or nivolumab or nivolumab + ipilimumab therapy in patients < 18 years of age, children are excluded from this study, but will be eligible for future pediatric trials
- Eastern Cooperative Oncology Group (ECOG) performance status: 0 or 1
- Women must not be pregnant or breast-feeding, as the effects of ipilimumab + nivolumab or dabrafenib + trametinib on the developing human fetus are unknown * All females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to rule out pregnancy * A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- The effects of dabrafenib and trametinib or ipilimumab and nivolumab on the developing human fetus are unknown; furthermore, dabrafenib has been reported to interfere with the effect of hormone based oral contraceptives; for this reason and because other therapeutic agents used in this trial are known to be teratogenic, women of child-bearing potential and sexually active males must agree to use at least two other accepted and effective methods of contraception and/or to abstain from sexual intercourse for the duration of their participation in the study, and for at least 4 weeks after treatment with dabrafenib or for 4 months after dabrafenib in combination with trametinib; women of child-bearing potential must use at least two other accepted and effective methods of contraception and/or to abstain from sexual intercourse for at least 5 months after the last dose of nivolumab and/or ipilimumab and sexually active males must use at least two other accepted and effective methods of contraception and/or abstain from sexual intercourse for at least 7 months after the last dose of nivolumab and/or ipilimumab; should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately
- Patients must have unresectable stage III or stage IV disease
- Patients must have measurable disease; all sites of disease must be evaluated within 4 weeks prior to randomization
- Patients must have histological or cytological confirmation of melanoma that is metastatic or unresectable and clearly progressive * NOTE: Any patient with BRAF V600 mutant melanoma (whether cutaneous, acral or mucosal primary) who meets the eligibility criteria is eligible for participation in this trial; patients with uveal melanoma are not eligible for this trial
- Patients must have BRAF V600 mutation, identified by a Food and Drug Administration (FDA)-approved test at a Clinical Laboratory Improvement Act (CLIA)-certified lab; if test at CLIA-certified lab used a non-FDA approved method, information about the assay must be provided (FDA approved tests for BRAF V600 mutations in melanoma include: THxID BRAF Detection Kit and Cobas 4800 BRAF V600 Mutation Test, Foundation Medicine); prompt information on tumor BRAF mutation status can also be obtained via Novartis “knowNow” Program
- Patients may have had prior systemic therapy in the adjuvant setting; however this adjuvant treatment must not have included a CTLA4 or PD1 pathway blocking antibody or a BRAF/MEK inhibitor. Also, patients may not have had any prior systemic treatment for advanced (measurable metastatic) disease
- Patients must have discontinued chemotherapy, immunotherapy or other investigational agents used in the adjuvant setting >= 4 weeks prior to entering the study and recovered from adverse events due to those agents; mitomycin and nitrosoureas must have been discontinued at least 6 weeks prior to entering the study; patients must have discontinued radiation therapy >= 1 week prior to entering the study and recovered from any adverse events associated with treatment; prior surgery must be >= 2 weeks from registration and patients must be fully recovered from post-surgical complications
- Patients must not receive any other investigational agents while on study or within four weeks prior to registration
- Patients are ineligible if they have any currently known active and definitive central nervous system (CNS) metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery [SRS]) could be eligible; patients must not have taken any steroids =< 10 days prior to randomization for the purpose of managing their brain metastases; repeat imaging after SRS or surgical resection is not required so long as baseline magnetic resonance imaging (MRI) is within 4 weeks of registration; patients with multiple brain metastases treated with SRS (with [w] or without [w/o] whole-brain radiotherapy [WBRT]), are not an exclusion; patients with definitive CNS metastases treated with only WBRT are ineligible; patients with potential CNS metastases that are too small for treatment with either SRS or surgery (e.g. 1-2 mm) and/or are of uncertain etiology are potentially eligible, but need to be discussed with and approved by the study principal investigator (PI)
- Patients must not have other current malignancies, other than basal cell skin cancer, squamous cell skin cancer, in situ cervical cancer, ductal or lobular carcinoma in situ of the breast; patients with other malignancies are eligible if they have been continuously disease-free for > 2 years prior to the time of registration
- White blood count >= 3,000/uL (obtained within 4 weeks prior to randomization)
- Absolute neutrophil count (ANC) >= 1,500/uL (obtained within 4 weeks prior to randomization)
- Platelet count >= 100,000/uL (obtained within 4 weeks prior to randomization)
- Hemoglobin > 8 g/dL (obtained within 4 weeks prior to randomization)
- Serum creatinine =< 1.5 x upper limit of normal (ULN) or serum creatinine clearance (CrCl) >= 40 ml/min (obtained within 4 weeks prior to randomization)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x ULN (=< 5 x ULN for patients with documented liver metastases) (obtained within 4 weeks prior to randomization)
- Alkaline phosphatase =< 2 x ULN (=< 5 x ULN for patients with known liver involvement and =< 7 x ULN for patients with known bone involvement) (obtained within 4 weeks prior to randomization)
- Total bilirubin =< 1.5 x ULN except subjects with normal direct bilirubin or those with known Gilbert’s syndrome (obtained within 4 weeks prior to randomization)
- Patients must not have any serious or unstable pre-existing medical conditions (aside from malignancy exceptions specified above), including but not limited to, ongoing or active infection requiring parenteral antibiotics on day 1, or psychiatric illness/social situations that would limit compliance with study requirements, interfere with subject’s safety, or obtaining informed consent; therapeutic level dosing of warfarin can be used with close monitoring of prothrombin time (PT)/international normalized ratio (INR) by the site; exposure may be decreased due to enzyme induction when on treatment, thus warfarin dosing may need to be adjusted based upon PT/INR; consequently, when discontinuing dabrafenib, warfarin exposure may be increased and thus close monitoring via PT/INR and warfarin dose adjustments must be made as clinically appropriate; prophylactic low dose warfarin may be given to maintain central catheter patency
- Patients must not have a history of or evidence of cardiovascular risks including any of the following: * QT interval corrected for heart rate using the Bazett’s formula (QTcB) >= 480 msec. at baseline * History of acute coronary syndromes (including myocardial infarction or unstable angina), coronary angioplasty, or stenting within the past 24 weeks prior to registration * History prior to registration or evidence of current >= class II congestive heart failure as defined by the New York Heart Association (NYHA) functional classification system * Left ventricular ejection fraction (LVEF) =< 45% on cardiac echocardiogram (echo) or multi gated acquisition scan (MUGA) * Intra-cardiac defibrillator
- Individuals who are known to be human immunodeficiency virus (HIV) infected are ineligible (note: HIV testing is not required for entry into the study)
- Patients with active autoimmune disease or history of autoimmune disease that might recur, which may affect vital organ function or require immune suppressive treatment including systemic corticosteroids, should be excluded; these include but are not limited to patients with a history of immune related neurologic disease, multiple sclerosis, autoimmune (demyelinating) neuropathy, Guillain-Barre syndrome, myasthenia gravis; systemic autoimmune disease such as systemic lupus erythematosus (SLE), connective tissue diseases, scleroderma, inflammatory bowel disease (IBD), Crohn’s, ulcerative colitis, hepatitis; and patients with a history of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome, or phospholipid syndrome should be excluded because of the risk of recurrence or exacerbation of disease; patients with vitiligo, endocrine deficiencies including thyroiditis managed with replacement hormones including physiologic corticosteroids are eligible; patients with rheumatoid arthritis and other arthropathies, Sjogren’s syndrome and psoriasis controlled with topical medication and patients with positive serology, such as antinuclear antibodies (ANA), should be evaluated for the presence of target organ involvement and potential need for systemic treatment; if no systemic immune suppression is deemed necessary they can be eligible
- The following medications or non-drug therapies are also prohibited while on treatment in this study: * Other anti-cancer therapies * Other investigational drugs * Patients taking any medications or substances that are strong inhibitors or inducers of CYP3A or CYP2C8 are ineligible
- Patients must not have history of retinal vein occlusion (RVO)
- Patients must not have evidence of interstitial lung disease or pneumonitis
- Patients must not have malabsorption, swallowing difficulty, or other conditions that would interfere with the ingestion or absorption of dabrafenib or trametinib
- STEP 2 (CROSSOVER ARMS): The patient must have met all eligibility criteria (except as detailed below) at the time of crossover * RECIST defined measurable disease is not required * Only prior systemic therapy as part of step 1 is allowed; patients who received allowed systemic therapy in the adjuvant setting prior to Step 1 and were eligible for Step 1 are not excluded from proceeding to Step 2 if they meet other eligibility criteria * Malabsorption, swallowing difficulty, or other conditions that would interfere with the ingestion or absorption of dabrafenib or trametinib, or history of retinal vein occlusion are acceptable for patients crossing over to Arm D (ipilimumab + nivolumab) treatment * History of autoimmune disease, excluding interstitial lung disease or pneumonitis, is allowed in patients crossing over to Arm C (dabrafenib/trametinib) therapy * Patients crossing over from Arm A (nivolumab/ipilimumab) to Arm C (dabrafenib/trametinib) who underwent surgery or SRS to CNS metastases need not be off of steroids to start treatment * There is no restriction on serum lactate dehydrogenase (LDH) at crossover * Patients with a history of cardiovascular risks that developed during step 1 of therapy should be discussed with study principal investigator (PI) at time of crossover
- STEP 2 (CROSSOVER ARMS): Patients randomized to Arm A on Step 1 must have melanoma that is metastatic and clearly progressive on Step 1 therapy prior to crossing over to Arm C * NOTE: Patients should (if possible) be at least 1 week from documented PD on Step 1 of current study. All sites of disease must be evaluated within 4 weeks prior to registration
- STEP 2 (CROSSOVER ARMS): Patients randomized to Arm B on Step 1 may cross over to Arm D at or prior to disease progression * NOTE: If possible, patients should wait to cross over until after the cycle with the next protocol-required imaging assessment is completed; all sites of disease must be evaluated within 4 weeks prior to Step 2 registration * NOTE: Patients should start Arm D treatment at least 1 week after stopping dabrafenib and trametinib, unless otherwise clinically indicated * NOTE: Baseline labs and QOL assessments should be completed, and patients should follow the Arm D schedule
- STEP 2 (CROSSOVER ARMS): Patients must have recovered from adverse events (toxicities resolved to grade 1 or less) of prior therapy; patients with immune related toxicities from ipilimumab + nivolumab may continue onto Step 2 even if still on steroids to control side effects, so long as toxicity has resolved to grade 1 or less
- STEP 2 (CROSSOVER ARMS): Patients must have discontinued radiation therapy prior to registering to Step 2 of the study and recovered from any adverse events associated with treatment; prior surgery must be >= 2 weeks from registration to Step 2 and patients must be fully recovered from post-surgical complications
- STEP 2 (CROSSOVER ARMS): Patients are ineligible if they have any currently active and definitive CNS metastases; patients who have treated brain metastases (with either surgical resection or stereotactic radiosurgery [SRS]) could be eligible to proceed; patients crossing over from Arm B (dabrafenib/trametinib) to Arm D (nivolumab [nivo]/ipilimumab [ipi]) must not have taken any steroids =< 10 days prior to Step 2 registration for the purpose of managing their brain metastases; patients with only whole brain irradiation for treatment of CNS metastases are ineligible; patients with definitive CNS metastases treated with only WBRT are ineligible; patients with potential CNS metastases that are too small for treatment with either SRS or surgery (e.g. 1-2 mm) and/or are of uncertain etiology are potentially eligible, but need to be discussed with and approved by the study PI
- STEP 2 (CROSSOVER ARMS): Patients must not have other current malignancies
- STEP 2 (CROSSOVER ARMS): Women must not be pregnant or breast-feeding, as the effects of ipilimumab + nivolumab or dabrafenib + trametinib on the developing human fetus are unknown; all females of childbearing potential must have a blood test or urine study within 2 weeks prior to registration to Step 2 crossover to rule out pregnancy; a female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months
- STEP 2 (CROSSOVER ARMS): The effects of dabrafenib and trametinib or ipilimumab and nivolumab on the developing human fetus are unknown; furthermore, dabrafenib has been reported to interfere with the effect of hormone based oral contraceptives; for this reason and because other therapeutic agents used in this trial are known to be teratogenic, women of child-bearing potential and sexually active males must agree to continue to use the same contraception requirements as on Step 1 of this study (i.e.: use at least two other accepted and effective methods of contraception and/or to abstain from sexual intercourse for the duration of their participation in the study, and for at least 4 weeks after treatment with dabrafenib or for 4 months after dabrafenib in combination with trametinib; women of child-bearing potential must use at least two other accepted and effective methods of contraception and/or to abstain from sexual intercourse for at least 5 months after the last dose of nivolumab and/or ipilimumab and sexually active males must use at least two other accepted and effective methods of contraception and/or to abstain from sexual intercourse for at least 7 months after the last dose of nivolumab and/or ipilimumab); should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately
United States
AK
Anchorage
Alaska Breast Care and Surgery LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Women's Cancer Care
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Associates in Radiation Medicine
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Oncology Centre
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Anchorage Radiation Therapy Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Fairbanks
Fairbanks Memorial Hospital
Contact: Site Public Contact
Email: Veronica.Stevenson@foundationhealth.org
AL
Birmingham
University of Alabama at Birmingham Cancer Center
Contact: Site Public Contact
Email: tmyrick@uab.edu
AR
Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Little Rock
University of Arkansas for Medical Sciences
Contact: Site Public Contact
AZ
Goodyear
CTCA at Western Regional Medical Center
Contact: Site Public Contact
Kingman
Kingman Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Phoenix
Cancer Center at Saint Joseph's
Contact: Site Public Contact
CA
Anaheim
Kaiser Permanente-Anaheim
Contact: Site Public Contact
Email: clinical.trials@kp.org
Arroyo Grande
Mission Hope Medical Oncology - Arroyo Grande
Contact: Site Public Contact
Email: research@dignityhealth.org
PCR Oncology
Contact: Site Public Contact
Email: research@sncrf.org
Auburn
Sutter Auburn Faith Hospital
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Sutter Cancer Centers Radiation Oncology Services-Auburn
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Baldwin Park
Kaiser Permanente-Baldwin Park
Contact: Site Public Contact
Email: clinical.trials@kp.org
Bellflower
Kaiser Permanente-Bellflower
Contact: Site Public Contact
Email: clinical.trials@kp.org
Berkeley
Alta Bates Summit Medical Center-Herrick Campus
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Burbank
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Contact: Site Public Contact
Email: Najee.Boucher@providence.org
Burlingame
Mills-Peninsula Medical Center
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Castro Valley
Eden Hospital Medical Center
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Chico
Adventist Health Cancer Care Center Chico
Contact: Site Public Contact
Email: hs-ccnctrials@ucdavis.edu
Davis
Sutter Davis Hospital
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Duarte
City of Hope Comprehensive Cancer Center
Contact: Site Public Contact
Email: becomingapatient@coh.org
Dublin
Kaiser Permanente Dublin
Contact: Site Public Contact
Fontana
Kaiser Permanente-Fontana
Contact: Site Public Contact
Email: clinical.trials@kp.org
Fremont
Palo Alto Medical Foundation-Fremont
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Fresno
Kaiser Permanente-Fresno
Contact: Site Public Contact
Email: Kpoct@kp.org
Harbor City
Kaiser Permanente - Harbor City
Contact: Site Public Contact
Email: clinical.trials@kp.org
Irvine
Kaiser Permanente-Irvine
Contact: Site Public Contact
Email: clinical.trials@kp.org
Los Angeles
Kaiser Permanente Los Angeles Medical Center
Contact: Site Public Contact
Email: clinical.trials@kp.org
Kaiser Permanente West Los Angeles
Contact: Site Public Contact
Email: clinical.trials@kp.org
UCLA / Jonsson Comprehensive Cancer Center
Contact: Site Public Contact
Modesto
Kaiser Permanente-Modesto
Contact: Site Public Contact
Email: Kpoct@kp.org
Memorial Medical Center
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Mountain View
Palo Alto Medical Foundation-Camino Division
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Palo Alto Medical Foundation-Gynecologic Oncology
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Novato
Sutter Cancer Research Consortium
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Oakland
Kaiser Permanente-Oakland
Contact: Site Public Contact
Email: Kpoct@kp.org
Ontario
Kaiser Permanente-Ontario
Contact: Site Public Contact
Email: clinical.trials@kp.org
Palo Alto
Palo Alto Medical Foundation Health Care
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Panorama City
Kaiser Permanente - Panorama City
Contact: Site Public Contact
Email: clinical.trials@kp.org
Rancho Mirage
Eisenhower Medical Center
Contact: Site Public Contact
Richmond
Kaiser Permanente-Richmond
Contact: Site Public Contact
Email: Kpoct@kp.org
Riverside
Kaiser Permanente-Riverside
Contact: Site Public Contact
Email: clinical.trials@kp.org
Roseville
Kaiser Permanente-Roseville
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Cancer Centers Radiation Oncology Services-Roseville
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Sutter Roseville Medical Center
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Sacramento
Kaiser Permanente - Sacramento
Contact: Site Public Contact
Email: Kpoct@kp.org
Kaiser Permanente Downtown Commons
Contact: Site Public Contact
Email: kpoct@kp.org
Kaiser Permanente-South Sacramento
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Medical Center Sacramento
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
San Diego
Kaiser Permanente-San Diego Mission
Contact: Site Public Contact
Email: clinical.trials@kp.org
Kaiser Permanente-San Diego Zion
Contact: Site Public Contact
Email: clinical.trials@kp.org
San Francisco
California Pacific Medical Center-Pacific Campus
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
San Jose
Kaiser Permanente-Santa Teresa-San Jose
Contact: Site Public Contact
Email: Kpoct@kp.org
San Leandro
Kaiser Permanente San Leandro
Contact: Site Public Contact
Email: Kpoct@kp.org
San Luis Obispo
Pacific Central Coast Health Center-San Luis Obispo
Contact: Site Public Contact
Email: Diane.DeVos-Schmidt@DignityHealth.org
San Marcos
Kaiser Permanente-San Marcos
Contact: Site Public Contact
Email: clinical.trials@kp.org
San Mateo
Mills Health Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
San Rafael
Kaiser Permanente-San Rafael
Contact: Site Public Contact
Email: Kpoct@kp.org
Kaiser San Rafael-Gallinas
Contact: Site Public Contact
Email: Kpoct@kp.org
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
Contact: Site Public Contact
Email: Kpoct@kp.org
Santa Cruz
Palo Alto Medical Foundation-Santa Cruz
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Santa Maria
Mission Hope Medical Oncology - Santa Maria
Contact: Site Public Contact
Email: research@dignityhealth.org
Santa Rosa
Sutter Pacific Medical Foundation
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Stockton
Kaiser Permanente-Stockton
Contact: Site Public Contact
Email: Kpoct@kp.org
Sunnyvale
Palo Alto Medical Foundation-Sunnyvale
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Upland
City of Hope Upland
Contact: Site Public Contact
Email: becomingapatient@coh.org
Vacaville
Kaiser Permanente Medical Center-Vacaville
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Vallejo
Kaiser Permanente-Vallejo
Contact: Site Public Contact
Email: Kpoct@kp.org
Sutter Solano Medical Center/Cancer Center
Contact: Site Public Contact
Email: bernicl@sutterhealth.org
Walnut Creek
Kaiser Permanente-Walnut Creek
Contact: Site Public Contact
Email: Kpoct@kp.org
Woodland Hills
Kaiser Permanente-Woodland Hills
Contact: Site Public Contact
Email: clinical.trials@kp.org
CO
Aurora
The Medical Center of Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
UCHealth University of Colorado Hospital
Contact: Site Public Contact
Boulder
Boulder Community Hospital
Contact: Site Public Contact
Email: jbloomfield@co-cancerresearch.org
Colorado Springs
Memorial Hospital North
Contact: Site Public Contact
Penrose-Saint Francis Healthcare
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Penrose
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Saint Francis Cancer Center
Contact: Site Public Contact
UCHealth Memorial Hospital Central
Contact: Site Public Contact
Denver
Porter Adventist Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Presbyterian - Saint Lukes Medical Center - Health One
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Rose Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
SCL Health Saint Joseph Hospital
Contact: Site Public Contact
Email: alan.franklin@sclhealth.org
Durango
Mercy Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Southwest Oncology PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Englewood
Mountain Blue Cancer Care Center - Swedish
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Swedish Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Fort Collins
Poudre Valley Hospital
Contact: Site Public Contact
Golden
Mountain Blue Cancer Care Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Grand Junction
Grand Valley Oncology
Contact: Site Public Contact
Email: gvoclinicaltrials@gjhosp.org
Greeley
Banner North Colorado Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Lakewood
Rocky Mountain Cancer Centers-Lakewood
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Saint Anthony Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Littleton
Littleton Adventist Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Lone Tree
Sky Ridge Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Longmont
Longmont United Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Longmont
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Loveland
Banner McKee Medical Center
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Parker
Parker Adventist Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Rocky Mountain Cancer Centers-Parker
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Pueblo
Rocky Mountain Cancer Centers - Pueblo
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Saint Mary Corwin Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Thornton
Rocky Mountain Cancer Centers-Thornton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
Wheat Ridge
SCL Health Lutheran Medical Center
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
CT
Hartford
Smilow Cancer Hospital Care Center at Saint Francis
Contact: Site Public Contact
Email: canceranswers@yale.edu
New Haven
Smilow Cancer Center/Yale-New Haven Hospital
Contact: Site Public Contact
Email: canceranswers@yale.edu
Yale University
Contact: Site Public Contact
Email: canceranswers@yale.edu
Norwich
Eastern Connecticut Hematology and Oncology Associates
Contact: Site Public Contact
Stamford
Stamford Hospital/Bennett Cancer Center
Contact: Site Public Contact
DC
Washington
MedStar Georgetown University Hospital
Contact: Site Public Contact
MedStar Washington Hospital Center
Contact: Site Public Contact
DE
Newark
Christiana Care Health System-Christiana Hospital
Contact: Site Public Contact
Email: mhayden@christianacare.org
Christiana Gynecologic Oncology LLC
Contact: Gregory Andrew Masters
Delaware Clinical and Laboratory Physicians PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Helen F Graham Cancer Center
Contact: Site Public Contact
Email: mhayden@christianacare.org
Medical Oncology Hematology Consultants PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Wilmington
Christiana Care Health System-Wilmington Hospital
Contact: Site Public Contact
Email: mhayden@christianacare.org
FL
Aventura
Mount Sinai Comprehensive Cancer Center at Aventura
Contact: Site Public Contact
Email: yenrique@msmc.com
Coral Gables
UM Sylvester Comprehensive Cancer Center at Coral Gables
Contact: Site Public Contact
Daytona Beach
Halifax Health Medical Center-Centers for Oncology
Contact: Site Public Contact
Deerfield Beach
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Contact: Site Public Contact
Fort Lauderdale
Holy Cross Hospital
Contact: Site Public Contact
Lakeland
Lakeland Regional Health Hollis Cancer Center
Contact: Site Public Contact
Miami
UM Sylvester Comprehensive Cancer Center at Kendall
Contact: Site Public Contact
University of Miami Miller School of Medicine-Sylvester Cancer Center
Contact: Site Public Contact
Miami Beach
Mount Sinai Medical Center
Contact: Site Public Contact
Email: yenrique@msmc.com
Orlando
Orlando Health Cancer Institute
Contact: Site Public Contact
Email: CancerClinicalTrials@orlandohealth.com
Plantation
UM Sylvester Comprehensive Cancer Center at Plantation
Contact: Site Public Contact
GA
Athens
University Cancer and Blood Center LLC
Contact: Site Public Contact
Email: research@universitycancer.com
Atlanta
Emory Saint Joseph's Hospital
Contact: Site Public Contact
Emory University Hospital/Winship Cancer Institute
Contact: Site Public Contact
Northside Hospital
Contact: Site Public Contact
Email: ClinicalTrials@northside.com
Augusta
Augusta University Medical Center
Contact: Site Public Contact
Email: ga_cares@augusta.edu
Cumming
Northside Hospital-Forsyth
Contact: Site Public Contact
Email: clinicaltrials@northside.com
Decatur
Dekalb Medical Center
Contact: Site Public Contact
Email: clinicaltrialsoncology@dekalbmedical.org
Duluth
Northside Hospital - Duluth
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Lawrenceville
Northside Hospital - Gwinnett
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
Summit Cancer Care-Candler
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Snellville
Suburban Hematology Oncology Associates - Snellville
Contact: Site Public Contact
Email: Clinical.trials@northside.com
HI
Aiea
Hawaii Cancer Care - Westridge
Contact: Site Public Contact
Email: info@hawaiicancercare.com
Pali Momi Medical Center
Contact: Site Public Contact
Queen's Cancer Center - Pearlridge
Contact: Site Public Contact
Straub Pearlridge Clinic
Contact: Site Public Contact
The Cancer Center of Hawaii-Pali Momi
Contact: Site Public Contact
Ewa Beach
The Queen's Medical Center - West Oahu
Contact: Site Public Contact
Email: rohta@queens.org
Honolulu
Hawaii Cancer Care Inc - Waterfront Plaza
Contact: Site Public Contact
Email: i.webster@hawaiicancercare.com
Hawaii Cancer Care Inc-Liliha
Contact: Site Public Contact
Hawaii Diagnostic Radiology Services LLC
Contact: Site Public Contact
Email: mmiyoshi@hawaiidrs.com
Island Urology
Contact: Site Public Contact
Email: virginia@cc.hawaii.edu
Kaiser Permanente Moanalua Medical Center
Contact: Site Public Contact
Email: shelley.a.clark@kp.org
Kapiolani Medical Center for Women and Children
Contact: Site Public Contact
Kuakini Medical Center
Contact: Site Public Contact
Queen's Cancer Cenrer - POB I
Contact: Site Public Contact
Queen's Cancer Center - Kuakini
Contact: Site Public Contact
Queen's Medical Center
Contact: Site Public Contact
Straub Clinic and Hospital
Contact: Site Public Contact
The Cancer Center of Hawaii-Liliha
Contact: Site Public Contact
University of Hawaii Cancer Center
Contact: Site Public Contact
Kahului
Straub Medical Center - Kahului Clinic
Contact: Site Public Contact
Email: lori.kam@hawaiipacifichealth.org
Kailua
Castle Medical Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Contact: Site Public Contact
IA
Ames
Mary Greeley Medical Center
Contact: Site Public Contact
McFarland Clinic - Ames
Contact: Site Public Contact
Email: ksoder@mcfarlandclinic.com
Boone
McFarland Clinic - Boone
Contact: Site Public Contact
Clive
Mercy Cancer Center-West Lakes
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Mission Cancer and Blood - West Des Moines
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Council Bluffs
Alegent Health Mercy Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Creston
Greater Regional Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Des Moines
Mercy Medical Center - Des Moines
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Mission Cancer and Blood - Laurel
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Fort Dodge
McFarland Clinic - Trinity Cancer Center
Contact: Site Public Contact
Jefferson
McFarland Clinic - Jefferson
Contact: Site Public Contact
Marshalltown
McFarland Clinic - Marshalltown
Contact: Site Public Contact
Sioux City
Siouxland Regional Cancer Center
Contact: Site Public Contact
Email: HoopingarnerT@jencc.com
West Des Moines
Mercy Medical Center-West Lakes
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
ID
Boise
Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact
Email: eslinget@slhs.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Fruitland
Saint Luke's Cancer Institute - Fruitland
Contact: Site Public Contact
Email: eslinget@slhs.org
Meridian
Idaho Urologic Institute-Meridian
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Meridian
Contact: Site Public Contact
Email: eslinget@slhs.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Luke's Cancer Institute - Nampa
Contact: Site Public Contact
Email: eslinget@slhs.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Cancer Institute - Twin Falls
Contact: Site Public Contact
Email: eslinget@slhs.org
IL
Aurora
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Joseph Medical Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Chicago
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Rush University Medical Center
Contact: Site Public Contact
Email: clinical_trials@rush.edu
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@carle.com
DeKalb
Northwestern Medicine Cancer Center Kishwaukee
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
Contact: Site Public Contact
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Geneva
Northwestern Medicine Cancer Center Delnor
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Contact: Site Public Contact
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Contact: Site Public Contact
Joliet
Duly Health and Care Joliet
Contact: Site Public Contact
Email: Karen.Sceniak@dulyhealthandcare.com
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Lake Forest
Northwestern Medicine Lake Forest Hospital
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Maywood
Loyola University Medical Center
Contact: Site Public Contact
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Medical Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Springfield
Memorial Medical Center
Contact: Site Public Contact
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Warrenville
Northwestern Medicine Cancer Center Warrenville
Contact: Site Public Contact
Email: Donald.Smith3@nm.org
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Evansville
Deaconess Clinic Downtown
Contact: Site Public Contact
Email: Research@Deaconess.com
Indianapolis
Franciscan Health Indianapolis
Contact: Site Public Contact
Indiana University/Melvin and Bren Simon Cancer Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Kendrick Colon and Rectal Center-Indianapolis
Contact: Site Public Contact
Sidney and Lois Eskenazi Hospital
Contact: Site Public Contact
Email: iutrials@iu.edu
Springmill Medical Center
Contact: Site Public Contact
Email: iutrials@iu.edu
Michigan City
Woodland Cancer Care Center
Contact: Site Public Contact
Email: sally.arnett@franciscanalliance.org
Mooresville
Franciscan Health Mooresville
Contact: Site Public Contact
Newburgh
Chancellor Center for Oncology
Contact: Site Public Contact
Email: Research@Deaconess.com
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
KS
Chanute
Cancer Center of Kansas - Chanute
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Coffeyville
Coffeyville Regional Medical Center
Contact: Site Public Contact
Dodge City
Cancer Center of Kansas - Dodge City
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
El Dorado
Cancer Center of Kansas - El Dorado
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Fort Scott
Cancer Center of Kansas - Fort Scott
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Saint Catherine Hospital
Contact: Site Public Contact
Email: info@cccancer.com
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
Saint Rose Ambulatory and Surgery Center
Contact: Site Public Contact
Hays
HaysMed
Contact: Site Public Contact
Independence
Cancer Center of Kansas-Independence
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Kansas City
University of Kansas Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
University of Kansas Cancer Center-West
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Kingman
Cancer Center of Kansas-Kingman
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Lawrence
Lawrence Memorial Hospital
Contact: Site Public Contact
Email: Stephanie.Norris@LMH.ORG
Liberal
Cancer Center of Kansas-Liberal
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Manhattan
Cancer Center of Kansas-Manhattan
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
McPherson
Cancer Center of Kansas - McPherson
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Newton
Cancer Center of Kansas - Newton
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Olathe
Olathe Health Cancer Center
Contact: Site Public Contact
Email: Jeni.wakefield@olathehealth.org
Overland Park
Menorah Medical Center
Contact: Site Public Contact
Email: aroland@kccop.org
University of Kansas Cancer Center-Overland Park
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Parsons
Cancer Center of Kansas - Parsons
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Pittsburg
Ascension Via Christi - Pittsburg
Contact: Site Public Contact
Email: jennifer.jameson@ascension.org
Pratt
Cancer Center of Kansas - Pratt
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Salina
Cancer Center of Kansas - Salina
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Salina Regional Health Center
Contact: Site Public Contact
Email: mleepers@srhc.com
Topeka
University of Kansas Health System Saint Francis Campus
Contact: Site Public Contact
Wellington
Cancer Center of Kansas - Wellington
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Westwood
University of Kansas Hospital-Westwood Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Associates In Womens Health
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
Winfield
Cancer Center of Kansas - Winfield
Contact: Site Public Contact
Email: Keisha.humphries@ascension.org
KY
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Corbin
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Crestview Hills
Oncology Hematology Care Inc-Crestview
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Lexington
Saint Joseph Hospital East
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
London
Saint Joseph London
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Louisville
Jewish Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
The James Graham Brown Cancer Center at University of Louisville
Contact: Site Public Contact
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
LA
Baton Rouge
LSU Health Baton Rouge-North Clinic
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Louisiana Hematology Oncology Associates LLC
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Mary Bird Perkins Cancer Center
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Medical Center of Baton Rouge
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org
Ochsner Health Center-Summa
Contact: Site Public Contact
Email: Camille.Beck@Ochsner.org
Ochsner High Grove
Contact: Site Public Contact
Email: Gregory.Johnstone@ochsner.org
Our Lady of the Lake Physician Group
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Covington
Mary Bird Perkins Cancer Center - Covington
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Northshore Oncology Associates-Covington
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Houma
Mary Bird Perkins Cancer Center - Houma
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Oncology Center of The South Incorporated
Contact: Site Public Contact
Email: clinicalresearch@marybird.com
Kenner
Ochsner Medical Center Kenner
Contact: Site Public Contact
Email: cris.molina@ochsner.org
Monroe
Ochsner LSU Health Monroe Medical Center
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Ochsner Medical Center Jefferson
Contact: Site Public Contact
Email: Gregory.Johnstone@ochsner.org
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Shreveport
LSU Health Sciences Center at Shreveport
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
MA
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Mercy Medical Center
Contact: Site Public Contact
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Baltimore
Greater Baltimore Medical Center
Contact: Site Public Contact
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Contact: Site Public Contact
Saint Agnes Hospital
Contact: Site Public Contact
Frederick
FMH James M Stockman Cancer Institute
Contact: Site Public Contact
Frederick Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@fmh.org
MI
Adrian
Hickman Cancer Center
Contact: Site Public Contact
Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
University of Michigan Comprehensive Cancer Center
Contact: Site Public Contact
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Medical Center - Brighton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Medical Center - Canton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Caro
Caro Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Chelsea
Chelsea Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Dearborn
Corewell Health Dearborn Hospital
Contact: Site Public Contact
Detroit
Ascension Saint John Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Wayne State University/Karmanos Cancer Institute
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
East China
Great Lakes Cancer Management Specialists-Doctors Park
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Escanaba
OSF Saint Francis Hospital and Medical Group
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Farmington Hills
Weisberg Cancer Treatment Center
Contact: Site Public Contact
Email: ctoadmin@karmanos.org
Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Hurley Medical Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Grosse Pointe Woods
Academic Hematology Oncology Specialists
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Grosse Pointe Woods
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Jackson
Allegiance Health
Contact: Site Public Contact
Email: CTOResearch@hfhs.org
Kalamazoo
Borgess Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Lansing
University of Michigan Health - Sparrow Lansing
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Macomb Township
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Monroe
Toledo Clinic Cancer Centers-Monroe
Contact: Site Public Contact
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Pontiac
Hope Cancer Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Michigan Healthcare Professionals Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Joseph Mercy Oakland Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Port Huron
Huron Medical Center PC
Contact: Site Public Contact
Email: research@sncrf.org
Lake Huron Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saginaw
MyMichigan Medical Center Saginaw
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Tawas City
MyMichigan Medical Center Tawas
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Great Lakes Cancer Management Specialists-Macomb Professional Building
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Michigan Breast Specialists-Warren
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint John Macomb-Oakland Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
MN
Aitkin
Riverwood Healthcare Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Brainerd
Essentia Health Saint Joseph's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Duluth
Essentia Health Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Miller-Dwan Hospital
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Contact: Site Public Contact
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Virginia
Essentia Health Virginia Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact
MO
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: swooden@mail.crmc.org
Kansas City
Kansas City Veterans Affairs Medical Center
Contact: Site Public Contact
Research Medical Center
Contact: Site Public Contact
Email: aroland@kccop.org
The University of Kansas Cancer Center-South
Contact: Site Public Contact
Email: ctnursenav@kumc.edu
University Health Truman Medical Center
Contact: Site Public Contact
University of Kansas Cancer Center - North
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Lee's Summit
University of Kansas Cancer Center - Lee's Summit
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Missouri Baptist Medical Center
Contact: Site Public Contact
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
MS
Jackson
University of Mississippi Medical Center
Contact: Site Public Contact
Pascagoula
Singing River Hospital
Contact: Site Public Contact
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Saint Vincent Frontier Cancer Center
Contact: Site Public Contact
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Missoula
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org
NC
Asheville
AdventHealth Infusion Center Asheville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
Clemmons
Wake Forest University at Clemmons
Contact: Site Public Contact
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Wayne Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Hendersonville
Margaret R Pardee Memorial Hospital
Contact: Site Public Contact
Email: karen.morris@unchealth.unc.edu
Jacksonville
Onslow Memorial Hospital
Contact: Site Public Contact
Email: ecooke@cancersmoc.com
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kenansville
ECU Health Oncology Kenansville
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Kinston
ECU Health Oncology Kinston
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Richlands
ECU Health Oncology Richlands
Contact: Site Public Contact
Email: Carla.Zimmerman@vidanthealth.com
Statesville
Wake Forest Baptist Health - Hematology Oncology - Statesville
Contact: Site Public Contact
Wilkesboro
Wake Forest Baptist Health - Wilkes Medical Center
Contact: Site Public Contact
Winston-Salem
Wake Forest University Health Sciences
Contact: Site Public Contact
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Clinic North-Fargo
Contact: Preston D. Steen
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Jamestown
Essentia Health - Jamestown Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
NE
Bellevue
Nebraska Medicine-Bellevue
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Grand Island
Nebraska Cancer Specialists/Oncology Hematology West PC
Contact: Site Public Contact
Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Heartland Hematology and Oncology
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Lincoln
Cancer Partners of Nebraska
Contact: Site Public Contact
Email: research@cancerpartners.com
Nebraska Cancer Research Center
Contact: Site Public Contact
Nebraska Hematology and Oncology
Contact: Site Public Contact
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Norfolk
Faith Regional Health Services Carson Cancer Center
Contact: Site Public Contact
Email: mwilwerding@canceralliance-ne.org
North Platte
Great Plains Health Callahan Cancer Center
Contact: Site Public Contact
Email: mwilwerding@canceralliance-ne.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Creighton University Medical Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Hematology and Oncology Consultants PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Nebraska Cancer Specialists - Omaha
Contact: Site Public Contact
Email: mwilwerding@canceralliance-ne.org
Nebraska Medicine-Village Pointe
Contact: Site Public Contact
Nebraska Methodist Hospital
Contact: Site Public Contact
Oncology Hematology West PC
Contact: Site Public Contact
University of Nebraska Medical Center
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Scottsbluff
Regional West Medical Center Cancer Center
Contact: Site Public Contact
Email: mwilwerding@canceralliance-ne.org
NJ
Hackensack
Hackensack University Medical Center
Contact: Site Public Contact
NM
Albuquerque
Lovelace Medical Center-Saint Joseph Square
Contact: Site Public Contact
Email: AYost@nmcca.org
New Mexico Oncology Hematology Consultants
Contact: Site Public Contact
Email: CLee@nmcca.org
Presbyterian Kaseman Hospital
Contact: Site Public Contact
Email: WBurman@phs.org
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: LByatt@nmcca.org
Las Cruces
Memorial Medical Center - Las Cruces
Contact: Site Public Contact
Email: Kim.Hoffman@lpnt.net
Rio Rancho
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Contact: Site Public Contact
Email: WBurman@phs.org
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Albany
New York Oncology Hematology PC - Albany Medical Center
Contact: Site Public Contact
Email: jennifer.moran@usoncology.com
Buffalo
Roswell Park Cancer Institute
Contact: Site Public Contact
Email: askroswell@roswellpark.org
Cooperstown
Mary Imogene Bassett Hospital
Contact: Site Public Contact
Email: CancerClinicalTrials@bassett.org
Rochester
University of Rochester
Contact: Site Public Contact
Stony Brook
Stony Brook University Medical Center
Contact: Site Public Contact
Syracuse
State University of New York Upstate Medical University
Contact: Site Public Contact
OH
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: sheree@columbusccop.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Oncology Hematology Care Inc-Anderson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Blue Ash
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Eden Park
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Oncology Hematology Care Inc-Mercy West
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
University of Cincinnati Cancer Center-UC Medical Center
Contact: Site Public Contact
Email: cancer@uchealth.com
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Cleveland Clinic Cancer Center/Fairview Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Cleveland Clinic Foundation
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
MetroHealth Medical Center
Contact: Site Public Contact
Email: dstrater@metrohealth.org
Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: sheree@columbusccop.org
Doctors Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grant Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel East Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel Health Center West
Contact: Site Public Contact
Email: sheree@columbusccop.org
Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu
Riverside Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
The Mark H Zangmeister Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Good Samaritan Hospital - Dayton
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grady Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dublin
Dublin Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Fairfield
Oncology Hematology Care Inc-Healthplex
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Independence
Cleveland Clinic Cancer Center Independence
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Kettering
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Lima
Saint Rita's Medical Center
Contact: Site Public Contact
Mansfield
Cleveland Clinic Cancer Center Mansfield
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Maumee
Toledo Clinic Cancer Centers-Maumee
Contact: Site Public Contact
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
Contact: Site Public Contact
Mayfield Heights
Hillcrest Hospital Cancer Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Middletown
Dayton Physicians LLC-Signal Point
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark Radiation Oncology
Contact: Site Public Contact
Email: sheree@columbusccop.org
Oregon
Saint Charles Hospital
Contact: Site Public Contact
Perrysburg
Mercy Health Perrysburg Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Sandusky
North Coast Cancer Care
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Sidney
Dayton Physicians LLC-Wilson
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Strongsville
Cleveland Clinic Cancer Center Strongsville
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Toledo
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mercy Health - Saint Vincent Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Toledo Clinic Cancer Centers-Toledo
Contact: Site Public Contact
University of Toledo
Contact: Site Public Contact
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warrensville Heights
South Pointe Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
West Chester
University of Cincinnati Cancer Center-West Chester
Contact: Site Public Contact
Email: cancer@uchealth.com
Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Westlake
UHHS-Westlake Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Wooster
Cleveland Clinic Wooster Family Health and Surgery Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
OK
Oklahoma City
Integris Southwest Medical Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org
Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Oregon City
Providence Willamette Falls Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Portland
Oregon Health and Science University
Contact: Site Public Contact
Email: trials@ohsu.edu
Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact
PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Beaver
UPMC-Heritage Valley Health System Beaver
Contact: Site Public Contact
Email: haneydl@upmc.edu
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's University Hospital-Bethlehem Campus
Contact: Site Public Contact
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: mhayden@christianacare.org
Chambersburg
Chambersburg Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Danville
Geisinger Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Ephrata
Ephrata Cancer Center
Contact: Site Public Contact
Ephrata Community Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Gettysburg
Adams Cancer Center
Contact: Site Public Contact
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact
Hanover
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Hazleton
Geisinger Medical Center-Cancer Center Hazleton
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Hershey
Penn State Milton S Hershey Medical Center
Contact: Site Public Contact
Email: CTO@hmc.psu.edu
Johnstown
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Contact: Site Public Contact
Lebanon
Sechler Family Cancer Center
Contact: Site Public Contact
Email: doxenberg@wellspan.org
Lewisburg
Geisinger Medical Oncology-Lewisburg
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Lewistown
Lewistown Hospital
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact
Moon Township
UPMC Hillman Cancer Center in Coraopolis
Contact: Site Public Contact
Pittsburgh
Allegheny General Hospital
Contact: Site Public Contact
UPMC-Magee Womens Hospital
Contact: Site Public Contact
UPMC-Passavant Hospital
Contact: Site Public Contact
UPMC-Presbyterian Hospital
Contact: Site Public Contact
UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact
UPMC-Saint Margaret
Contact: Site Public Contact
UPMC-Shadyside Hospital
Contact: Site Public Contact
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact
West Penn Hospital
Contact: Site Public Contact
Pottsville
Geisinger Cancer Services-Pottsville
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Sayre
Guthrie Medical Group PC-Robert Packer Hospital
Contact: Site Public Contact
Scranton
Community Medical Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Selinsgrove
Geisinger Medical Oncology-Selinsgrove
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact
State College
Geisinger Medical Group
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
Uniontown
UPMC Uniontown Hospital Radiation Oncology
Contact: Site Public Contact
Washington
UPMC Washington Hospital Radiation Oncology
Contact: Site Public Contact
Email: cancer@washingtonhospital.org
West Reading
Reading Hospital
Contact: Site Public Contact
Wexford
Wexford Health and Wellness Pavilion
Contact: Site Public Contact
Email: ddefazio@wpahs.org
Wilkes-Barre
Geisinger Wyoming Valley/Henry Cancer Center
Contact: Site Public Contact
Email: HemonCCTrials@geisinger.edu
York
WellSpan Health-York Cancer Center
Contact: Site Public Contact
WellSpan Health-York Hospital
Contact: Site Public Contact
RI
Providence
Rhode Island Hospital
Contact: Site Public Contact
SC
Anderson
AnMed Health Cancer Center
Contact: Site Public Contact
Email: rhonda.ballew@anmedhealth.org
Bluffton
Saint Joseph's/Candler - Bluffton Campus
Contact: Site Public Contact
Email: underberga@sjchs.org
Boiling Springs
Prisma Health Cancer Institute - Spartanburg
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Charleston
Charleston Oncology - Roper
Contact: Site Public Contact
Email: Heather.Dubose@choasc.com
Charleston Oncology - Saint Francis
Contact: Site Public Contact
Email: Heather.Dubose@choasc.com
Medical University of South Carolina
Contact: Site Public Contact
Email: hcc-clinical-trials@musc.edu
Roper Hospital
Contact: Site Public Contact
Email: Courtney.Roldan@RoperSaintFrancis.com
Easley
Prisma Health Cancer Institute - Easley
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Greenville
Prisma Health Cancer Institute - Butternut
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Prisma Health Cancer Institute - Eastside
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Prisma Health Cancer Institute - Faris
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Prisma Health Greenville Memorial Hospital
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Saint Francis Cancer Center
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Saint Francis Hospital
Contact: Site Public Contact
Email: melissa_beckman@bshsi.org
Greer
Prisma Health Cancer Institute - Greer
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
Hilton Head Island
South Carolina Cancer Specialists PC
Contact: Site Public Contact
Email: underberga@sjchs.org
The Radiation Oncology Center-Hilton Head/Bluffton
Contact: Site Public Contact
Email: underberga@sjchs.org
Seneca
Prisma Health Cancer Institute - Seneca
Contact: Site Public Contact
Email: kim.williams3@prismahealth.org
SD
Sioux Falls
Avera Cancer Institute
Contact: Site Public Contact
Email: OncRegulatory@avera.org
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org
TN
Bristol
Bristol Regional Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Wellmont Medical Associates Oncology and Hematology-Bristol
Contact: Site Public Contact
Chattanooga
Erlanger Medical Center
Contact: Site Public Contact
Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Contact: Site Public Contact
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Kingsport
Ballad Health Cancer Care – Kingsport
Contact: Site Public Contact
Email: Justin.reynolds@balladhealth.org
Wellmont Holston Valley Hospital and Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Knoxville
Thompson Cancer Survival Center
Contact: Site Public Contact
Thompson Cancer Survival Center - West
Contact: Site Public Contact
Maryville
Thompson Oncology Group-Maryville
Contact: Site Public Contact
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Contact: Site Public Contact
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
Oak Ridge
Thompson Oncology Group-Oak Ridge
Contact: Site Public Contact
Ooltewah
Memorial GYN Plus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
TX
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Dallas
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT
American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Cedar City
Sandra L Maxwell Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Logan
Logan Regional Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Murray
Intermountain Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Ogden
McKay-Dee Hospital Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Provo
Utah Valley Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Riverton
Riverton Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Saint George
Saint George Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Salt Lake City
Huntsman Cancer Institute/University of Utah
Contact: Site Public Contact
Email: cancerinfo@hci.utah.edu
LDS Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Utah Cancer Specialists-Salt Lake City
Contact: Site Public Contact
Email: officeofresearch@imail.org
VA
Bristol
Wellmont Medical Associates-Bristol
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: uvacancertrials@hscmail.mcc.virginia.edu
Lynchburg
Centra Alan B Pearson Regional Cancer Center
Contact: Site Public Contact
Email: Kevin.Patel@centrahealth.com
Norton
Southwest VA Regional Cancer Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Richmond
Virginia Commonwealth University/Massey Cancer Center
Contact: Site Public Contact
Email: CTOclinops@vcu.edu
WA
Aberdeen
Providence Regional Cancer System-Aberdeen
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Anacortes
Cancer Care Center at Island Hospital
Contact: Site Public Contact
Email: eoates@islandhospital.org
Auburn
MultiCare Auburn Medical Center
Contact: Site Public Contact
Email: research@multicare.org
Bainbridge Island
Virginia Mason Bainbridge Island Medical Center
Contact: Site Public Contact
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Swedish Cancer Institute-Eastside Oncology Hematology
Contact: Site Public Contact
Email: CancerResearch@swedish.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Centralia
Providence Regional Cancer System-Centralia
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Edmonds
Swedish Cancer Institute-Edmonds
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Enumclaw
Saint Elizabeth Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Everett
Providence Regional Cancer Partnership
Contact: Site Public Contact
Email: marilyn.birchman@providence.org
Federal Way
Saint Francis Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Virginia Mason Federal Way Medical Center
Contact: Site Public Contact
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Gig Harbor
MultiCare Gig Harbor Medical Park
Contact: Site Public Contact
Email: research@multicare.org
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Contact: Site Public Contact
Email: info@tacomaradiation.com
Issaquah
Swedish Cancer Institute-Issaquah
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Contact: Site Public Contact
Email: research@kadlecmed.org
Northwest Cancer Clinic
Contact: Site Public Contact
Email: info@tacomaradiation.com
Lacey
Providence Regional Cancer System-Lacey
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Lakewood
Saint Clare Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Longview
PeaceHealth Saint John Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Lynnwood
Virginia Mason Lynnwood Medical Center
Contact: Site Public Contact
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Peninsula Cancer Center
Contact: Site Public Contact
Email: doctors@peninsulacancercenter.com
Puyallup
MultiCare Good Samaritan Hospital
Contact: Site Public Contact
Email: research@multicare.org
Tacoma/Valley Radiation Oncology Centers-Puyallup
Contact: Site Public Contact
Email: info@tacomaradiation.com
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Seattle
Kaiser Permanente Washington
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Minor and James Medical PLLC
Contact: Site Public Contact
Pacific Gynecology Specialists
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Virginia Mason Medical Center
Contact: Site Public Contact
Email: vmmc.cancer_clinical_research@VirginiaMason.org
Sedro-Woolley
PeaceHealth United General Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Shelton
Providence Regional Cancer System-Shelton
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Silverdale
Saint Michael Cancer Center
Contact: Site Public Contact
Email: conchitapurchase@chifranciscan.org
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Deaconess Cancer and Blood Specialty Center - North
Contact: Site Public Contact
Email: research@multicare.org
Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Contact: Site Public Contact
Email: research@multicare.org
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Mary Bridge Children's Hospital and Health Center
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Tacoma General Hospital
Contact: Site Public Contact
Email: research@multicare.org
Northwest Medical Specialties PLLC
Contact: Site Public Contact
Email: research@southsoundcare.org
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
Contact: Site Public Contact
Email: info@tacomaradiation.com
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Contact: Site Public Contact
Email: info@tacomaradiation.com
Vancouver
PeaceHealth Southwest Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Contact: Site Public Contact
Email: Cheryl.Dodd@providence.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Contact: Site Public Contact
Email: Memorial-ClinicalTrials@yvmh.org
Yelm
Providence Regional Cancer System-Yelm
Contact: Site Public Contact
Email: deidre.dillon@providence.org
WI
Antigo
Langlade Hospital and Cancer Center
Contact: Site Public Contact
Email: Juli.Alford@aspirus.org
Ashland
Duluth Clinic Ashland
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Northwest Wisconsin Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Chippewa Falls
Marshfield Clinic-Chippewa Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Eau Claire
Marshfield Clinic Cancer Center at Sacred Heart
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Green Bay
Bellin Memorial Hospital
Contact: Site Public Contact
Green Bay Oncology Limited at Saint Mary's Hospital
Contact: Brian Leslie Burnette
Green Bay Oncology at Saint Vincent Hospital
Contact: Brian Leslie Burnette
Saint Vincent Hospital Cancer Center Green Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Saint Vincent Hospital Cancer Center at Saint Mary's
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Johnson Creek
University of Wisconsin Carbone Cancer Center - Johnson Creek
Contact: Site Public Contact
Email: lynda.persico@uwmf.wisc.edu
La Crosse
Gundersen Lutheran Medical Center
Contact: Site Public Contact
Email: cancerctr@gundersenhealth.org
Ladysmith
Marshfield Medical Center - Ladysmith
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Madison
University of Wisconsin Carbone Cancer Center - University Hospital
Contact: Site Public Contact
Manitowoc
Holy Family Memorial Hospital
Contact: Site Public Contact
Marinette
Saint Vincent Hospital Cancer Center at Marinette
Contact: Site Public Contact
Email: Christy.Gilchrist@hshs.org
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Medford
Aspirus Medford Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Milwaukee
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Medical College of Wisconsin
Contact: Site Public Contact
Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Rice Lake
Lakeview Medical Center-Marshfield Clinic
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sheboygan
HSHS Saint Nicholas Hospital
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sturgeon Bay
Green Bay Oncology - Sturgeon Bay
Contact: Brian Leslie Burnette
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Wausau
Aspirus Regional Cancer Center
Contact: Site Public Contact
Marshfield Clinic-Wausau Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Aspirus Cancer Care - Wisconsin Rapids
Contact: Site Public Contact
Marshfield Clinic - Wisconsin Rapids Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
WV
Bridgeport
United Hospital Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
Huntington
Edwards Comprehensive Cancer Center
Contact: Site Public Contact
Martinsburg
WVUH-Berkely Medical Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu
Morgantown
West Virginia University Healthcare
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu
Parkersburg
Camden Clark Medical Center
Contact: Site Public Contact
Email: cancertrialsinfo@hsc.wvu.edu
PRIMARY OBJECTIVE: I. To determine whether initial treatment with either combination ipilimumab + nivolumab (with subsequent dabrafenib mesylate [dabrafenib] in combination with trametinib dimethyl sulfoxide [trametinib]) or dabrafenib in combination with trametinib (with subsequent ipilimumab + nivolumab) significantly improves 2 year overall survival (OS) in patients with unresectable stage III or stage IV BRAFV600 mutant melanoma. SECONDARY CLINICAL OBJECTIVES: I. To evaluate the impact of initial treatment on median OS and hazard ratio for death. II. To determine whether initial treatment choice significantly improves 3 year OS. III. To evaluate the anti-tumor activities (Response Evaluation Criteria in Solid Tumors [RECIST]-defined response rate, median progression-free survival [PFS]) and safety profiles of ipilimumab + nivolumab and dabrafenib-trametinib in a Cooperative Group trial of patients with V600 mutant melanoma. IV. To evaluate the activity (RECIST-defined response rate, median PFS) and safety of dabrafenib + trametinib in patients who have had disease progression on ipilimumab + nivolumab and in comparison to its activity and safety in ipilimumab + nivolumab naive patients. V. To evaluate the activity of ipilimumab + nivolumab (RECIST-defined response rate, median PFS) and safety in patients who have had disease progression on dabrafenib + trametinib and in comparison to its activity and safety in dabrafenib + trametinib naive patients. VI. To assess the feasibility of crossover to the alternative treatment strategy (percentage of patients who are able to crossover from one arm to the other and complete at least an initial course [12 weeks] of treatment after cross-over without intervening symptomatic disease progression or treatment limiting toxicity). SECONDARY LABORATORY OBJECTIVES: I. Association of inherited variation with immune mediated adverse events and response to ipilimumab + nivolumab. Ia. To determine the association of inherited genetic variation and immune-associated adverse events in patients with metastatic melanoma treated with ipilimumab containing regimens by completing candidate-based gene and pathway analyses of genes involved in lymphocyte activation, cytokines, cytokine receptors and within the major histocompatibility complex (MHC) region and an agnostic genome-wide single nucleotide polymorphism (SNP)-based approach; Ib. To investigate the association between inherited genetics and survival in patients with metastatic melanoma treated with ipilimumab containing regimens by completing candidate-based gene and pathway analyses of genes involved in lymphocyte activation, cytokines profile, cytokine receptors and within the MHC region and an agnostic genome-wide SNP-based approach; Ic. To replicate genomic markers identified in the above aims in an independent sample set of patients treated with ipilimumab containing regimens and preliminarily characterize their potential functional role by completing replication of variation as associated with immune-related adverse events (irAEs) and survival and bio-informatic assessment of genomic markers. II. To determine the utility of circulating BRAF levels in determining the response and resistance to either BRAF/MEK directed and/or combination immunotherapy in patients with BRAF mutant melanoma. IIa. To determine if changes in blood BRAF levels utilizing peripheral blood BRAFV600 mutational testing in patients with stage IV BRAF mutant melanoma correlate with response and resistance to combination BRAF/MEK directed therapy; IIb. To determine if changes in blood BRAF levels utilizing peripheral blood BRAFV600 mutational testing in patients with stage IV BRAF mutant melanoma correlate with response and resistance to combination immunotherapy; IIc. To compare the kinetics of peripheral blood BRAFV600 levels during response and resistance in groups of patients receiving BRAF targeted therapy or combination immunotherapy as initial therapy; IId. To compare the kinetics of peripheral blood BRAFV600 levels during response and resistance to combination BRAF targeted therapy or combination immunotherapy in individual patients (initial treatment versus [vs] crossover treatment). SECONDARY PATIENT REPORTED OUTCOMES OBJECTIVES: I. To evaluate differences in overall health between initial treatment arms (dabrafenib + trametinib vs. ipilimumab + nivolumab immunotherapy) at 2 years, accounting for toxicities and overall survival. (Primary) II. To assess differences in overall function over 2 years between initial treatment with dabrafenib + trametinib vs. ipilimumab + nivolumab. (Secondary) III. To document the effects of treatment crossover and treatment administration sequence on symptom burden and overall function. (Secondary) IIIa. To compare differences in function and symptoms by treatment sequence for ipilimumab + nivolumab (arm A vs. D), and dabrafenib + trametinib, (arm B vs. C) at baseline, 6 weeks, 12 weeks, and 6 months after the initiation of each treatment; IIIb. To describe the frequency and severity of treatment toxicities at baseline, 6 weeks, 12 weeks, and 6 months after initiation of each treatment. EXPLORATORY TOBACCO USE OBJECTIVES: I. To determine the effects of tobacco, operationalized as combustible tobacco (1a), other forms of tobacco (1b), and environmental tobacco exposure (ETS) (1c) on provider-reported cancer-treatment toxicity (adverse events [both clinical and hematologic] and dose modifications). II. To determine the effects of tobacco on patient-reported physical symptoms and psychological symptoms. III. To examine quitting behaviors and behavioral counseling/support and cessation medication utilization. IV. To explore the effect of tobacco use and exposure on treatment duration, relative dose intensity, and therapeutic benefit. EXPLORATORY CORRELATIVE OBJECTIVES: I. To assess serum based biomarkers of efficacy and adverse events due to treatment with immune checkpoint inhibitors. II. To monitor tumor response by comparing changes in circulating cell-free mutant tumor deoxyribonucleic acid (DNA) (ctDNA) as a readout of tumor burden (a) at week 12 relative to baseline before treatment in responders and non-responders; (b) before and during immunosuppressive treatment to control irAEs. III. To monitor organ-specific adverse events (irAEs) using circulating cell-free, tissue-specific methylated DNA (cmeDNA) as a readout of tissue-specific toxicity (a) at the time of grade 3-4 irAE relative to baseline and control patients without irAEs; (b) during immunosuppressive treatment for irAEs. OUTLINE: Patients are randomized to 1 of 2 treatment arms (Arm A or Arm B). ARM A: IMMUNOTHERAPY INDUCTION (CYCLES 1-2): Patients receive nivolumab intravenously (IV) over 30-60 minutes and ipilimumab IV over 30-90 minutes on days 1 and 22. Treatment repeats every 6 weeks for 2 cycles in the absence of disease progression or unacceptable toxicity. IMMUNOTHERAPY MAINTENANCE (CYCLES 3-14): Patients receive nivolumab IV over 30-60 minutes on days 1, 15, and 29. Treatment repeats every 6 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Upon disease progression (or before), patients re-register and cross over to Arm C. ARM C: Patients receive dabrafenib mesylate orally (PO) twice daily (BID) and trametinib dimethyl sulfoxide PO daily on days 1-42. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. ARM B: Patients receive dabrafenib mesylate PO BID and trametinib dimethyl sulfoxide PO daily on days 1-42. Cycles repeat every 6 weeks in the absence of disease progression or unacceptable toxicity. Upon disease progression (or before), patients re-register and cross over to Arm D. ARM D: IMMUNOTHERAPY INDUCTION (CYCLES 1-2): Patients receive nivolumab IV over 30-60 minutes and ipilimumab IV over 30-90 minutes on days 1 and 22. Treatment repeats every 6 weeks for 2 cycles in the absence of disease progression or unacceptable toxicity. IMMUNOTHERAPY MAINTENANCE (CYCLES 3-14): Patients receive nivolumab IV over 30-60 minutes on days 1, 15, and 29. Treatment repeats every 6 weeks for up to 12 cycles in the absence of disease progression or unacceptable toxicity. All patients also undergo computed tomography (CT), echocardiography (ECHO) or multigated acquisition scan (MUGA), and collection of blood samples throughout the trial. After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 3 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed and conducted this trial with funding from the National Cancer Institute through its National Clinical Trials Network.
![EA6134 / DREAMseq (Closed)](https://ecog-acrin.org/wp-content/uploads/2020/12/NO-TAG-LINE-ECOG-ACRIN_Logo_700px-wide-1.jpg)