Lung Cancer
EA5182
Osimertinib with or without Bevacizumab as Initial Treatment for Patients with EGFR-Mutant Lung Cancer
STATUS: Active
This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling pathways that control cell division and survival. Sometimes, mutations in the EGFR gene cause EGFR proteins to be made in higher than normal amounts on some types of cancer cells. This causes cancer cells to divide more rapidly. Osimertinib may stop the growth of tumor cells by blocking EGFR that is needed for cell growth in this type of cancer. Monoclonal antibodies, such as bevacizumab, may interfere with the ability of tumor cells to grow and spread. Giving osimertinib with bevacizumab may control cancer for longer and help patients live longer as compared to osimertinib alone.
- Patient must have a pathologically-confirmed diagnosis of non-squamous, non-small cell lung cancer (NSCLC)
- Patient must have advanced disease, defined as - either stage IV disease, stage IIIB disease not amenable to definitive multi-modality therapy, or recurrent disease after a prior diagnosis of stage I-III disease. All staging is via the American Joint Committee on Cancer (AJCC)/International Association for the Study of Lung Cancer (IASLC) 8th edition staging criteria
- Patient must have somatic activating sensitizing mutation in EGFR (e.g. but not limited to Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I). Patients with non-sensitizing mutations in EGFR (EGFR exon 20 insertions) are not eligible. Test results originating from a Clinical Laboratory Improvement Act (CLIA)-certified or similarly accredited laboratory are acceptable; no specific assay is mandated. Plasma, cytology, or tumor tissue can be utilized for mutation testing
- Patient must not have received any prior treatment with an anti-VEGF agent * NOTE: Prior treatment with an EGFR TKI is not allowed, however if a candidate for this study has already started osimertinib within 21 days prior to randomization, the exact osimertinib start date is known, and the patient had the required study baseline imaging completed prior to the osimertinib start date, the patient will be eligible
- Patients that have received prior radiation therapy are eligible. Radiation (limited field stereotactic radiation or conventional radiation) must have been completed at least one week prior to study drug initiation and more extensive field radiation (i.e., whole-brain radiotherapy [WBRT]) must have been completed at least two weeks prior to drug initiation
- Patient must not have any risk factors for anti-VEGF administration, specifically, hemoptysis, active cardiovascular disease, uncontrolled hypertension, significant proteinuria (screening urinalysis > 300 mg/dl) and tumor invading major blood vessels
- Patient must have measurable disease. Baseline measurements of sites of disease must be obtained within 4 weeks prior to study randomization. If a potential target lesion is previously irradiated without subsequent growth and/or is radiated after the imaging from which baseline measurements are obtained, they cannot be included as target lesions, and additional target lesions are required to meet criteria for measurable disease
- Patient must not have had any prior systemic treatment for metastatic disease
- Patient must be ≥ 18 years of age
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used
- All females of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy
- A female of childbearing potential is defined as any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patient of childbearing potential and sexually active males must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for 2 weeks prior to the start of treatment, while on study treatment, and for * 6 weeks after the last dose of protocol treatment for female patients on the osimertinib (AZD9291) alone arm * 4 months after the last dose of protocol treatment for male patients on osimertinib (AZD9291) alone arm * 6 months after the last dose of protocol treatment for all patients on osimertinib (AZD9291) plus bevacizumab combination arm * NOTE: Female patients should also not breastfeed while on treatment and for 6 months after the last dose bevacizumab
- Leukocytes >= 3,000/mcL (obtained =< 14 days prior to randomization)
- Absolute neutrophil count >= 1,500/mcL (obtained =< 14 days prior to randomization)
- Platelets >= 100,000/mcL (obtained =< 14 days prior to randomization)
- Hemoglobin >= 9 g/dL (obtained =< 14 days prior to randomization)
- Total bilirubin and creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained =< 14 days prior to randomization)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (obtained =< 14 days prior to randomization)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients with treated brain metastases are eligible if neurologically stable without glucocorticoid therapy after the stated washout period from radiation therapy (RT) or surgery provided the metastatic lesions are non-hemorrhagic
- Patients with untreated brain metastases or leptomeningeal disease are eligible if the treating physician determines that immediate CNS specific treatment is not required provided the metastatic lesions are non-hemorrhagic and are neurologically stable without glucocorticoid therapy
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- Patients with known history or current symptoms of cardiac disease, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
- Patient must have the ability to understand and the willingness to sign a written informed consent document and comply with study requirements
- Patient must not have had treatment with any investigational drug within five half-lives or 3 months (whichever is greater), prior to study initiation
- Patient must not be currently receiving (or unable to stop use prior to receiving the first dose of study treatment) medications or herbal supplements known to be strong inducers of CYP3A4. For any patient currently receiving such inducers of CYP3A4, they must discontinue use prior to first dose of study treatment. All patients must try to avoid concomitant use of any medications, herbal supplements and/or ingestion of foods with known inducer effects on CYP3A4
- Patient must not have any unresolved toxicities from prior therapy greater than Common Terminology Criteria for Adverse Events (CTCAE) grade 1 at the time of randomization, with the exception of alopecia and grade 2 prior platinum-therapy–related neuropathy
- Patient must not have any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator’s opinion makes it challenging for the patient to participate in the study. Screening for chronic conditions is not required
- Patient must not have refractory nausea and vomiting, chronic gastrointestinal diseases, the inability to swallow the osimertinib tablets or previous significant bowel resection that would preclude adequate absorption of osimertinib
- Patient must not have a medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease
- Patient must not have a history of hypersensitivity to active or inactive excipients of osimertinib or drugs with a similar chemical structure or class to osimertinib
- Patient must not have mean resting corrected QT interval (QTc) > 470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc value (using Bazett’s correction)
- Patient must not have any clinically important abnormalities in rhythm, conduction or morphology of resting ECG e.g. complete left bundle branch block, third degree heart block and second-degree heart block
- Patient must not have any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, electrolyte abnormalities (including: potassium < lower limit of normal [LLN]; magnesium < LLN; calcium < LLN), congenital long QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval and cause torsades de pointes
United States
AK
Anchorage
Alaska Breast Care and Surgery LLC
Contact: Site Public Contact
Email: AKPAMC.OncologyResearchSupport@providence.org
Alaska Oncology and Hematology LLC
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Alaska Women's Cancer Care
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Anchorage Associates in Radiation Medicine
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Anchorage Oncology Centre
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Anchorage Radiation Therapy Center
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Email: AKPAMC.OncologyResearchSupport@providence.org
Katmai Oncology Group
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Email: AKPAMC.OncologyResearchSupport@providence.org
Providence Alaska Medical Center
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Email: AKPAMC.OncologyResearchSupport@providence.org
Fairbanks
Fairbanks Memorial Hospital
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Email: Veronica.Stevenson@foundationhealth.org
AR
Ft. Smith
Mercy Hospital Fort Smith
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Hot Springs
CHI Saint Vincent Cancer Center Hot Springs
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Email: ResearchInstituteInquiries@CommonSpirit.org
Jonesboro
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Email: Emily.Carvell@bmhcc.org
AZ
Phoenix
Cancer Center at Saint Joseph's
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Email: ResearchInstituteInquiries@CommonSpirit.org
CA
Antioch
Kaiser Permanente-Deer Valley Medical Center
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Email: Kpoct@kp.org
Arroyo Grande
Mission Hope Medical Oncology - Arroyo Grande
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Email: ResearchInstituteInquiries@CommonSpirit.org
Burbank
Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Email: Najee.Boucher@providence.org
Dublin
Kaiser Permanente Dublin
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Fremont
Kaiser Permanente-Fremont
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Email: Kpoct@kp.org
Washington Hospital
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Fresno
Kaiser Permanente-Fresno
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Email: Kpoct@kp.org
La Jolla
UC San Diego Moores Cancer Center
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Email: cancercto@ucsd.edu
Modesto
Kaiser Permanente-Modesto
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Oakland
Kaiser Permanente-Oakland
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Palo Alto
Stanford Cancer Institute Palo Alto
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Email: ccto-office@stanford.edu
Richmond
Kaiser Permanente-Richmond
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Roseville
Kaiser Permanente-Roseville
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Sacramento
Kaiser Permanente Downtown Commons
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Kaiser Permanente-South Sacramento
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University of California Davis Comprehensive Cancer Center
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Salinas
Salinas Valley Memorial
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Email: tnielsen2@svmh.com
San Francisco
Kaiser Permanente-San Francisco
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Email: Kpoct@kp.org
San Jose
Kaiser Permanente-Santa Teresa-San Jose
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San Leandro
Kaiser Permanente San Leandro
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San Luis Obispo
Pacific Central Coast Health Center-San Luis Obispo
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Email: ResearchInstituteInquiries@CommonSpirit.org
San Rafael
Kaiser San Rafael-Gallinas
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Email: Kpoct@kp.org
Santa Clara
Kaiser Permanente Medical Center - Santa Clara
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Email: Kpoct@kp.org
Santa Maria
Mission Hope Medical Oncology - Santa Maria
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Email: ResearchInstituteInquiries@CommonSpirit.org
Santa Rosa
Kaiser Permanente-Santa Rosa
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Email: Kpoct@kp.org
South San Francisco
Kaiser Permanente-South San Francisco
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Email: Kpoct@kp.org
Stockton
Kaiser Permanente-Stockton
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Email: Kpoct@kp.org
Vacaville
Kaiser Permanente Medical Center-Vacaville
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Email: Kpoct@kp.org
Vallejo
Kaiser Permanente-Vallejo
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Email: Kpoct@kp.org
Walnut Creek
Kaiser Permanente-Walnut Creek
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Email: Kpoct@kp.org
CO
Aurora
Rocky Mountain Cancer Centers-Aurora
Contact: Site Public Contact
Email: info@westernstatesncorp.org
The Medical Center of Aurora
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Email: info@westernstatesncorp.org
Boulder
Boulder Community Foothills Hospital
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Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Boulder
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Email: info@westernstatesncorp.org
Centennial
Rocky Mountain Cancer Centers - Centennial
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Email: info@westernstatesncorp.org
Colorado Springs
Penrose-Saint Francis Healthcare
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Email: ResearchInstituteInquiries@CommonSpirit.org
Rocky Mountain Cancer Centers-Penrose
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Email: ResearchInstituteInquiries@CommonSpirit.org
Denver
Colorado Blood Cancer Institute
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Email: info@westernstatesncorp.org
Kaiser Permanente-Franklin
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Email: kristi.m.bronkan@kp.org
Porter Adventist Hospital
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Email: ResearchTracking@Centura.Org
Presbyterian - Saint Lukes Medical Center - Health One
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Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Midtown
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Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers-Rose
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Email: info@westernstatesncorp.org
Rose Medical Center
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Email: ccrp@co-cancerresearch.org
The Women's Imaging Center
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Email: info@westernstatesncorp.org
Western Surgical Care
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Durango
Mercy Medical Center
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Email: ResearchInstituteInquiries@CommonSpirit.org
Southwest Oncology PC
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Email: ResearchInstituteInquiries@CommonSpirit.org
Englewood
Mountain Blue Cancer Care Center - Swedish
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Email: info@westernstatesncorp.org
Rocky Mountain Cancer Centers - Swedish
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Email: info@westernstatesncorp.org
Swedish Medical Center
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Email: info@westernstatesncorp.org
The Melanoma and Skin Cancer Institute
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Email: ryan.weight@theskincancerinstitute.com
Greeley
Banner North Colorado Medical Center
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Email: BMDACCResearchCOMailbox@bannerhealth.com
Lafayette
Kaiser Permanente-Rock Creek
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Email: kristi.m.bronkan@kp.org
Lakewood
Rocky Mountain Cancer Centers-Lakewood
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Email: info@westernstatesncorp.org
Saint Anthony Hospital
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Email: ResearchInstituteInquiries@CommonSpirit.org
Littleton
Littleton Adventist Hospital
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Email: ResearchTracking@Centura.Org
Rocky Mountain Cancer Centers-Littleton
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Email: info@westernstatesncorp.org
Lone Tree
Kaiser Permanente-Lone Tree
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Email: kristi.m.bronkan@kp.org
Rocky Mountain Cancer Centers-Sky Ridge
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Email: info@westernstatesncorp.org
Sky Ridge Medical Center
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Email: info@westernstatesncorp.org
Longmont
Longmont United Hospital
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Email: ResearchInstituteInquiries@CommonSpirit.org
Rocky Mountain Cancer Centers-Longmont
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Email: ResearchTracking@Centura.Org
Loveland
Banner McKee Medical Center
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Email: BMDACCResearchCOMailbox@bannerhealth.com
Parker
Parker Adventist Hospital
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Email: ResearchTracking@Centura.Org
Pueblo
Saint Mary Corwin Medical Center
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Email: ResearchInstituteInquiries@CommonSpirit.org
Thornton
Rocky Mountain Cancer Centers-Thornton
Contact: Site Public Contact
Email: info@westernstatesncorp.org
CT
Derby
Smilow Cancer Hospital-Derby Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Fairfield
Smilow Cancer Hospital Care Center-Fairfield
Contact: Site Public Contact
Email: canceranswers@yale.edu
Glastonbury
Smilow Cancer Hospital Care Center at Glastonbury
Contact: Site Public Contact
Email: canceranswers@yale.edu
Greenwich
Smilow Cancer Hospital Care Center at Greenwich
Contact: Site Public Contact
Email: canceranswers@yale.edu
Guilford
Smilow Cancer Hospital Care Center - Guilford
Contact: Site Public Contact
Email: canceranswers@yale.edu
Hartford
Hartford Hospital
Contact: Site Public Contact
Smilow Cancer Hospital Care Center at Saint Francis
Contact: Site Public Contact
Email: canceranswers@yale.edu
New Haven
Yale University
Contact: Site Public Contact
Email: canceranswers@yale.edu
North Haven
Yale-New Haven Hospital North Haven Medical Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Orange
Smilow Cancer Hospital-Orange Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Stamford
Smilow Cancer Hospital Care Center at Long Ridge
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Email: canceranswers@yale.edu
Stamford Hospital/Bennett Cancer Center
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Torrington
Smilow Cancer Hospital-Torrington Care Center
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Email: canceranswers@yale.edu
Trumbull
Smilow Cancer Hospital Care Center-Trumbull
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterford
Smilow Cancer Hospital Care Center - Waterford
Contact: Site Public Contact
Email: canceranswers@yale.edu
DE
Lewes
Beebe Medical Center
Contact: Site Public Contact
Email: research@beebehealthcare.org
Millville
Beebe South Coastal Health Campus
Contact: Site Public Contact
Email: research@beebehealthcare.org
Newark
Christiana Care Health System-Christiana Hospital
Contact: Site Public Contact
Email: lbarone@christianacare.org
Delaware Clinical and Laboratory Physicians PA
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Email: mhayden@christianacare.org
Helen F Graham Cancer Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Medical Oncology Hematology Consultants PA
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Email: lbarone@christianacare.org
Rehoboth Beach
Beebe Health Campus
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Email: research@beebehealthcare.org
Seaford
TidalHealth Nanticoke / Allen Cancer Center
Contact: Site Public Contact
Email: anna-maria.howard@peninsula.org
Wilmington
Christiana Care Health System-Wilmington Hospital
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Email: lbarone@christianacare.org
FL
Fort Lauderdale
Holy Cross Hospital
Contact: Site Public Contact
Email: eileen.georgi@holy-cross.com
GA
Atlanta
Emory University Hospital Midtown
Contact: Site Public Contact
Emory University Hospital/Winship Cancer Institute
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Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
HI
Aiea
Hawaii Cancer Care - Westridge
Contact: Site Public Contact
Email: info@hawaiicancercare.com
Pali Momi Medical Center
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Queen's Cancer Center - Pearlridge
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The Cancer Center of Hawaii-Pali Momi
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Honolulu
Hawaii Cancer Care Inc - Waterfront Plaza
Contact: Site Public Contact
Email: i.webster@hawaiicancercare.com
Kaiser Permanente Moanalua Medical Center
Contact: Site Public Contact
Email: shelley.a.clark@kp.org
Kapiolani Medical Center for Women and Children
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Kuakini Medical Center
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Queen's Cancer Cenrer - POB I
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Queen's Cancer Center - Kuakini
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Queen's Medical Center
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Straub Clinic and Hospital
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The Cancer Center of Hawaii-Liliha
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University of Hawaii Cancer Center
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Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Contact: Site Public Contact
IA
Ames
Mary Greeley Medical Center
Contact: Site Public Contact
McFarland Clinic - Ames
Contact: Site Public Contact
Email: ksoder@mcfarlandclinic.com
Ankeny
Mission Cancer and Blood - Ankeny
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Boone
McFarland Clinic - Boone
Contact: Site Public Contact
Carroll
Saint Anthony Regional Hospital
Contact: Site Public Contact
Email: sbenson@iora.org
Clive
Mercy Cancer Center-West Lakes
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Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - West Des Moines
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Council Bluffs
Alegent Health Mercy Hospital
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Email: ResearchInstituteInquiries@CommonSpirit.org
Creston
Greater Regional Medical Center
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Email: cancerresearch@mercydesmoines.org
Des Moines
Broadlawns Medical Center
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Iowa Lutheran Hospital
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Iowa Methodist Medical Center
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Mercy Medical Center - Des Moines
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Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - Des Moines
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Mission Cancer and Blood - Laurel
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Fort Dodge
McFarland Clinic - Trinity Cancer Center
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Trinity Regional Medical Center
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Jefferson
McFarland Clinic - Jefferson
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Marshalltown
McFarland Clinic - Marshalltown
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West Des Moines
Mercy Medical Center-West Lakes
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Email: cancerresearch@mercydesmoines.org
Methodist West Hospital
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ID
Boise
Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact
Email: eslinget@slhs.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Fruitland
Saint Luke's Cancer Institute - Fruitland
Contact: Site Public Contact
Email: eslinget@slhs.org
Meridian
Idaho Urologic Institute-Meridian
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Meridian
Contact: Site Public Contact
Email: eslinget@slhs.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Luke's Cancer Institute - Nampa
Contact: Site Public Contact
Email: eslinget@slhs.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Cancer Institute - Twin Falls
Contact: Site Public Contact
Email: eslinget@slhs.org
IL
Alton
Saint Anthony's Health
Contact: Site Public Contact
Aurora
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Chicago
Jesse Brown Veterans Affairs Medical Center
Contact: Site Public Contact
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Swedish Covenant Hospital
Contact: Site Public Contact
University of Illinois
Contact: Site Public Contact
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@Carle.com
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Harvey
Ingalls Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@ingalls.org
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Mount Vernon
Good Samaritan Regional Health Center
Contact: Site Public Contact
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Springfield
Memorial Medical Center
Contact: Site Public Contact
Email: pallante.beth@mhsil.com
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Crown Point
Northwest Cancer Center - Main Campus
Contact: Site Public Contact
Dyer
Northwest Oncology LLC
Contact: Site Public Contact
Hobart
Northwest Cancer Center - Hobart
Contact: Site Public Contact
Saint Mary Medical Center
Contact: Site Public Contact
Email: CancerResearch@COMHS.org
Indianapolis
Saint Catherine Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Munster
The Community Hospital
Contact: Site Public Contact
Women's Diagnostic Center - Munster
Contact: Site Public Contact
Email: mnicholson@comhs.org
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Valparaiso
Northwest Cancer Center - Valparaiso
Contact: Site Public Contact
Email: CancerResearch@COMHS.org
KS
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: research@viachristi.org
KY
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Corbin
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lexington
Saint Joseph Hospital East
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
London
Saint Joseph London
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Louisville
Jewish Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: ctoinfo@louisville.edu
Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
MA
Beverly
Beverly Hospital
Contact: Site Public Contact
Burlington
Lahey Hospital and Medical Center
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
Gloucester
Addison Gilbert Hospital
Contact: Site Public Contact
Peabody
Lahey Medical Center-Peabody
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
Winchester
Winchester Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Bethesda
Walter Reed National Military Medical Center
Contact: Site Public Contact
MI
Adrian
Hickman Cancer Center
Contact: Site Public Contact
Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Caro
Caro Cancer Center
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Chelsea
Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Dearborn
Corewell Health Dearborn Hospital
Contact: Site Public Contact
Detroit
Ascension Saint John Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
East China
Great Lakes Cancer Management Specialists-Doctors Park
Contact: Site Public Contact
Email: karen.forman@ascension.org
Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: wstrong@ghci.org
Hurley Medical Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Grosse Pointe Woods
Academic Hematology Oncology Specialists
Contact: Site Public Contact
Email: karen.forman@ascension.org
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Grosse Pointe Woods
Contact: Site Public Contact
Email: karen.forman@ascension.org
Lansing
University of Michigan Health - Sparrow Lansing
Contact: Site Public Contact
Email: harsha.trivedi@umhsparrow.org
Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Macomb Township
Contact: Site Public Contact
Email: karen.forman@ascension.org
Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Monroe
Toledo Clinic Cancer Centers-Monroe
Contact: Site Public Contact
Pontiac
Hope Cancer Center
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Michigan Healthcare Professionals Pontiac
Contact: Site Public Contact
Email: Emily.Crofts@trinity-health.org
Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Saint Joseph Mercy Oakland Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Royal Oak
Corewell Health William Beaumont University Hospital
Contact: Site Public Contact
Saginaw
MyMichigan Medical Center Saginaw
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: karen.forman@ascension.org
Tawas City
MyMichigan Medical Center Tawas
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Troy
Corewell Health Beaumont Troy Hospital
Contact: Site Public Contact
Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Great Lakes Cancer Management Specialists-Macomb Professional Building
Contact: Site Public Contact
Email: karen.forman@ascension.org
Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Michigan Breast Specialists-Warren
Contact: Site Public Contact
Email: karen.forman@ascension.org
Saint John Macomb-Oakland Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
MN
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Chesterfield
Saint Luke's Hospital
Contact: Site Public Contact
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: amy.franken@health.missouri.edu
Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net
Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: research@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact
Mercy Hospital South
Contact: Site Public Contact
Email: Danielle.Werle@mercy.net
Missouri Baptist Medical Center
Contact: Site Public Contact
Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
Washington
Mercy Hospital Washington
Contact: Site Public Contact
MS
Columbus
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Grenada
Baptist Cancer Center-Grenada
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls Clinic
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Missoula
Community Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org
NC
Charlotte
Novant Health Presbyterian Medical Center
Contact: Site Public Contact
Email: kashah@novanthealth.org
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Huntersville
Novant Health Cancer Institute - Huntersville
Contact: Site Public Contact
Email: kashah@novanthealth.org
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kenansville
ECU Health Oncology Kenansville
Contact: Site Public Contact
Email: research@ecuhealth.org
Kernersville
Novant Health Cancer Institute - Kernersville
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
Kinston
ECU Health Oncology Kinston
Contact: Site Public Contact
Email: research@ecuhealth.org
Matthews
Novant Health Cancer Institute - Matthews
Contact: Site Public Contact
Email: kashah@novanthealth.org
Mooresville
Novant Health Cancer Institute - Mooresville
Contact: Site Public Contact
Email: kashah@novanthealth.org
Mount Airy
Novant Health Cancer Institute - Mount Airy
Contact: Site Public Contact
Email: asmarrs@novanthealth.org
North Wilkesboro
Novant Health Cancer Institute - Wilkesboro
Contact: Site Public Contact
Email: pjordan@novanthealth.org
Richlands
ECU Health Oncology Richlands
Contact: Site Public Contact
Email: research@ecuhealth.org
Stateville
Novant Health Cancer Institute - Statesville
Contact: Site Public Contact
Email: pjordan@novanthealth.org
Thomasville
Novant Health Cancer Institute - Thomasville
Contact: Site Public Contact
Email: pjordan@novanthealth.org
Winston-Salem
Novant Health Forsyth Medical Center
Contact: Site Public Contact
Email: pjordan@novanthealth.org
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Medical Center Fargo
Contact: Site Public Contact
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Southpointe-Sanford Medical Center Fargo
Contact: Site Public Contact
NE
Grand Island
Nebraska Cancer Specialists/Oncology Hematology West PC
Contact: Site Public Contact
Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lincoln
Cancer Partners of Nebraska
Contact: Site Public Contact
Email: research@cancerpartners.com
Cancer Partners of Nebraska - Pine Lake
Contact: Site Public Contact
Email: research@cancerpartners.com
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Creighton University Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
NJ
Basking Ridge
Memorial Sloan Kettering Basking Ridge
Contact: Site Public Contact
Jersey City
Jersey City Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Lakewood
Monmouth Medical Center Southern Campus
Contact: Site Public Contact
Email: mary.danish@rwjbh.org
Livingston
Saint Barnabas Medical Center
Contact: Site Public Contact
Email: joanne.loeb@rwjbh.org
Long Branch
Monmouth Medical Center
Contact: Site Public Contact
Email: mary.danish@rwjbh.org
Middletown
Memorial Sloan Kettering Monmouth
Contact: Site Public Contact
Montvale
Memorial Sloan Kettering Bergen
Contact: Site Public Contact
New Brunswick
Rutgers Cancer Institute of New Jersey
Contact: Site Public Contact
Paramus
The Valley Hospital - Luckow Pavilion
Contact: Site Public Contact
Email: clinicaltrialsresearch@valleyhealth.com
Ridgewood
Neurosurgeons of New Jersey-Ridgewood
Contact: Site Public Contact
Email: ctsucontact@westat.com
Valley Health System Ridgewood Campus
Contact: Site Public Contact
Email: clinicaltrialsresearch@valleyhealth.com
Somerville
Robert Wood Johnson University Hospital Somerset
Contact: Site Public Contact
Email: Siby.Varughese@rwjbh.org
Westwood
Valley Health System-Hematology/Oncology
Contact: Site Public Contact
Email: ctsucontact@westat.com
NM
Albuquerque
New Mexico Oncology Hematology Consultants
Contact: Site Public Contact
Email: CLee@nmcca.org
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: HSC-ClinicalTrialInfo@salud.unm.edu
NY
Bronx
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org
Buffalo
Roswell Park Cancer Institute
Contact: Site Public Contact
Email: askroswell@roswellpark.org
Commack
Memorial Sloan Kettering Commack
Contact: Site Public Contact
East Hills
The Cancer Institute at Saint Francis Hospital
Contact: Site Public Contact
Email: Stephanie.Solito@chsli.org
Glens Falls
Glens Falls Hospital
Contact: Site Public Contact
New York
Memorial Sloan Kettering Cancer Center
Contact: Site Public Contact
Mount Sinai Chelsea
Contact: Site Public Contact
Email: CCTO@mssm.edu
Mount Sinai Hospital
Contact: Site Public Contact
Email: CCTO@mssm.edu
Oswego
Upstate Cancer Center at Oswego
Contact: Site Public Contact
Email: McDowelE@upstate.edu
Syracuse
State University of New York Upstate Medical University
Contact: Site Public Contact
Uniondale
Memorial Sloan Kettering Nassau
Contact: Site Public Contact
Verona
Upstate Cancer Center at Verona
Contact: Site Public Contact
Email: McDowelE@upstate.edu
West Harrison
Memorial Sloan Kettering Westchester
Contact: Site Public Contact
West Islip
Good Samaritan University Hospital
Contact: Site Public Contact
White Plains
Dickstein Cancer Treatment Center
Contact: Site Public Contact
Email: mcortese@wphospital.org
OH
Avon
UH Seidman Cancer Center at UH Avon Health Center
Contact: Site Public Contact
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Chardon
Geauga Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
University of Cincinnati Cancer Center-UC Medical Center
Contact: Site Public Contact
Email: cancer@uchealth.com
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Cleveland Clinic Foundation
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Doctors Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Grant Medical Center
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Mount Carmel East Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mount Carmel Health Center West
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Riverside Methodist Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
The Mark H Zangmeister Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Premier Blood and Cancer Center
Contact: Site Public Contact
Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Grady Memorial Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Dublin
Dublin Methodist Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Gahanna
Central Ohio Breast and Endocrine Surgery
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Cancer Care and Infusion
Contact: Site Public Contact
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Kettering
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Lima
Saint Rita's Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mansfield
Cleveland Clinic Cancer Center Mansfield
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
OhioHealth Mansfield Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: Jennifer.Sexton@ohiohealth.com
Marysville
Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mayfield Heights
Hillcrest Hospital Cancer Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Newark Radiation Oncology
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Parma
University Hospitals Parma Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Sandusky
UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Toledo
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Mercy Health - Saint Vincent Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Toledo Clinic Cancer Centers-Toledo
Contact: Site Public Contact
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Wadsworth
University Hospitals Sharon Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warrensville Heights
South Pointe Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
West Chester
University of Cincinnati Cancer Center-West Chester
Contact: Site Public Contact
Email: cancer@uchealth.com
Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
Westlake
UH Seidman Cancer Center at Saint John Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: Jeffh@columbusccop.org
OK
Oklahoma City
Integris Cancer Institute of Oklahoma
Contact: Site Public Contact
Integris Southwest Medical Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
Mercy Hospital Oklahoma City
Contact: Site Public Contact
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org
Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Oregon City
Providence Willamette Falls Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Portland
Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact
PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Bryn Mawr
Bryn Mawr Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Chambersburg
Chambersburg Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Collegeville
Main Line Health Center-Collegeville
Contact: Site Public Contact
Email: turzoe@mlhs.org
East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Ephrata
Ephrata Cancer Center
Contact: Site Public Contact
Exton
Main Line Health Center-Exton
Contact: Site Public Contact
Email: turzoe@mlhs.org
Gettysburg
Adams Cancer Center
Contact: Site Public Contact
Hanover
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Hazleton
Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Lebanon
Sechler Family Cancer Center
Contact: Site Public Contact
Email: doxenberg@wellspan.org
Media
Riddle Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Paoli
Paoli Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact
Sayre
Guthrie Medical Group PC-Robert Packer Hospital
Contact: Site Public Contact
Wynnewood
Lankenau Medical Center
Contact: Site Public Contact
Email: turzoe@mlhs.org
York
Cancer Care Associates of York
Contact: Site Public Contact
WellSpan Health-York Cancer Center
Contact: Site Public Contact
WellSpan Health-York Hospital
Contact: Site Public Contact
RI
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu
SC
Charleston
Medical University of South Carolina
Contact: Site Public Contact
Email: hcc-clinical-trials@musc.edu
SD
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org
TN
Collierville
Baptist Memorial Hospital and Cancer Center-Collierville
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Nashville
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
TX
Baytown
Houston Methodist San Jacinto Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Dallas
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern Simmons Cancer Center - RedBird
Contact: Site Public Contact
Email: canceranswerline@utsouthwestern.edu
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Fort Worth
UT Southwestern/Simmons Cancer Center-Fort Worth
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Houston
Houston Methodist Hospital
Contact: Site Public Contact
Houston Methodist West Hospital
Contact: Site Public Contact
Methodist Willowbrook Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Nassau Bay
Houston Methodist Saint John Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Richardson
UT Southwestern Clinical Center at Richardson/Plano
Contact: Site Public Contact
Email: Suzanne.cole@utsouthwestern.edu
Sugar Land
Houston Methodist Sugar Land Hospital
Contact: Site Public Contact
The Woodlands
Houston Methodist The Woodlands Hospital
Contact: Site Public Contact
Email: hmthewoodlands@houstonmethodist.org
VA
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: uvacancertrials@hscmail.mcc.virginia.edu
WA
Aberdeen
Providence Regional Cancer System-Aberdeen
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Contact: Site Public Contact
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Centralia
Providence Regional Cancer System-Centralia
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Edmonds
Swedish Cancer Institute-Edmonds
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Enumclaw
Saint Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Everett
Providence Regional Cancer Partnership
Contact: Site Public Contact
Email: marilyn.birchman@providence.org
Federal Way
Saint Francis Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Issaquah
Swedish Cancer Institute-Issaquah
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Contact: Site Public Contact
Email: research@kadlecmed.org
Lacey
Providence Regional Cancer System-Lacey
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Lakewood
Saint Clare Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Longview
PeaceHealth Saint John Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Seattle
Pacific Gynecology Specialists
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Sedro-Woolley
PeaceHealth United General Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Shelton
Providence Regional Cancer System-Shelton
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Silverdale
Saint Michael Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Northwest Medical Specialties PLLC
Contact: Site Public Contact
Email: research@southsoundcare.org
Vancouver
PeaceHealth Southwest Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Contact: Site Public Contact
Email: Cheryl.Dodd@providence.org
Yelm
Providence Regional Cancer System-Yelm
Contact: Site Public Contact
Email: deidre.dillon@providence.org
WI
Eau Claire
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Janesville
Mercyhealth Hospital and Cancer Center - Janesville
Contact: Site Public Contact
Email: oncologyclinicaltrials@mhemail.org
La Crosse
Gundersen Lutheran Medical Center
Contact: Site Public Contact
Email: cancerctr@gundersenhealth.org
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Milwaukee
Medical College of Wisconsin
Contact: Site Public Contact
Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mukwonago
ProHealth D N Greenwald Center
Contact: Site Public Contact
Email: research.institute@phci.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Contact: Site Public Contact
Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Stevens Point
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Waukesha
ProHealth Waukesha Memorial Hospital
Contact: Site Public Contact
UW Cancer Center at ProHealth Care
Contact: Site Public Contact
Email: Chanda.miller@phci.org
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
WV
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
WY
Cheyenne
Cheyenne Regional Medical Center-West
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
Cody
Billings Clinic-Cody
Contact: Site Public Contact
Email: research@billingsclinic.org
Sheridan
Welch Cancer Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
PRIMARY OBJECTIVE: I. To evaluate progression-free survival (PFS) of osimertinib (AZD9291) and bevacizumab versus osimertinib (AZD9291) alone as first-line treatment for patients with metastatic EGFR-mutant lung cancers. SECONDARY OBJECTIVES: I. To evaluate overall survival (OS). II. To evaluate best objective response rate and duration of objective response. III. To evaluate time to central nervous system (CNS) progression and CNS PFS. IV. To evaluate toxicity of the combination regimen. CORRELATIVE OBJECTIVES: I. To characterize mechanisms of resistance to osimertinib (AZD9291) and osimertinib (AZD9291) with bevacizumab first-line therapy through post-progression circulating tumor-derived deoxyribonucleic acid (ctDNA). II. To assess for ctDNA clearance on study treatment and associate ctDNA clearance with clinical outcomes. OUTLINE: Patients are randomized to 1 of 2 arms. ARM A: Patients receive osimertinib orally (PO) once daily (QD) on days 1-21. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. ARM B: Patients receive osimertinib PO QD on days 1-21 and bevacizumab intravenously (IV) over 30-90 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients undergo echocardiography (ECHO), multigated acquisition scan (MUGA), computed tomography (CT) and may undergo magnetic resonance imaging (MRI) and blood sample collection on study. After completion of study treatment, patients are followed up every 3 months for 10 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its National Clinical Trials Network.
![EA5182 Home Page](https://ecog-acrin.org/wp-content/uploads/2020/12/NO-TAG-LINE-ECOG-ACRIN_Logo_700px-wide-1.jpg)