Lung Cancer
EA5163 / S1709 / INSIGNA
Testing the Timing of Pembrolizumab Alone or With Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer
STATUS: Closed to Accrual
This phase III trial studies whether pembrolizumab alone as a first-line treatment, followed by pemetrexed and carboplatin with or without pembrolizumab after disease progression is superior to induction with pembrolizumab, pemetrexed and carboplatin followed by pembrolizumab and pemetrexed maintenance in treating patients with stage IV non-squamous non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as pemetrexed, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. It is not yet known whether giving first-line pembrolizumab followed by pemetrexed and carboplatin with or without pembrolizumab works better in treating patients with non-squamous non-small cell cancer.
- Patients must have histologically or cytologically confirmed stage IV non-squamous non‐small cell lung cancer (NSCLC) (includes M1a, M1b, and M1c stage disease, American Joint Committee on Cancer [AJCC] 8th edition). Patients with stage IIIB and IIIC disease are eligible if they are not candidates for combined chemotherapy and radiation. Prior chemo-radiation therapy (RT) for stage III with recurrence is allowed
- Patients must have PD-L1 expression Tumor Proportion Score (TPS) >= 1% in tumor cells. If PD-L1 expression TPS is unevaluable or the testing could not be completed, the patients are not eligible. The assay must have been performed by a Clinical Laboratory Improvement Act (CLIA) (or equivalent) certified laboratory
- Patients must have measurable or non-measurable disease. The presence of malignant pleural fluid alone is sufficient to satisfy this eligibility criterion. Baseline imaging assessments and measurements used to evaluate all measurable or non-measurable sites of disease must be done within 4 weeks prior to study registration * NOTE: If patient receives pemetrexed, follow institutional guidelines to drain fluids * NOTE: An additional 15 days is allowed to account for any infection/exposure related logistical delays
- Patients must be >= 18 years of age
- Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
- Patients must NOT have received the following: * Prior systemic chemotherapy or immunotherapy for advanced metastatic NSCLC. Patients treated with any prior checkpoint inhibitors for metastatic lung cancer are ineligible. Chemotherapy for non-metastatic disease (e.g. adjuvant therapy) or immunotherapy for locally advanced stage III disease, or treated with neoadjuvant IO is allowed if at least 6 months have elapsed between the last dose of the prior therapy and study registration. Local therapy, e.g. palliative radiation, is allowed as long as a period of 14 days has passed between completion of local therapy and the start of protocol treatment. Registration during the 14 days is allowed. Palliative radiation must be to non-target lesions. Palliative radiation to pre-existing lesions while on protocol treatment is allowed as long as these areas have not grown to RECIST defined progression. Development of any new metastasis is considered progression. Concurrent radiation and protocol treatment is not allowed; protocol treatment may resume after completion of radiation as long as patient does not have greater than grade 2 side effects from radiation per physician discretion. * Methotrexate (MTX) given in low doses for non-malignant conditions with last dose at least 14 days prior to date of registration will be allowed. Other low dose chemotherapeutics for non-malignant conditions will be considered, but review by the study chair is required * Palliative radiation to non-target lesions (bone metastasis) is allowed if the patient develops symptoms
- Patients with known EGFR mutations (except exon 20 insertion), BRAF mutations (V600) or ALK or ROS1 translocations or other driver mutations that can be treated with oral tyrosine kinase inhibitors are excluded
- Patients with treated brain metastases are eligible if follow-up brain imaging obtained at least 14 days after central nervous system (CNS)-directed therapy shows no evidence of progression. CNS progression counts as progression and patients must move on to the next phase after CNS treatment. Patients with asymptomatic new (at screening) or progressive brain metastases (active brain metastases at screening) are eligible if the treating physician determines that immediate CNS specific treatment is not required and is unlikely to be required during the first cycle of therapy * Patients are eligible if off steroids for at least 14 days prior to protocol treatment * Anticonvulsants are allowed * Patients with asymptomatic, sub-centimeter brain metastasis who at the discretion of investigators do not need immediate CNS directed therapies are eligible
- Patients with prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- Patients must not have known pre-existing and clinically active interstitial lung disease, or a known history of (non infectious) pneumonitis that required steroids, or current pneumonitis
- Patients must not have significant gastrointestinal disorders with diarrhea as a major symptom (e.g., Crohn’s disease, malabsorption, etc.)
- Patients must not have history of auto-immune condition (including Guillain-Barre Syndrome or Multiple Sclerosis) requiring ongoing or intermittent systemic treatment in the past 2 years prior to registration (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
- Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
- Patients must not have any other concomitant serious illness or organ system dysfunction that in the opinion of the investigator would either compromise patient safety or interfere with the evaluation of the safety of the study drug
- Patients must not receive any other investigational agents during the course of therapy
- Patients must not be pregnant or breast-feeding due to potential harm to the fetus or infant from cytotoxic chemotherapy and the unknown risk of pembrolizumab (MK-3475). All patients of childbearing potential must have a blood test or urine study within 72 hours prior to registration to rule out pregnancy. A patient of childbearing potential is anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point; 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
- Patients must use accepted and effective method(s) of contraception or by abstaining from sexual intercourse from time of registration, while on study treatment, and continue for 120 days after the last dose of study treatment
- Absolute neutrophil count (ANC) >= 1500/mm^3 (within 14 days prior to randomization)
- Platelets >= 100,000/mm^3 (within 14 days prior to randomization)
- Prothrombin time (PT)/international normalized ratio (INR) (only if on active anticoagulation with warfarin or any formulations of heparin) =< 3.0 (within 14 day prior to randomization)
- Total bilirubin =< 1.5 mg/dL (obtained within 14 days prior to randomization)
- Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) < 5 x upper limit of normal (ULN) (obtained within 14 days prior to randomization)
- Serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) < 5 x upper limit of normal (ULN) (obtained within 14 days prior to randomization)
- Calculated creatinine clearance >= 45 ml/min to be eligible to receive pemetrexed (obtained within 14 days prior to randomization)
- Serum creatinine =< 1.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to randomization)
- Patients must not have a known history of active tuberculosis (TB)
- Patients must not have a diagnosis of immunodeficiency or receive systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of protocol treatment
- Patients must not have received a live vaccine within 30 days prior to randomization. Patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and COVID-19 (Note: intranasal influenza vaccines, such as Flu-Mist [registered trademark] are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events)
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable or on suppressive therapy, if indicated. Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
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La Jolla
UC San Diego Moores Cancer Center
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Cedars Sinai Medical Center
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Fremont - Rideout Cancer Center
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Merced
Mercy Cancer Center
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Sutter Cancer Research Consortium
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Saint Joseph Hospital - Orange
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Palo Alto Medical Foundation Health Care
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Kaiser Permanente-Rancho Cordova Cancer Center
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Mercy Cancer Center - Rocklin
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Rohnert Park Cancer Center
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Saint Helena Hospital
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Mercy Medical Center
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Mountain Blue Cancer Care Center - Swedish
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Mountain Blue Cancer Care Center
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Grand Valley Oncology
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Greeley
Banner North Colorado Medical Center
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UCHealth Highlands Ranch Hospital
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Good Samaritan Hospital - Cancer Centers of Colorado
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Rocky Mountain Cancer Centers-Lakewood
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Saint Anthony Hospital
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Littleton Adventist Hospital
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Longmont United Hospital
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Banner McKee Medical Center
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Parker
Parker Adventist Hospital
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Pueblo
Rocky Mountain Cancer Centers - Pueblo
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Thornton
National Jewish Health-Northern Hematology Oncology
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Rocky Mountain Cancer Centers-Thornton
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Wheat Ridge
Intermountain Health Lutheran Hospital
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CT
Derby
Smilow Cancer Hospital-Derby Care Center
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Fairfield
Smilow Cancer Hospital Care Center-Fairfield
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Guilford
Smilow Cancer Hospital Care Center - Guilford
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Hartford
Smilow Cancer Hospital Care Center at Saint Francis
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New Haven
Smilow Cancer Center/Yale-New Haven Hospital
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Yale University
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North Haven
Yale-New Haven Hospital North Haven Medical Center
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Orange
Smilow Cancer Hospital-Orange Care Center
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Stamford
Smilow Cancer Hospital Care Center at Long Ridge
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Stamford Hospital/Bennett Cancer Center
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Torrington
Smilow Cancer Hospital-Torrington Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Trumbull
Smilow Cancer Hospital Care Center-Trumbull
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterbury
Smilow Cancer Hospital-Waterbury Care Center
Contact: Site Public Contact
Email: canceranswers@yale.edu
Waterford
Smilow Cancer Hospital Care Center - Waterford
Contact: Site Public Contact
Email: canceranswers@yale.edu
West Haven
Veterans Affairs Connecticut Healthcare System-West Haven Campus
Contact: Site Public Contact
DC
Washington
George Washington University Medical Center
Contact: Site Public Contact
MedStar Georgetown University Hospital
Contact: Site Public Contact
MedStar Washington Hospital Center
Contact: Site Public Contact
Sibley Memorial Hospital
Contact: Site Public Contact
Email: jquiver1@jhmi.edu
DE
Lewes
Beebe Medical Center
Contact: Site Public Contact
Email: research@beebehealthcare.org
Millville
Beebe South Coastal Health Campus
Contact: Site Public Contact
Email: research@beebehealthcare.org
Newark
Christiana Care Health System-Christiana Hospital
Contact: Site Public Contact
Email: lbarone@christianacare.org
Delaware Clinical and Laboratory Physicians PA
Contact: Site Public Contact
Email: mhayden@christianacare.org
Helen F Graham Cancer Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Medical Oncology Hematology Consultants PA
Contact: Site Public Contact
Email: lbarone@christianacare.org
Rehoboth Beach
Beebe Health Campus
Contact: Site Public Contact
Email: research@beebehealthcare.org
Seaford
TidalHealth Nanticoke / Allen Cancer Center
Contact: Site Public Contact
Email: anna-maria.howard@peninsula.org
Wilmington
Christiana Care Health System-Wilmington Hospital
Contact: Site Public Contact
Email: lbarone@christianacare.org
FL
Aventura
GenesisCare USA - Aventura
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
GenesisCare USA - Aventura FP
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Mount Sinai Comprehensive Cancer Center at Aventura
Contact: Site Public Contact
Email: yenrique@msmc.com
Boca Raton
GenesisCare USA - Boca Ration FP06
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
GenesisCare USA - Boca Raton FP02
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Fort Lauderdale
Holy Cross Hospital
Contact: Site Public Contact
Fort Myers
GenesisCare USA - Gladiolus
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Gainesville
University of Florida Health Science Center - Gainesville
Contact: Site Public Contact
Email: cancer-center@ufl.edu
Jacksonville
Mayo Clinic in Florida
Contact: Site Public Contact
Key West
GenesisCare USA - Key West
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Lakewood Ranch
GenesisCare USA - Lakewood Ranch
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Miami Beach
Mount Sinai Medical Center
Contact: Site Public Contact
Email: yenrique@msmc.com
Palm Beach Gardens
GenesisCare USA - Palm Beach Gardens
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Pensacola
Sacred Heart Hospital
Contact: Site Public Contact
Email: eebrou@ascension.org
Plantation
GenesisCare USA - Plantation
Contact: Site Public Contact
Email: Rudi.Ross@usa.genesiscare.com
Tampa
Moffitt Cancer Center
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
Moffitt Cancer Center - McKinley Campus
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
Moffitt Cancer Center-International Plaza
Contact: Site Public Contact
Email: ClinicalTrials@moffitt.org
West Palm Beach
Good Samaritan Medical Center
Contact: Site Public Contact
Weston
Cleveland Clinic-Weston
Contact: Site Public Contact
Email: CancerAnswer@ccf.org
GA
Athens
University Cancer and Blood Center LLC
Contact: Site Public Contact
Email: research@universitycancer.com
Atlanta
Emory Saint Joseph's Hospital
Contact: Site Public Contact
Emory University Hospital Midtown
Contact: Site Public Contact
Emory University Hospital/Winship Cancer Institute
Contact: Site Public Contact
Northside Hospital
Contact: Site Public Contact
Email: ClinicalTrials@northside.com
Augusta
Augusta Oncology Associates PC-D'Antignac
Contact: Site Public Contact
Augusta Oncology Associates PC-Wheeler
Contact: Site Public Contact
Augusta University Medical Center
Contact: Site Public Contact
Email: ga_cares@augusta.edu
Braselton
Northeast Georgia Medical Center Braselton
Contact: Site Public Contact
Email: cancerpatient.navigator@nghs.com
Decatur
Atlanta VA Medical Center
Contact: Site Public Contact
Duluth
Northside Hospital - Duluth
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Gainesville
Northeast Georgia Medical Center-Gainesville
Contact: Site Public Contact
Email: cancerpatient.navigator@nghs.com
The Longstreet Clinic - Gainesville
Contact: Site Public Contact
Lawrenceville
Northside Hospital - Gwinnett
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Savannah
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Contact: Site Public Contact
Email: underberga@sjchs.org
Summit Cancer Care-Candler
Contact: Site Public Contact
Snellville
Suburban Hematology Oncology Associates - Snellville
Contact: Site Public Contact
Email: Clinical.trials@northside.com
Thomasville
Lewis Hall Singletary Oncology Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Valdosta
South Georgia Medical Center/Pearlman Cancer Center
Contact: Site Public Contact
Email: maryann.heddon@sgmc.org
GU
Tamuning
FHP Health Center-Guam
Contact: Site Public Contact
HI
Aiea
Hawaii Cancer Care - Westridge
Contact: Site Public Contact
Email: info@hawaiicancercare.com
Pali Momi Medical Center
Contact: Site Public Contact
Queen's Cancer Center - Pearlridge
Contact: Site Public Contact
Straub Pearlridge Clinic
Contact: Site Public Contact
The Cancer Center of Hawaii-Pali Momi
Contact: Site Public Contact
Ewa Beach
The Queen's Medical Center - West Oahu
Contact: Site Public Contact
Email: rohta@queens.org
Honolulu
Hawaii Cancer Care Inc - Waterfront Plaza
Contact: Site Public Contact
Email: i.webster@hawaiicancercare.com
Hawaii Cancer Care Inc-Liliha
Contact: Site Public Contact
Hawaii Diagnostic Radiology Services LLC
Contact: Site Public Contact
Email: mmiyoshi@hawaiidrs.com
Island Urology
Contact: Site Public Contact
Email: virginia@cc.hawaii.edu
Kaiser Permanente Moanalua Medical Center
Contact: Site Public Contact
Email: shelley.a.clark@kp.org
Kapiolani Medical Center for Women and Children
Contact: Site Public Contact
Kuakini Medical Center
Contact: Site Public Contact
Queen's Cancer Cenrer - POB I
Contact: Site Public Contact
Queen's Cancer Center - Kuakini
Contact: Site Public Contact
Queen's Medical Center
Contact: Site Public Contact
Straub Clinic and Hospital
Contact: Site Public Contact
The Cancer Center of Hawaii-Liliha
Contact: Site Public Contact
University of Hawaii Cancer Center
Contact: Site Public Contact
Kahului
Straub Medical Center - Kahului Clinic
Contact: Site Public Contact
Email: lori.kam@hawaiipacifichealth.org
Kailua
Castle Medical Center
Contact: Site Public Contact
Email: ctsucontact@westat.com
Lihue
Wilcox Memorial Hospital and Kauai Medical Clinic
Contact: Site Public Contact
IA
Ames
Mary Greeley Medical Center
Contact: Site Public Contact
McFarland Clinic - Ames
Contact: Site Public Contact
Email: ksoder@mcfarlandclinic.com
Ankeny
Mission Cancer and Blood - Ankeny
Contact: Site Public Contact
Bettendorf
University of Iowa Healthcare Cancer Services Quad Cities
Contact: Site Public Contact
Email: kedaprile@rccqc.com
Boone
McFarland Clinic - Boone
Contact: Site Public Contact
Carroll
Saint Anthony Regional Hospital
Contact: Site Public Contact
Email: sbenson@iora.org
Cedar Rapids
Mercy Hospital
Contact: Site Public Contact
Oncology Associates at Mercy Medical Center
Contact: Site Public Contact
Clive
Mercy Cancer Center-West Lakes
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - West Des Moines
Contact: Site Public Contact
Council Bluffs
Alegent Health Mercy Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Heartland Oncology and Hematology LLP
Contact: Site Public Contact
Methodist Jennie Edmundson Hospital
Contact: Site Public Contact
Email: kathryn.bartz@nmhs.org
Creston
Greater Regional Medical Center
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Des Moines
Broadlawns Medical Center
Contact: Site Public Contact
Iowa Lutheran Hospital
Contact: Site Public Contact
Iowa Methodist Medical Center
Contact: Site Public Contact
Mercy Medical Center - Des Moines
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Mission Cancer and Blood - Des Moines
Contact: Site Public Contact
Mission Cancer and Blood - Laurel
Contact: Site Public Contact
Fort Dodge
McFarland Clinic - Trinity Cancer Center
Contact: Site Public Contact
Trinity Regional Medical Center
Contact: Site Public Contact
Iowa City
University of Iowa/Holden Comprehensive Cancer Center
Contact: Site Public Contact
Jefferson
McFarland Clinic - Jefferson
Contact: Site Public Contact
Marshalltown
McFarland Clinic - Marshalltown
Contact: Site Public Contact
Sioux City
Siouxland Regional Cancer Center
Contact: Site Public Contact
Email: HoopingarnerT@jencc.com
Waterloo
MercyOne Waterloo Cancer Center
Contact: Site Public Contact
Email: Karrie.McCabeCheeseman@mercyhealth.com
West Des Moines
Mercy Medical Center-West Lakes
Contact: Site Public Contact
Email: cancerresearch@mercydesmoines.org
Methodist West Hospital
Contact: Site Public Contact
ID
Boise
Saint Alphonsus Cancer Care Center-Boise
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Boise
Contact: Site Public Contact
Email: eslinget@slhs.org
Caldwell
Saint Alphonsus Cancer Care Center-Caldwell
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Coeur D'Alene
Kootenai Health - Coeur d'Alene
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Emmett
Walter Knox Memorial Hospital
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Fruitland
Saint Luke's Cancer Institute - Fruitland
Contact: Site Public Contact
Email: eslinget@slhs.org
Meridian
Idaho Urologic Institute-Meridian
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saint Luke's Cancer Institute - Meridian
Contact: Site Public Contact
Email: eslinget@slhs.org
Nampa
Saint Alphonsus Cancer Care Center-Nampa
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Luke's Cancer Institute - Nampa
Contact: Site Public Contact
Email: eslinget@slhs.org
Post Falls
Kootenai Clinic Cancer Services - Post Falls
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Sandpoint
Kootenai Clinic Cancer Services - Sandpoint
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Twin Falls
Saint Luke's Cancer Institute - Twin Falls
Contact: Site Public Contact
Email: eslinget@slhs.org
IL
Alton
Saint Anthony's Health
Contact: Site Public Contact
Aurora
Rush - Copley Medical Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
Barrington
Advocate Good Shepherd Hospital
Contact: Site Public Contact
Bloomington
Illinois CancerCare-Bloomington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Burr Ridge
Loyola Center for Health at Burr Ridge
Contact: Site Public Contact
Canton
Illinois CancerCare-Canton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Carbondale
Memorial Hospital of Carbondale
Contact: Site Public Contact
Email: clinical.research@sih.net
Carterville
SIH Cancer Institute
Contact: Site Public Contact
Email: clinical.research@sih.net
Carthage
Illinois CancerCare-Carthage
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Centralia
Centralia Oncology Clinic
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Saint Mary's Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Chicago
Advocate Illinois Masonic Medical Center
Contact: Site Public Contact
Jesse Brown Veterans Affairs Medical Center
Contact: Site Public Contact
John H Stroger Jr Hospital of Cook County
Contact: Site Public Contact
Northwestern University
Contact: Site Public Contact
Email: cancer@northwestern.edu
Rush University Medical Center
Contact: Site Public Contact
Email: clinical_trials@rush.edu
Swedish Covenant Hospital
Contact: Site Public Contact
University of Chicago Comprehensive Cancer Center
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
Crystal Lake
AMG Crystal Lake - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocate.com
Danville
Carle at The Riverfront
Contact: Site Public Contact
Email: Research@Carle.com
Decatur
Cancer Care Specialists of Illinois - Decatur
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Decatur Memorial Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Dixon
Illinois CancerCare-Dixon
Contact: Site Public Contact
Downers Grove
Advocate Good Samaritan Hospital
Contact: Site Public Contact
Email: Barbara.barhamand@advocatehealth.com
Effingham
Carle Physician Group-Effingham
Contact: Site Public Contact
Email: Research@carle.com
Crossroads Cancer Center
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Elgin
Advocate Sherman Hospital
Contact: Site Public Contact
Elmhurst
Elmhurst Memorial Hospital
Contact: Site Public Contact
Email: Jrohde@emhc.org
Eureka
Illinois CancerCare-Eureka
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Evanston
NorthShore University HealthSystem-Evanston Hospital
Contact: Site Public Contact
Freeport
Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
Contact: Site Public Contact
Galesburg
Illinois CancerCare-Galesburg
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Western Illinois Cancer Treatment Center
Contact: Site Public Contact
Glenview
NorthShore University HealthSystem-Glenbrook Hospital
Contact: Site Public Contact
Hazel Crest
Advocate South Suburban Hospital
Contact: Site Public Contact
Highland Park
NorthShore University HealthSystem-Highland Park Hospital
Contact: Site Public Contact
Hines
Edward Hines Jr VA Hospital
Contact: Site Public Contact
Hinsdale
AMITA Health Cancer Institute and Outpatient Center
Contact: Site Public Contact
Homer Glen
Loyola Medicine Homer Glen
Contact: Site Public Contact
Joliet
Duly Health and Care Joliet
Contact: Site Public Contact
Email: Karen.Sceniak@dulyhealthandcare.com
Kewanee
Illinois CancerCare-Kewanee Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Lake Forest
Northwestern Medicine Lake Forest Hospital
Contact: Site Public Contact
Email: cancertrials@northwestern.edu
Libertyville
AMG Libertyville - Oncology
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Condell Memorial Hospital
Contact: Site Public Contact
Email: advocateresearch@advocatehealth.com
Macomb
Illinois CancerCare-Macomb
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Mattoon
Carle Physician Group-Mattoon/Charleston
Contact: Site Public Contact
Email: Research@carle.com
Maywood
Loyola University Medical Center
Contact: Site Public Contact
Melrose Park
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Contact: Site Public Contact
Mount Vernon
Good Samaritan Regional Health Center
Contact: Site Public Contact
Naperville
Edward Hospital/Cancer Center
Contact: Site Public Contact
New Lenox
UC Comprehensive Cancer Center at Silver Cross
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
O'Fallon
Cancer Care Center of O'Fallon
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
HSHS Saint Elizabeth's Hospital
Contact: Site Public Contact
Email: morganthaler.jodi@mhsil.com
Oak Lawn
Advocate Christ Medical Center
Contact: Site Public Contact
Orland Park
Northwestern Medicine Orland Park
Contact: Site Public Contact
Email: nctnprogram_rhlccc@northwestern.edu
University of Chicago Medicine-Orland Park
Contact: Site Public Contact
Email: cancerclinicaltrials@bsd.uchicago.edu
Ottawa
Illinois CancerCare-Ottawa Clinic
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Park Ridge
Advocate Lutheran General Hospital
Contact: Site Public Contact
Pekin
Illinois CancerCare-Pekin
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peoria
Illinois CancerCare-Peoria
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Methodist Medical Center of Illinois
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Peru
Illinois CancerCare-Peru
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Valley Radiation Oncology
Contact: Site Public Contact
Plainfield
Edward Hospital/Cancer Center?Plainfield
Contact: Site Public Contact
Email: Cancerresearch@edward.org
Princeton
Illinois CancerCare-Princeton
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Rockford
UW Health Carbone Cancer Center Rockford
Contact: Site Public Contact
Email: lkline@uwhealth.org
Springfield
Memorial Medical Center
Contact: Site Public Contact
Email: pallante.beth@mhsil.com
Southern Illinois University School of Medicine
Contact: Site Public Contact
Springfield Clinic
Contact: Site Public Contact
Swansea
Southwest Illinois Health Services LLP
Contact: Site Public Contact
Email: lynns@thecancercenter.com
Urbana
Carle Cancer Center
Contact: Site Public Contact
Email: Research@carle.com
The Carle Foundation Hospital
Contact: Site Public Contact
Email: Research@carle.com
Washington
Illinois CancerCare - Washington
Contact: Site Public Contact
Email: andersonj@illinoiscancercare.com
Yorkville
Rush-Copley Healthcare Center
Contact: Site Public Contact
Email: Cancer.Research@rushcopley.com
IN
Richmond
Reid Health
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
KS
Chanute
Cancer Center of Kansas - Chanute
Contact: Site Public Contact
Email: research@viachristi.org
Coffeyville
Coffeyville Regional Medical Center
Contact: Site Public Contact
Dodge City
Cancer Center of Kansas - Dodge City
Contact: Site Public Contact
Email: research@viachristi.org
El Dorado
Cancer Center of Kansas - El Dorado
Contact: Site Public Contact
Email: research@viachristi.org
Fairway
University of Kansas Clinical Research Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Garden City
Central Care Cancer Center - Garden City
Contact: Site Public Contact
Email: aroland@kccop.org
Great Bend
Central Care Cancer Center - Great Bend
Contact: Site Public Contact
Email: aroland@kccop.org
Hays
HaysMed
Contact: Site Public Contact
Independence
Cancer Center of Kansas-Independence
Contact: Site Public Contact
Email: research@viachristi.org
Kansas City
University of Kansas Cancer Center-West
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Kingman
Cancer Center of Kansas-Kingman
Contact: Site Public Contact
Email: research@viachristi.org
Lawrence
Lawrence Memorial Hospital
Contact: Site Public Contact
Email: Stephanie.Norris@LMH.ORG
Liberal
Cancer Center of Kansas-Liberal
Contact: Site Public Contact
Email: research@viachristi.org
Manhattan
Cancer Center of Kansas-Manhattan
Contact: Site Public Contact
Email: research@viachristi.org
McPherson
Cancer Center of Kansas - McPherson
Contact: Site Public Contact
Email: research@viachristi.org
Newton
Cancer Center of Kansas - Newton
Contact: Site Public Contact
Email: research@viachristi.org
Olathe
Olathe Health Cancer Center
Contact: Site Public Contact
Email: Jeni.wakefield@olathehealth.org
Overland Park
Saint Luke's South Hospital
Contact: Site Public Contact
Email: aroland@kccop.org
University of Kansas Cancer Center-Overland Park
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Parsons
Cancer Center of Kansas - Parsons
Contact: Site Public Contact
Email: research@viachristi.org
Pittsburg
Ascension Via Christi - Pittsburg
Contact: Site Public Contact
Email: jennifer.jameson@ascension.org
Freeman Physician Group of Pittsburg
Contact: Site Public Contact
Email: BNMathew@freemanhealth.com
Pratt
Cancer Center of Kansas - Pratt
Contact: Site Public Contact
Email: research@viachristi.org
Salina
Cancer Center of Kansas - Salina
Contact: Site Public Contact
Email: research@viachristi.org
Salina Regional Health Center
Contact: Site Public Contact
Email: mleepers@srhc.com
Topeka
University of Kansas Health System Saint Francis Campus
Contact: Site Public Contact
Wellington
Cancer Center of Kansas - Wellington
Contact: Site Public Contact
Email: research@viachristi.org
Westwood
University of Kansas Hospital-Westwood Cancer Center
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Wichita
Ascension Via Christi Hospitals Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas - Wichita
Contact: Site Public Contact
Email: research@viachristi.org
Cancer Center of Kansas-Wichita Medical Arts Tower
Contact: Site Public Contact
Email: research@viachristi.org
Winfield
Cancer Center of Kansas - Winfield
Contact: Site Public Contact
Email: research@viachristi.org
KY
Bardstown
Flaget Memorial Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Corbin
Commonwealth Cancer Center-Corbin
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Lexington
Saint Joseph Hospital
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Saint Joseph Hospital East
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saint Joseph Radiation Oncology Resource Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
London
Saint Joseph London
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Louisville
Jewish Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Saints Mary and Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
UofL Health Medical Center Northeast
Contact: Site Public Contact
Email: ctoinfo@louisville.edu
Mount Sterling
Saint Joseph Mount Sterling
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Paducah
Mercy Health - Paducah Cancer Center
Contact: Site Public Contact
Email: BJWarner@mercy.com
Shepherdsville
Jewish Hospital Medical Center South
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
LA
Marrero
West Jefferson Medical Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Monroe
Ochsner LSU Health Monroe Medical Center
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
New Orleans
Louisiana State University Health Science Center
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
University Medical Center New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Veteran's Administration Medical Center - New Orleans
Contact: Site Public Contact
Email: emede1@lsuhsc.edu
Shreveport
LSU Health Sciences Center at Shreveport
Contact: Site Public Contact
Email: LPost@lsuhsc.edu
MA
Beverly
Beverly Hospital
Contact: Site Public Contact
Burlington
Lahey Hospital and Medical Center
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
Gloucester
Addison Gilbert Hospital
Contact: Site Public Contact
Lowell
Lowell General Hospital
Contact: Site Public Contact
Email: ghincks@lowellgeneral.org
Peabody
Lahey Medical Center-Peabody
Contact: Site Public Contact
Email: lhmc-cancer-clinical-trials@lahey.org
Springfield
Baystate Medical Center
Contact: Site Public Contact
Email: tamara.wrenn@baystatehealth.org
Mercy Medical Center
Contact: Site Public Contact
Winchester
Winchester Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Worcester
UMass Memorial Medical Center - University Campus
Contact: Site Public Contact
Email: cancer.research@umassmed.edu
MD
Baltimore
Greater Baltimore Medical Center
Contact: Site Public Contact
Johns Hopkins University/Sidney Kimmel Cancer Center
Contact: Site Public Contact
Email: jhcccro@jhmi.edu
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Contact: Site Public Contact
MedStar Good Samaritan Hospital
Contact: Site Public Contact
Email: Barbara.rector@medstar.net
Easton
University of Maryland Shore Medical Center at Easton
Contact: Site Public Contact
Email: Christina.weisenborn@umm.edu
Elkton
Christiana Care - Union Hospital
Contact: Site Public Contact
Email: sstewart@uhcc.com
ME
Bangor
Eastern Maine Medical Center
Contact: Site Public Contact
Brewer
Lafayette Family Cancer Center-EMMC
Contact: Site Public Contact
MI
Adrian
Hickman Cancer Center
Contact: Site Public Contact
Ann Arbor
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Battle Creek
Bronson Battle Creek
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Brighton
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Brighton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Canton
Trinity Health IHA Medical Group Hematology Oncology - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Medical Center - Canton
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Caro
Caro Cancer Center
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Chelsea
Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Clarkston
Hematology Oncology Consultants-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Michigan Healthcare Professionals Clarkston
Contact: Site Public Contact
Email: rudi.ross@profoundresearch.io
Newland Medical Associates-Clarkston
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Detroit
Henry Ford Health Saint John Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
East China
Great Lakes Cancer Management Specialists-Doctors Park
Contact: Site Public Contact
Email: karen.forman@ascension.org
Escanaba
OSF Saint Francis Hospital and Medical Group
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Farmington Hills
Michigan Healthcare Professionals Farmington
Contact: Site Public Contact
Email: rudi.ross@profoundresearch.io
Flint
Genesee Cancer and Blood Disease Treatment Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesee Hematology Oncology PC
Contact: Site Public Contact
Email: wstrong@ghci.org
Genesys Hurley Cancer Institute
Contact: Site Public Contact
Email: wstrong@ghci.org
Hurley Medical Center
Contact: Site Public Contact
Email: wstrong@ghci.org
Grand Rapids
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Trinity Health Grand Rapids Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Grosse Pointe Woods
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Contact: Site Public Contact
Email: karen.forman@ascension.org
Henry Ford Saint John Hospital - Academic
Contact: Site Public Contact
Email: karen.forman@ascension.org
Henry Ford Saint John Hospital - Breast
Contact: Site Public Contact
Email: karen.forman@ascension.org
Kalamazoo
Ascension Borgess Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Borgess Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Bronson Methodist Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
West Michigan Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Lansing
University of Michigan Health - Sparrow Lansing
Contact: Site Public Contact
Livonia
Hope Cancer Clinic
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Trinity Health Saint Mary Mercy Livonia Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Macomb
Michigan Healthcare Professionals Macomb
Contact: Site Public Contact
Email: rudi.ross@profoundresearch.io
Macomb Township
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Contact: Site Public Contact
Email: karen.forman@ascension.org
Henry Ford Warren Hospital - Breast Macomb
Contact: Site Public Contact
Email: karen.forman@ascension.org
Madison Heights
Michigan Healthcare Professionals Madison Heights
Contact: Site Public Contact
Email: rudi.ross@profoundresearch.io
Marlette
Saint Mary's Oncology/Hematology Associates of Marlette
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Monroe
Toledo Clinic Cancer Centers-Monroe
Contact: Site Public Contact
Muskegon
Trinity Health Muskegon Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Niles
Corewell Health Lakeland Hospitals - Niles Hospital
Contact: Site Public Contact
Norton Shores
Cancer and Hematology Centers of Western Michigan - Norton Shores
Contact: Site Public Contact
Email: connie.szczepanek@crcwm.org
Novi
Henry Ford Health Providence Novi Hospital
Contact: Site Public Contact
Email: karen.fife@ascension.org
Pontiac
Hope Cancer Center
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Michigan Healthcare Professionals Pontiac
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Newland Medical Associates-Pontiac
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health Saint Joseph Mercy Oakland Hospital
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Port Huron
Huron Medical Center PC
Contact: Site Public Contact
Email: research@sncrf.org
Lake Huron Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Reed City
Corewell Health Reed City Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Rochester Hills
Great Lakes Cancer Management Specialists-Rochester Hills
Contact: Site Public Contact
Email: stephanie.couch@stjoeshealth.org
Saginaw
MyMichigan Medical Center Saginaw
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Oncology Hematology Associates of Saginaw Valley PC
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Saint Joseph
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Southfield
Henry Ford Health Providence Southfield Hospital
Contact: Site Public Contact
Email: karen.fife@ascension.org
Sterling Heights
Bhadresh Nayak MD PC-Sterling Heights
Contact: Site Public Contact
Email: karen.forman@ascension.org
Tawas City
MyMichigan Medical Center Tawas
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Traverse City
Munson Medical Center
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Troy
Michigan Healthcare Professionals Troy
Contact: Site Public Contact
Email: rudi.ross@profoundresearch.io
Warren
Advanced Breast Care Center PLLC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Great Lakes Cancer Management Specialists-Macomb Professional Building
Contact: Site Public Contact
Email: karen.forman@ascension.org
Henry Ford Madison Heights Hospital - Breast
Contact: Site Public Contact
Email: karen.forman@ascension.org
Macomb Hematology Oncology PC
Contact: Site Public Contact
Email: karen.forman@ascension.org
Saint John Macomb-Oakland Hospital
Contact: Site Public Contact
Email: karen.forman@ascension.org
West Branch
Saint Mary's Oncology/Hematology Associates of West Branch
Contact: Site Public Contact
Email: lori.srebinski@ascension.org
Wyoming
University of Michigan Health - West
Contact: Site Public Contact
Email: crcwm-regulatory@crcwm.org
Ypsilanti
Huron Gastroenterology PC
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Contact: Site Public Contact
Email: MCRCwebsitecontactform@stjoeshealth.org
MN
Aitkin
Riverwood Healthcare Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Albert Lea
Mayo Clinic Health System in Albert Lea
Contact: Site Public Contact
Baxter
Essentia Health - Baxter Clinic
Contact: Site Public Contact
Bemidji
Sanford Joe Lueken Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Brainerd
Essentia Health Saint Joseph's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Burnsville
Fairview Ridges Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minnesota Oncology - Burnsville
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Cambridge
Cambridge Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Coon Rapids
Mercy Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Deer River
Essentia Health - Deer River Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Detroit Lakes
Essentia Health Saint Mary's - Detroit Lakes Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Duluth
Essentia Health Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Essentia Health Saint Mary's Medical Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Miller-Dwan Hospital
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Edina
Fairview Southdale Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Ely
Essentia Health - Ely Clinic
Contact: Site Public Contact
Fergus Falls
Lake Region Healthcare Corporation-Cancer Care
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fosston
Essentia Health - Fosston
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Fridley
Unity Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hibbing
Essentia Health Hibbing Clinic
Contact: Site Public Contact
International Falls
Essentia Health - International Falls Clinic
Contact: Site Public Contact
Mankato
Mayo Clinic Health Systems-Mankato
Contact: Site Public Contact
Maple Grove
Fairview Clinics and Surgery Center Maple Grove
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Maplewood
Minnesota Oncology Hematology PA-Maplewood
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint John's Hospital - Healtheast
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis
Abbott-Northwestern Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Health Partners Inc
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Hennepin County Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Minneapolis VA Medical Center
Contact: Site Public Contact
Monticello
Monticello Cancer Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Moose Lake
Essentia Health - Moose Lake Clinic
Contact: Site Public Contact
New Ulm
New Ulm Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Park Rapids
Essentia Health - Park Rapids
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Princeton
Fairview Northland Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Robbinsdale
North Memorial Medical Health Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Rochester
Mayo Clinic in Rochester
Contact: Site Public Contact
Saint Louis Park
Park Nicollet Clinic - Saint Louis Park
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Saint Paul
Regions Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
United Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Sandstone
Essentia Health Sandstone
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Shakopee
Saint Francis Regional Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Stillwater
Lakeview Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Thief River Falls
Sanford Thief River Falls Medical Center
Contact: Site Public Contact
Virginia
Essentia Health Virginia Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Waconia
Ridgeview Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Willmar
Rice Memorial Hospital
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Woodbury
Minnesota Oncology Hematology PA-Woodbury
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Worthington
Sanford Cancer Center Worthington
Contact: Site Public Contact
Wyoming
Fairview Lakes Medical Center
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
MO
Ballwin
Saint Louis Cancer and Breast Institute-Ballwin
Contact: Site Public Contact
Bolivar
Central Care Cancer Center - Bolivar
Contact: Site Public Contact
Email: aroland@kccop.org
Bonne Terre
Parkland Health Center-Bonne Terre
Contact: Site Public Contact
Branson
Cox Cancer Center Branson
Contact: Site Public Contact
Cape Girardeau
Saint Francis Medical Center
Contact: Site Public Contact
Email: sfmc@sfmc.net
Southeast Cancer Center
Contact: Site Public Contact
Chesterfield
Saint Luke's Hospital
Contact: Site Public Contact
Farmington
Parkland Health Center - Farmington
Contact: Site Public Contact
Jefferson City
MU Health Care Goldschmidt Cancer Center
Contact: Site Public Contact
Email: amy.franken@health.missouri.edu
Joplin
Freeman Health System
Contact: Site Public Contact
Email: LJCrockett@freemanhealth.com
Mercy Hospital Joplin
Contact: Site Public Contact
Email: esmeralda.carrillo@mercy.net
Kansas City
Saint Luke's Hospital of Kansas City
Contact: Site Public Contact
Email: aroland@kccop.org
The University of Kansas Cancer Center-South
Contact: Site Public Contact
Email: ctnursenav@kumc.edu
University Health Truman Medical Center
Contact: Site Public Contact
University of Kansas Cancer Center - North
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Lee's Summit
Saint Luke's East - Lee's Summit
Contact: Site Public Contact
Email: aroland@kccop.org
University of Kansas Cancer Center - Lee's Summit
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
North Kansas City
University of Kansas Cancer Center at North Kansas City Hospital
Contact: Site Public Contact
Email: KUCC_Navigation@kumc.edu
Osage Beach
Lake Regional Hospital
Contact: Site Public Contact
Email: clinicaltrials@lakeregional.com
Rolla
Delbert Day Cancer Institute at PCRMC
Contact: Site Public Contact
Email: research@phelpshealth.org
Mercy Clinic-Rolla-Cancer and Hematology
Contact: Site Public Contact
Saint Joseph
Heartland Regional Medical Center
Contact: Site Public Contact
Email: linda.schumacher@mymlc.com
Saint Louis
Mercy Hospital Saint Louis
Contact: Site Public Contact
Mercy Hospital South
Contact: Site Public Contact
Email: Danielle.Werle@mercy.net
Missouri Baptist Medical Center
Contact: Site Public Contact
Saint Louis Cancer and Breast Institute-South City
Contact: Site Public Contact
Sainte Genevieve
Sainte Genevieve County Memorial Hospital
Contact: Site Public Contact
Springfield
CoxHealth South Hospital
Contact: Site Public Contact
Mercy Hospital Springfield
Contact: Site Public Contact
Sullivan
Missouri Baptist Sullivan Hospital
Contact: Site Public Contact
Sunset Hills
BJC Outpatient Center at Sunset Hills
Contact: Site Public Contact
Washington
Mercy Hospital Washington
Contact: Site Public Contact
MS
Columbus
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Grenada
Baptist Cancer Center-Grenada
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
New Albany
Baptist Memorial Hospital and Cancer Center-Union County
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Oxford
Baptist Memorial Hospital and Cancer Center-Oxford
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Pascagoula
Singing River Hospital
Contact: Site Public Contact
Southhaven
Baptist Memorial Hospital and Cancer Center-Desoto
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
MT
Anaconda
Community Hospital of Anaconda
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Billings
Billings Clinic Cancer Center
Contact: Site Public Contact
Email: research@billingsclinic.org
Saint Vincent Frontier Cancer Center
Contact: Site Public Contact
Saint Vincent Healthcare
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bozeman
Bozeman Health Deaconess Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Butte
Saint James Community Hospital and Cancer Treatment Center
Contact: Site Public Contact
Great Falls
Benefis Sletten Cancer Institute
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Great Falls Clinic
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Helena
Saint Peter's Community Hospital
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Kalispell
Kalispell Regional Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Missoula
Community Medical Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Saint Patrick Hospital - Community Hospital
Contact: Site Public Contact
Email: amy.hanneman@providence.org
NC
Albemarle
Atrium Health Stanly/LCI-Albemarle
Contact: Site Public Contact
Asheville
AdventHealth Infusion Center Asheville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
Mission Hospital
Contact: Site Public Contact
Email: NCDV.ResearchRegulatory@HCAHealthcare.com
Chapel Hill
UNC Lineberger Comprehensive Cancer Center
Contact: Site Public Contact
Email: cancerclinicaltrials@med.unc.edu
Charlotte
Atrium Health Pineville/LCI-Pineville
Contact: Site Public Contact
Atrium Health University City/LCI-University
Contact: Site Public Contact
Carolinas Medical Center/Levine Cancer Institute
Contact: Site Public Contact
Levine Cancer Institute-Ballantyne
Contact: Site Public Contact
Levine Cancer Institute-SouthPark
Contact: Site Public Contact
Clinton
Southeastern Medical Oncology Center-Clinton
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Clyde
AdventHealth Infusion Center Haywood
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
Concord
Atrium Health Cabarrus/LCI-Concord
Contact: Site Public Contact
Durham
Durham VA Medical Center
Contact: Site Public Contact
Email: VHADURcancertrials@va.gov
Forest City
Levine Cancer Institute - Rutherford
Contact: Site Public Contact
Gastonia
Levine Cancer Institute-Gaston
Contact: Site Public Contact
Goldsboro
Southeastern Medical Oncology Center-Goldsboro
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Greenville
East Carolina University
Contact: Site Public Contact
Email: eubankss@ecu.edu
Hendersonville
AdventHealth Hendersonville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
Margaret R Pardee Memorial Hospital
Contact: Site Public Contact
Email: pardeecancerresearch@unchealth.unc.edu
Jacksonville
Southeastern Medical Oncology Center-Jacksonville
Contact: Site Public Contact
Email: jfields@cancersmoc.com
Kenansville
ECU Health Oncology Kenansville
Contact: Site Public Contact
Email: research@ecuhealth.org
Kinston
ECU Health Oncology Kinston
Contact: Site Public Contact
Email: research@ecuhealth.org
Lincolnton
Atrium Health Lincoln/LCI-Lincolnton
Contact: Site Public Contact
Matthews
Levine Cancer Institute - Union West
Contact: Site Public Contact
Monroe
Atrium Health Union/LCI-Union
Contact: Site Public Contact
Richlands
ECU Health Oncology Richlands
Contact: Site Public Contact
Email: research@ecuhealth.org
Salisbury
WG Hefner VA Medical Center
Contact: Site Public Contact
Shelby
Atrium Health Cleveland/LCI-Cleveland
Contact: Site Public Contact
Weaverville
AdventHealth Infusion Center Weaverville
Contact: Site Public Contact
Email: AMBER.WHEELER@AdventHealth.com
ND
Bismarck
Sanford Bismarck Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Fargo
Essentia Health Cancer Center-South University Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Sanford Broadway Medical Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford Medical Center Fargo
Contact: Site Public Contact
Sanford Roger Maris Cancer Center
Contact: Site Public Contact
Email: OncologyClinicalTrialsFargo@sanfordhealth.org
Sanford South University Medical Center
Contact: Site Public Contact
Southpointe-Sanford Medical Center Fargo
Contact: Site Public Contact
Jamestown
Essentia Health - Jamestown Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
NE
Bellevue
Nebraska Medicine-Bellevue
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Grand Island
Nebraska Cancer Specialists/Oncology Hematology West PC
Contact: Site Public Contact
Kearney
CHI Health Good Samaritan
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Heartland Hematology and Oncology
Contact: Site Public Contact
Lincoln
Saint Elizabeth Regional Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Omaha
Alegent Health Bergan Mercy Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Immanuel Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Alegent Health Lakeside Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Creighton University Medical Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Hematology and Oncology Consultants PC
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Contact: Site Public Contact
Nebraska Medicine-Village Pointe
Contact: Site Public Contact
Nebraska Methodist Hospital
Contact: Site Public Contact
Oncology Associates PC
Contact: Site Public Contact
Email: info@oa-oc.com
University of Nebraska Medical Center
Contact: Site Public Contact
Email: unmcrsa@unmc.edu
Papillion
Midlands Community Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
NH
Concord
New Hampshire Oncology Hematology PA-Concord
Contact: Site Public Contact
Lebanon
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Contact: Site Public Contact
Email: cancer.research.nurse@dartmouth.edu
Manchester
Elliot Hospital
Contact: Site Public Contact
Solinsky Center for Cancer Care
Contact: Site Public Contact
NJ
Moorestown
Virtua Samson Cancer Center
Contact: Site Public Contact
Morristown
Morristown Medical Center
Contact: Site Public Contact
Mullica Hill
Inspira Medical Center Mullica Hill
Contact: Site Public Contact
Email: DeNigrisJ@ihn.org
Summit
Overlook Hospital
Contact: Site Public Contact
Voorhees
Virtua Voorhees
Contact: Site Public Contact
NM
Albuquerque
University of New Mexico Cancer Center
Contact: Site Public Contact
Email: HSC-ClinicalTrialInfo@salud.unm.edu
NV
Carson City
Carson Tahoe Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Henderson
Cancer and Blood Specialists-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Henderson
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pebble
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Seven Hills
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Green Valley
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Contact: Site Public Contact
Email: research@sncrf.org
Ann M Wierman MD LTD
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Shadow
Contact: Site Public Contact
Email: research@sncrf.org
Cancer and Blood Specialists-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Central Valley
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada - Town Center
Contact: Site Public Contact
Email: research@sncrf.org
Comprehensive Cancer Centers of Nevada-Summerlin
Contact: Site Public Contact
Email: research@sncrf.org
Desert West Surgery
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Las Vegas
Contact: Site Public Contact
Email: research@sncrf.org
GenesisCare USA - Vegas Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Contact: Site Public Contact
Email: research@sncrf.org
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Contact: Site Public Contact
Email: research@sncrf.org
Hope Cancer Care of Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Cancer Center-Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Prostate Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Cathedral Rock
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Pecos
Contact: Site Public Contact
Email: research@sncrf.org
Las Vegas Urology - Smoke Ranch
Contact: Site Public Contact
Email: research@smcrf.org
Las Vegas Urology - Sunset
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Charleston
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at Fort Apache
Contact: Site Public Contact
Email: research@sncrf.org
OptumCare Cancer Care at MountainView
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Central
Contact: Site Public Contact
Email: research@sncrf.org
Radiation Oncology Centers of Nevada Southeast
Contact: Site Public Contact
Email: research@sncrf.org
Summerlin Hospital Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Sunrise Hospital and Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
University Cancer Center
Contact: Site Public Contact
Email: research@sncrf.org
University Medical Center of Southern Nevada
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Central
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Northwest
Contact: Site Public Contact
Email: research@sncrf.org
Urology Specialists of Nevada - Southwest
Contact: Site Public Contact
Email: research@sncrf.org
Pahrump
Hope Cancer Care of Nevada-Pahrump
Contact: Site Public Contact
Email: research@sncrf.org
Reno
Radiation Oncology Associates
Contact: Site Public Contact
Email: research@sncrf.org
Renown Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
Saint Mary's Regional Medical Center
Contact: Site Public Contact
Email: research@sncrf.org
NY
Auburn
Hematology Oncology Associates of Central New York-Auburn
Contact: Site Public Contact
Binghamton
Lourdes Hospital
Contact: Site Public Contact
Bronx
James J Peters VA Medical Center
Contact: Site Public Contact
Email: kl2965@cumc.columbia.edu
Montefiore Medical Center - Moses Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Einstein Campus
Contact: Site Public Contact
Email: eskwak@montefiore.org
Montefiore Medical Center-Weiler Hospital
Contact: Site Public Contact
Email: eskwak@montefiore.org
Camillus
Hematology Oncology Associates of CNY at Camillus
Contact: Site Public Contact
East Syracuse
Hematology Oncology Associates of Central New York-East Syracuse
Contact: Site Public Contact
Glens Falls
Glens Falls Hospital
Contact: Site Public Contact
New York
Laura and Isaac Perlmutter Cancer Center at NYU Langone
Contact: Site Public Contact
Email: CancerTrials@nyulangone.org
Mount Sinai Chelsea
Contact: Site Public Contact
Email: CCTO@mssm.edu
Mount Sinai Hospital
Contact: Site Public Contact
Email: CCTO@mssm.edu
Mount Sinai West
Contact: Site Public Contact
Email: CCTO@mssm.edu
Oswego
Upstate Cancer Center at Oswego
Contact: Site Public Contact
Email: McDowelE@upstate.edu
Rochester
University of Rochester
Contact: Site Public Contact
Stony Brook
Stony Brook University Medical Center
Contact: Site Public Contact
Syracuse
SUNY Upstate Medical Center-Community Campus
Contact: Site Public Contact
State University of New York Upstate Medical University
Contact: Site Public Contact
Verona
Upstate Cancer Center at Verona
Contact: Site Public Contact
Email: McDowelE@upstate.edu
Webster
Wilmot Cancer Institute at Webster
Contact: Site Public Contact
Email: WCICTOresearch@urmc.rochester.edu
OH
Avon
UH Seidman Cancer Center at UH Avon Health Center
Contact: Site Public Contact
Beachwood
UHHS-Chagrin Highlands Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Beavercreek
Indu and Raj Soin Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Belpre
Strecker Cancer Center-Belpre
Contact: Site Public Contact
Email: sheree@columbusccop.org
Boardman
Saint Elizabeth Boardman Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Canton
Cleveland Clinic Mercy Hospital
Contact: Site Public Contact
Mercy Hematology and Oncology Associates Inc
Contact: Site Public Contact
Centerville
Dayton Physicians LLC-Miami Valley South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital South
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Chardon
Geauga Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Chillicothe
Adena Regional Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Cincinnati
Bethesda North Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Good Samaritan Hospital - Cincinnati
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Oncology Hematology Care Inc-Kenwood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
TriHealth Cancer Institute-Anderson
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
TriHealth Cancer Institute-Westside
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
University of Cincinnati Cancer Center-UC Medical Center
Contact: Site Public Contact
Email: cancer@uchealth.com
Cleveland
Case Western Reserve University
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Cleveland Clinic Cancer Center/Fairview Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Cleveland Clinic Foundation
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
MetroHealth Medical Center
Contact: Site Public Contact
Email: ababal@metrohealth.org
Columbus
Columbus Oncology and Hematology Associates Inc
Contact: Site Public Contact
Email: sheree@columbusccop.org
Doctors Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grant Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel East Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mount Carmel Health Center West
Contact: Site Public Contact
Email: sheree@columbusccop.org
Ohio State University Comprehensive Cancer Center
Contact: Site Public Contact
Email: Jamesline@osumc.edu
Riverside Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
The Mark H Zangmeister Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dayton
Dayton Physician LLC - Englewood
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Good Samaritan Hospital - Dayton
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Hospital North
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Premier Blood and Cancer Center
Contact: Site Public Contact
Delaware
Delaware Health Center-Grady Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Grady Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dublin
Columbus Oncology and Hematology Associates
Contact: Site Public Contact
Email: sheree@columbusccop.org
Dublin Methodist Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Elyria
Mercy Cancer Center-Elyria
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Findlay
Armes Family Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Blanchard Valley Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Orion Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Franklin
Atrium Medical Center-Middletown Regional Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Dayton Physicians LLC-Atrium
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Gahanna
Central Ohio Breast and Endocrine Surgery
Contact: Site Public Contact
Email: sheree@columbusccop.org
Greenville
Dayton Physicians LLC-Wayne
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Miami Valley Cancer Care and Infusion
Contact: Site Public Contact
Wayne Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Grove City
Mount Carmel Grove City Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Zangmeister Center Grove City
Contact: Site Public Contact
Email: sheree@columbusccop.org
Independence
Cleveland Clinic Cancer Center Independence
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Kettering
First Dayton Cancer Care
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Greater Dayton Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Kettering Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Lancaster
Fairfield Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Lima
Saint Rita's Medical Center
Contact: Site Public Contact
Mansfield
Cleveland Clinic Cancer Center Mansfield
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
OhioHealth Mansfield Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marietta
Marietta Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marion
OhioHealth Marion General Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Marysville
Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Maumee
Toledo Clinic Cancer Centers-Maumee
Contact: Site Public Contact
Email: pshoup@toledoclinic.com
Mayfield Heights
Hillcrest Hospital Cancer Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
UH Seidman Cancer Center at Landerbrook Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Mentor
UH Seidman Cancer Center at Lake Health Mentor Campus
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Middleburg Heights
UH Seidman Cancer Center at Southwest General Hospital
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Mount Vernon
Knox Community Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
New Albany
Mount Carmel New Albany Surgical Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark
Licking Memorial Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Newark Radiation Oncology
Contact: Site Public Contact
Email: sheree@columbusccop.org
Parma
University Hospitals Parma Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Perrysburg
Mercy Health Perrysburg Cancer Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Portsmouth
Southern Ohio Medical Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Ravenna
University Hospitals Portage Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Sandusky
North Coast Cancer Care
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
UH Seidman Cancer Center at Firelands Regional Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Springfield
Springfield Regional Cancer Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Springfield Regional Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Steubenville
Trinity's Tony Teramana Cancer Center
Contact: Site Public Contact
Strongsville
Cleveland Clinic Cancer Center Strongsville
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Toledo
Mercy Health Sylvania Radiation Oncology Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mercy Health - Saint Anne Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Mercy Health - Saint Vincent Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Toledo Clinic Cancer Centers-Toledo
Contact: Site Public Contact
Troy
Dayton Physicians LLC - Troy
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Upper Valley Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
WPAFB
Wright-Patterson Medical Center
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Wadsworth
University Hospitals Sharon Health Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Warren
Saint Joseph Warren Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Warrensville Heights
South Pointe Hospital
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
West Chester
University of Cincinnati Cancer Center-West Chester
Contact: Site Public Contact
Email: cancer@uchealth.com
Westerville
Saint Ann's Hospital
Contact: Site Public Contact
Email: sheree@columbusccop.org
Westlake
UH Seidman Cancer Center at Saint John Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
UHHS-Westlake Medical Center
Contact: Site Public Contact
Email: CTUReferral@UHhospitals.org
Wilmington
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
Contact: Site Public Contact
Wooster
Cleveland Clinic Wooster Family Health and Surgery Center
Contact: Site Public Contact
Email: TaussigResearch@ccf.org
Youngstown
Saint Elizabeth Youngstown Hospital
Contact: Site Public Contact
Email: clinical.trials@daytonncorp.org
Zanesville
Genesis Healthcare System Cancer Care Center
Contact: Site Public Contact
Email: sheree@columbusccop.org
OK
Oklahoma City
Mercy Hospital Oklahoma City
Contact: Site Public Contact
University of Oklahoma Health Sciences Center
Contact: Site Public Contact
Email: ou-clinical-trials@ouhsc.edu
Tulsa
Oklahoma Cancer Specialists and Research Institute-Tulsa
Contact: Site Public Contact
OR
Baker City
Saint Alphonsus Cancer Care Center-Baker City
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Bend
Saint Charles Health System
Contact: Site Public Contact
Email: nosall@stcharleshealthcare.org
Clackamas
Clackamas Radiation Oncology Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Cancer Institute Clackamas Clinic
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Coos Bay
Bay Area Hospital
Contact: Site Public Contact
Email: cherie.cox@bayareahospital.org
Newberg
Providence Newberg Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Ontario
Saint Alphonsus Cancer Care Center-Ontario
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
Oregon City
Providence Willamette Falls Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Portland
Providence Portland Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Providence Saint Vincent Medical Center
Contact: Site Public Contact
Email: CanRsrchStudies@providence.org
Redmond
Saint Charles Health System-Redmond
Contact: Site Public Contact
PA
Allentown
Lehigh Valley Hospital-Cedar Crest
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Altoona
UPMC Altoona
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Bethel Park
UPMC Cancer Center-Bethel Park
Contact: Site Public Contact
Bethlehem
Lehigh Valley Hospital - Muhlenberg
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Bryn Mawr
Bryn Mawr Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Camp Hill
UPMC Camp Hill
Contact: Site Public Contact
Carlisle
Carlisle Regional Cancer Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Chadds Ford
Christiana Care Health System-Concord Health Center
Contact: Site Public Contact
Email: lbarone@christianacare.org
Chambersburg
Chambersburg Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
East Stroudsburg
Pocono Medical Center
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Ephrata
Ephrata Cancer Center
Contact: Site Public Contact
Ephrata Community Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Erie
UPMC Hillman Cancer Center Erie
Contact: Site Public Contact
Email: haneydl@upmc.edu
Gettysburg
Adams Cancer Center
Contact: Site Public Contact
Greensburg
UPMC Cancer Centers - Arnold Palmer Pavilion
Contact: Site Public Contact
Hanover
WellSpan Medical Oncology and Hematology
Contact: Site Public Contact
Harrisburg
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Contact: Site Public Contact
Email: klitchfield@PINNACLEHEALTH.org
UPMC Pinnacle Harrisburg
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Hazleton
Lehigh Valley Hospital-Hazleton
Contact: Site Public Contact
Email: Morgan_M.Horton@lvhn.org
Lebanon
Sechler Family Cancer Center
Contact: Site Public Contact
Email: doxenberg@wellspan.org
McKeesport
UPMC Cancer Center at UPMC McKeesport
Contact: Site Public Contact
Mechanicsburg
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Contact: Site Public Contact
Email: haneydl@upmc.edu
Media
Riddle Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
North Huntingdon
Arnold Palmer Cancer Center Medical Oncology Norwin
Contact: Site Public Contact
Email: haneydl@upmc.edu
Paoli
Paoli Memorial Hospital
Contact: Site Public Contact
Email: turzoe@mlhs.org
Philadelphia
Fox Chase Cancer Center
Contact: Site Public Contact
Penn Presbyterian Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Temple University Hospital
Contact: Site Public Contact
University of Pennsylvania/Abramson Cancer Center
Contact: Site Public Contact
Pittsburgh
Oncology Hematology Association
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
UPMC-Mercy Hospital
Contact: Site Public Contact
UPMC-Passavant Hospital
Contact: Site Public Contact
UPMC-Saint Clair Hospital Cancer Center
Contact: Site Public Contact
UPMC-Saint Margaret
Contact: Site Public Contact
University of Pittsburgh Cancer Institute (UPCI)
Contact: Site Public Contact
Pottstown
Pottstown Hospital
Contact: Site Public Contact
Seneca
UPMC Cancer Center at UPMC Northwest
Contact: Site Public Contact
Washington
UPMC Cancer Center-Washington
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Wynnewood
Lankenau Medical Center
Contact: Site Public Contact
Email: turzoe@mlhs.org
York
Cancer Care Associates of York
Contact: Site Public Contact
UPMC Memorial
Contact: Site Public Contact
WellSpan Health-York Cancer Center
Contact: Site Public Contact
WellSpan Health-York Hospital
Contact: Site Public Contact
RI
Warwick
Kent Hospital
Contact: Site Public Contact
Westerly
Smilow Cancer Hospital Care Center - Westerly
Contact: Site Public Contact
Email: canceranswers@yale.edu
SC
Bluffton
Saint Joseph's/Candler - Bluffton Campus
Contact: Site Public Contact
Email: underberga@sjchs.org
Boiling Springs
Prisma Health Cancer Institute - Spartanburg
Contact: Site Public Contact
Charleston
Medical University of South Carolina
Contact: Site Public Contact
Email: hcc-clinical-trials@musc.edu
Ralph H Johnson VA Medical Center
Contact: Site Public Contact
Email: ashley.salvo@va.gov
Columbia
Prisma Health Richland Hospital
Contact: Site Public Contact
Gaffney
Gibbs Cancer Center-Gaffney
Contact: Site Public Contact
Email: kmertz-rivera@gibbscc.org
Georgetown
Tidelands Georgetown Memorial Hospital
Contact: Site Public Contact
Email: broe@tidelandshealth.org
Greenville
Prisma Health Cancer Institute - Butternut
Contact: Site Public Contact
Prisma Health Cancer Institute - Eastside
Contact: Site Public Contact
Prisma Health Cancer Institute - Faris
Contact: Site Public Contact
Prisma Health Greenville Memorial Hospital
Contact: Site Public Contact
Greenwood
Self Regional Healthcare
Contact: Site Public Contact
Email: nmcgaha@selfregional.org
Greer
Gibbs Cancer Center-Pelham
Contact: Site Public Contact
Email: kmertz-rivera@gibbscc.org
Prisma Health Cancer Institute - Greer
Contact: Site Public Contact
Hilton Head Island
South Carolina Cancer Specialists PC
Contact: Site Public Contact
Email: underberga@sjchs.org
Myrtle Beach
Carolina Regional Cancer Center
Contact: Site Public Contact
Rock Hill
Levine Cancer Institute-Rock Hill
Contact: Site Public Contact
Seneca
Prisma Health Cancer Institute - Seneca
Contact: Site Public Contact
Spartanburg
North Grove Medical Park
Contact: Site Public Contact
Spartanburg Medical Center
Contact: Site Public Contact
Email: kmertz-rivera@gibbscc.org
Spartanburg Medical Center - Mary Black Campus
Contact: Site Public Contact
Union
MGC Hematology Oncology-Union
Contact: Site Public Contact
Email: kmertz-rivera@gibbscc.org
SD
Rapid City
Rapid City Regional Hospital
Contact: Site Public Contact
Email: research@rcrh.org
Sioux Falls
Sanford Cancer Center Oncology Clinic
Contact: Site Public Contact
Email: OncologyClinicTrialsSF@sanfordhealth.org
Sanford USD Medical Center - Sioux Falls
Contact: Site Public Contact
Email: OncologyClinicalTrialsSF@SanfordHealth.org
TN
Alcoa
University Cancer Specialists - Alcoa
Contact: Site Public Contact
Email: bherbert@utmck.edu
Bristol
Bristol Regional Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Chattanooga
Memorial Hospital
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Collierville
Baptist Memorial Hospital and Cancer Center-Collierville
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Franklin
Vanderbilt-Ingram Cancer Center Cool Springs
Contact: Site Public Contact
Vanderbilt-Ingram Cancer Center at Franklin
Contact: Site Public Contact
Hixson
Pulmonary Medicine Center of Chattanooga-Hixson
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Kingsport
Ballad Health Cancer Care – Kingsport
Contact: Site Public Contact
Email: Justin.reynolds@balladhealth.org
Wellmont Holston Valley Hospital and Medical Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Knoxville
University of Tennessee - Knoxville
Contact: Site Public Contact
Memphis
Baptist Memorial Hospital and Cancer Center-Memphis
Contact: Site Public Contact
Email: BCCclintrials@bmhcc.org
Nashville
Vanderbilt Breast Center at One Hundred Oaks
Contact: Site Public Contact
Vanderbilt University/Ingram Cancer Center
Contact: Site Public Contact
Ooltewah
Memorial GYN Plus
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
TX
Baytown
Houston Methodist San Jacinto Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Bryan
Saint Joseph Regional Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Dallas
Dallas VA Medical Center
Contact: Site Public Contact
Email: ecog.rss@jimmy.harvard.edu
Parkland Memorial Hospital
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
UT Southwestern Simmons Cancer Center - RedBird
Contact: Site Public Contact
Email: canceranswerline@utsouthwestern.edu
UT Southwestern/Simmons Cancer Center-Dallas
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Fort Worth
Tarrant County Hospital District/JPS Health Network
Contact: Site Public Contact
Email: macosta02@jpshealth.org
UT Southwestern/Simmons Cancer Center-Fort Worth
Contact: Site Public Contact
Email: canceranswerline@UTSouthwestern.edu
Houston
Houston Methodist Hospital
Contact: Site Public Contact
Houston Methodist West Hospital
Contact: Site Public Contact
Methodist Willowbrook Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Nassau Bay
Houston Methodist Saint John Hospital
Contact: Site Public Contact
Email: ctsucontact@westat.com
Richardson
UT Southwestern Clinical Center at Richardson/Plano
Contact: Site Public Contact
Email: Suzanne.cole@utsouthwestern.edu
Sugar Land
Houston Methodist Sugar Land Hospital
Contact: Site Public Contact
The Woodlands
Houston Methodist The Woodlands Hospital
Contact: Site Public Contact
Email: hmthewoodlands@houstonmethodist.org
UT
American Fork
American Fork Hospital / Huntsman Intermountain Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Cedar City
Sandra L Maxwell Cancer Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Logan
Logan Regional Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Murray
Intermountain Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Ogden
McKay-Dee Hospital Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Provo
Utah Valley Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Riverton
Riverton Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Saint George
Saint George Regional Medical Center
Contact: Site Public Contact
Email: officeofresearch@imail.org
Salt Lake City
LDS Hospital
Contact: Site Public Contact
Email: officeofresearch@imail.org
Utah Cancer Specialists-Salt Lake City
Contact: Site Public Contact
Email: officeofresearch@imail.org
VA
Bristol
Wellmont Medical Associates-Bristol
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Charlottesville
University of Virginia Cancer Center
Contact: Site Public Contact
Email: uvacancertrials@hscmail.mcc.virginia.edu
Fishersville
Augusta Health Center for Cancer and Blood Disorders
Contact: Site Public Contact
Norton
Southwest VA Regional Cancer Center
Contact: Site Public Contact
Email: justin.reynolds@wellmont.org
Richmond
VCU Massey Cancer Center at Stony Point
Contact: Site Public Contact
Email: ctoclinops@vcu.edu
Virginia Cancer Institute
Contact: Site Public Contact
Email: smoore@vacancer.com
Virginia Commonwealth University/Massey Cancer Center
Contact: Site Public Contact
Email: CTOclinops@vcu.edu
South Hill
VCU Community Memorial Health Center
Contact: Site Public Contact
Email: nemer.elmouallem@vcuhealth.org
VT
Berlin
Central Vermont Medical Center/National Life Cancer Treatment
Contact: Site Public Contact
Burlington
University of Vermont Medical Center
Contact: Site Public Contact
Email: rpo@uvm.edu
University of Vermont and State Agricultural College
Contact: Site Public Contact
Email: rpo@uvm.edu
Saint Johnsbury
Dartmouth Cancer Center - North
Contact: Site Public Contact
Email: cancer.research.nurse@hitchcock.org
WA
Aberdeen
Providence Regional Cancer System-Aberdeen
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Auburn
MultiCare Auburn Medical Center
Contact: Site Public Contact
Email: research@multicare.org
Bellevue
Overlake Medical Center
Contact: Site Public Contact
Email: OHMCResearch@overlakehospital.org
Bellingham
PeaceHealth Saint Joseph Medical Center
Contact: Site Public Contact
Bremerton
Harrison HealthPartners Hematology and Oncology-Bremerton
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Burien
Highline Medical Center-Main Campus
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Centralia
Providence Regional Cancer System-Centralia
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Edmonds
Swedish Cancer Institute-Edmonds
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Enumclaw
Saint Elizabeth Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Everett
Providence Regional Cancer Partnership
Contact: Site Public Contact
Email: marilyn.birchman@providence.org
Federal Way
Saint Francis Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Gig Harbor
MultiCare Gig Harbor Medical Park
Contact: Site Public Contact
Email: research@multicare.org
Issaquah
Swedish Cancer Institute-Issaquah
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Kennewick
Kadlec Clinic Hematology and Oncology
Contact: Site Public Contact
Email: research@kadlecmed.org
Lacey
Providence Regional Cancer System-Lacey
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Lakewood
Saint Clare Hospital
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Longview
PeaceHealth Saint John Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Port Townsend
Jefferson Healthcare
Contact: Site Public Contact
Poulsbo
Harrison HealthPartners Hematology and Oncology-Poulsbo
Contact: Site Public Contact
Email: clinicaltrials@sfmc-gi.org
Puyallup
MultiCare Good Samaritan Hospital
Contact: Site Public Contact
Email: research@multicare.org
Renton
Valley Medical Center
Contact: Site Public Contact
Email: research@valleymed.org
Seattle
Kaiser Permanente Washington
Contact: Site Public Contact
Email: KPWAoncologytrials@kp.org
Pacific Gynecology Specialists
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Ballard Campus
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-Cherry Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Swedish Medical Center-First Hill
Contact: Site Public Contact
Email: PCRC-NCORP@Swedish.org
Sedro-Woolley
PeaceHealth United General Medical Center
Contact: Site Public Contact
Email: lkey@peacehealth.org
Shelton
Providence Regional Cancer System-Shelton
Contact: Site Public Contact
Email: deidre.dillon@providence.org
Silverdale
Saint Michael Cancer Center
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Spokane
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Deaconess Cancer and Blood Specialty Center - North
Contact: Site Public Contact
Email: research@multicare.org
Spokane Valley
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
Contact: Site Public Contact
Email: research@multicare.org
Tacoma
Franciscan Research Center-Northwest Medical Plaza
Contact: Site Public Contact
Email: ResearchInstituteInquiries@CommonSpirit.org
Mary Bridge Children's Hospital and Health Center
Contact: Site Public Contact
Email: research@multicare.org
MultiCare Tacoma General Hospital
Contact: Site Public Contact
Email: research@multicare.org
Northwest Medical Specialties PLLC
Contact: Site Public Contact
Email: research@southsoundcare.org
Vancouver
PeaceHealth Southwest Medical Center
Contact: Site Public Contact
Email: kmakin-bond@peacehealth.org
Walla Walla
Providence Saint Mary Regional Cancer Center
Contact: Site Public Contact
Email: Cheryl.Dodd@providence.org
Yakima
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Contact: Site Public Contact
Email: Memorial-ClinicalTrials@yvmh.org
Yelm
Providence Regional Cancer System-Yelm
Contact: Site Public Contact
Email: deidre.dillon@providence.org
WI
Antigo
Langlade Hospital and Cancer Center
Contact: Site Public Contact
Email: Juli.Alford@aspirus.org
Appleton
Ascension Saint Elizabeth Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
Ashland
Duluth Clinic Ashland
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Northwest Wisconsin Cancer Center
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Baraboo
SSM Health Dean Medical Group - Baraboo
Contact: Site Public Contact
Brookfield
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Burlington
Aurora Cancer Care-Southern Lakes VLCC
Contact: Site Public Contact
Email: ncorp@aurora.org
Chilton
Ascension Calumet Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
Cudahy
Aurora Saint Luke's South Shore
Contact: Site Public Contact
Email: ncorp@aurora.org
Eau Claire
HSHS Sacred Heart Hospital
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Marshfield Medical Center-EC Cancer Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mayo Clinic Health System Eau Claire Hospital-Luther Campus
Contact: Site Public Contact
Mayo Clinic Health System-Eau Claire Clinic
Contact: Site Public Contact
Fond Du Lac
Aurora Health Center-Fond du Lac
Contact: Site Public Contact
Email: ncorp@aurora.org
Franklin
Ascension Saint Francis - Reiman Cancer Center
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Germantown
Aurora Health Care Germantown Health Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Grafton
Aurora Cancer Care-Grafton
Contact: Site Public Contact
Email: ncorp@aurora.org
Green Bay
Aurora BayCare Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Saint Vincent Hospital Cancer Center Green Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Saint Vincent Hospital Cancer Center at Saint Mary's
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Hayward
Essentia Health-Hayward Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Janesville
Mercyhealth Hospital and Cancer Center - Janesville
Contact: Site Public Contact
Email: oncologyclinicaltrials@mhemail.org
SSM Health Dean Medical Group - Janesville
Contact: Site Public Contact
Kenosha
Aurora Cancer Care-Kenosha South
Contact: Site Public Contact
Email: ncorp@aurora.org
La Crosse
Gundersen Lutheran Medical Center
Contact: Site Public Contact
Email: cancerctr@gundersenhealth.org
Mayo Clinic Health System-Franciscan Healthcare
Contact: Site Public Contact
Madison
SSM Health Dean Medical Group - South Madison Campus
Contact: Site Public Contact
University of Wisconsin Carbone Cancer Center - University Hospital
Contact: Site Public Contact
Manitowoc
Holy Family Memorial Hospital
Contact: Site Public Contact
Marinette
Aurora Bay Area Medical Group-Marinette
Contact: Site Public Contact
Email: ncorp@aurora.org
Saint Vincent Hospital Cancer Center at Marinette
Contact: Site Public Contact
Email: Christy.Gilchrist@hshs.org
Marshfield
Marshfield Medical Center-Marshfield
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Medford
Aspirus Medford Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Mequon
Ascension Columbia Saint Mary's Hospital Ozaukee
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Milwaukee
Ascension Columbia Saint Mary's Hospital - Milwaukee
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Milwaukee
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Saint Luke's Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Aurora Sinai Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Minocqua
Marshfield Clinic-Minocqua Center
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Mukwonago
ProHealth D N Greenwald Center
Contact: Site Public Contact
Email: research.institute@phci.org
New Richmond
Cancer Center of Western Wisconsin
Contact: Site Public Contact
Email: mmcorc@healthpartners.com
Oconomowoc
ProHealth Oconomowoc Memorial Hospital
Contact: Site Public Contact
Oconto Falls
Saint Vincent Hospital Cancer Center at Oconto Falls
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Oshkosh
Ascension Mercy Hospital
Contact: Site Public Contact
Email: AWRI.inquiry@ascension.org
Vince Lombardi Cancer Clinic - Oshkosh
Contact: Site Public Contact
Email: ncorp@aurora.org
Racine
Ascension All Saints Hospital
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Racine
Contact: Site Public Contact
Email: ncorp@aurora.org
Rhinelander
Ascension Saint Mary's Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Rice Lake
Marshfield Medical Center-Rice Lake
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sheboygan
HSHS Saint Nicholas Hospital
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Saint Vincent Hospital Cancer Center at Sheboygan
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Sheboygan Phyisicans Group
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Vince Lombardi Cancer Clinic-Sheboygan
Contact: Site Public Contact
Email: ncorp@aurora.org
Spooner
Essentia Health-Spooner Clinic
Contact: Site Public Contact
Email: CancerTrials@EssentiaHealth.org
Stevens Point
Ascension Saint Michael's Hospital
Contact: Site Public Contact
Email: Beth.Knetter@aspirus.org
Marshfield Medical Center-River Region at Stevens Point
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Sturgeon Bay
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Contact: Site Public Contact
Email: ewd_research_admin@hshs.org
Summit
Aurora Medical Center in Summit
Contact: Site Public Contact
Email: ncorp@aurora.org
Superior
Essentia Health Saint Mary's Hospital - Superior
Contact: Site Public Contact
Two Rivers
Vince Lombardi Cancer Clinic-Two Rivers
Contact: Site Public Contact
Email: ncorp@aurora.org
Waukesha
ProHealth Waukesha Memorial Hospital
Contact: Site Public Contact
UW Cancer Center at ProHealth Care
Contact: Site Public Contact
Email: Chanda.miller@phci.org
Wausau
Aspirus Regional Cancer Center
Contact: Site Public Contact
Wauwatosa
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Contact: Site Public Contact
Email: AWRI.Inquiry@Ascension.org
Aurora Cancer Care-Milwaukee West
Contact: Site Public Contact
Email: ncorp@aurora.org
West Allis
Aurora West Allis Medical Center
Contact: Site Public Contact
Email: ncorp@aurora.org
Weston
Marshfield Medical Center - Weston
Contact: Site Public Contact
Email: oncology.clinical.trials@marshfieldresearch.org
Wisconsin Rapids
Aspirus Cancer Care - Wisconsin Rapids
Contact: Site Public Contact
WV
Charleston
West Virginia University Charleston Division
Contact: Site Public Contact
Huntington
Edwards Comprehensive Cancer Center
Contact: Site Public Contact
Email: Christina.Cole@chhi.org
WY
Cheyenne
Cheyenne Regional Medical Center-West
Contact: Site Public Contact
Email: ccrp@co-cancerresearch.org
Cody
Billings Clinic-Cody
Contact: Site Public Contact
Email: research@billingsclinic.org
Sheridan
Welch Cancer Center
Contact: Site Public Contact
Email: mccinfo@mtcancer.org
PRIMARY OBJECTIVE: I. To evaluate overall survival (OS) in each of the 2 experimental arms (Arms A and B) to control (Arm C). SECONDARY OBJECTIVES: I. To evaluate progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 for Arm C versus each of Arms A and B. II. To evaluate best objective response rates per RECIST 1.1 for Arm C versus each of Arms A and B. III. To estimate toxicity within each of the treatment arms via the Common Terminology Criteria for Adverse Events (CTCAE) criteria. IV. To compare outcomes between Arms A and B. V. To compare outcomes by treatment arm within subgroups defined by a cutpoint of PD-L1 expression at >= 50%. BIOMARKER OBJECTIVE: I. To collect and bank tissue and blood for future research studies, including potential development of a prognostic and predictive signature for pembrolizumab (MK-3475) in combination with chemotherapy versus pembrolizumab (MK-3475) alone. EXPLORATORY IMAGING OBJECTIVES: I. To collect and bank standard of care computed tomography (CT) imaging at baseline and first three follow-up post-treatment scans on first line treatment for validating the radiomic risk score with the following exploratory objectives: Ia. To determine the negative predictive value (NPV) by validating the Radiomic Risk score on pre-treatment scans as well as compute differences between pre- and post- treatment scans (delta features) in determining which patients will benefit from first line pembrolizumab in the metastatic setting in both low (< 50%) and high (> 50%) PD-L1 cohorts using patients in Arm 1 and Arm 2 of the trial where pembrolizumab is used as first line treatment. Ib. To determine the positive predictive value (PPV) by validating the Radiomic Risk score in order to predict which patients would benefit from combination pembrolizumab and subsequent chemotherapy vs. immunotherapy alone in both low (< 50%) and high (> 50%) PD-L1 cohorts using patients who went on to receive chemotherapy as second line and stratifying the patients based on those who received benefit from pembrolizumab plus chemotherapy versus (vs.) pembrolizumab alone. OUTLINE: Patients are randomized to 1 of 3 arms. ARM A: Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pemetrexed IV over 10 minutes and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then may receive pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity. ARM B: Patients receive pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. Within 6 weeks of disease progression, patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed. ARM C: Patients receive pembrolizumab IV over 30 minutes, pemetrexed IV over 10 minutes, and carboplatin IV over 30 minutes on day 1. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive pembrolizumab IV over 30 minutes and pemetrexed IV over 10 minutes on day 1. Cycles repeat every 21 days for up to 2 years for pembrolizumab in the absence of disease progression or unacceptable toxicity and until to disease progression for pemetrexed. Patients undergo magnetic resonance imaging (MRI) during screening, CT scan and blood sample collection throughout the study, and may undergo position emission tomography (PET) scan throughout the study. After completion of study treatment, patients are followed up for 5 years.
Interactive content above is from the official study record on the National Cancer Institute website, cancer.gov.
The ECOG-ACRIN Cancer Research Group designed this trial and is conducting it with funding from the National Cancer Institute through its National Clinical Trials Network.