Constantine A. Gatsonis, PhD, has been affiliated with the organization as a statistical leader since 1999. He is a leading authority on the design and analysis of clinical trials of diagnostic and screening modalities. He also has extensive involvement in methodologic research in medical technology assessment, health services research, and comparative effectiveness research. Under his leadership of the ECOG-ACRIN Biostatistics and Data Management Center, located at the Brown University School of Public Health in Providence, Rhode Island, he is the lead statistician for the Tomosynthesis Mammographic Imaging Screening Trial (TMIST) and several other ECOG-ACRIN clinical trials, both ongoing and planned. The Digital Mammography Imaging Screening Trial (DMIST) and the National Lung Screening Trial (NLST) occurred under his methodologic leadership. He was the lead statistician for the International Breast Magnetic Resonance Imaging Consortium, whose study published in 2004.
He is a professor of biostatistics at Brown University. He works extensively on the development of statistical methods for the evaluation of diagnostic tests and biomarkers. He has published on a methodology for receiver operating characteristic analysis, the assessment of the predictive value of tests, and the design of reader studies, as well as on broader issues in the evaluation and validation of diagnostic tests and imaging biomarkers.
Dr. Gatsonis first became part of the Group as the Network Statistician for the American College of Radiology Imaging Network (ACRIN) when the network was founded in 1999. When ACRIN merged with the Eastern Cooperative Oncology Group in 2012 to form the ECOG-ACRIN Cancer Research Group, Dr. Gatsonis became a Group Statistician for ECOG-ACRIN.
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