The addition of annual screening ultrasound to mammography, or the addition of a single screening with magnetic resonance imaging (MRI) after 3 years of both annual mammography and ultrasound screenings, was associated with a breast cancer detection benefit in women with an increased risk of breast cancer and dense breasts in the ACRIN 6666 clinical trial, the results of which were published in the April 4, 2012 issue of the Journal of the American Medical Association.
“For women with dense breasts who are at increased risk for breast cancer, adding ultrasound to mammography will increase the chance of finding invasive cancer before it spreads to lymph nodes,” says the trial’s principal investigator Wendie Berg, MD, PhD, and Professor of Radiology at the University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC. “MRI detected additional invasive cancers not seen on mammography or ultrasound; however, we found that MRI was significantly less tolerable than mammography or ultrasound for many study participants. Of participants offered an MRI, only 58% accepted the invitation.”
Complete author list: Wendie A. Berg, Zheng Zhang, Daniel Lehrer, Roberta A. Jong, Etta D. Pisano, Richard G. Barr, Marcela Böhm-Vélez, Mary C. Mahoney, W. Phil Evans, Linda H. Larsen, Marilyn J. Morton, Ellen B. Mendelson, Dione M. Farria, Jean B. Cormack, Helga S. Marques, Amanda Adams, Nolin M. Yeh, and Glenna Gabrielli; for the ACRIN 6666 Investigators.
Citation: Berg WA, Zhang Z, Lehrer D, et al. Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk. JAMA. 2012;307(13):1394-1404.
View the video of an interview with lead author Wendie Berg, MD, conducted at the 2011 meeting of the Radiological Society of North America
Trial Registration at www.ClinicalTrials.gov: NCT00072501