Testing Interleukin-12 to Determine Its Potential in Treating Advanced Cervical Cancer (A Phase II Trial)
Eastern Cooperative Oncology Group, through the NCI-sponsored Cancer Cooperative Group Program
Purpose of the Study
Interleukin-12 is an experimental drug that enhances the body’s disease-fighting ability and kills some types of cancer cells. The purpose of this phase II trial was to test the anticancer effect of Interleukin-12 in treating cervical cancer that has advanced, returned or cannot be treated with surgery and to evaluate the side effects of this treatment.
While interleukin-12 enhanced patients’ ability to fight some viruses associated with cervical cancer, it did not slow, stop or decrease cancer growth. The study showed that interleukin-12 is not a promising therapy for advanced, recurrent or inoperable cervical cancer.
July 17, 1997
May 8, 2001
Number of Participating Patients
Patients had measurable cervical cancer that could not be treated with conventional therapy or that had returned or not been stopped by previous radiation or surgery.
Patients received one dose of interleukin-12 to help their bodies get used to the drug. Two weeks later, each patient received daily injections of the interleukin-12 in a vein for five days. The five daily injections were repeated every three weeks for a total of 16 injections.
The most frequent side effects were anemia, liver problems, fever, nausea, and lowered susceptibility to infection.
Additional Information at ClinicalTrials.gov