Using Interferon Gamma to Treat Malignant Carcinoid Tumors That Have Spread and Are No Longer Treatable with Surgery or Radiation (A Phase II Trial)
Eastern Cooperative Oncology Group through the NCI-sponsored Cancer Cooperative Group Program
Purpose of the Study
Inteferon gamma has been shown in preliminary trials to slow the growth of some carcinoid cancer cells. The purpose of this study is to determine the safety, usefulness and side effects of interferon gamma in treating malignant carcinoid tumors.
This study showed that interferon gamma does not have a significant anti-cancer effect in treating carcinoid tumors. Only 6.25 percent of patients in the study had a decrease in the size or extent of their tumor. The tumor stayed about the same in 58.3 percent and in 31.3 percent of patients, the disease progressed.
Interferon gamma has only minimal antitumor effects in carcinoid tumor. It should not be considered standard therapy, and there are currently no plans for future study.
March 28, 1996
February 27, 1998
Number of Participating Patients
Patients were at least 18 years old, had measurable carcinoid tumors, had no bone or central nervous system disease, no previous chemotherapy or biological therapy and no recent radiation therapy or surgery.
Patients received interferon gamma by injection under the skin each day for at least eight weeks. If after eight weeks their disease improved or stayed the same, they continued daily injections for as long as they were helped. Treatment was stopped if their condition became worse.
The most common side effects included lowering of blood counts, fever, fatigue, flu-like symptoms, nausea and vomiting.